Robert Hänsel-Hertsch
@epistrucstab.bsky.social
Junior Group Leader, Center for Molecular Medicine Cologne, University of Cologne, DE
Reposted by Robert Hänsel-Hertsch
🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS.
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...
The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation - Nature Aging
Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...
www.nature.com
September 3, 2025 at 9:19 AM
🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS.
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...
Reposted by Robert Hänsel-Hertsch
New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...
FEBS Press
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient-derived neurons and C. elegans models, w...
febs.onlinelibrary.wiley.com
September 2, 2025 at 7:11 AM
New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Robert Hänsel-Hertsch
I am beyond excited and incredibly proud to share that our work is now out in @nature.com This discovery was made possible thanks to the first author Kostas kelepouras, my fantastic lab , and the unique research environment here in Cologne in collaboration with the Hospital bambino Gesu in Rome.
STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD - Nature
Nature - STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD
www.nature.com
August 21, 2025 at 6:12 AM
I am beyond excited and incredibly proud to share that our work is now out in @nature.com This discovery was made possible thanks to the first author Kostas kelepouras, my fantastic lab , and the unique research environment here in Cologne in collaboration with the Hospital bambino Gesu in Rome.
Congratulations Debora, fantastic news!
🚨 Happy to share our first pre-print 🎉 on the causes of ribosome-associated degradation of CFTR and other transmembrane proteins.
We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇
www.biorxiv.org/content/10.1...
We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇
www.biorxiv.org/content/10.1...
Principles of ribosome-associated protein quality control during the synthesis of CFTR
Prolonged translational arrests caused by defective mRNAs activate the ribosome-associated protein quality control (RQC) pathway, which marks harmful incomplete proteins for degradation. Multipass tra...
www.biorxiv.org
August 1, 2025 at 1:57 PM
Congratulations Debora, fantastic news!
Reposted by Robert Hänsel-Hertsch
DynaTag for efficient mapping of transcription factors in low-input samples and at single-cell resolution @natcomms.nature.com @epistrucstab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
DynaTag for efficient mapping of transcription factors in low-input samples and at single-cell resolution - Nature Communications
Transcription factors shape cell identity, but mapping their genomic targets remains challenging. Here the authors present DynaTag, a modified CUT&Tag method for profiling TF occupancy in bulk and...
www.nature.com
July 29, 2025 at 5:29 PM
DynaTag for efficient mapping of transcription factors in low-input samples and at single-cell resolution @natcomms.nature.com @epistrucstab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Robert Hänsel-Hertsch
A great skeetorial on a new and much improved method for mapping transcription factor landscapes, with a beautiful image by our own Gloria Fuentes @gloglita.bsky.social from Life Science Editors @lifescienceeditors.bsky.social
🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
July 28, 2025 at 5:02 PM
A great skeetorial on a new and much improved method for mapping transcription factor landscapes, with a beautiful image by our own Gloria Fuentes @gloglita.bsky.social from Life Science Editors @lifescienceeditors.bsky.social
Reposted by Robert Hänsel-Hertsch
🚀Big news from CRC 1678!
Robert Hänsel-Hertsch @epistrucstab.bsky.social and team unveil DynaTag—a single-cell method to map protein-DNA binding with stunning precision. Outshines ChIP-seq & CUT&RUN.
🧬Cancer research & gene regulation just got a major upgrade. #Genomics #DynaTag #PrecisionMedicine
Robert Hänsel-Hertsch @epistrucstab.bsky.social and team unveil DynaTag—a single-cell method to map protein-DNA binding with stunning precision. Outshines ChIP-seq & CUT&RUN.
🧬Cancer research & gene regulation just got a major upgrade. #Genomics #DynaTag #PrecisionMedicine
🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
July 28, 2025 at 3:30 PM
🚀Big news from CRC 1678!
