Antoine Molaro
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antoinemolaro.bsky.social
Antoine Molaro
@antoinemolaro.bsky.social
1.5K followers 1.4K following 61 posts
Group Leader @GReD_Clermont
Chargé de Recherche @INSERM
Evolutionary biologist studying chromatin also drummer.
Jazz and epistemology. he/his
https://www.igred.fr/en/team/evolutionary-epigenomics-and-genetic-conflicts/
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antoinemolaro.bsky.social
Antoine Molaro @antoinemolaro.bsky.social · Mar 31
Hello World! Are you passionate about epigenomics and evolution 🧪🧬🐭🐵 ? Are you looking for a postdoc in a stimulating and inclusive environment ? Look no further... We are seeking creative postdocs for our ERC project EvoEpi @igred.fr ! 👇Details👇
tinyurl.com/PostdocEvoEp...
Repost are appreciated
Reposted by Antoine Molaro
lucievirevolte.bsky.social
Yay! Joy & excitement for the #science ahead & for our #team @ciri-lyon.bsky.social, who is getting @erc.europa.eu #Consolidator grant support to work on the FUNctional EVOlution of mammalian innate immunity #FUNEVO ! So thankful to #ERC and #everyone who contributed & provided support along the way
erc.europa.eu European Research Council (ERC) @erc.europa.eu · 13h
The results of the ERC Consolidator Grant call have been announced! 📣

349 researchers have been selected for funding. Congratulations to all! #ERCCogG!

👉 buff.ly/uu62uFV

#FrontierResearch #EUfunded #HorizonEurope

@scienceinnovation.ec.europa.eu
December 9, 2025 at 5:17 PM
Reposted by Antoine Molaro
polosophie.bsky.social
Sophie Polo has been awarded an Impulscience grant from the Bettencourt Schueller Foundation to fund a research project on the establishment and maintenance of the inactive X chromosome in response to DNA breaks. This is wonderful news for the lab! We thank the Foundation for their support.
Sophie Polo
Les chromosomes, gardiens de notre identité génétique, subissent des dommages qui peuvent compromettre la santé et le destin des cellules.
www.fondationbs.org
December 9, 2025 at 10:34 AM
Reposted by Antoine Molaro
erc.europa.eu
The results of the ERC Consolidator Grant call have been announced! 📣

349 researchers have been selected for funding. Congratulations to all! #ERCCogG!

👉 buff.ly/uu62uFV

#FrontierResearch #EUfunded #HorizonEurope

@scienceinnovation.ec.europa.eu
December 9, 2025 at 11:01 AM
Reposted by Antoine Molaro
doudna-lab.bsky.social
✨New preprint!

🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬

🔗👇
December 9, 2025 at 7:52 AM
Reposted by Antoine Molaro
jrossibarra.bsky.social
Amazing. Got my first unsolicited email review of a paper from an AI company, also telling me what follow up work to do. So inexpensive to get even more insights! This is wonderful, and I am planning to budget for this in all future work, right below the priority to fund a space circus on the moon.
December 8, 2025 at 8:36 PM
Reposted by Antoine Molaro
levine-lab.bsky.social
How to keep in step when your (protein) partner speeds up…

Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.

Congrats to whole team!

www.science.org/doi/10.1126/...
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity
Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such comp...
www.science.org
November 28, 2025 at 5:22 PM
Reposted by Antoine Molaro
pasquelab.bsky.social
We have just published a tribute to John Gurdon, reflecting on his scientific legacy and the profound influence he had on generations of developmental biologists.

The piece is available open access in Nature Communications:
www.nature.com/articles/s41...
Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon - Nature Communications
Nature Communications - Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon
www.nature.com
December 5, 2025 at 8:05 AM
Reposted by Antoine Molaro
brancolab.bsky.social
More marsupial fun from @lab-turner.bsky.social. Congrats @sermenchero.bsky.social
Marsupial single-cell transcriptomics identifies temporal diversity in mammalian developmental programs - PubMed
Single-cell transcriptomics has demonstrated conserved and divergent programs of organogenesis in mammals, but existing studies have focused on eutherians. Marsupials exhibit short gestation and complete development externally, necessitating accelerated differentiation of anterior features required …
pubmed.ncbi.nlm.nih.gov
December 4, 2025 at 8:35 AM
Reposted by Antoine Molaro
brancolab.bsky.social
Another envelope protein in the human genome. Expressed in the placenta, of course.
The human endogenous retroviral envelope HEMO protein interacts with BACE2: Novel partnership acquired in the primate lineage - PubMed
Endogenous retroviruses (ERV) represent 8 to 10% of mammalian genome. While most ERV are defective, a few retroviral genes, such as the envelope syncytins, were exapted during evolution and likely contributed to the emergence of placental mammals. We have previously identified the oldest full-length …
pubmed.ncbi.nlm.nih.gov
December 4, 2025 at 8:32 AM
Reposted by Antoine Molaro
official-smbe.bsky.social
SMBE2026 Symposium 4 | Mining the archive: evolutionary genomics from public repositories

