Hani Goodarzi
@genophoria.bsky.social
Core Investigator @ Arc Institute | Associate Professor @ UCSF | {Computational, Systems, Cancer, RNA} biologist | Co-founder @exaibio @vevo_ai
Reposted by Hani Goodarzi
Arc Core Investigator @genophoria.bsky.social will speak on a free, online panel with @tkaraletsos.bsky.social, @emmalundberg.bsky.social, and @ronalfa.bsky.social on Wed., Oct. 29, as part of GENbio's “The State of AI in Drug Discovery in 2025.” Register at: webinars.liebertpub.com/e/the-state-...
October 24, 2025 at 5:32 PM
Arc Core Investigator @genophoria.bsky.social will speak on a free, online panel with @tkaraletsos.bsky.social, @emmalundberg.bsky.social, and @ronalfa.bsky.social on Wed., Oct. 29, as part of GENbio's “The State of AI in Drug Discovery in 2025.” Register at: webinars.liebertpub.com/e/the-state-...
Reposted by Hani Goodarzi
Hear how Arc, Ultima Genomics, and @10xgenomics.bsky.social are partnering to generate perturbation data at the scale needed to train virtual cell models on The Bio Report podcast with guests @genophoria.bsky.social, Gilad Almogy, and
Serge Saxonov: thebioreport.podbean.com/e/transformi...
Serge Saxonov: thebioreport.podbean.com/e/transformi...
October 9, 2025 at 4:51 PM
Hear how Arc, Ultima Genomics, and @10xgenomics.bsky.social are partnering to generate perturbation data at the scale needed to train virtual cell models on The Bio Report podcast with guests @genophoria.bsky.social, Gilad Almogy, and
Serge Saxonov: thebioreport.podbean.com/e/transformi...
Serge Saxonov: thebioreport.podbean.com/e/transformi...
Reposted by Hani Goodarzi
#CELLFIE for CAR T screening—a new mRNA-based platform for screening primary cells. CAR + gRNA library are delivered by lentivirus, CRISPR modifiers as electroporated mRNA. That’s more flexible and effective than existing T cell screening methods. (1/7)
September 24, 2025 at 3:48 PM
#CELLFIE for CAR T screening—a new mRNA-based platform for screening primary cells. CAR + gRNA library are delivered by lentivirus, CRISPR modifiers as electroporated mRNA. That’s more flexible and effective than existing T cell screening methods. (1/7)
Reposted by Hani Goodarzi
New work from stellar scientists Jeremy Williams and Roman Camarda. Many contributors including the amazing Zena Werb and Atul Butte
Work explores how breast cancer cells interact directly with adipocytes via gap junctions, leading to lipid release.
@ctbatucsf.bsky.social @ucsfcancer.bsky.social
Work explores how breast cancer cells interact directly with adipocytes via gap junctions, leading to lipid release.
@ctbatucsf.bsky.social @ucsfcancer.bsky.social
Tumor cell-adipocyte gap junctions activate lipolysis and contribute to breast tumorigenesis
Nature Communications - Breast cancer cells interact with neighbouring adipocytes, but the mechanisms are not fully understood. Here, the authors show that triple-negative breast cancer (TNBC)...
www.nature.com
August 20, 2025 at 10:19 AM
New work from stellar scientists Jeremy Williams and Roman Camarda. Many contributors including the amazing Zena Werb and Atul Butte
Work explores how breast cancer cells interact directly with adipocytes via gap junctions, leading to lipid release.
@ctbatucsf.bsky.social @ucsfcancer.bsky.social
Work explores how breast cancer cells interact directly with adipocytes via gap junctions, leading to lipid release.
@ctbatucsf.bsky.social @ucsfcancer.bsky.social
Reposted by Hani Goodarzi
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
August 6, 2025 at 3:36 PM
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
Reposted by Hani Goodarzi
My colleagues at Nature Biomedical Engineering @natbiomedeng.nature.com are hiring an associate or senior editor. Ideal applicant will have expertise in immunology, immunotherapy, or immuno-oncology.
Please feel to ask me questions!
springernature.wd3.myworkdayjobs.com/SpringerNatu...
Please feel to ask me questions!
springernature.wd3.myworkdayjobs.com/SpringerNatu...
