Faraz Mardakheh
@mardakheh.bsky.social
Associate Professor at the Department of Biochemistry, University of Oxford. Fellow of Brasenose College.
Studying RNA binding proteins in cancer.
https://mardakhehlab.info
https://www.bioch.ox.ac.uk/research/mardakheh
Studying RNA binding proteins in cancer.
https://mardakhehlab.info
https://www.bioch.ox.ac.uk/research/mardakheh
Reposted by Faraz Mardakheh
We’ll soon be advertising a postdoc position (3 years) to study how mRNA-specific translational regulation shapes the innate immune system, in collaboration with @alf-castello.bsky.social. The formal ad will be out soon but get in touch if you’d like an informal chat! #RNASky
November 11, 2025 at 3:53 PM
We’ll soon be advertising a postdoc position (3 years) to study how mRNA-specific translational regulation shapes the innate immune system, in collaboration with @alf-castello.bsky.social. The formal ad will be out soon but get in touch if you’d like an informal chat! #RNASky
Reposted by Faraz Mardakheh
Check out the latest work from our lab, led by Daniel Lin and Lara Elcavage: www.biorxiv.org/content/10.1... (1/3)
mRNA 3′ UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growth
MicroRNAs direct downregulation of target mRNAs. Sometimes, however, this regulatory paradigm inverts, and a target RNA triggers the degradation of a microRNA. This target-directed microRNA degradatio...
www.biorxiv.org
November 7, 2025 at 6:33 PM
Check out the latest work from our lab, led by Daniel Lin and Lara Elcavage: www.biorxiv.org/content/10.1... (1/3)
Reposted by Faraz Mardakheh
🚨 #RNAsky 🚨
Exciting news for the RNA research community!
The Human RNome Project has been launched: a global effort to map all human RNAs and their chemical modifications. Proud to support it and contribute to the article in Genome Biology doi.org/10.1186/s130...
#RNA #bioinformatics #RNAstructure #modomics
The Human RNome Project has been launched: a global effort to map all human RNAs and their chemical modifications. Proud to support it and contribute to the article in Genome Biology doi.org/10.1186/s130...
#RNA #bioinformatics #RNAstructure #modomics
Unlocking the regulatory code of RNA: launching the Human RNome Project - Genome Biology
The human RNome, the complete set of RNA molecules in human cells, arises through complex processing and includes diverse molecular species. While research traditionally focuses on four canonical nucl...
genomebiology.biomedcentral.com
October 26, 2025 at 6:02 PM
🚨 #RNAsky 🚨
Reposted by Faraz Mardakheh
🧬 New preprint!
SNU-Seq maps nascent transcription at single-nucleotide resolution using 4sU labeling.
Together with sf4sU-Seq, it shows how epigenetically primed chromatin rapidly activates transcription after IFN-γ.
📄 doi.org/10.1101/2021...
#SNUSeq #RNAseq
SNU-Seq maps nascent transcription at single-nucleotide resolution using 4sU labeling.
Together with sf4sU-Seq, it shows how epigenetically primed chromatin rapidly activates transcription after IFN-γ.
📄 doi.org/10.1101/2021...
#SNUSeq #RNAseq
Single Nucleotide Resolution 4sU Sequencing (SNU-Seq) reveals the transcriptional responsiveness of an epigenetically primed human genome
Genomes are pervasively transcribed, leading to stable and unstable transcripts that influence 3-dimensional genome organisation and gene regulation. High sensitivity and nucleotide resolution are req...
doi.org
October 24, 2025 at 6:34 PM
🧬 New preprint!
SNU-Seq maps nascent transcription at single-nucleotide resolution using 4sU labeling.
Together with sf4sU-Seq, it shows how epigenetically primed chromatin rapidly activates transcription after IFN-γ.
📄 doi.org/10.1101/2021...
#SNUSeq #RNAseq
SNU-Seq maps nascent transcription at single-nucleotide resolution using 4sU labeling.
