CSConn
@csconn-phd.bsky.social
Assistant Prof @PennMedicine interest in #RNA regulation, mRNA translation, and adaptative stress responses in cancer bio.
Advocate for Science, Research, Healthy living & Equality #STEM #FirstGen #Nonbinary They/Them
Advocate for Science, Research, Healthy living & Equality #STEM #FirstGen #Nonbinary They/Them
So much already this Fall!
Fantastic posters by our undergraduates, Celebrating Nora's 1% on her F31, our annual pumpkin picking outing, & invited Book Chapter just accepted this week (will share when out).
Happy Fall to All :)
Fantastic posters by our undergraduates, Celebrating Nora's 1% on her F31, our annual pumpkin picking outing, & invited Book Chapter just accepted this week (will share when out).
Happy Fall to All :)
October 17, 2025 at 9:04 PM
So much already this Fall!
Fantastic posters by our undergraduates, Celebrating Nora's 1% on her F31, our annual pumpkin picking outing, & invited Book Chapter just accepted this week (will share when out).
Happy Fall to All :)
Fantastic posters by our undergraduates, Celebrating Nora's 1% on her F31, our annual pumpkin picking outing, & invited Book Chapter just accepted this week (will share when out).
Happy Fall to All :)
Happy to have another Summer complete for SUPERS'25! They are a phenomenal group that I'm fortunate to interact with for our 10wk program. Special Congratulations to the Winners of the Stephen W. Tuttle Research Award Orly Perez Frid & Kaitlin Chung & hope to have this program another 5+yrs!
August 19, 2025 at 9:40 PM
Happy to have another Summer complete for SUPERS'25! They are a phenomenal group that I'm fortunate to interact with for our 10wk program. Special Congratulations to the Winners of the Stephen W. Tuttle Research Award Orly Perez Frid & Kaitlin Chung & hope to have this program another 5+yrs!
More of this please:
“As biologists, we know that rigid binary definitions of sex and gender are not supported by scientific observations,” the authors wrote. “As people, we know that insistence on these rigid definitions harms and marginalizes many who do not easily fit within them.”
“As biologists, we know that rigid binary definitions of sex and gender are not supported by scientific observations,” the authors wrote. “As people, we know that insistence on these rigid definitions harms and marginalizes many who do not easily fit within them.”
July 31, 2025 at 10:03 PM
More of this please:
“As biologists, we know that rigid binary definitions of sex and gender are not supported by scientific observations,” the authors wrote. “As people, we know that insistence on these rigid definitions harms and marginalizes many who do not easily fit within them.”
“As biologists, we know that rigid binary definitions of sex and gender are not supported by scientific observations,” the authors wrote. “As people, we know that insistence on these rigid definitions harms and marginalizes many who do not easily fit within them.”
Reposted by CSConn
Reposted by CSConn
📌 Pin to your calendars!
🧪 Protein synthesis and translational control🧪
⏳Don't miss these deadlines
Abstracts Jun 1
✏️ Register
On-site Jul 23
Virtual Aug 27
🖱️https://buff.ly/hs1wWTS
#ProteinSynthesis ##TranslationalControl #mRNAtranslation
🧪 Protein synthesis and translational control🧪
⏳Don't miss these deadlines
Abstracts Jun 1
✏️ Register
On-site Jul 23
Virtual Aug 27
🖱️https://buff.ly/hs1wWTS
#ProteinSynthesis ##TranslationalControl #mRNAtranslation
April 4, 2025 at 11:42 AM
📌 Pin to your calendars!
