Antoine Molaro
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antoinemolaro.bsky.social
Antoine Molaro
@antoinemolaro.bsky.social
1.5K followers 1.3K following 56 posts
Group Leader @GReD_Clermont
Chargé de Recherche @INSERM
Evolutionary biologist studying chromatin also drummer.
Jazz and epistemology. he/his
https://www.igred.fr/en/team/evolutionary-epigenomics-and-genetic-conflicts/
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antoinemolaro.bsky.social
Antoine Molaro @antoinemolaro.bsky.social · Mar 31
Hello World! Are you passionate about epigenomics and evolution 🧪🧬🐭🐵 ? Are you looking for a postdoc in a stimulating and inclusive environment ? Look no further... We are seeking creative postdocs for our ERC project EvoEpi @igred.fr ! 👇Details👇
tinyurl.com/PostdocEvoEp...
Repost are appreciated
Reposted by Antoine Molaro
sinamajidian.bsky.social
Our trilogy of orthology publications is online!
Review on Hierarchical Orthologous Groups doi.org/10.1007/s00239-025-10277-1

OrthoXML-Tools doi.org/10.1007/s00239-025-10271-7

A great community effort on Quest for Orthologs in the era of Data Deluge and AI doi.org/10.1007/s00239-025-10272-6
https://link.springer.com/article/10.1007/s00239-025-10277-1 Conceptual overview of hierarchical orthologous groups. An example of one HOG, or gene family. A Species tree with four taxa: plant (green), fish (blue), human (orange), and mouse (yellow), each with one or more genes. B The implied gene tree, dubbed “HOG tree,” and inferred nested HOG composition. Duplication nodes (red) can be deduced based on the species tree topology and clusters of homologous genes at each level. Ancestral genes from which the HOGs descended are shown in gray. C HOGs returned at different taxonomic levels. Consider a gene family that was present in the last eukaryotic common ancestor (LECA). At this level, a single HOG encompasses all genes descending from that ancestral gene. At the Vertebrata level, this gene underwent duplication, leading to two distinct copies, i.e., HOGs. At the Mammalia level, a second duplication further subdivides one of these HOGs, showing how deeper HOGs split into nested subHOGs at more recent levels. The HOG composition implies that a loss event occurred after the mammalian speciation https://link.springer.com/article/10.1007/s00239-025-10272-6 Summary of the QfO8 meeting. a Hot topics and future directions in method development and applications within the QfO community, namely artificial intelligence, protein domains, protein structure, RNA and splicing isoforms. b Definition of orthology and paralogy, including various paralogous subtypes (e.g. in-paralogs and out-paralogs). c Duplications and functional divergence. d Applications of orthology https://link.springer.com/article/10.1007/s00239-025-10271-7 Overview of the OrthoXML File Format (simplified). A schematic representation of an OrthoXML file, a standardized XML-based format for representing orthology data. OrthoXML follows a hierarchical structure where elements are enclosed within opening < tag > and closing </tag > tags. < orthoXML > is the root element enclosing other elements. The < species > element contains information about genes. An OrthoXML file can include a < taxonomy > element, which specifies the species tree used to generate the file. Additionally, the < groups > element encapsulates the orthology and paralogy relationships among genes
November 21, 2025 at 4:26 PM
Reposted by Antoine Molaro
bpucker.bsky.social
Excited to share DupyliCate - our new tool for discovery and characterization of gene duplications:

"DupyliCate - mining, classifying, and characterizing gene duplications"

doi.org/10.1101/2025...

#Bioinformatics #Python #Genomics #Evolution
@puckerlab.bsky.social
DupyliCate - mining, classifying, and characterizing gene duplications
Paralogs, copies of a gene, form an important basis for novelty during evolution. Analysis of such gene duplications is important to understand the emergence of novel traits during evolution. DupyliCa...
doi.org
October 14, 2025 at 5:26 AM
Reposted by Antoine Molaro
eddaschulz.bsky.social
📣 SAVE THE DATE
Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social
Poster advertising the 6th X-inactivation meeting from Oct 19-23 2026 in Sapporo, Japan. The organizers are Asato Kuriowa, Edda Schulz, Ikuhiro Okamoto, Rafael Galupa, Takashi Sado, Mitinori Saitou.
November 17, 2025 at 11:39 AM
Reposted by Antoine Molaro
aruizherrera.bsky.social
🚨 New Paper Alert!

