Cameron Osborne
@cameronosborne.bsky.social
Interrogating three-dimensional gene regulatory programs in development and disease.
Murdoch Children's Research Institute (MCRI)
Naarm/Melbourne, Australia
🇨🇦 |🇦🇺
Murdoch Children's Research Institute (MCRI)
Naarm/Melbourne, Australia
🇨🇦 |🇦🇺
Reposted by Cameron Osborne
Tomorrow - Join the NIC for the Human HSC Ontogeny webinar with speakers Hanna Mikkola and Elizabeth Ng. View the webinar details and register on www.iseh.org/ISEHWebinars
August 19, 2025 at 7:15 PM
Tomorrow - Join the NIC for the Human HSC Ontogeny webinar with speakers Hanna Mikkola and Elizabeth Ng. View the webinar details and register on www.iseh.org/ISEHWebinars
Reposted by Cameron Osborne
Please RP.
We are thrilled to announce that our lab’s first preprint is out!
”Whole-genome single-cell multimodal history tracing to reveal cell identity transition”
We report HisTrac-seq, a multiomic single-cell molecular recording platform.
www.biorxiv.org/content/10.1...
We are thrilled to announce that our lab’s first preprint is out!
”Whole-genome single-cell multimodal history tracing to reveal cell identity transition”
We report HisTrac-seq, a multiomic single-cell molecular recording platform.
www.biorxiv.org/content/10.1...
August 16, 2025 at 7:15 AM
Please RP.
We are thrilled to announce that our lab’s first preprint is out!
”Whole-genome single-cell multimodal history tracing to reveal cell identity transition”
We report HisTrac-seq, a multiomic single-cell molecular recording platform.
www.biorxiv.org/content/10.1...
We are thrilled to announce that our lab’s first preprint is out!
”Whole-genome single-cell multimodal history tracing to reveal cell identity transition”
We report HisTrac-seq, a multiomic single-cell molecular recording platform.
www.biorxiv.org/content/10.1...
Reposted by Cameron Osborne
Multiple TF-coactivators regulate enhancer/promoter activity. Right?
But how can just one histone modification (H3K27ac) distinguish an enhancer from a non-enhancer?
While still a valuable indicator, it is just one component of a complex feature.
But how can just one histone modification (H3K27ac) distinguish an enhancer from a non-enhancer?
While still a valuable indicator, it is just one component of a complex feature.
“Our findings suggest the existence of tens of thousands of enhancers that remain undiscovered by currently available chromatin data, underscoring the continued need for expanding resources for enhancer discovery.”
Great paper and very important finding - many congrats Axel & team! 👏👏
Great paper and very important finding - many congrats Axel & team! 👏👏
August 8, 2025 at 9:50 PM
Multiple TF-coactivators regulate enhancer/promoter activity. Right?
But how can just one histone modification (H3K27ac) distinguish an enhancer from a non-enhancer?
While still a valuable indicator, it is just one component of a complex feature.
But how can just one histone modification (H3K27ac) distinguish an enhancer from a non-enhancer?
While still a valuable indicator, it is just one component of a complex feature.
Reposted by Cameron Osborne
🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
July 28, 2025 at 9:10 AM
🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Reposted by Cameron Osborne
🚨 New paper alert 🚨
I am excited to share our new work on epigenetic enhancer priming in early mammalian development
genomebiology.biomedcentral.com/articles/10....
Fantastic collaboration with Wolf Reik’s team, with key contributions from many others, led by the excellent Chris Todd.
Short 🧵
I am excited to share our new work on epigenetic enhancer priming in early mammalian development
genomebiology.biomedcentral.com/articles/10....
Fantastic collaboration with Wolf Reik’s team, with key contributions from many others, led by the excellent Chris Todd.
Short 🧵
Epigenetic priming of mammalian embryonic enhancer elements coordinates developmental gene networks - Genome Biology
Background Embryonic development requires the accurate spatiotemporal execution of cell lineage-specific gene expression programs, which are controlled by transcriptional enhancers. Developmental enha...
genomebiology.biomedcentral.com
July 22, 2025 at 10:26 PM
🚨 New paper alert 🚨
I am excited to share our new work on epigenetic enhancer priming in early mammalian development
genomebiology.biomedcentral.com/articles/10....
Fantastic collaboration with Wolf Reik’s team, with key contributions from many others, led by the excellent Chris Todd.