🧪 Protein synthesis and translational control🧪
⏳Don't miss these deadlines
Abstracts Jun 1
✏️ Register
On-site Jul 23
Virtual Aug 27
🖱️https://buff.ly/hs1wWTS
#ProteinSynthesis ##TranslationalControl #mRNAtranslation
🧪 Protein synthesis and translational control🧪
⏳Don't miss these deadlines
Abstracts Jun 1
✏️ Register
On-site Jul 23
Virtual Aug 27
🖱️https://buff.ly/hs1wWTS
#ProteinSynthesis ##TranslationalControl #mRNAtranslation
Cool new work explaining the dynamics of mRNA translation with the ribosome to inhibit SG localization- by the Moon Lab
#ribosomes #uORF #mRNATranslation #StressResponse
genesdev.cshlp.org/content/earl...
#ribosomes #uORF #mRNATranslation #StressResponse
genesdev.cshlp.org/content/earl...
Ribosome association inhibits stress-induced gene mRNA localization to stress granules
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
genesdev.cshlp.org
May 15, 2025 at 2:00 PM
Cool new work explaining the dynamics of mRNA translation with the ribosome to inhibit SG localization- by the Moon Lab
#ribosomes #uORF #mRNATranslation #StressResponse
genesdev.cshlp.org/content/earl...
#ribosomes #uORF #mRNATranslation #StressResponse
genesdev.cshlp.org/content/earl...
Reposted by CSConn
This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: Translation dysregulation in cancer as a source for targetable antigens www.sciencedirect.com/science/arti...
Highlight: Translation dysregulation in cancer as a source for targetable antigens www.sciencedirect.com/science/arti...
bims-proteo 2025-04-06 papers
biomed.news
April 6, 2025 at 5:59 AM
This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: Translation dysregulation in cancer as a source for targetable antigens www.sciencedirect.com/science/arti...
Highlight: Translation dysregulation in cancer as a source for targetable antigens www.sciencedirect.com/science/arti...
Reposted by CSConn
🚨New paper!🚨
A comprehensive take on the origins and evolution of translation factors & how these essential players evolved across the tree of life. 🌍🧬
Led by Evrim Fer @uwmadisonmdtp.bsky.social grad student! 👏
Free access: www.sciencedirect.com/science/arti... @cp-trendsgenetics.bsky.social
A comprehensive take on the origins and evolution of translation factors & how these essential players evolved across the tree of life. 🌍🧬
Led by Evrim Fer @uwmadisonmdtp.bsky.social grad student! 👏
Free access: www.sciencedirect.com/science/arti... @cp-trendsgenetics.bsky.social
March 24, 2025 at 2:46 PM
🚨New paper!🚨
A comprehensive take on the origins and evolution of translation factors & how these essential players evolved across the tree of life. 🌍🧬
Led by Evrim Fer @uwmadisonmdtp.bsky.social grad student! 👏
Free access: www.sciencedirect.com/science/arti... @cp-trendsgenetics.bsky.social
A comprehensive take on the origins and evolution of translation factors & how these essential players evolved across the tree of life. 🌍🧬
Led by Evrim Fer @uwmadisonmdtp.bsky.social grad student! 👏
Free access: www.sciencedirect.com/science/arti... @cp-trendsgenetics.bsky.social
Reposted by CSConn
They are cutting cancer research. They are cutting cancer research. They can deny it all they want, but they are cutting cancer research. These are the cuts being made the DoD CDMRP cancer funding mechanism www.fightcancer.org/sites/defaul...
March 27, 2025 at 10:11 AM
They are cutting cancer research. They are cutting cancer research. They can deny it all they want, but they are cutting cancer research. These are the cuts being made the DoD CDMRP cancer funding mechanism www.fightcancer.org/sites/defaul...
Oooo pretty new MassSpec data coming in (only slightly hung-up on the 1/78 samples that wasn't perfect lol)
January 31, 2025 at 9:58 PM
Oooo pretty new MassSpec data coming in (only slightly hung-up on the 1/78 samples that wasn't perfect lol)
Looking forward to sharing our research @rutgersupress.bsky.social tomorrow @12 Nelson D406
January 24, 2025 at 4:20 AM
Looking forward to sharing our research @rutgersupress.bsky.social tomorrow @12 Nelson D406
Reposted by CSConn
Excited to share our review article "Finding functional microproteins", published in @TrendsGenetics. It was fun writing it together with Alex and @FeiyueYang1 in the lab. #microprotein authors.elsevier.com/a/1kNCscQbJB...