Robert Hänsel-Hertsch @epistrucstab.bsky.social and team unveil DynaTag—a single-cell method to map protein-DNA binding with stunning precision. Outshines ChIP-seq & CUT&RUN.
🧬Cancer research & gene regulation just got a major upgrade. #Genomics #DynaTag #PrecisionMedicine
Robert Hänsel-Hertsch @epistrucstab.bsky.social and team unveil DynaTag—a single-cell method to map protein-DNA binding with stunning precision. Outshines ChIP-seq & CUT&RUN.
🧬Cancer research & gene regulation just got a major upgrade. #Genomics #DynaTag #PrecisionMedicine
Reposted by Robert Hänsel-Hertsch
🔬 DynaTag by CRC 1678 project leader Robert Hänsel-Hertsch @epistrucstab.bsky.social maps protein-DNA binding at single-cell level—boosting precision in cancer & gene research. #CRC1678 #DynaTag #UniCologne
🔬 New: Method for mapping protein-DNA interactions developed 💡
@epistrucstab.bsky.social #UniCologne has developed DynaTag, a method that detects the binding of proteins to DNA even in a single cell. This is crucial for gene regulation and the development of diseases like cancer. 🧬👇
uni.koeln/LXJQE
@epistrucstab.bsky.social #UniCologne has developed DynaTag, a method that detects the binding of proteins to DNA even in a single cell. This is crucial for gene regulation and the development of diseases like cancer. 🧬👇
uni.koeln/LXJQE
New method developed for mapping protein binding to DNA
A research team at the University of Cologne has developed a method called DynaTag, which can detect the binding of proteins to DNA, even in an individual cell. Interactions of proteins with DNA are c...
uni.koeln
July 28, 2025 at 3:35 PM
🔬 DynaTag by CRC 1678 project leader Robert Hänsel-Hertsch @epistrucstab.bsky.social maps protein-DNA binding at single-cell level—boosting precision in cancer & gene research. #CRC1678 #DynaTag #UniCologne
Reposted by Robert Hänsel-Hertsch
🧪New method for anyone interested in protein-DNA interactions and TF mapping, from the lab of @epistrucstab.bsky.social at @unicologne.bsky.social!👇
🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
July 28, 2025 at 11:44 AM
🧪New method for anyone interested in protein-DNA interactions and TF mapping, from the lab of @epistrucstab.bsky.social at @unicologne.bsky.social!👇
Reposted by Robert Hänsel-Hertsch
Highly recommended read for everyone interested in interactions of proteins and DNA: Impressive new method on single cell level introduced by @epistrucstab.bsky.social from @unicologne.bsky.social!
🔬 New: Method for mapping protein-DNA interactions developed 💡
@epistrucstab.bsky.social #UniCologne has developed DynaTag, a method that detects the binding of proteins to DNA even in a single cell. This is crucial for gene regulation and the development of diseases like cancer. 🧬👇
uni.koeln/LXJQE
@epistrucstab.bsky.social #UniCologne has developed DynaTag, a method that detects the binding of proteins to DNA even in a single cell. This is crucial for gene regulation and the development of diseases like cancer. 🧬👇
uni.koeln/LXJQE
New method developed for mapping protein binding to DNA
A research team at the University of Cologne has developed a method called DynaTag, which can detect the binding of proteins to DNA, even in an individual cell. Interactions of proteins with DNA are c...
uni.koeln
July 28, 2025 at 10:41 AM
Highly recommended read for everyone interested in interactions of proteins and DNA: Impressive new method on single cell level introduced by @epistrucstab.bsky.social from @unicologne.bsky.social!
Reposted by Robert Hänsel-Hertsch
Die neue Methode übertrifft bestehende Methoden wie #ChIP-seq und #CUT&RUN in Bezug auf Sensitivität und Auflösung der Ergebnisse. 📈
Die Studie wurde in @natcomms.nature.com veröffentlicht👇
www.nature.com/articles/s41...
Die Studie wurde in @natcomms.nature.com veröffentlicht👇
www.nature.com/articles/s41...