📨 Abstract submission
smbe2026.org/abstracts

📋 Programme details
smbe2026.org/programme

#SMBE2026
SMBE2026 Symposium 4 | Mining the archive: evolutionary genomics from public repositories
December 4, 2025 at 9:38 AM
Reposted by Antoine Molaro
arnausebe.bsky.social
Open postdoc position at @sangerinstitute.bsky.social Tree of Life to contribute to the Biodiversity Cell Atlas, with a focus on spatial transcriptomics.

Apply by January 4
sanger.wd103.myworkdayjobs.com/en-GB/Wellco...

Please share with anyone who might be interested!
Postdoctoral Fellow - Biodiversity Cell Atlas
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
sanger.wd103.myworkdayjobs.com
December 3, 2025 at 12:27 PM
Reposted by Antoine Molaro
pjmurphy249.bsky.social
New Paper from the Murphy Lab - A Collaboration w Mitch O'Connell's group at URMC. Led by our joint student Brandon Park. Check it out!!
CUT&Tag Overcomes Biases of ChIP and Establishes Chromatin Patterns for Repetitive Genomic Loci: iScience www.cell.com/iscience/ful...
CUT&Tag Overcomes Biases of ChIP and Establishes Chromatin Patterns for Repetitive Genomic Loci
New in situ chromatin profiling methods, such as CUT&Tag, have streamlined studies of chromatin features by eliminating the need for up-front purification, but we find that some features are not equal...
www.cell.com
October 17, 2025 at 5:48 PM
Reposted by Antoine Molaro
pjmurphy249.bsky.social
Pls Repost: I am putting together an edition of “Methods in Molecular Biology” focused on early development, encompassing gastrulation. I am making a list of potential authors for chapters. If interested, please contact me - An excellent opportunity for trainees to co-author with their advisors.
December 3, 2025 at 12:43 PM
Reposted by Antoine Molaro
embo.org
Congratulations to the new cohort of 28 EMBO Young Investigators! They are joining an international network of more than 800 life scientists – Welcome!

Read the press release here:
https://www.embo.org/press-releases/twenty-eight-group-leaders-become-embo-young-investigators/
December 2, 2025 at 1:06 PM
Reposted by Antoine Molaro
bryonyleeke.bsky.social
Join @mpercharde.bsky.social Lab at the MRC LMS! We have an 18mo postdoc position to cover a couple of projects (maternity leave and paper revisions). The projects are focussed on chromatin in early mouse embryos and metabolism in mouse embryonic stem cells and pluripotency.
November 27, 2025 at 2:18 PM
Reposted by Antoine Molaro
jxhoffman.bsky.social
Sign up to present your work in the @fnucleosome.bsky.social seminar series!
November 24, 2025 at 7:21 PM
Reposted by Antoine Molaro
maitreya.bsky.social
Open faculty position (Assistant or Associate) in UW Medical Genetics. As you might expect, faculty often end up also interacting with Genome Sciences, so we're hoping for some great prospects! Note the clinical requirements for the position. apply.interfolio.com/176466
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
November 24, 2025 at 7:23 PM
Reposted by Antoine Molaro
molbioevol.bsky.social
This article has made the cover of the November 2025 edition of Molecular Biology and Evolution.
November 24, 2025 at 9:56 AM
Reposted by Antoine Molaro
sinamajidian.bsky.social
Our trilogy of orthology publications is online!
Review on Hierarchical Orthologous Groups doi.org/10.1007/s00239-025-10277-1