Associate or Senior Editor, Nature Biomedical Engineering
Job Title: Associate or Senior Editor, Nature Biomedical Engineering Organization: Nature Portfolio Location: New York, Jersey City, Shanghai or Beijing – Hybrid Working Closing date: August 20, 2025 ...
springernature.wd3.myworkdayjobs.com
July 30, 2025 at 6:21 PM
My colleagues at Nature Biomedical Engineering @natbiomedeng.nature.com are hiring an associate or senior editor. Ideal applicant will have expertise in immunology, immunotherapy, or immuno-oncology.
Please feel to ask me questions!
springernature.wd3.myworkdayjobs.com/SpringerNatu...
Please feel to ask me questions!
springernature.wd3.myworkdayjobs.com/SpringerNatu...
Go @exai.bio! Looking forward to working with Mike as our incoming CEO and our amazing board members.
We’re excited to welcome Michael Nall as CEO and Board Director and new Board Directors - Steve Kafka, PhD, of S32, Dusan Perovic of Two Sigma Ventures and Emir Sandhu, MD, of Blue Venture Fund. Their leadership will be invaluable as we advance our RNA & AI liquid biopsy platform.
July 24, 2025 at 5:01 PM
Go @exai.bio! Looking forward to working with Mike as our incoming CEO and our amazing board members.
Reposted by Hani Goodarzi
Are you currently in the ERE related field & want to find new collaborative opportunities? Join our Chairs @chiappinellilab.bsky.social, @shenhui1986.bsky.social, Ting & Tao at #EREHD25 this Nov!
🎙️Talk Submission extended to 03 Sept
💰Final few $500 grants remaining
Don't Miss out! bit.ly/4eRq9Mp
🎙️Talk Submission extended to 03 Sept
💰Final few $500 grants remaining
Don't Miss out! bit.ly/4eRq9Mp
July 17, 2025 at 3:23 PM
Are you currently in the ERE related field & want to find new collaborative opportunities? Join our Chairs @chiappinellilab.bsky.social, @shenhui1986.bsky.social, Ting & Tao at #EREHD25 this Nov!
🎙️Talk Submission extended to 03 Sept
💰Final few $500 grants remaining
Don't Miss out! bit.ly/4eRq9Mp
🎙️Talk Submission extended to 03 Sept
💰Final few $500 grants remaining
Don't Miss out! bit.ly/4eRq9Mp
Reposted by Hani Goodarzi
Our ENS is vital to gut-brain health. When it breaks down, so does health. Treatments? Almost none.
Access to functional human enteric neurons at scale powers disease modeling and therapeutic discovery. Grateful to everyone who made this possible. www.nature.com/articles/s41...
Access to functional human enteric neurons at scale powers disease modeling and therapeutic discovery. Grateful to everyone who made this possible. www.nature.com/articles/s41...
June 25, 2025 at 9:06 PM
Our ENS is vital to gut-brain health. When it breaks down, so does health. Treatments? Almost none.
Access to functional human enteric neurons at scale powers disease modeling and therapeutic discovery. Grateful to everyone who made this possible. www.nature.com/articles/s41...
Access to functional human enteric neurons at scale powers disease modeling and therapeutic discovery. Grateful to everyone who made this possible. www.nature.com/articles/s41...
Oh no! I am devastated!
Atul Butte died yesterday.
The world lost a giant.
A big bear of a man.
With a huge smile.
With love for everyone.
With energy that could power a room.
I loved everything about Atul.
I loved how he was always happy.
I loved how excited he was about science and helping people.
The world lost a giant.
A big bear of a man.
With a huge smile.
With love for everyone.
With energy that could power a room.
I loved everything about Atul.
I loved how he was always happy.
I loved how excited he was about science and helping people.
June 14, 2025 at 7:00 PM
Oh no! I am devastated!
Reposted by Hani Goodarzi
Check out this amazing work from @genophoria.bsky.social’s lab, revealing a novel post-transcriptional tumour suppressive programme in breast cancer 👇👇
Been going back and forth on whether it makes sense to post science in the midst of all that is happening. But here it goes with a couple of days of delay:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Integrative analysis of mRNA stability regulation uncovers a metastasis-suppressive program in breast cancer
Heterogeneity in cancer gene expression is typically linked to genetic and epigenetic alterations, yet post-transcriptional regulation likely influences these patterns as well. However, the quantitati...
www.biorxiv.org
June 9, 2025 at 1:38 PM
Check out this amazing work from @genophoria.bsky.social’s lab, revealing a novel post-transcriptional tumour suppressive programme in breast cancer 👇👇
Been going back and forth on whether it makes sense to post science in the midst of all that is happening. But here it goes with a couple of days of delay:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Integrative analysis of mRNA stability regulation uncovers a metastasis-suppressive program in breast cancer
Heterogeneity in cancer gene expression is typically linked to genetic and epigenetic alterations, yet post-transcriptional regulation likely influences these patterns as well. However, the quantitati...
www.biorxiv.org
June 9, 2025 at 1:33 PM
Been going back and forth on whether it makes sense to post science in the midst of all that is happening. But here it goes with a couple of days of delay:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Hani Goodarzi
🧬💊 @science.org Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase | Science www.science.org/doi/10.1126/...