Short 🧵
I am excited to share our new work on epigenetic enhancer priming in early mammalian development
genomebiology.biomedcentral.com/articles/10....
Fantastic collaboration with Wolf Reik’s team, with key contributions from many others, led by the excellent Chris Todd.
Short 🧵
Reposted by Cameron Osborne
Delighted & excited to share our latest preprint on non-canonical enhancers in human pluripotent stem cells, the result of a fantastic and fun collaboration with @guenesdoganlab.bsky.social:
www.biorxiv.org/content/10.1...
🧵 below
www.biorxiv.org/content/10.1...
🧵 below
Non-canonical enhancers control gene expression and cell fate in human pluripotent stem cells
Enhancers are key gene regulatory elements that ensure the precise spatiotemporal execution of developmental gene expression programmes. However recent findings indicate that approaches to identify en...
www.biorxiv.org
June 2, 2025 at 11:26 PM
Delighted & excited to share our latest preprint on non-canonical enhancers in human pluripotent stem cells, the result of a fantastic and fun collaboration with @guenesdoganlab.bsky.social:
www.biorxiv.org/content/10.1...
🧵 below
www.biorxiv.org/content/10.1...
🧵 below
Reposted by Cameron Osborne
Excited our paper is out in Cell @cp-cell.bsky.social!
🧬⚡ DNA photo-crosslinking proteomics in living cells
🎯 Pinpoints protein-DNA interactions to single amino acids
🌎 Globally quantifies DNA binding for >1800 proteins at a timescale of minutes
🔗 www.cell.com/cell/fulltex...
🧵
🧬⚡ DNA photo-crosslinking proteomics in living cells
🎯 Pinpoints protein-DNA interactions to single amino acids
🌎 Globally quantifies DNA binding for >1800 proteins at a timescale of minutes
🔗 www.cell.com/cell/fulltex...
🧵
The human proteome with direct physical access to DNA
Zero-distance photo-crosslinking reveals direct protein-DNA interactions in living
cells, enabling quantitative analysis of the DNA-interacting proteome on a timescale
of minutes with single-amino-aci...
www.cell.com
May 23, 2025 at 7:06 AM
Excited our paper is out in Cell @cp-cell.bsky.social!
🧬⚡ DNA photo-crosslinking proteomics in living cells
🎯 Pinpoints protein-DNA interactions to single amino acids
🌎 Globally quantifies DNA binding for >1800 proteins at a timescale of minutes
🔗 www.cell.com/cell/fulltex...
🧵
🧬⚡ DNA photo-crosslinking proteomics in living cells
🎯 Pinpoints protein-DNA interactions to single amino acids
🌎 Globally quantifies DNA binding for >1800 proteins at a timescale of minutes
🔗 www.cell.com/cell/fulltex...
🧵
Reposted by Cameron Osborne
Delighted to share the latest preprint from the lab led by Janith Seneviratne
We reveal novel roles for #embryonic regulators DPPA2/4 in facilitating a H2AK119Ub primed #chromatin state when aberrantly up-regulated in non-small cell lung #cancers 🧬🔬 (1/6)
www.biorxiv.org/content/10.1...
We reveal novel roles for #embryonic regulators DPPA2/4 in facilitating a H2AK119Ub primed #chromatin state when aberrantly up-regulated in non-small cell lung #cancers 🧬🔬 (1/6)
www.biorxiv.org/content/10.1...
April 28, 2025 at 11:07 AM
Delighted to share the latest preprint from the lab led by Janith Seneviratne
We reveal novel roles for #embryonic regulators DPPA2/4 in facilitating a H2AK119Ub primed #chromatin state when aberrantly up-regulated in non-small cell lung #cancers 🧬🔬 (1/6)
www.biorxiv.org/content/10.1...
We reveal novel roles for #embryonic regulators DPPA2/4 in facilitating a H2AK119Ub primed #chromatin state when aberrantly up-regulated in non-small cell lung #cancers 🧬🔬 (1/6)
www.biorxiv.org/content/10.1...
Reposted by Cameron Osborne
Canadians 🇨🇦 abroad - you can register to vote in the election! You need to do it soon. www.elections.ca/content2.asp...
Voting by mail – Elections Canada
Apply to vote by mail, Eligible electors can apply to vote by special ballot. With a special ballot, you can vote by mail from anywhere in the world, 2025.
www.elections.ca
April 11, 2025 at 8:51 AM
Canadians 🇨🇦 abroad - you can register to vote in the election! You need to do it soon. www.elections.ca/content2.asp...