Our latest perspective piece is out, and it’s one you won’t want to miss- 'The Genomic Kaleidoscope'

academic.oup.com/gbe/article/...

Co-lead by @mbrasovives.bsky.social @jrotwitguez.bsky.social & @diegoharta.bsky.social

📌 Check the full post here👇
November 14, 2025 at 4:25 PM
Reposted by Antoine Molaro
arvidagren.bsky.social
Wonderful talks and discussion from @jenncoughlan.bsky.social
and @ecmoore.bsky.social y.social!

If you missed it, the recording will soon be available at internalconflictsstn.wordpress.com/seminars/

Pencil in December 16 for the last seminar of the year.
arvidagren.bsky.social Arvid Ågren @arvidagren.bsky.social · 19d
Speciation special with @jenncoughlan.bsky.social and @ecmoore.bsky.social!

Thursday November 13.
November 13, 2025 at 4:43 PM
Reposted by Antoine Molaro
harmitmalik.bsky.social
Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on.

(Please repost to reach a broad audience.)
November 12, 2025 at 4:49 AM
Reposted by Antoine Molaro
sandraduharcourt.bsky.social
Excited to share our new preprint on BioRxiv!
A collaborative effort spanning many years and several labs to uncover what the germline chromosomes of Paramecium really look like. 🔗 www.biorxiv.org/content/10.1...
1/5
The tiny germline chromosomes of Paramecium aurelia have an exceptionally high recombination rate and are capped by a new class of Helitrons
Background. Paramecia belong to the ciliate phylum of unicellular eukaryotes characterized by nuclear dimorphism. A diploid germline micronucleus (MIC) transmits genetic information across sexual gene...
www.biorxiv.org
November 10, 2025 at 9:21 AM
Reposted by Antoine Molaro
odedrechavi.bsky.social
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
November 6, 2025 at 2:49 PM
Reposted by Antoine Molaro
itaiyanai.bsky.social
Is science too obsessed with metrics, large-scale projects & “blockbuster” outputs? Desai & Jun argued that preserving the "auteur" spirit of individual creativity, exploration and risk-taking is essential for maintaining the creativity that drew us into science in the 1st place.
November 3, 2025 at 2:50 AM
Reposted by Antoine Molaro
harmitmalik.bsky.social
Dr. Steven Henikoff receives the 55th Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research.
www.brandeis.edu/rosenstiel/r...

(Personal note: I continue to be inspired and astonished by my postdoctoral mentor & current colleague)
Brandeis University honors Fred Hutch molecular biologist
Dr. Steven Henikoff, a molecular biologist at Fred Hutch Cancer Center, has won the prestigious Rosenstiel Award for Distinguished Work in Basic Medical Research from Brandeis University recognizing h...
www.fredhutch.org
October 31, 2025 at 12:48 AM
Reposted by Antoine Molaro
leahhouri.bsky.social
What does mating look like when you only have a single shot at getting it right?

