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@cvasilescu.bsky.social

To honour the #MitochondrialDisease #AwarenessWeek 💚 we bring a new collection of recently-published research papers related to mitochondrial disease:
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Cryo-EM of the prohibitin complex

Hong et al, Cryo-EM structure of the prohibitin complex in open conformation

https://www.pnas.org/doi/10.1073/pnas.2512430122

September 21, 2025 at 9:18 AM

Catalina Vasilescu, PhD

@cvasilescu.bsky.social

Starting the #MitochondrialDisease Awareness Week with a new collection of papers from #week37! 📚 💚 🤍
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Highlights
ABCA7 variants impact phosphatidylcholine and mitochondria in neurons

Maydell et al,
ABCA7 variants impact phosphatidylcholine and mitochondria in neurons
https://www.nature.com/articles/s41586-025-09520-y

September 14, 2025 at 11:37 AM

Catalina Vasilescu, PhD

@cvasilescu.bsky.social

Wonderful selections of papers on #MitochondrialDisease from #week35 and #week36! 📚

biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

RTN4IP1 required for the final stages of mito CI assembly and CoQ synthesis

Olahova et al, RTN4IP1 is required for the final stages of mitochondrial complex I assembly and CoQ biosynthesis

September 7, 2025 at 10:29 AM

Catalina Vasilescu, PhD

@cvasilescu.bsky.social

Depiction of Mitochondria in Time

August 31, 2025 at 9:02 AM

Catalina Vasilescu, PhD

@cvasilescu.bsky.social

Last two weeks of literature relevant for #MitochondrialDisease! 📚

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social

Please browse the collections here! 👇
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...

August 24, 2025 at 8:58 AM

Catalina Vasilescu, PhD

@cvasilescu.bsky.social

#MitochondrialDisease collection of papers from #week32! 📚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Highlights

Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson's disease

Marutani et al, Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson's disease
https://www.nature.com/articles/s41593-025-02010-4

August 10, 2025 at 6:47 AM

Catalina Vasilescu, PhD

@cvasilescu.bsky.social

Weekly selection of papers on #mitochondrialdisease!
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

The mitochondrial methylation potential gates mitoribosome assembly @wredenberglab.bsky.social
pmc.ncbi.nlm.nih.gov/articles/PMC...

Glasgow et al, The mitochondrial methylation potential gates mitoribosome assembly
https://pmc.ncbi.nlm.nih.gov/articles/PMC12198368/

June 29, 2025 at 11:17 AM

Catalina Vasilescu, PhD

@cvasilescu.bsky.social

New #mitochondrialdisease selection of papers published last week!
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mito-news.bsky.social

MtDNA oxidation propagates autoimmunity by enabling plasmacytoid dendritic cells to induce TFH dif

Xian et al, 2025,

Mitochondrial DNA oxidation propagates autoimmunity by enabling plasmacytoid dendritic cells to induce TFH differentiation

https://www.nature.com/articles/s41590-025-02179-7

June 22, 2025 at 12:45 PM

Catalina Vasilescu, PhD

@cvasilescu.bsky.social

Weekly report of #mitochondrialdisease literature!
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mito-news.bsky.social @mitoscientists.bsky.social

Unraveling mitochondrial influence on mammalian pluripotency via enforced mitophagy

Schmitz et al, Unraveling mitochondrial influence on mammalian pluripotency via enforced mitophagy
https://www.cell.com/cms/10.1016/j.cell.2025.05.020/asset/5ad06967-23ff-47d3-927b-91fc7f674a40/main.assets/fx1_lrg.jpg

June 15, 2025 at 12:17 PM

Catalina Vasilescu, PhD

@cvasilescu.bsky.social

Here it is! The latest collection of articles on #mitochondrialdisease! 📚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mito-news.bsky.social

The low endoribonuclease activity and lack of rNMP preference of h-mt top1 protects against ...

Bader et al, The low endoribonuclease activity and lack of rNMP preference of human mitochondrial topoisomerase 1 protect against ribonucleotide-dependent deletions
https://academic.oup.com/nar/article/53/11/gkaf475/8158034?login=true

June 11, 2025 at 9:26 AM

Catalina Vasilescu, PhD

@cvasilescu.bsky.social

Weekly report on #mitochondrialdisease literature!
biomed.news/bims-mitdis/...