OrthoXML-Tools doi.org/10.1007/s00239-025-10271-7

A great community effort on Quest for Orthologs in the era of Data Deluge and AI doi.org/10.1007/s00239-025-10272-6
https://link.springer.com/article/10.1007/s00239-025-10277-1 Conceptual overview of hierarchical orthologous groups. An example of one HOG, or gene family. A Species tree with four taxa: plant (green), fish (blue), human (orange), and mouse (yellow), each with one or more genes. B The implied gene tree, dubbed “HOG tree,” and inferred nested HOG composition. Duplication nodes (red) can be deduced based on the species tree topology and clusters of homologous genes at each level. Ancestral genes from which the HOGs descended are shown in gray. C HOGs returned at different taxonomic levels. Consider a gene family that was present in the last eukaryotic common ancestor (LECA). At this level, a single HOG encompasses all genes descending from that ancestral gene. At the Vertebrata level, this gene underwent duplication, leading to two distinct copies, i.e., HOGs. At the Mammalia level, a second duplication further subdivides one of these HOGs, showing how deeper HOGs split into nested subHOGs at more recent levels. The HOG composition implies that a loss event occurred after the mammalian speciation https://link.springer.com/article/10.1007/s00239-025-10272-6 Summary of the QfO8 meeting. a Hot topics and future directions in method development and applications within the QfO community, namely artificial intelligence, protein domains, protein structure, RNA and splicing isoforms. b Definition of orthology and paralogy, including various paralogous subtypes (e.g. in-paralogs and out-paralogs). c Duplications and functional divergence. d Applications of orthology https://link.springer.com/article/10.1007/s00239-025-10271-7 Overview of the OrthoXML File Format (simplified). A schematic representation of an OrthoXML file, a standardized XML-based format for representing orthology data. OrthoXML follows a hierarchical structure where elements are enclosed within opening < tag > and closing </tag > tags. < orthoXML > is the root element enclosing other elements. The < species > element contains information about genes. An OrthoXML file can include a < taxonomy > element, which specifies the species tree used to generate the file. Additionally, the < groups > element encapsulates the orthology and paralogy relationships among genes
November 21, 2025 at 4:26 PM
Reposted by Antoine Molaro
bpucker.bsky.social
Excited to share DupyliCate - our new tool for discovery and characterization of gene duplications:

"DupyliCate - mining, classifying, and characterizing gene duplications"

doi.org/10.1101/2025...

#Bioinformatics #Python #Genomics #Evolution
@puckerlab.bsky.social
DupyliCate - mining, classifying, and characterizing gene duplications
Paralogs, copies of a gene, form an important basis for novelty during evolution. Analysis of such gene duplications is important to understand the emergence of novel traits during evolution. DupyliCa...
doi.org
October 14, 2025 at 5:26 AM
Reposted by Antoine Molaro
eddaschulz.bsky.social
📣 SAVE THE DATE
Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social
Poster advertising the 6th X-inactivation meeting from Oct 19-23 2026 in Sapporo, Japan. The organizers are Asato Kuriowa, Edda Schulz, Ikuhiro Okamoto, Rafael Galupa, Takashi Sado, Mitinori Saitou.
November 17, 2025 at 11:39 AM
Reposted by Antoine Molaro
aruizherrera.bsky.social
🚨 New Paper Alert!

Our latest perspective piece is out, and it’s one you won’t want to miss- 'The Genomic Kaleidoscope'

academic.oup.com/gbe/article/...

Co-lead by @mbrasovives.bsky.social @jrotwitguez.bsky.social & @diegoharta.bsky.social

📌 Check the full post here👇
November 14, 2025 at 4:25 PM
Reposted by Antoine Molaro
arvidagren.bsky.social
Wonderful talks and discussion from @jenncoughlan.bsky.social
and @ecmoore.bsky.social y.social!

If you missed it, the recording will soon be available at internalconflictsstn.wordpress.com/seminars/

Pencil in December 16 for the last seminar of the year.
arvidagren.bsky.social Arvid Ågren @arvidagren.bsky.social · Nov 4
Speciation special with @jenncoughlan.bsky.social and @ecmoore.bsky.social!

Thursday November 13.
November 13, 2025 at 4:43 PM
Reposted by Antoine Molaro
harmitmalik.bsky.social
Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on.

(Please repost to reach a broad audience.)
November 12, 2025 at 4:49 AM
Reposted by Antoine Molaro
sandraduharcourt.bsky.social
Excited to share our new preprint on BioRxiv!
A collaborative effort spanning many years and several labs to uncover what the germline chromosomes of Paramecium really look like. 🔗 www.biorxiv.org/content/10.1...
1/5
The tiny germline chromosomes of Paramecium aurelia have an exceptionally high recombination rate and are capped by a new class of Helitrons
Background. Paramecia belong to the ciliate phylum of unicellular eukaryotes characterized by nuclear dimorphism. A diploid germline micronucleus (MIC) transmits genetic information across sexual gene...
www.biorxiv.org
November 10, 2025 at 9:21 AM