Reposted by Cameron Osborne
ISEH is thrilled to announce the recipients of the 2025 Society Awards, which will be presented at the ISEH 54th Annual Scientific Meeting. Read more about each award recipient on www.simplyblood.org
March 11, 2025 at 3:40 PM
ISEH is thrilled to announce the recipients of the 2025 Society Awards, which will be presented at the ISEH 54th Annual Scientific Meeting. Read more about each award recipient on www.simplyblood.org
Reposted by Cameron Osborne
💥💥We are excited to announce our first GOA seminar speaker for 2025 is @namekawasatoshi.bsky.social 🌟🌟 please join us on the 18th of March via this link: unimelb.zoom.us/webinar/regi...
Welcome! You are invited to join a webinar: March GOA Webinar: Satoshi Namekawa. After registering, you will receive a confirmation email about joining the webinar.
Welcome! You are invited to join a webinar: March GOA Webinar: Satoshi Namekawa. After registering, you will receive a confirmation email about joining the webinar.
unimelb.zoom.us
March 5, 2025 at 6:00 AM
💥💥We are excited to announce our first GOA seminar speaker for 2025 is @namekawasatoshi.bsky.social 🌟🌟 please join us on the 18th of March via this link: unimelb.zoom.us/webinar/regi...
Reposted by Cameron Osborne
Welcome to our YouTube channel, 𝗔𝗡𝗨 𝗜𝗻𝗱𝗶𝗴𝗲𝗻𝗼𝘂𝘀 𝗚𝗲𝗻𝗼𝗺𝗶𝗰𝘀. We are delighted to have you join us as we explore the fascinating world of Indigenous genomics research.
Watch the video here: www.youtube.com/watch?v=So6d...
Be sure to subscribe and stay tuned for more insightful content.
Watch the video here: www.youtube.com/watch?v=So6d...
Be sure to subscribe and stay tuned for more insightful content.
This is a very important story about our Mob’s Health
YouTube video by ANU National Centre for Indigenous Genomics
www.youtube.com
February 20, 2025 at 3:08 AM
Welcome to our YouTube channel, 𝗔𝗡𝗨 𝗜𝗻𝗱𝗶𝗴𝗲𝗻𝗼𝘂𝘀 𝗚𝗲𝗻𝗼𝗺𝗶𝗰𝘀. We are delighted to have you join us as we explore the fascinating world of Indigenous genomics research.
Watch the video here: www.youtube.com/watch?v=So6d...
Be sure to subscribe and stay tuned for more insightful content.
Watch the video here: www.youtube.com/watch?v=So6d...
Be sure to subscribe and stay tuned for more insightful content.
Reposted by Cameron Osborne
As part of the #TeamCanada Trade Mission to Australia, Genome Canada is proud to announce a new collaboration with @ausgenomics.bsky.social to strengthen the impact of genomics technologies for both countries.
New Canada-Australia genomics collaboration to strengthen research impact - GenomeCanada
Genome Canada is thrilled to strengthen our long-standing relationship with Australia’s genomics community and our partners at Australian Genomics
genomecanada.ca
February 18, 2025 at 9:50 PM
As part of the #TeamCanada Trade Mission to Australia, Genome Canada is proud to announce a new collaboration with @ausgenomics.bsky.social to strengthen the impact of genomics technologies for both countries.
Reposted by Cameron Osborne
February 11, 2025 at 7:45 AM
Reposted by Cameron Osborne
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
February 8, 2025 at 9:21 PM
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
Reposted by Cameron Osborne
📢 CUT&Tag version 3
Sometimes the preprint to paper route can be quite the odyssey. And so in that vein, we are delighted to give you version 3 of our CUT&Tag optimization and benchmarking manuscript:
www.biorxiv.org/content/10.1...
Sometimes the preprint to paper route can be quite the odyssey. And so in that vein, we are delighted to give you version 3 of our CUT&Tag optimization and benchmarking manuscript:
www.biorxiv.org/content/10.1...
CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks
Techniques for genome-wide epigenetic profiling have been undergoing accelerated development toward recovery of high-quality data from bulk and single cell samples. DNA-protein interactions have tradi...
www.biorxiv.org
January 30, 2025 at 3:22 PM
📢 CUT&Tag version 3
Sometimes the preprint to paper route can be quite the odyssey. And so in that vein, we are delighted to give you version 3 of our CUT&Tag optimization and benchmarking manuscript:
www.biorxiv.org/content/10.1...
