Catalina Vasilescu, PhD
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cvasilescu.bsky.social
Catalina Vasilescu, PhD
@cvasilescu.bsky.social
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Biomedical researcher studying mitochondrial disorders. PhD from Anu Suomalainen lab, Helsinki. Postdoc at Prokisch lab, Munich.
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Catalina Vasilescu, PhD @cvasilescu.bsky.social · Nov 15
#Therapies for #mitochondrial #disorders community.

You are welcome to join by commenting below!

go.bsky.app/BnMQq9C

#therapy #mitochondria #mitochondrialdisease
cvasilescu.bsky.social
Rich collections of papers on #mitochondrialdisease from the last 2 weeks! 📚
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...

@biomednews.bsky.social @mitoscientist.bsky.social
@gavinmcstay.bsky.social

Demethoxy-CoQ and NUDT5 in nucleotide synthesis
www.nature.com/articles/s42...
Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism
A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...
www.nature.com
November 23, 2025 at 11:59 AM
Reposted by Catalina Vasilescu, PhD
frezzalab.bsky.social
Good Sunday, all. What a great week for #cancermetabolism and #mitochondrialbiology. Find here a selection of groundbreaking discoveries: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"Trying to define yourself is like trying to bite your own teeth."-Alan Watts
November 23, 2025 at 6:51 AM
Reposted by Catalina Vasilescu, PhD
gzaffagnini.bsky.social
Ho ho ho, happy Sunday egg-ficionados! Here is another great issue of #cebooc: biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/41241715/
Runner-up: pubmed.ncbi.nlm.nih.gov/41271398/

Thanks @biomednews.bsky.social for preselecting!
November 23, 2025 at 8:01 AM
Reposted by Catalina Vasilescu, PhD
ritahorvath.bsky.social
www.gimjournal.org/article/S109...
I am very proud of this new paper! Congratulations to Thiloka and the team of young researchers! 👍
Charting the phenotypic landscape of mitochondrial diseases through a systematic evaluation of pathogenic mitochondrial DNA and nuclear gene variants
Primary mitochondrial diseases (PMD) arise from variants in the mitochondrial or nuclear genomes. Phenotype-based recognition of specific PMD genotypes remains difficult, prolonging the diagnostic ody...
www.gimjournal.org
November 22, 2025 at 8:47 AM
Reposted by Catalina Vasilescu, PhD
ryanlab.bsky.social
Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism

This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.

Please check it out!

www.nature.com/articles/s41...
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice - Nature Communications
Inherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNAAla mutation (m.5019A>G) in mice and demonstrate that macrophages...
www.nature.com
November 20, 2025 at 4:09 PM
Reposted by Catalina Vasilescu, PhD
frisophagy.bsky.social
Only good papers on mitophagy this week!

biomed.news/bims-tofagi/...

Highlights:
-The bottleneck for maternal transmission of mtDNA is linked to purifying selection by autophagy
-Piecemeal Mitochondrial degradation in plants
-Allophagy?!

Thanks to @biomednews.bsky.social
Altered bottleneck and mitochondrial turnover affect mtDNA mutation load and selection efficiency. (A) Mutational burden was quantified as the total number of mtDNA variants detected per animal. (B) For each animal, the mtDNA N/S ratio was calculated by dividing the number of nonsynonymous variants, normalized to the number of possible nonsynonymous variants in the mitochondrial genome, by the number of synonymous variants, normalized to the number of possible synonymous sites. For (A) and (B): dashed line, median value of the Polg+/+ control group; dotted line, modal value of the Polg+/+ control group; gray, Polg+/+ control group; orange, Polg+/+ Tfam+/− group; blue, Polg+/+ Tfam+/OE group; green, Polg+/+ Bcl2l13−/− group; and pink, Polg+/+ Ulk2−/− group.
November 16, 2025 at 10:53 AM
Reposted by Catalina Vasilescu, PhD
cyrilpedia.bsky.social
"Ora a ciência contribui de forma ampla para o desenvolvimento de toda a sociedade: não é necessário subordinar o seu financiamento ao Ministério da Economia para gerar crescimento económico (...) Este é um erro de conceção."
Por uma ciência autónoma, ambiciosa e responsável
Reformas desta escala, quando feitas sem um claro desenho institucional, modelo de governança e plano de transição rigoroso, correm o risco de gerar incerteza, inércia e paralisia administrativa.
www.publico.pt
November 16, 2025 at 10:42 AM
Reposted by Catalina Vasilescu, PhD
frezzalab.bsky.social
Good Sunday!. A wonderful selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"99.9 per cent of everything you think, and of everything you do, is for yourself—and there isn't one."
-Wei Wu Wei
November 16, 2025 at 7:04 AM
Reposted by Catalina Vasilescu, PhD
gzaffagnini.bsky.social
It's Sunday again and a new issue of #cebooc is out!
biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/41223274/ on the maternal #mitochondria selection

Runner-up: pubmed.ncbi.nlm.nih.gov/41210958/

Thanks @biomednews.bsky.social for preselecting!
November 16, 2025 at 8:27 AM
Reposted by Catalina Vasilescu, PhD
jourdainlab.bsky.social
Very excited to share the published version of our #uridine #CRISPR screen in naturemetabolism.bsky.social! 🎉

Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team!

#NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social

🔗 www.nature.com/articles/s42...
🧵1/17
Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism
A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...
www.nature.com
November 13, 2025 at 10:19 AM
Reposted by Catalina Vasilescu, PhD
ryanlab.bsky.social
Last week's #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

Intracellular Salmonella hijacks the mitochondrial citrate carrier to evade host oxidative defenses
November 10, 2025 at 9:23 AM
Reposted by Catalina Vasilescu, PhD
theresearch.bsky.social
Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social

includes research on: vector-stimuli-responsive magnetorheological fibrous materials, mechanophore crosslinkers, humidity responsive origami metamaterials, & more 🧪
Vector-stimuli-responsive magnetorheological fibrous materials - Nature
Vector-stimuli-responsive magnetorheological fibrous materials can be mass-produced, which can be assembled into yarns and woven into a variety of fabrics with actuation and stiffening abilities.
www.nature.com
November 9, 2025 at 4:45 PM
Reposted by Catalina Vasilescu, PhD
andreamorandi.bsky.social
Here is my weekly selection of #anticancer #therapy and #metabolic #reprogramming! Super interesting papers this issue (including our last study😂🤩😛) Enjoy! 🙏 @biomednews.bsky.social biomed.news/bims-meract/...
a man says i need you to pick one
ALT: a man says i need you to pick one
media.tenor.com
November 9, 2025 at 8:23 AM
Reposted by Catalina Vasilescu, PhD
asofiahcosta.bsky.social
This week's manually curated selection of novel methods for small molecule analysis

biomed.news/bims-metlip/...

A collaboration with @biomednews.bsky.social
#metabolomics #lipidomics
a man wearing a shirt that says training to kill thanos
ALT: a man wearing a shirt that says training to kill thanos
media.tenor.com
November 9, 2025 at 3:54 PM
Reposted by Catalina Vasilescu, PhD
tommytang.bsky.social
1/ Everyone’s chasing AI.
But in bioinformatics, solid foundations still win.
Here’s why mastering the basics matters more than ever. 🧵
November 9, 2025 at 2:45 PM
Reposted by Catalina Vasilescu, PhD
ericchevet.bsky.social
#ER_literature
November 9, 2025 at 3:31 PM
Reposted by Catalina Vasilescu, PhD
korolchuklab.bsky.social
#Autophagy and #mTOR papers from last three weeks, enjoy!

biomed.news/bims-auttor/...

biomed.news/bims-auttor/...

biomed.news/bims-auttor/...
bims-auttor 2025-10-26 papers
biomed.news
November 9, 2025 at 12:59 PM
Reposted by Catalina Vasilescu, PhD
gzaffagnini.bsky.social
What an egg-cellent Sunday for oocyte papers! This week we have even TWO highlights:

pubmed.ncbi.nlm.nih.gov/41188464/ by T. Kitajima

and pubmed.ncbi.nlm.nih.gov/41184483/ by @binyammogessie.bsky.social

Read the full issue here: biomed.news/bims-cebooc/...

#cebooc
@biomednews.bsky.social
November 9, 2025 at 9:24 AM
Reposted by Catalina Vasilescu, PhD
frezzalab.bsky.social
Good Sunday, all. The weekly curated issue of papers in #cancermetabolism and #mitochondrialbiology is out, a concentrate of groundbreaking discoveries:

biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading

"There are years that ask questions and years that answer."-Zora Neale Hurston
November 9, 2025 at 6:28 AM
Reposted by Catalina Vasilescu, PhD
embojournal.org
Mechanism of #autophagy initiation by transmembrane selective autophagy receptors
@elias-adriaenssens.bsky.social & @martenslab.bsky.social review emerging mechanistic differences between soluble and transmembrane autophagy receptors
www.embopress.org/doi/full/10....
November 6, 2025 at 4:20 PM
cvasilescu.bsky.social
A new collection of papers on #mitochondrialdisease from #week45! 📚 💚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Mito complex III-derived ROS amplify immunometab changes in astrocytes and promote dementia
www.nature.com/articles/s42...
Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology - Nature Metabolism
Barnett et al. disentangle the differential contribution of mitochondrial complex I- and complex III-derived ROS to astrocytic function, with CIII-derived ROS being a major driver of neuroinflammatory...
www.nature.com
November 9, 2025 at 12:53 PM
Reposted by Catalina Vasilescu, PhD
odedrechavi.bsky.social
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
November 6, 2025 at 2:49 PM
Reposted by Catalina Vasilescu, PhD
aemonten.bsky.social
The authors introduced precise DNA breaks (w/Cas 9) & tracked changes in genome organization & gene activity. They found that even after the DNA was repaired, the affected regions remained misfolded & showed reduced gene expression, & these changes were passed on to daughter cells
Repair of DNA double-strand breaks leaves heritable impairment to genome function
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...
www.science.org
November 7, 2025 at 2:12 PM
cvasilescu.bsky.social
A new collection of papers related to #mitochondrialdisease from #week44! 📚 💚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social

Super mitochondria-enriched extracellular vesicles enable enhanced mito transfer
www.nature.com/articles/s41...
Super mitochondria-enriched extracellular vesicles enable enhanced mitochondria transfer - Nature Communications
In mitochondria transplantation, the limited activity and yield of mitochondria constrain their clinical application for mitochondrial diseases. Here, authors develop a method for producing mitochondr...
www.nature.com
November 2, 2025 at 12:33 PM
Reposted by Catalina Vasilescu, PhD
theresearch.bsky.social
Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social

includes research on: photosynthetic #biomanufacuturing, programming cellular condensates for living material, DNA synthetic cells, & more 🧪
Photosynthetic Biomanufacturing in Mechanically Robust, 3D Printed Hydrogels
Engineered living materials (ELMs) integrate synthetic polymers with engineered cells to create systems that sense, respond, and adapt to their environment. While promising as sustainable alternatives...
pubs.acs.org
November 2, 2025 at 6:09 AM