Grant Rowe
@bloodandtime.bsky.social
Physician-Scientist at Boston Children's/Dana-Farber. Pediatric bone marrow failure, hematopoietic stem cell transplantation, developmental hematopoiesis, disease modeling, pluripotent stem cells.
There are two types of people in academic medicine - those who are there because it is their lifetime calling, others who are there to take home a paycheck.
The fundamental problem is that those there for the paycheck hold all of the power.
The fundamental problem is that those there for the paycheck hold all of the power.
September 12, 2025 at 12:20 PM
There are two types of people in academic medicine - those who are there because it is their lifetime calling, others who are there to take home a paycheck.
The fundamental problem is that those there for the paycheck hold all of the power.
The fundamental problem is that those there for the paycheck hold all of the power.
Reposted by Grant Rowe
The ISEH just launched a brand new website! Check it out and join our society today to network with your colleagues and keep abreast of the latest advances in basic and translational experimental hematology research!
iseh.org
iseh.org
Home
iseh.org
September 10, 2025 at 6:22 PM
The ISEH just launched a brand new website! Check it out and join our society today to network with your colleagues and keep abreast of the latest advances in basic and translational experimental hematology research!
iseh.org
iseh.org
I really enjoyed reading this paper. Use of basic culture-based and in vivo differentiation models with targeted application of -omics.
Cell cycle shortening precedes the restriction of lymphoid and myeloid potentials. buff.ly/a3DeNsO #hemesky
August 12, 2025 at 12:37 AM
I really enjoyed reading this paper. Use of basic culture-based and in vivo differentiation models with targeted application of -omics.
Excellent obituary summarizing the contributions of Dr Till's foundational work in defining the hematopoietic hierarchy in Experimental Hematology
@isehsociety.bsky.social
www.exphem.org/article/S030...
@isehsociety.bsky.social
www.exphem.org/article/S030...
Remembering James Till, 1931-2025
It has been 64 years since the publication of the classic 1961 Till & McCulloch paper
that described spleen colonies in lethally irradiated mice following a bone marrow
transplant [1]. On May 18, 2024...
www.exphem.org
June 30, 2025 at 3:58 PM
Excellent obituary summarizing the contributions of Dr Till's foundational work in defining the hematopoietic hierarchy in Experimental Hematology
@isehsociety.bsky.social
www.exphem.org/article/S030...
@isehsociety.bsky.social
www.exphem.org/article/S030...
Here is the first in a planned series of article commentaries in Experimental Hematology
@isehsociety.bsky.social - thanks to @challenlab.bsky.social and @lindemileslab.bsky.social!
www.exphem.org/article/S030...
@isehsociety.bsky.social - thanks to @challenlab.bsky.social and @lindemileslab.bsky.social!
www.exphem.org/article/S030...
Cell-extrinsic factors contribute toward myeloid-biased expansion in Tet2-mutant clonal hematopoiesis
Hematopoietic stem cells (HSCs) acquire somatic mutations throughout life, with the
frequency of mutational incidence increasing with age [1]. Occasionally, certain mutations
confer a fitness advantag...
www.exphem.org
May 27, 2025 at 1:19 PM
Here is the first in a planned series of article commentaries in Experimental Hematology
@isehsociety.bsky.social - thanks to @challenlab.bsky.social and @lindemileslab.bsky.social!
www.exphem.org/article/S030...
@isehsociety.bsky.social - thanks to @challenlab.bsky.social and @lindemileslab.bsky.social!
www.exphem.org/article/S030...
Reposted by Grant Rowe
What an interesting read...did you know that Developmental Hematopoiesis pioneer Elaine Dzierzak was also an artist? Read on to learn more in a recent issue of Experimental Hematology!
The developmental clock: where art and science meet - Experimental Hematology www.exphem.org/article/S030...
The developmental clock: where art and science meet - Experimental Hematology www.exphem.org/article/S030...
The developmental clock: where art and science meet
Elaine DzierzakDrs. Elaine Dzierzak and Anna Bigas recently edited a special collection
for Experimental Hematology entitled “Making blood: mechanisms of early hematopoietic
development” [1]. This is ...
www.exphem.org
February 28, 2025 at 1:09 PM
What an interesting read...did you know that Developmental Hematopoiesis pioneer Elaine Dzierzak was also an artist? Read on to learn more in a recent issue of Experimental Hematology!
The developmental clock: where art and science meet - Experimental Hematology www.exphem.org/article/S030...
The developmental clock: where art and science meet - Experimental Hematology www.exphem.org/article/S030...