@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social @mitoscientists.bsky.social @mitoworld.bsky.social

CoQ imbalance drives reverse electron transport to disrupt liver metabolism

Goncalves et al, CoQ imbalance drives reverse electron transport to disrupt liver metabolism
https://www.nature.com/articles/s41586-025-09072-1

June 1, 2025 at 10:20 AM

Catalina Vasilescu, PhD

@cvasilescu.bsky.social

This week's collection of new papers on #mitochondrialdisease!
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social @mitoworld.bsky.social

Silencing mitochondrial gene expression in living cells

Silencing mitochondrial gene expression in living cells
https://www.science.org/doi/10.1126/science.adr3498?utm_campaign=Science&utm_source=Bluesky&utm_medium=ownedSocial

May 25, 2025 at 10:34 AM

Catalina Vasilescu, PhD

@cvasilescu.bsky.social

Here it is, a new collection of papers related to #mitochondrialdisease! 📚

biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social @mitoworld.bsky.social

ALDH4A1 functions as an active component of the MPC complex

Hsu et al, ALDH4A1 functions as an active component of the MPC complex maintaining mitochondrial pyruvate import for TCA cycle entry and tumour suppression
https://pubmed.ncbi.nlm.nih.gov/40355545/

May 18, 2025 at 11:56 AM

Catalina Vasilescu, PhD

@cvasilescu.bsky.social

Last week's publications on #mitochondrialdisease! A few highlights below, many more inside!

biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social

A cysteine in Fis1 targeted to prevent excessive mitochondrial fission

Pokhrel et al, A hidden cysteine in Fis1 targeted to prevent excessive mitochondrial fission and dysfunction under oxidative stress
https://www.nature.com/articles/s41467-025-59434-6

May 11, 2025 at 11:27 AM

Catalina Vasilescu, PhD

@cvasilescu.bsky.social

A new collection of #mitochondrialdisease papers from last week!

biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social @mitoworld.bsky.social

Pleiotropic effects of MORC2 derive from its epigenetic signature

May 4, 2025 at 8:46 AM

Catalina Vasilescu, PhD

@cvasilescu.bsky.social

Latest issue of #mitochondrialdisease literature published last week! 📚

biomed.news/bims-mitdis/...

@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social @mitoscientists.bsky.social

Loss of intracellular ATP affects axoplasmic viscosity and pathological prot. aggregation

Guillaud et al, Loss of intracellular ATP affects axoplasmic viscosity and pathological protein aggregation in mammalian neurons
https://pmc.ncbi.nlm.nih.gov/articles/PMC12017319/

April 27, 2025 at 10:37 AM

Catalina Vasilescu, PhD

@cvasilescu.bsky.social

Great new issue of #mitochondrialdisease papers! 📚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitowomen.bsky.social
@mitoworld.bsky.social

Valenzuela et al, Small molecules restore mutant mitochondrial DNA polymerase activity

Valenzuela et al, Small molecules restore mutant mitochondrial DNA polymerase activity | Nature
https://www.nature.com/articles/s41586-025-08856-9

April 13, 2025 at 8:02 AM

Catalina Vasilescu, PhD

@cvasilescu.bsky.social

New collection of papers on #mitochondrialdisease published last week! 📚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoworld.bsky.social

Pathogenic mutation impairs functional dynamics of Hsp60 in mono- and oligomeric states

Torielli et al, Pathogenic mutation impairs functional dynamics of Hsp60 in mono- and oligomeric states
https://www.nature.com/articles/s41467-025-57958-5

April 6, 2025 at 11:41 AM

Catalina Vasilescu, PhD

@cvasilescu.bsky.social

A pretty good guess for me

ChatGPT drawing how Catalina looks like.

April 3, 2025 at 4:42 PM

Catalina Vasilescu, PhD

@cvasilescu.bsky.social

Here are some pretty #mitochondria to cheer up your day! 🤍💕

#MitochondriaInTime
#SpringMitos

April 2, 2025 at 10:59 AM

Catalina Vasilescu, PhD

@cvasilescu.bsky.social

A great #mitochondrialdisease collection of papers published last week!
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mito-news.bsky.social @mitoscientists.bsky.social

A human brain map of mitochondrial respiratory capacity and diversity

Mosharov et al, A human brain map of mitochondrial respiratory capacity and diversity

March 30, 2025 at 10:51 AM

Catalina Vasilescu, PhD

@cvasilescu.bsky.social

Many awesome discoveries in the current collection of papers on #mitochondrialdisease! Structures, natural history, genetics and much more!

biomed.news/bims-mitdis/...
@biomednews.bsky.social @mito-news.bsky.social

Highlights below
NR & NMN facilitate NAD+ synthesis via enterohepatic circulation