Together with sf4sU-Seq, it shows how epigenetically primed chromatin rapidly activates transcription after IFN-γ.
📄 doi.org/10.1101/2021...
#SNUSeq #RNAseq
Reposted by Faraz Mardakheh
Our paper describing enhanced hybridization-proximity labeling technology is finally out! Enhanced HyPro can identify proteins associated with small RNA compartments and even some individual transcripts, such as pathological C9orf72 transcripts: www.nature.com/articles/s41...
Enhanced hybridization-proximity labeling discovers protein interactomes of single RNA molecules - Nature Communications
Systematic discovery of proteins interacting with low-abundance RNAs is challenging. Here, the authors develop an enhanced HyPro technology to identify proteins associated with compact RNA compartment...
www.nature.com
October 21, 2025 at 8:46 AM
Our paper describing enhanced hybridization-proximity labeling technology is finally out! Enhanced HyPro can identify proteins associated with small RNA compartments and even some individual transcripts, such as pathological C9orf72 transcripts: www.nature.com/articles/s41...
Reposted by Faraz Mardakheh
new out in Nature www.nature.com/articles/d41...
John Gurdon obituary: Biologist who made cloning possible
He showed that specialized cells retain the genes to form an organism.
www.nature.com
October 21, 2025 at 7:22 AM
new out in Nature www.nature.com/articles/d41...
Reposted by Faraz Mardakheh
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
October 17, 2025 at 2:56 PM
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
Reposted by Faraz Mardakheh
The enzyme cGAS senses DNA damage, but in humans and mice it inhibits a DNA repair pathway (homologous recombination), which reduces genome stability. In naked mole-rats, altering 4 amino acids in cGAS changes its role: instead of hampering repair, it boosts it.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that na...
www.science.org
October 18, 2025 at 12:42 PM
The enzyme cGAS senses DNA damage, but in humans and mice it inhibits a DNA repair pathway (homologous recombination), which reduces genome stability. In naked mole-rats, altering 4 amino acids in cGAS changes its role: instead of hampering repair, it boosts it.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Faraz Mardakheh
New BBSRC funded PhD opportunity in my group with Inspiralis Ltd and @conradn.bsky.social. If you are interested in RNA - protein interactions and RNA modifications check the details below for how to apply. @nrpdtp.bsky.social @biouea.bsky.social @earlhaminst.bsky.social tinyurl.com/bdzvn4dr
How do RNA molecules shape genome regulation in the nervous system? (AKAY_U26CASE) | Doctoral Training Partnership
This PhD project will investigate how RNA modifications influence the activity of topoisomerase I (TOP1), a crucial enzyme that regulates DNA supercoiling during replication and transcription. Using C...
biodtp.norwichresearchpark.ac.uk
October 12, 2025 at 7:43 PM
New BBSRC funded PhD opportunity in my group with Inspiralis Ltd and @conradn.bsky.social. If you are interested in RNA - protein interactions and RNA modifications check the details below for how to apply. @nrpdtp.bsky.social @biouea.bsky.social @earlhaminst.bsky.social tinyurl.com/bdzvn4dr
Reposted by Faraz Mardakheh
During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!
apply.interfolio.com/174756
apply.interfolio.com/174756
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 14, 2025 at 5:35 PM
During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!
apply.interfolio.com/174756
apply.interfolio.com/174756
Reposted by Faraz Mardakheh
We’re offering a 4y MRC PhD studentship with Fadri Martinez-Perez @mrc-lms.bsky.social Check it out!
lms.mrc.ac.uk/work-and-stu...
lms.mrc.ac.uk/work-and-stu...
Studentships and PhD training
We have two core PhD programmes - traditional and transdisciplinary. Our PhD students are registered with Imperial and are embedded in our dedicated research facility.
lms.mrc.ac.uk
October 14, 2025 at 2:50 PM
We’re offering a 4y MRC PhD studentship with Fadri Martinez-Perez @mrc-lms.bsky.social Check it out!
lms.mrc.ac.uk/work-and-stu...
lms.mrc.ac.uk/work-and-stu...