DynaTag for efficient mapping of transcription factors in low-input samples and at single-cell resolution - Nature Communications
Transcription factors shape cell identity, but mapping their genomic targets remains challenging. Here the authors present DynaTag, a modified CUT&Tag method for profiling TF occupancy in bulk and...
www.nature.com
July 28, 2025 at 9:45 AM
Die neue Methode übertrifft bestehende Methoden wie #ChIP-seq und #CUT&RUN in Bezug auf Sensitivität und Auflösung der Ergebnisse. 📈
Die Studie wurde in @natcomms.nature.com veröffentlicht👇
www.nature.com/articles/s41...
Die Studie wurde in @natcomms.nature.com veröffentlicht👇
www.nature.com/articles/s41...
Reposted by Robert Hänsel-Hertsch
🔬Neue Methode zur Kartierung von Proteinbindung an DNA entwickelt💡
@epistrucstab.bsky.social #UniKöln hat DynaTag entwickelt, eine Methode, die die Bindung von Proteinen an die DNA sogar in einer einzelnen Zelle nachweist 🧬👇https://uni.koeln/SCLU6
@epistrucstab.bsky.social #UniKöln hat DynaTag entwickelt, eine Methode, die die Bindung von Proteinen an die DNA sogar in einer einzelnen Zelle nachweist 🧬👇https://uni.koeln/SCLU6
Neue Methode zur Kartierung von Proteinbindung an DNA entwickelt
Ein Forschungsteam der Universität zu Köln hat eine Methode mit dem Namen DynaTag entwickelt, die die Bindung von Proteinen an die DNA sogar in einer einzelnen Zelle nachweist. Interaktionen von Prote...
uni.koeln
July 28, 2025 at 9:45 AM
🔬Neue Methode zur Kartierung von Proteinbindung an DNA entwickelt💡
@epistrucstab.bsky.social #UniKöln hat DynaTag entwickelt, eine Methode, die die Bindung von Proteinen an die DNA sogar in einer einzelnen Zelle nachweist 🧬👇https://uni.koeln/SCLU6
@epistrucstab.bsky.social #UniKöln hat DynaTag entwickelt, eine Methode, die die Bindung von Proteinen an die DNA sogar in einer einzelnen Zelle nachweist 🧬👇https://uni.koeln/SCLU6
🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
July 28, 2025 at 9:10 AM
🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Very proud of Dalya Hiluf being among the poster prize winners at the recent EMBO | EMBL Symposium 'The ageing genome'. Great stuff and congratulations!
June 27, 2025 at 12:44 PM
Very proud of Dalya Hiluf being among the poster prize winners at the recent EMBO | EMBL Symposium 'The ageing genome'. Great stuff and congratulations!
Reposted by Robert Hänsel-Hertsch
🧬🖥️ SARS-CoV-2 mRNA vaccination induces persistent H3K27 acetylation at macrophage promoters; especially those in guanine-rich DNA regions. Adds to my understanding of "immune training". Work by Jan Rybniker, @epistrucstab.bsky.social & teams in @molsystbiol.org www.embopress.org/do... 🧪
April 3, 2025 at 11:25 AM
🧬🖥️ SARS-CoV-2 mRNA vaccination induces persistent H3K27 acetylation at macrophage promoters; especially those in guanine-rich DNA regions. Adds to my understanding of "immune training". Work by Jan Rybniker, @epistrucstab.bsky.social & teams in @molsystbiol.org www.embopress.org/do... 🧪
Reposted by Robert Hänsel-Hertsch
Very nice paper showing that mRNA vaccines not merely elicit adaptive responses, but also epigenetically train innate immunity, too. 👇🏻👇🏻
April 3, 2025 at 11:25 AM
Very nice paper showing that mRNA vaccines not merely elicit adaptive responses, but also epigenetically train innate immunity, too. 👇🏻👇🏻
Reposted by Robert Hänsel-Hertsch
New research by Jan Rybniker and @epistrucstab.bsky.social reveals that the SARS-CoV-2 mRNA vaccine triggers innate immune memory by establishing persistent H3K27ac epigenetic marks in human macrophages. Two consecutive doses are needed for this persistence ➡️ www.embopress.org/doi/full/10....