Reposted by Grant Rowe
Absolute pleasure to chat with those two brilliant scientists! Do yourself a favour and have a look at their preprints! #hemesky
@alessandrodonada.bsky.social sat down with @dpastoors.bsky.social and @tjflemin.bsky.social for a deep dive on their latest AML biology preprints. Watch the #SimplyBlood 🩸 interview today https://www.simplyblood.org/
February 27, 2025 at 7:09 AM
Absolute pleasure to chat with those two brilliant scientists! Do yourself a favour and have a look at their preprints! #hemesky
I failed a billing audit this week and it was like I had left the new coversheets off of my TPS reports #medicaladministrativestate
February 21, 2025 at 1:13 PM
I failed a billing audit this week and it was like I had left the new coversheets off of my TPS reports #medicaladministrativestate
We are very proud of this new content spearheaded by @alessandrodonada.bsky.social!
Our lab is very grateful to Alessandro for highlighting our two recent preprints.
Our lab is very grateful to Alessandro for highlighting our two recent preprints.
This month's #PreprintWatch covers some exciting new results on the impact of microenvironment on hematopoietic progenitors and novel approaches to long-standing questions like self-renewal and stem cell activity! Read now on https://www.simplyblood.org/
February 19, 2025 at 12:56 AM
We are very proud of this new content spearheaded by @alessandrodonada.bsky.social!
Our lab is very grateful to Alessandro for highlighting our two recent preprints.
Our lab is very grateful to Alessandro for highlighting our two recent preprints.
Reposted by Grant Rowe
@isehsociety.bsky.social community: if you’re interested in HSC research in humans then this is a must read from leaders in the field. www.exphem.org/article/S030...
Methodological Considerations on How to Identify Human Hematopoietic Stem Cells
The hematopoietic system is highly regenerative and is organized hierarchically with
hematopoietic stem cells (HSCs) sitting at the apex. Despite being some of the most
widely studied stem cells, ques...
www.exphem.org
February 6, 2025 at 10:03 AM
@isehsociety.bsky.social community: if you’re interested in HSC research in humans then this is a must read from leaders in the field. www.exphem.org/article/S030...
Reposted by Grant Rowe
Uridine Metabolism as a Targetable Metabolic Achilles' Heel for chemo-resistant B-ALL https://www.biorxiv.org/content/10.1101/2025.01.27.635108v1
January 30, 2025 at 10:49 AM
Uridine Metabolism as a Targetable Metabolic Achilles' Heel for chemo-resistant B-ALL https://www.biorxiv.org/content/10.1101/2025.01.27.635108v1
Second preprint of the day:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Path of differentiation defines human macrophage identity
Macrophages play central roles in immunity, wound healing, and homeostasis - a functional diversity that is underpinned by varying developmental origins. The impact of ontogeny on properties of human ...
www.biorxiv.org
January 25, 2025 at 1:39 AM
Second preprint of the day:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Grant Rowe
Look at that, a trifecta of ISEH member preprints @bloodandtime.bsky.social @dorrancelab.bsky.social @kentlab.bsky.social
biorxiv.org/content/earl...
biorxiv.org/content/earl...
biorxiv.org/content/earl...
biorxiv.org/content/earl...
biorxiv.org/content/earl...
biorxiv.org/content/earl...
January 24, 2025 at 1:27 PM
Look at that, a trifecta of ISEH member preprints @bloodandtime.bsky.social @dorrancelab.bsky.social @kentlab.bsky.social
biorxiv.org/content/earl...
biorxiv.org/content/earl...
biorxiv.org/content/earl...
biorxiv.org/content/earl...
biorxiv.org/content/earl...
biorxiv.org/content/earl...
Here's a new preprint from our group. This manuscript continues our efforts to understand the mechanisms that distinguish fetal/juvenile versus adult hematopoiesis to better understand pediatric blood diseases.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Dynamic activity of Erg promotes aging of the hematopoietic system
Hematopoiesis changes to adapt to the physiology of development and aging. Temporal changes in hematopoiesis parallel age-dependent incidences of blood diseases. Several heterochronic regulators of he...
www.biorxiv.org
January 24, 2025 at 10:05 AM
Here's a new preprint from our group. This manuscript continues our efforts to understand the mechanisms that distinguish fetal/juvenile versus adult hematopoiesis to better understand pediatric blood diseases.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Early morning swimming in the cold at Stanford.
January 17, 2025 at 5:47 PM
Early morning swimming in the cold at Stanford.
Reposted by Grant Rowe
I really enjoy putting those together, please if you see your preprint in this list do not hesitate to get in touch!
#hemesky 🔬🩸
#hemesky 🔬🩸
The first Preprint Watch for 2025 is plentiful: 9 preprints focusing on Acute Myeloid Leukemia, but also spatial fate mapping meets barcoding, how cell fate decisions occur in hematopoietic progenitors, and more! Read now➡️ simplyblood.org
January 10, 2025 at 8:01 AM
I really enjoy putting those together, please if you see your preprint in this list do not hesitate to get in touch!
#hemesky 🔬🩸
#hemesky 🔬🩸
Reposted by Grant Rowe
This week on Simply Blood, we're highlighting selected articles on HSC metabolism in Experimental Hematology. Read curated articles on this topic and explore new findings ➡️ www.simplyblood.org
December 27, 2024 at 8:03 PM
Interesting mechanistic work on reticular dysgenesis from my former colleague Dr Weinacht @bloodjournal.bsky.social
ashpublications.org/blood/articl...
ashpublications.org/blood/articl...