Reposted by Faraz Mardakheh
Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇
Oxidative stress sensing by the translation elongation machinery promotes production of detoxifying selenoproteins
Selenocysteine, incorporated into polypeptides at recoded termination codons, plays an essential role in redox biology. Using GPX1 and GPX4, selenoenzymes that mitigate oxidative stress, as reporters,...
www.biorxiv.org
October 14, 2025 at 10:28 PM
Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇
Reposted by Faraz Mardakheh
Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com
October 15, 2025 at 6:33 AM
Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com
Reposted by Faraz Mardakheh
Last week we were in the Washington Post for our characterization of Robertsonian chromosomes. This week we are entering our 10th day of being shut down and all of our research is on hold. To help me feel not-so-bad, here is a thread of some studies we released right before the shutdown 🧵 [1/n]...
October 10, 2025 at 3:24 PM
Last week we were in the Washington Post for our characterization of Robertsonian chromosomes. This week we are entering our 10th day of being shut down and all of our research is on hold. To help me feel not-so-bad, here is a thread of some studies we released right before the shutdown 🧵 [1/n]...
Reposted by Faraz Mardakheh
Wonderful opportunity to work with Martin Howard and my group trying to understand how chromatin influences gene transcription and expression. Integration of theory, modelling, and experimentation. Come and join the team!
Please repost!
jobs.jic.ac.uk/Details.asp?...
Please repost!
jobs.jic.ac.uk/Details.asp?...
John Innes Centre
jobs.jic.ac.uk
October 8, 2025 at 9:04 AM
Wonderful opportunity to work with Martin Howard and my group trying to understand how chromatin influences gene transcription and expression. Integration of theory, modelling, and experimentation. Come and join the team!
Please repost!
jobs.jic.ac.uk/Details.asp?...
Please repost!
jobs.jic.ac.uk/Details.asp?...
Reposted by Faraz Mardakheh
Prestigious CRUK funded PhD studentship available in my lab for students with Black heritage backgrounds. See 👇Please apply and repost. UK home tuition fee status students only.
Are you interested in doing a #PhD in #cancerresearch?
🧪👩🏿🔬🧫🦠🔬
Do you want to develop new #biotherapeutics?
Are you of black heritage?
Applications for our fully funded 4-year BLiC PhD programme starting in Autumn 2026 are open now!
bit.ly/485QAga
#uclcancer #QMBCI #KCLcancer_pharm #KCL #TheCrick
🧪👩🏿🔬🧫🦠🔬
Do you want to develop new #biotherapeutics?
Are you of black heritage?
Applications for our fully funded 4-year BLiC PhD programme starting in Autumn 2026 are open now!
bit.ly/485QAga
#uclcancer #QMBCI #KCLcancer_pharm #KCL #TheCrick
Black Leaders PhD programme
For students of black ethnicity embarking on their research career
Applications for 2026 PhD studentships are open! Application through Cancer Research UK/ Windsor Fellowship required in addition!
W...
bit.ly
October 2, 2025 at 2:46 PM
Prestigious CRUK funded PhD studentship available in my lab for students with Black heritage backgrounds. See 👇Please apply and repost. UK home tuition fee status students only.
Reposted by Faraz Mardakheh
We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...
October 2, 2025 at 3:49 PM
We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...
Reposted by Faraz Mardakheh
#RNAsky 😎
Collective homeostasis of condensation-prone proteins via their mRNAs | Nature share.google/zkKumKefL83G...
Collective homeostasis of condensation-prone proteins via their mRNAs - Nature
The authors discover a homeostatic process termed interstasis, in which an increased concentration of proteins within RNA–protein condensates induces the sequestration of their own mRNAs.
share.google
September 28, 2025 at 8:42 PM
#RNAsky 😎
Reposted by Faraz Mardakheh
AWESOME CONFERENCE ALERT!!
I had an absolute blast at the Fusion “Genome Regulation Through RNA” meeting back in 2024, and psyched to see its upcoming return! Let’s geek out about all things Chromatin and RNA together, in Cancun!