@sternberglab.bsky.social @isaacwitte.bsky.social eitzingersimon.bsky.social + al. #CRISPR #Medicine #Science #Evolution #Genome #evoCAST
@sternberglab.bsky.social @isaacwitte.bsky.social eitzingersimon.bsky.social + al. #CRISPR #Medicine #Science #Evolution #Genome #evoCAST
May 17, 2025 at 7:50 PM
🧬💊 @science.org Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase | Science www.science.org/doi/10.1126/...
@sternberglab.bsky.social @isaacwitte.bsky.social eitzingersimon.bsky.social + al. #CRISPR #Medicine #Science #Evolution #Genome #evoCAST
@sternberglab.bsky.social @isaacwitte.bsky.social eitzingersimon.bsky.social + al. #CRISPR #Medicine #Science #Evolution #Genome #evoCAST
Really excited to see this published! From observations we made in our lab… to a blood test that works in real life scenarios… all thanks to the many scientists, ML researchers and engineers at @exai.bio who have worked on bringing this to the clinic. Kudos @babak-a.bsky.social and the team!
💥New Publication Alert in Clinical Cancer Research💥
We are thrilled to announce our latest publication on our novel RNA and generative AI liquid biopsy platform for early colorectal cancer detection. #EarlyDetection #LiquidBiopsy #RNA
Read the full publication here: aacrjournals.org/clincancerre...
We are thrilled to announce our latest publication on our novel RNA and generative AI liquid biopsy platform for early colorectal cancer detection. #EarlyDetection #LiquidBiopsy #RNA
Read the full publication here: aacrjournals.org/clincancerre...
Detection of Early-Stage Colorectal Cancer Using Cell-Free oncRNA Biomarkers and Artificial Intelligence
Abstract. Purpose: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide, and early detection significantly improves treatment outcomes, but existing blood-based tests...
aacrjournals.org
May 15, 2025 at 8:14 PM
Really excited to see this published! From observations we made in our lab… to a blood test that works in real life scenarios… all thanks to the many scientists, ML researchers and engineers at @exai.bio who have worked on bringing this to the clinic. Kudos @babak-a.bsky.social and the team!
Reposted by Hani Goodarzi
Excited for this summer’s NYC Chromatin Club!
Grad students & postdocs: submit your abstracts for a chance to present a poster or talk. Come connect w/ fellow epigenetic New Yorkers!
#NYCChromatinClub
@dshechter.bsky.social @vivrisca.bsky.social @epicypher.bsky.social
@kjarmache.bsky.social
Grad students & postdocs: submit your abstracts for a chance to present a poster or talk. Come connect w/ fellow epigenetic New Yorkers!
#NYCChromatinClub
@dshechter.bsky.social @vivrisca.bsky.social @epicypher.bsky.social
@kjarmache.bsky.social
May 5, 2025 at 3:01 AM
Excited for this summer’s NYC Chromatin Club!
Grad students & postdocs: submit your abstracts for a chance to present a poster or talk. Come connect w/ fellow epigenetic New Yorkers!
#NYCChromatinClub
@dshechter.bsky.social @vivrisca.bsky.social @epicypher.bsky.social
@kjarmache.bsky.social
Grad students & postdocs: submit your abstracts for a chance to present a poster or talk. Come connect w/ fellow epigenetic New Yorkers!
#NYCChromatinClub
@dshechter.bsky.social @vivrisca.bsky.social @epicypher.bsky.social
@kjarmache.bsky.social
Reposted by Hani Goodarzi
Delighted to see this out! Fun fact: I actually started my lab @ UCSF w/ goal of understanding tRNA txn regulation, which aligned perfectly w/ @genophoria.bsky.social & Sohail! 6+ years of amazing collaboration & stellar work by Siyu, Albertas, & co & we're making real progress w/ more to come!