Sometimes the preprint to paper route can be quite the odyssey. And so in that vein, we are delighted to give you version 3 of our CUT&Tag optimization and benchmarking manuscript:
www.biorxiv.org/content/10.1...
Reposted by Cameron Osborne
Why can a human tolerate a drug that globally inhibits transcription? Why do transcription inhibitors not cure cancer? Our first paper of 2025 may help explain (some) of this!
So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work!
www.cell.com/molecular-ce...
So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work!
www.cell.com/molecular-ce...
mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription
Transcription inhibitors also disrupt nuclear export. Here, Williams et al. reveal that mRNA export factors sense transcription inhibition and adapt by storing mature export-competent mRNA in nuclear speckles. This enables rapid release when transcription resumes and ensures retention of cellular identity and viability during a transient global transcription insult.
www.cell.com
January 2, 2025 at 8:03 PM
Why can a human tolerate a drug that globally inhibits transcription? Why do transcription inhibitors not cure cancer? Our first paper of 2025 may help explain (some) of this!
So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work!
www.cell.com/molecular-ce...
So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work!
www.cell.com/molecular-ce...
Reposted by Cameron Osborne
Shareable link to @carlzimmer.bsky.social article in NYTimes on serious concerns over mirror bacteria, published in Science today.
www.nytimes.com/2024/12/12/s...
www.nytimes.com/2024/12/12/s...
A ‘Second Tree of Life’ Could Wreak Havoc, Scientists Warn (Gift Article)
Research on so-called mirror cells, which defy fundamental properties of living organisms, should be prohibited as too dangerous, biologists said.
www.nytimes.com
December 12, 2024 at 7:51 PM
Shareable link to @carlzimmer.bsky.social article in NYTimes on serious concerns over mirror bacteria, published in Science today.
www.nytimes.com/2024/12/12/s...
www.nytimes.com/2024/12/12/s...
Reposted by Cameron Osborne
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 11, 2024 at 4:29 PM
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
Reposted by Cameron Osborne
Major milestone: Tabula Sapiens 2.0 maps tissue composition & TF expression in 175 cell types, identifying 745 ubiquitous & 890 cell type-specific TFs (many still uncharacterized -> #Codebook) w/ roles in tissue homeostasis, stress response & metabolism. #SingleCell www.biorxiv.org/content/10.1...
Tabula Sapiens reveals transcription factor expression, senescence effects, and sex-specific features in cell types from 28 human organs and tissues
The Tabula Sapiens is a reference human cell atlas containing single cell transcriptomic data from more than two dozen organs and tissues. Here we report Tabula Sapiens 2.0 which includes data from ni...
www.biorxiv.org
December 8, 2024 at 8:55 AM
Major milestone: Tabula Sapiens 2.0 maps tissue composition & TF expression in 175 cell types, identifying 745 ubiquitous & 890 cell type-specific TFs (many still uncharacterized -> #Codebook) w/ roles in tissue homeostasis, stress response & metabolism. #SingleCell www.biorxiv.org/content/10.1...
Reposted by Cameron Osborne
Just in time for #ASH24, our latest paper is out. We performed scRNA-seq on HSPCs over human development, maturation, and postnatal aging. We looked at dynamics of HSPC subsets, lineage biases, HSC level priming, and identified a developmentally restricted human HSC.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The dynamics of hematopoiesis over the human lifespan - Nature Methods
This Resource presents an atlas classifying the age-related changes in human hematopoietic stem and progenitor cells from gestation through aging.
www.nature.com
December 5, 2024 at 12:52 PM
Just in time for #ASH24, our latest paper is out. We performed scRNA-seq on HSPCs over human development, maturation, and postnatal aging. We looked at dynamics of HSPC subsets, lineage biases, HSC level priming, and identified a developmentally restricted human HSC.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Cameron Osborne
Now on biorxiv! The JUMP-Cell Painting Consortium’s paper:
“Morphological map of under- and over-expression of genes in human cells”
This is the genetic perturbation portion of the JUMP’s dataset; our chemical perturbation paper will come in a few months
www.biorxiv.org/content/10.1...