Very excited to share our work on an almost-invisible female control, rapidly evolving mating recognition systems, and species that break the rules and take over the world. IN MOSQUITOES>
The male genitalia of an 𝘈𝘦𝘥𝘦𝘴 𝘢𝘭𝘣𝘰𝘱𝘪𝘤𝘵𝘶𝘴 mosquito
October 28, 2025 at 8:57 PM
Reposted by Antoine Molaro
dodonova-sveta.bsky.social
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
October 28, 2025 at 3:07 PM
antoinemolaro.bsky.social
Today we lost a music legend and role model for many of us. I remember vividly hearing Jack Dejohnette for the first time in my late teens. It changed my life and approach to drumming forever. Take a minute to listen to some of his music today, your ears will thank you.
www.npr.org/2025/10/27/n...
Jack DeJohnette, dynamic and instantly recognizable jazz drummer, dies at 83
Jack DeJohnette, of the most daring and singular jazz drummers of the last 60 years, died on Sunday.
www.npr.org
October 27, 2025 at 3:20 PM
Reposted by Antoine Molaro
martijnschenkel.bsky.social
Working on internal conflicts? Please submit to the Internal Conflicts STN special issue with @jevbio.bsky.social! We invite work on all forms of within-organism conflict, and are very keen to receive research manuscripts. See the link for more info, or reach out to me if you have any questions.
evoldir.bsky.social EvolDir @evoldir.bsky.social · 27d
Call for Papers for a special issue on "Foundations of Internal Conflicts" in the Journal of Evolutionary Biology. Submit by Feb 28, 2026. Contact Martijn Schenkel for details: martijn.schenkel@wur.nl
[jeb.office@eseb.org](mailto:jeb.office@eseb.org)
October 27, 2025 at 6:35 AM
Reposted by Antoine Molaro
cecilecourret.bsky.social
I'm thrilled to announce that I’m opening my own research team in the Department of Genome Biology at I2BC @i2bcparissaclay.bsky.social ! #ATIP-Avenir
Very excited to start this new adventure! www.i2bc.paris-saclay.fr/equipe-intra...
Equipe Courret – Institute for Integrative Biology of the Cell
www.i2bc.paris-saclay.fr
October 24, 2025 at 3:39 PM
Reposted by Antoine Molaro
sedonamurphy.bsky.social
My new lab at the @molgen.mpg.de will be following up on some of the nuclear organization aspects of ecDNA so please do reach out if this is of interest :)
October 21, 2025 at 9:43 AM
Reposted by Antoine Molaro
arnausebe.bsky.social
We are happy to share our latest work in @nature.com . We study the genomic and cellular basis of facultative symbiosis in Oculina patagonica - a Mediterranean coral remarkable for its ability to survive long periods without algal symbionts. Led by Shani Levy and @xgrau.bsky.social
rdcu.be/eLbaZ
October 15, 2025 at 7:58 PM
Reposted by Antoine Molaro
odedrechavi.bsky.social
Here's the link to the system, try it! qedscience.com
@qedscience.bsky.social
q.e.d Science
Critical Thinking AI for constructive criticism and science evaluation
qedscience.com
October 15, 2025 at 12:22 PM
antoinemolaro.bsky.social
Hello World ! Today and tomorrow we celebrate the legacy of Vincent Colot and Eric Meyer! Thankful for their contribution to science and mentorship of young scientists!
October 13, 2025 at 7:26 PM
Reposted by Antoine Molaro
claudele.bsky.social
How does catalysis emerge from non-catalytic domains?

In our new paper, we show that catalytic activity can arise without conserved active-site residues — through multimerization and electrostatic features instead.

A striking case of catalysis evolving from binding.
October 8, 2025 at 2:32 PM
Reposted by Antoine Molaro
gurdoninstitute.bsky.social
A Nobel-winning scientist of great modesty and humour, John Gurdon died on 7 Oct. Not only did he make a discovery that laid the foundations for stem cell research, he also created one of the best environments for research at the Wellcome/CRUK Gurdon Institute wellcome.org/news/sir-joh...
Sir John Gurdon, 1933-2025 | Wellcome
A Nobel-winning scientist of great modesty and humour, John Gurdon died on 7 October. He made a discovery that opened up the field of cloning research, and created one of the best environments for res...
wellcome.org
October 9, 2025 at 1:39 PM
Reposted by Antoine Molaro
sheilateves.bsky.social
How does a “universal” transcription factor evolve to do species-specific jobs?
Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes.

Read it here 👉

www.biorxiv.org/content/10.1...

#MolecularEvolution #Transcription
Molecular determinants underlying functional divergence of TBP homologs
The TATA-box binding protein (TBP) is a highly conserved basal transcription factor and a core component of the pre-initiation complex (PIC) for all three eukaryotic RNA polymerases (RNA Pols). Despit...
www.biorxiv.org
October 7, 2025 at 7:43 PM
Reposted by Antoine Molaro
jamesbriscoe.bsky.social
Very sad news, John Gurdon has died.

A developmental biologist's developmental biologist, Nobel prize winner

His work is the foundation of much of today's dev & stem cell bio.

An inspiration to many, including me. Always asking questions & wanting the answers

www.magd.cam.ac.uk/news/profess...
Professor Sir John Gurdon FRS (1933-2025) | Magdalene College
Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.
www.magd.cam.ac.uk
October 7, 2025 at 4:02 PM
Reposted by Antoine Molaro
pjie2.bsky.social
I’ve seen several huge screens like this and they all seem to look at every TF in the genome EXCEPT the couple I’m interested in. It’s beginning to feel personal. What have these big screen folks got against ZFX and ZFY?
October 7, 2025 at 7:43 AM
antoinemolaro.bsky.social
Hello World! It took a minute, but much improved version (thank you peer review) of Joris paper is out
@genomebiolevol.bsky.social

bsky.app/profile/geno...
October 6, 2025 at 11:54 AM