April 1, 2025 at 10:49 AM
New research by Jan Rybniker and @epistrucstab.bsky.social reveals that the SARS-CoV-2 mRNA vaccine triggers innate immune memory by establishing persistent H3K27ac epigenetic marks in human macrophages. Two consecutive doses are needed for this persistence ➡️ www.embopress.org/doi/full/10....
Something positive on a topic that influenced us in so many ways. Happy that Jan and his team approached me to be a part of this endeavour. I‘m grateful to all my supporters, my lab, and funders. @crc1678.bsky.social #crc1399 #RU5504 #CMMC @cecad.bsky.social @dfg.de #Fritz_Thyssen_Foundation
🧬💡 #mRNA vaccines against COVID-19 not only trigger classical #immuneresponses, but also have a persistent effect on the innate #immunesystem📚
That shows a study by the team of Jan Rybniker and @epistrucstab.bsky.social #UniCologne in Molecular Systems Biology @embopress.org🦠👇
uni.koeln/43N7Y
#covid
That shows a study by the team of Jan Rybniker and @epistrucstab.bsky.social #UniCologne in Molecular Systems Biology @embopress.org🦠👇
uni.koeln/43N7Y
#covid
mRNA-Coronaimpfung trainiert das „Langzeitgedächtnis“ des Immunsystems
Forschende der Universität zu Köln zeigen, dass COVID-19-Impfstoffe auf der Grundlage von mRNA das angeborene Immunsystem langfristig prägen. Diese Mechanismen können bewirken, dass der menschliche Kö...
uni.koeln
March 26, 2025 at 1:54 PM
Something positive on a topic that influenced us in so many ways. Happy that Jan and his team approached me to be a part of this endeavour. I‘m grateful to all my supporters, my lab, and funders. @crc1678.bsky.social #crc1399 #RU5504 #CMMC @cecad.bsky.social @dfg.de #Fritz_Thyssen_Foundation
Something positive on a topic that influenced us in so many ways. Happy that Jan and his team approached me to be a part of this endeavour. I‘m grateful to all my supporters, my lab, and funders. @crc1678.bsky.social #crc1399 #RU5504 #CMMC @cecad.bsky.social @dfg.de #Fritz_Thyssen_Foundation
🧬💡 mRNA-Impfstoffe gegen COVID-19 rufen nicht nur klassische Immunantworten hervor, sondern prägen langfristig auch das angeborene #Immunsystem. 💉
Das zeigt ein Team um Jan Rybniker und @epistrucstab.bsky.social der #UniKöln und @uniklinikkoeln.bsky.social 🦠 👇
uni.koeln/EXDKG
#mrna #Impfung #covid
Das zeigt ein Team um Jan Rybniker und @epistrucstab.bsky.social der #UniKöln und @uniklinikkoeln.bsky.social 🦠 👇
uni.koeln/EXDKG
#mrna #Impfung #covid
mRNA-Coronaimpfung trainiert das „Langzeitgedächtnis“ des Immunsystems
Forschende der Universität zu Köln zeigen, dass COVID-19-Impfstoffe auf der Grundlage von mRNA das angeborene Immunsystem langfristig prägen. Diese Mechanismen können bewirken, dass der menschliche Kö...
uni.koeln
March 26, 2025 at 1:52 PM
Something positive on a topic that influenced us in so many ways. Happy that Jan and his team approached me to be a part of this endeavour. I‘m grateful to all my supporters, my lab, and funders. @crc1678.bsky.social #crc1399 #RU5504 #CMMC @cecad.bsky.social @dfg.de #Fritz_Thyssen_Foundation