January 2, 2025 at 9:55 PM
Excited to share our review article "Finding functional microproteins", published in @TrendsGenetics. It was fun writing it together with Alex and @FeiyueYang1 in the lab. #microprotein authors.elsevier.com/a/1kNCscQbJB...
Reposted by CSConn
Excited to share our @cp-trendsgenetics.bsky.social Spotlight Article highlighting the development of #ribo-seq by @nickingolia.bsky.social and how it has revolutionized the study of #microproteins!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Ribosome profiling reveals hidden world of small proteins
The development of ribosome profiling (Ribo-seq) by Ingolia et al. introduced a powerful new method for monitoring translation genome-wide. Applicatio…
www.sciencedirect.com
January 14, 2025 at 3:45 PM
Excited to share our @cp-trendsgenetics.bsky.social Spotlight Article highlighting the development of #ribo-seq by @nickingolia.bsky.social and how it has revolutionized the study of #microproteins!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by CSConn
Time to share our organelle proteome paper
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/
1/3 🧪
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/
1/3 🧪
January 14, 2025 at 4:03 PM
Time to share our organelle proteome paper
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/
1/3 🧪
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/
1/3 🧪
Reposted by CSConn
If you had any question that microproteins / micropeptides are the next wave in #cancer 🌊
Well this is the paper that you need to read.
🔎 microproteins
🧬 💻
#RNAsky
#genomics
#bioinformatics
www.biorxiv.org/content/10.1...
Well this is the paper that you need to read.
🔎 microproteins
🧬 💻
#RNAsky
#genomics
#bioinformatics
www.biorxiv.org/content/10.1...
Upstream open reading frame translation enhances immunogenic peptide presentation in mitotically arrested cancer cells
Mitosis is a critical phase of the cell cycle and a vulnerable point where cancer cells can be effectively disrupted, leading to cell death and inhibition of tumor growth. However, challenges such as ...
www.biorxiv.org
January 11, 2025 at 12:29 AM
If you had any question that microproteins / micropeptides are the next wave in #cancer 🌊
Well this is the paper that you need to read.
🔎 microproteins
🧬 💻
#RNAsky
#genomics
#bioinformatics
www.biorxiv.org/content/10.1...
Well this is the paper that you need to read.
🔎 microproteins
🧬 💻
#RNAsky
#genomics
#bioinformatics
www.biorxiv.org/content/10.1...
Reposted by CSConn
The first preprint of 2025! Together with Matvei, @halfacrocodile.bsky.social, & our amazing team, we are excited to share PARADE: an AI framework for designing mRNA UTRs with enhanced cell-type specificity & stability. www.biorxiv.org/content/10.1...
A generative framework for enhanced cell-type specificity in rationally designed mRNAs
mRNA delivery offers new opportunities for disease treatment by directing cells to produce therapeutic proteins. However, designing highly stable mRNAs with programmable cell type-specificity remains ...
www.biorxiv.org
January 2, 2025 at 1:10 PM
The first preprint of 2025! Together with Matvei, @halfacrocodile.bsky.social, & our amazing team, we are excited to share PARADE: an AI framework for designing mRNA UTRs with enhanced cell-type specificity & stability. www.biorxiv.org/content/10.1...
Reposted by CSConn
Congratulations to @fendtlab.bsky.social amd @ginevradoglioni.bsky.social
for this massive work
"Aspartate signalling drives lung metastasis via alternative translation"
www.nature.com/articles/s41...
for this massive work
"Aspartate signalling drives lung metastasis via alternative translation"
www.nature.com/articles/s41...
