Daniel Irimia
@daniel-irimia.bsky.social
Biomedical scientist studying how neutrophils cooperate during infections and how, sometime, they fail.
Reposted by Daniel Irimia
Researchers compared blood from Long Covid patients with healthy controls, focusing on two features: microclots and NETs (neutrophil extracellular traps). 2/
www.independent.co.uk/news/science...
www.independent.co.uk/news/science...
Long Covid has done something strange to people’s blood
Tiny clots appeared larger-than-normal in long Covid patients, study finds
www.independent.co.uk
November 17, 2025 at 12:25 PM
Researchers compared blood from Long Covid patients with healthy controls, focusing on two features: microclots and NETs (neutrophil extracellular traps). 2/
www.independent.co.uk/news/science...
www.independent.co.uk/news/science...
Reposted by Daniel Irimia
Research source: 'Circulating Microclots Are Structurally Associated With Neutrophil Extracellular Traps and Their Amounts Are Elevated in Long COVID Patients - Thierry et al - 2025 - Journal of Medical Virology - Wiley Online Library.' onlinelibrary.wiley.com/doi/10.1002/...
#LongCOVID
#LongCOVID
Circulating Microclots Are Structurally Associated With Neutrophil Extracellular Traps and Their Amounts Are Elevated in Long COVID Patients
The persistence of vasculo-thrombotic complications has been put forward as a possible contributing factor in the Long COVID (LC) syndrome. Given the recently reported separate demonstration of the a....
onlinelibrary.wiley.com
November 20, 2025 at 3:51 PM
Research source: 'Circulating Microclots Are Structurally Associated With Neutrophil Extracellular Traps and Their Amounts Are Elevated in Long COVID Patients - Thierry et al - 2025 - Journal of Medical Virology - Wiley Online Library.' onlinelibrary.wiley.com/doi/10.1002/...
#LongCOVID
#LongCOVID
Reposted by Daniel Irimia
To learn more about this NEJM Illustrated Glossary term, read the editorial “Defanging the Neutrophil to Treat Bronchiectasis” by Adam T. Hill, MD: nej.md/4cANv89
Explore more terms: nej.md/glossary
Explore more terms: nej.md/glossary
July 4, 2025 at 7:02 PM
To learn more about this NEJM Illustrated Glossary term, read the editorial “Defanging the Neutrophil to Treat Bronchiectasis” by Adam T. Hill, MD: nej.md/4cANv89
Explore more terms: nej.md/glossary
Explore more terms: nej.md/glossary
Reposted by Daniel Irimia
This is a technical feat showing the progress in sample processing an instrument sensitivity, as we estimate we inject 30pg of protein content from a single neutrophil. Yet we can detect >3,000 proteins from 500 neutrophils and >1,100 from a single GBM associated neutrophil!
July 27, 2025 at 12:28 PM
This is a technical feat showing the progress in sample processing an instrument sensitivity, as we estimate we inject 30pg of protein content from a single neutrophil. Yet we can detect >3,000 proteins from 500 neutrophils and >1,100 from a single GBM associated neutrophil!
While this inhibitor also reduces the potency of neutrophils against infections, it remains to be seen how much the risk for fungal and bacterial infections increases in the treated patients.
August 12, 2025 at 11:33 PM
While this inhibitor also reduces the potency of neutrophils against infections, it remains to be seen how much the risk for fungal and bacterial infections increases in the treated patients.
DPP1 cleaves the inactive proenzymes of neutrophil elastase (NE), proteinase 3 (PR3), and cathepsin G (CatG) in neutrophil precursor cells during their development in the bone marrow. In bronchiectasis (NCFB), the inhibition of DPP1 may reduce neutrophil-driven inflammation and avoid lung damage.
August 12, 2025 at 11:33 PM
DPP1 cleaves the inactive proenzymes of neutrophil elastase (NE), proteinase 3 (PR3), and cathepsin G (CatG) in neutrophil precursor cells during their development in the bone marrow. In bronchiectasis (NCFB), the inhibition of DPP1 may reduce neutrophil-driven inflammation and avoid lung damage.