Talk abstract deadline: 10/17
Details👇
I had an absolute blast at the Fusion “Genome Regulation Through RNA” meeting back in 2024, and psyched to see its upcoming return! Let’s geek out about all things Chromatin and RNA together, in Cancun!
Talk abstract deadline: 10/17
Details👇
September 19, 2025 at 11:44 PM
AWESOME CONFERENCE ALERT!!
I had an absolute blast at the Fusion “Genome Regulation Through RNA” meeting back in 2024, and psyched to see its upcoming return! Let’s geek out about all things Chromatin and RNA together, in Cancun!
Talk abstract deadline: 10/17
Details👇
I had an absolute blast at the Fusion “Genome Regulation Through RNA” meeting back in 2024, and psyched to see its upcoming return! Let’s geek out about all things Chromatin and RNA together, in Cancun!
Talk abstract deadline: 10/17
Details👇
Reposted by Faraz Mardakheh
Check it out! The team at Acepodia reports efficacy of cetuximab-conjugated allogenic gamma/delta-T cells against EGFR+ tumors in mice, off-the-shelf, safer alternative to CAR-T. Currently in phase 1 clinical study (NCT06415487). Cell-surface chemistry for the win 👏
jitc.bmj.com/content/13/7...
jitc.bmj.com/content/13/7...
Allogeneic cetuximab-armed gamma delta T cells using antibody-cell conjugation technology for the treatment of EGFR-expressing solid tumors
Background Targeting epidermal growth factor receptor (EGFR) has become a strategic approach in cancer therapy, using various modalities including chimeric antigen receptor (CAR)-αβT cell therapies. D...
jitc.bmj.com
September 12, 2025 at 5:18 AM
Check it out! The team at Acepodia reports efficacy of cetuximab-conjugated allogenic gamma/delta-T cells against EGFR+ tumors in mice, off-the-shelf, safer alternative to CAR-T. Currently in phase 1 clinical study (NCT06415487). Cell-surface chemistry for the win 👏
jitc.bmj.com/content/13/7...
jitc.bmj.com/content/13/7...
Reposted by Faraz Mardakheh
David Baltimore passed away this weekend. A pioneer of molecular virology who won the Nobel prize in medicine & physiology for his discovery of viral reverse transcriptase. This essay he wrote in 2018 reflecting of his 60yr career in science is a great read.
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
Sixty Years of Discovery | Annual Reviews
Each of us is a story. Mine is a story of doing science for 60 years, and I am honored to be asked to tell it. Even though this autobiography was written for the Annual Review of Immunology, I have ch...
www.annualreviews.org
September 8, 2025 at 1:43 AM
David Baltimore passed away this weekend. A pioneer of molecular virology who won the Nobel prize in medicine & physiology for his discovery of viral reverse transcriptase. This essay he wrote in 2018 reflecting of his 60yr career in science is a great read.
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
Reposted by Faraz Mardakheh
Looking forward to a few days of exciting discussions at the #EMBLProtein synthesis and translational control meeting www.embl.org/about/info/c...
Protein synthesis and translational control
www.embl.org
September 3, 2025 at 5:09 AM
Looking forward to a few days of exciting discussions at the #EMBLProtein synthesis and translational control meeting www.embl.org/about/info/c...
Reposted by Faraz Mardakheh
I'm thrilled to share our work from @weissmanlab.bsky.social (www.sciencedirect.com/science/arti...). We developed LOCL-TL, an optogenetic approach for monitoring localized translation in mammalian cells. LOCL-TL revealed two distinct strategies for mitochondrially localized translation.
August 27, 2025 at 9:44 PM
I'm thrilled to share our work from @weissmanlab.bsky.social (www.sciencedirect.com/science/arti...). We developed LOCL-TL, an optogenetic approach for monitoring localized translation in mammalian cells. LOCL-TL revealed two distinct strategies for mitochondrially localized translation.