Check out our latest preprint, led by Dr. Siyu Chen, that brings together an amazing team of scientists from several labs ( @vram142.bsky.social, Tavazoie, and Navickas) to tackle a fundamental problem in biology: how do cells regulate expression of their tRNAs? www.biorxiv.org/content/10.1...
Discovery of a tRNA-regulatory transcription factor that suppresses breast cancer metastasis
Transfer RNAs (tRNAs), once viewed as static adaptors in translation, are now recognized as dynamic regulators of gene expression. While recent studies have illuminated roles for tRNA stability, the u...
www.biorxiv.org
May 1, 2025 at 3:22 AM
Delighted to see this out! Fun fact: I actually started my lab @ UCSF w/ goal of understanding tRNA txn regulation, which aligned perfectly w/ @genophoria.bsky.social & Sohail! 6+ years of amazing collaboration & stellar work by Siyu, Albertas, & co & we're making real progress w/ more to come!
Check out our latest preprint, led by Dr. Siyu Chen, that brings together an amazing team of scientists from several labs ( @vram142.bsky.social, Tavazoie, and Navickas) to tackle a fundamental problem in biology: how do cells regulate expression of their tRNAs? www.biorxiv.org/content/10.1...
Discovery of a tRNA-regulatory transcription factor that suppresses breast cancer metastasis
Transfer RNAs (tRNAs), once viewed as static adaptors in translation, are now recognized as dynamic regulators of gene expression. While recent studies have illuminated roles for tRNA stability, the u...
www.biorxiv.org
April 30, 2025 at 11:49 PM
Check out our latest preprint, led by Dr. Siyu Chen, that brings together an amazing team of scientists from several labs ( @vram142.bsky.social, Tavazoie, and Navickas) to tackle a fundamental problem in biology: how do cells regulate expression of their tRNAs? www.biorxiv.org/content/10.1...
Reposted by Hani Goodarzi
Pleased to have our reviewed preprint out now @elife.bsky.social
Outstanding work by Drs. Rachel Nakagawa, Dan Van de Mark, and Andrew Beardsley. Shout out to @genophoria.bsky.social, Mary-Kate Hayward and many others
Press Release Here
elifesciences.org/for-the-pres...
@ucsfcancer.bsky.social
Outstanding work by Drs. Rachel Nakagawa, Dan Van de Mark, and Andrew Beardsley. Shout out to @genophoria.bsky.social, Mary-Kate Hayward and many others
Press Release Here
elifesciences.org/for-the-pres...
@ucsfcancer.bsky.social
Tumor Cell Spatial Organization Directs EGFR/RAS/RAF Pathway Primary Therapy Resistance through YAP Signaling
doi.org
April 29, 2025 at 8:48 PM
Pleased to have our reviewed preprint out now @elife.bsky.social
Outstanding work by Drs. Rachel Nakagawa, Dan Van de Mark, and Andrew Beardsley. Shout out to @genophoria.bsky.social, Mary-Kate Hayward and many others
Press Release Here
elifesciences.org/for-the-pres...
@ucsfcancer.bsky.social
Outstanding work by Drs. Rachel Nakagawa, Dan Van de Mark, and Andrew Beardsley. Shout out to @genophoria.bsky.social, Mary-Kate Hayward and many others
Press Release Here
elifesciences.org/for-the-pres...
@ucsfcancer.bsky.social
Reposted by Hani Goodarzi
Check out our latest work on one of the first multi-modal cell-free RNA foundation models for blood surveillance and liquid biopsy applications, led by @genophoria.bsky.social, @babak-a.bsky.social, @mehrankr.bsky.social and Aiden Sababi
Joining forces with the legendary @babak-a.bsky.social, @fhormozd.bsky.social, and @mkarimzadeh.bsky.social to bring you Exai-1; a multi-modal cell-free RNA foundation model for blood surveillance and liquid biopsy applications. Kudos to the broader @exai.bio team!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A multi-modal cell-free RNA language model for liquid biopsy applications
Cell-free RNA (cfRNA) profiling has emerged as a powerful tool for non-invasive disease detection, but its application is limited by data sparsity and complexity, especially in settings with constrain...
www.biorxiv.org
April 1, 2025 at 10:51 PM
Check out our latest work on one of the first multi-modal cell-free RNA foundation models for blood surveillance and liquid biopsy applications, led by @genophoria.bsky.social, @babak-a.bsky.social, @mehrankr.bsky.social and Aiden Sababi
Reposted by Hani Goodarzi
Super excited to share that our paper on a multi-modal cell-free RNA foundation model is out! A fantastic collaboration with @genophoria.bsky.social, @fhormozd.bsky.social and the @exai.bio team!