Aspartate signalling drives lung metastasis via alternative translation - Nature
Aspartate in the tumour environment activates the N-methyl-d-aspartate receptor in cancer cells to induce cellular programmes that increase the aggressiveness of metastasis.
www.nature.com
January 2, 2025 at 5:41 PM
Congratulations to @fendtlab.bsky.social amd @ginevradoglioni.bsky.social
for this massive work
"Aspartate signalling drives lung metastasis via alternative translation"
www.nature.com/articles/s41...
for this massive work
"Aspartate signalling drives lung metastasis via alternative translation"
www.nature.com/articles/s41...
Reposted by CSConn
Great work from Gloria Brar’s group on the role of paralogous RNA helicases in the heat shock response. Surprising increase in growth at high temperature and impact of a short motif! Also important implications of the role of biomolecular condensation. Awesome www.cell.com/cell-reports...
Analyses of translation factors Dbp1 and Ded1 reveal the cellular response to heat stress to be separable from stress granule formation
Kuwayama and Powers et al. reveal differences in function for two related RNA remodelers. Dbp1 is poor at stimulating translation, but, when expressed instead of Ded1, it prevents cells from halting growth upon heat stress. This depends on a short disordered Ded1 region but not stress granule formation or reduced translation.
www.cell.com
December 18, 2024 at 3:10 AM
Great work from Gloria Brar’s group on the role of paralogous RNA helicases in the heat shock response. Surprising increase in growth at high temperature and impact of a short motif! Also important implications of the role of biomolecular condensation. Awesome www.cell.com/cell-reports...
Reposted by CSConn
Direct RNA sequencing is featured as one of The Scientist 2024 Top 10 Innovations. Read to find out how the latest direct RNA #nanopore sequencing kit and flow cell has improved accuracy and output, enabling a more complete picture of the landscape of RNA
Read: www.the-scientist.com/2024-top-10-...
Read: www.the-scientist.com/2024-top-10-...
December 18, 2024 at 9:06 AM
Direct RNA sequencing is featured as one of The Scientist 2024 Top 10 Innovations. Read to find out how the latest direct RNA #nanopore sequencing kit and flow cell has improved accuracy and output, enabling a more complete picture of the landscape of RNA
Read: www.the-scientist.com/2024-top-10-...
Read: www.the-scientist.com/2024-top-10-...
What is the best distance-adjusting, multi-channel to go from Eppendorf 1.5/2mL tubes to 96-well plate format?
December 16, 2024 at 10:47 PM
What is the best distance-adjusting, multi-channel to go from Eppendorf 1.5/2mL tubes to 96-well plate format?
Reposted by CSConn
Our latest work is out in Nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 www.nature.com/articles/s41...
December 11, 2024 at 9:35 PM
Our latest work is out in Nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 www.nature.com/articles/s41...
Applications for our SUPERS 2025 Summer Internship open today! Share with undergraduates you know interested in learning/studying translational medicine from Cancer Bio, Radiobiology & Imaging, to Medical Physics med.upenn.edu/supers/
December 12, 2024 at 2:14 PM
Applications for our SUPERS 2025 Summer Internship open today! Share with undergraduates you know interested in learning/studying translational medicine from Cancer Bio, Radiobiology & Imaging, to Medical Physics med.upenn.edu/supers/
@themodzlab.bsky.social worlds colliding ;)
December 12, 2024 at 1:58 PM
@themodzlab.bsky.social worlds colliding ;)
Look forward to reading this in full!
Now online in Cancer Discovery: Androgen Receptor Inhibition Increases MHC Class I Expression and Improves Immune Response in Prostate Cancer - by Lisa Chesner, Felix Feng, Amy Moran, and colleagues @ucsfcancer.bsky.social @ohsunews.bsky.social doi.org/10.1158/2159...
December 11, 2024 at 6:59 PM
Look forward to reading this in full!
Reposted by CSConn