“Morphological map of under- and over-expression of genes in human cells”
This is the genetic perturbation portion of the JUMP’s dataset; our chemical perturbation paper will come in a few months
www.biorxiv.org/content/10.1...
Morphological map of under- and over-expression of genes in human cells
Cell Painting images offer valuable insights into the state of a cell and enable many biological applications, but publicly available arrayed datasets only include hundreds of genes perturbed. The JUM...
www.biorxiv.org
December 4, 2024 at 2:09 PM
Now on biorxiv! The JUMP-Cell Painting Consortium’s paper:
“Morphological map of under- and over-expression of genes in human cells”
This is the genetic perturbation portion of the JUMP’s dataset; our chemical perturbation paper will come in a few months
www.biorxiv.org/content/10.1...
“Morphological map of under- and over-expression of genes in human cells”
This is the genetic perturbation portion of the JUMP’s dataset; our chemical perturbation paper will come in a few months
www.biorxiv.org/content/10.1...
Reposted by Cameron Osborne
To quote @denisduboule.bsky.social , IMHO one of the best definition of curiosity-driven basic research & serendipity
"going off to look for mushrooms and coming back with blueberries. If you are payed to find the mushrooms, you won't come back with the blueberries. You will come back with nothing.
"going off to look for mushrooms and coming back with blueberries. If you are payed to find the mushrooms, you won't come back with the blueberries. You will come back with nothing.
I’ve seen some posts recently, about the value of basic research, in light of funding cuts and demands that research have immediate economic justification.
Let me collect some info here, in a thread, about why it’s a bad idea to attach those sorts of demands to funding. 🧵 🧪 ⚛️
Let me collect some info here, in a thread, about why it’s a bad idea to attach those sorts of demands to funding. 🧵 🧪 ⚛️
December 4, 2024 at 5:37 PM
To quote @denisduboule.bsky.social , IMHO one of the best definition of curiosity-driven basic research & serendipity
"going off to look for mushrooms and coming back with blueberries. If you are payed to find the mushrooms, you won't come back with the blueberries. You will come back with nothing.
"going off to look for mushrooms and coming back with blueberries. If you are payed to find the mushrooms, you won't come back with the blueberries. You will come back with nothing.
Reposted by Cameron Osborne
An amazing opportunity to be the Nossal Professor of Immunology @wehi-research.bsky.social An adventure of a lifetime! Bonuses: Vegemite at morning tea and chocolate Tim Tams last Friday of the month. Not a bad place to live either 🌞🏖️ Additional bonus unique 🇦🇺creatures 🦘🐍🕷️🐨
📢 World-leading Immunologists. The Nossal Endowed Chair of Immunology has just been announced @wehi-research.bsky.social. This is your chance to move (or return) to Australia to do ground-breaking research and join a thriving environment for discovery and translation.
WEHI - The Sir Gustav Nossal Professor of Immunology - Alumni Global
The Professor will lead transformative research into the complexities of the immune system, building on Sir Gustav Nossal’s pioneering work. By fostering a culture of scientific excellence and innovat...
alumniglobal.com
December 2, 2024 at 7:32 AM
An amazing opportunity to be the Nossal Professor of Immunology @wehi-research.bsky.social An adventure of a lifetime! Bonuses: Vegemite at morning tea and chocolate Tim Tams last Friday of the month. Not a bad place to live either 🌞🏖️ Additional bonus unique 🇦🇺creatures 🦘🐍🕷️🐨
Reposted by Cameron Osborne
Here it is! Congratuations to @jesskelley.bsky.social @edimitrova.bsky.social @neilblackledge.bsky.social @aleksszczurek.bsky.social and the rest of the team (Maciej, Amy, and Hieu). This was a fab collaboration with Arminja Kettenbach. Also see a lovely complementary paper from Fei Chen's group.
Very excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)
The PNUTS phosphatase complex controls transcription pause release
Kelley et al. discover that the PNUTS phosphatase complex plays an essential role
in gene transcription by controlling RNA polymerase II pause release. PNUTS achieves
this through its TND, which recog...
www.cell.com
November 26, 2024 at 5:03 PM
Here it is! Congratuations to @jesskelley.bsky.social @edimitrova.bsky.social @neilblackledge.bsky.social @aleksszczurek.bsky.social and the rest of the team (Maciej, Amy, and Hieu). This was a fab collaboration with Arminja Kettenbach. Also see a lovely complementary paper from Fei Chen's group.