Joining forces with the legendary @babak-a.bsky.social, @fhormozd.bsky.social, and @mkarimzadeh.bsky.social to bring you Exai-1; a multi-modal cell-free RNA foundation model for blood surveillance and liquid biopsy applications. Kudos to the broader @exai.bio team!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A multi-modal cell-free RNA language model for liquid biopsy applications
Cell-free RNA (cfRNA) profiling has emerged as a powerful tool for non-invasive disease detection, but its application is limited by data sparsity and complexity, especially in settings with constrain...
www.biorxiv.org
April 1, 2025 at 10:30 PM
Super excited to share that our paper on a multi-modal cell-free RNA foundation model is out! A fantastic collaboration with @genophoria.bsky.social, @fhormozd.bsky.social and the @exai.bio team!
Reposted by Hani Goodarzi
1/ It has been a privilege to have the opportunity of contributing to Exai-1. Shout out to my co-first author,
Aiden Sabadbi, and my amazing colleagues @exai.bio, particularly @fhormozd.bsky.social, @babak-a.bsky.social, and @genophoria.bsky.social who led the effort.
Aiden Sabadbi, and my amazing colleagues @exai.bio, particularly @fhormozd.bsky.social, @babak-a.bsky.social, and @genophoria.bsky.social who led the effort.
Joining forces with the legendary @babak-a.bsky.social, @fhormozd.bsky.social, and @mkarimzadeh.bsky.social to bring you Exai-1; a multi-modal cell-free RNA foundation model for blood surveillance and liquid biopsy applications. Kudos to the broader @exai.bio team!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A multi-modal cell-free RNA language model for liquid biopsy applications
Cell-free RNA (cfRNA) profiling has emerged as a powerful tool for non-invasive disease detection, but its application is limited by data sparsity and complexity, especially in settings with constrain...
www.biorxiv.org
April 1, 2025 at 10:29 PM
1/ It has been a privilege to have the opportunity of contributing to Exai-1. Shout out to my co-first author,
Aiden Sabadbi, and my amazing colleagues @exai.bio, particularly @fhormozd.bsky.social, @babak-a.bsky.social, and @genophoria.bsky.social who led the effort.
Aiden Sabadbi, and my amazing colleagues @exai.bio, particularly @fhormozd.bsky.social, @babak-a.bsky.social, and @genophoria.bsky.social who led the effort.
Joining forces with the legendary @babak-a.bsky.social, @fhormozd.bsky.social, and @mkarimzadeh.bsky.social to bring you Exai-1; a multi-modal cell-free RNA foundation model for blood surveillance and liquid biopsy applications. Kudos to the broader @exai.bio team!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A multi-modal cell-free RNA language model for liquid biopsy applications
Cell-free RNA (cfRNA) profiling has emerged as a powerful tool for non-invasive disease detection, but its application is limited by data sparsity and complexity, especially in settings with constrain...
www.biorxiv.org
April 1, 2025 at 10:02 PM
Joining forces with the legendary @babak-a.bsky.social, @fhormozd.bsky.social, and @mkarimzadeh.bsky.social to bring you Exai-1; a multi-modal cell-free RNA foundation model for blood surveillance and liquid biopsy applications. Kudos to the broader @exai.bio team!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Hani Goodarzi
Reposted by Hani Goodarzi
If you want a glimpse into the mind of @pdhsu.bsky.social and how he describes Evo 2 check out the clip in the post below along with the full video in the 🧵
1/ In this clip, Evo 2 co-author Patrick Hsu discusses how the multimodel, multiscale biological foundation model makes computational predictions of genetic variant effects, using BRCA1 as an example.
March 27, 2025 at 8:27 PM
If you want a glimpse into the mind of @pdhsu.bsky.social and how he describes Evo 2 check out the clip in the post below along with the full video in the 🧵
Plucking students one by one...! how can we make sure these students have the support that they need and the right representation? Beyond the uni statements?
An Iranian student in Alabama thecrimsonwhite.com/120415/news/...
UA student reportedly detained by ICE
This is a breaking news story and will continue to be updated. A UA student was reportedly detained by the U.S. Immigrations and Customs Enforcement early Tuesday morning. Alireza Doroudi, a doctora...
thecrimsonwhite.com
March 27, 2025 at 7:59 PM
Plucking students one by one...! how can we make sure these students have the support that they need and the right representation? Beyond the uni statements?