Failure of metabolic checkpoint control during late-stage granulopoiesis drives neutropenia in reticular dysgenesis
Key PointsActive metabolic checkpoints respond to AK2 deficiency by decreasing anabolic pathways to maintain nutrient homeostasis and proliferation.When me
ashpublications.org
December 27, 2024 at 12:51 AM
Interesting mechanistic work on reticular dysgenesis from my former colleague Dr Weinacht @bloodjournal.bsky.social
ashpublications.org/blood/articl...
ashpublications.org/blood/articl...
Reposted by Grant Rowe
Our latest work is now available to read on bioRxiv! Very proud of this and its potential implications for patients with acute myeloid leukemia 🩸 🧪 🔬💊 **eIF4A-mediated translation initiation as an AML cell vulnerability that can be co-targeted with BCL-2 inhibition** www.biorxiv.org/content/10.1...
December 23, 2024 at 12:54 PM
Our latest work is now available to read on bioRxiv! Very proud of this and its potential implications for patients with acute myeloid leukemia 🩸 🧪 🔬💊 **eIF4A-mediated translation initiation as an AML cell vulnerability that can be co-targeted with BCL-2 inhibition** www.biorxiv.org/content/10.1...
We are very proud of this new resource for the community. Thanks @alessandrodonada.bsky.social for leading this initiative!
Traveling for the holidays? Take this time to read the last #PreprintWatch installment of 2024! This month on #SimplyBlood🩸 we're featuring 17 preprints, including a new community submission ➡️ www.simplyblood.org
December 18, 2024 at 1:57 AM
We are very proud of this new resource for the community. Thanks @alessandrodonada.bsky.social for leading this initiative!
I am very proud to direct the Bone Marrow Failure Clinic at Dana-Farber/Boston Children's.
answers.childrenshospital.org/sadie-aplast...
answers.childrenshospital.org/sadie-aplast...
A small act of kindness: Blood donations get Sadie off the sidelines after her aplastic anemia diagnosis - Boston Children's Answers Sadie thrives with aplastic anemia
Sadie was sidelined by aplastic anemia. Now she's back in the game, thanks to life-saving blood transfusions and expert care.
answers.childrenshospital.org
December 18, 2024 at 1:50 AM
I am very proud to direct the Bone Marrow Failure Clinic at Dana-Farber/Boston Children's.
answers.childrenshospital.org/sadie-aplast...
answers.childrenshospital.org/sadie-aplast...
This paper still irritates me - harvesting marrow from one-day-old neonates (human!)
www.cell.com/developmenta...
www.cell.com/developmenta...
Temporal molecular program of human hematopoietic stem and progenitor cells after birth
Zhang et al. provided an integral transcriptomic analysis of HSPCs, defined their dynamics in post-natal steady-state hematopoiesis, and refined the heterogeneity of MPPs by CD52 expression. Neonate bone-marrow-derived HSCs exhibited higher reconstruction capability than cord blood HSCs. This resource will help understand hematopoiesis in development and disease.
www.cell.com
December 14, 2024 at 1:25 AM
This paper still irritates me - harvesting marrow from one-day-old neonates (human!)
www.cell.com/developmenta...
www.cell.com/developmenta...
Reposted by Grant Rowe
Hey all you #ASH24 people.
You need to look at this new paper in @naturemethods.bsky.social by Heme extraordinaires Grant Rowe and the Bluesky-less #HojunLi.
A paper that looks at Blood & Time from @bloodandtime.bsky.social himself!
#scRNAseq
#bioinformatics
🧬 💻
www.nature.com/articles/s41...
You need to look at this new paper in @naturemethods.bsky.social by Heme extraordinaires Grant Rowe and the Bluesky-less #HojunLi.
A paper that looks at Blood & Time from @bloodandtime.bsky.social himself!
#scRNAseq
#bioinformatics
🧬 💻
www.nature.com/articles/s41...
The dynamics of hematopoiesis over the human lifespan - Nature Methods
This Resource presents an atlas classifying the age-related changes in human hematopoietic stem and progenitor cells from gestation through aging.
www.nature.com
December 8, 2024 at 12:53 PM
Hey all you #ASH24 people.
You need to look at this new paper in @naturemethods.bsky.social by Heme extraordinaires Grant Rowe and the Bluesky-less #HojunLi.
A paper that looks at Blood & Time from @bloodandtime.bsky.social himself!
#scRNAseq
#bioinformatics
🧬 💻
www.nature.com/articles/s41...
You need to look at this new paper in @naturemethods.bsky.social by Heme extraordinaires Grant Rowe and the Bluesky-less #HojunLi.
A paper that looks at Blood & Time from @bloodandtime.bsky.social himself!
#scRNAseq
#bioinformatics
🧬 💻
www.nature.com/articles/s41...