Antoine Molaro
@antoinemolaro.bsky.social
Group Leader @GReD_Clermont
Chargé de Recherche @INSERM
Evolutionary biologist studying chromatin also drummer.
Jazz and epistemology. he/his
https://www.igred.fr/en/team/evolutionary-epigenomics-and-genetic-conflicts/
Chargé de Recherche @INSERM
Evolutionary biologist studying chromatin also drummer.
Jazz and epistemology. he/his
https://www.igred.fr/en/team/evolutionary-epigenomics-and-genetic-conflicts/
Pinned
Antoine Molaro
@antoinemolaro.bsky.social
· Mar 31
Hello World! Are you passionate about epigenomics and evolution 🧪🧬🐭🐵 ? Are you looking for a postdoc in a stimulating and inclusive environment ? Look no further... We are seeking creative postdocs for our ERC project EvoEpi @igred.fr ! 👇Details👇
tinyurl.com/PostdocEvoEp...
Repost are appreciated
tinyurl.com/PostdocEvoEp...
Repost are appreciated
Reposted by Antoine Molaro
📣 Please spread: we’re hiring a Lab Manager! It is a critical position in our new lab. As our lab moves to Barcelona and joins the @crg.eu, we’re looking for a Lab Manager to help build the lab and set the lab atmosphere.
🔗 Apply here 👉 recruitment.crg.eu/content/jobs...
🔗 Apply here 👉 recruitment.crg.eu/content/jobs...
January 23, 2026 at 6:41 AM
📣 Please spread: we’re hiring a Lab Manager! It is a critical position in our new lab. As our lab moves to Barcelona and joins the @crg.eu, we’re looking for a Lab Manager to help build the lab and set the lab atmosphere.
🔗 Apply here 👉 recruitment.crg.eu/content/jobs...
🔗 Apply here 👉 recruitment.crg.eu/content/jobs...
Reposted by Antoine Molaro
Getting asked about how academics can continue to do science & inspire trainees even in the midst of a continued (escalated) assault on science, reason, truth, & human rights. I don’t have great answers.
I would love to hear from mentors about advice they’re giving to trainees/ colleagues.
I would love to hear from mentors about advice they’re giving to trainees/ colleagues.
January 17, 2026 at 6:47 PM
Getting asked about how academics can continue to do science & inspire trainees even in the midst of a continued (escalated) assault on science, reason, truth, & human rights. I don’t have great answers.
I would love to hear from mentors about advice they’re giving to trainees/ colleagues.
I would love to hear from mentors about advice they’re giving to trainees/ colleagues.
Reposted by Antoine Molaro
I am very happy (and a bit scared) to present to you what we have been working on over the last 4 years. This manuscript is exactly what I dreamt of when I started the lab and I could not be happier and prouder of the outcome!
Evolutionary dynamics of temporal transcription factor series in the insect optic lobe https://www.biorxiv.org/content/10.64898/2026.01.08.698497v1
January 10, 2026 at 9:43 AM
I am very happy (and a bit scared) to present to you what we have been working on over the last 4 years. This manuscript is exactly what I dreamt of when I started the lab and I could not be happier and prouder of the outcome!
Reposted by Antoine Molaro
🚨Application for the MPI-IE international PhD program is ongoing🚨
If you are interested in #epigenetics #genomics #cellbiology #devbio & more, apply before February 6th!
My lab will recruit a student to work on the contribution of #transposable elements in development and disease 🧬🦠
If you are interested in #epigenetics #genomics #cellbiology #devbio & more, apply before February 6th!
My lab will recruit a student to work on the contribution of #transposable elements in development and disease 🧬🦠
Fully-funded #PhD positions in #epigenetics, #biophysics & #metabolism, gene regulation, cell biology and more…
Are you already on track to start an exciting research career @maxplanck.de & @uni-freiburg.de?
This is your timeline. Apply by February 6th, 2026
www.ie-freiburg.mpg.de/apply-imprs-...
Are you already on track to start an exciting research career @maxplanck.de & @uni-freiburg.de?
This is your timeline. Apply by February 6th, 2026
www.ie-freiburg.mpg.de/apply-imprs-...
January 8, 2026 at 3:41 PM
🚨Application for the MPI-IE international PhD program is ongoing🚨
If you are interested in #epigenetics #genomics #cellbiology #devbio & more, apply before February 6th!
My lab will recruit a student to work on the contribution of #transposable elements in development and disease 🧬🦠
If you are interested in #epigenetics #genomics #cellbiology #devbio & more, apply before February 6th!
My lab will recruit a student to work on the contribution of #transposable elements in development and disease 🧬🦠
Reposted by Antoine Molaro
Need a bit of escapism? Not exactly Lord of the Rings, but in similar vein:
doi.org/10.1038/s443...
doi.org/10.1038/s443...
Epimutations: raw material for evolution? - The EMBO Journal
Epigenetics is fundamental to cell differentiation as it enables cells with identical genomes to adopt distinct fates. Some epigenetic information can also be transmitted between generations, in a pro...
link.springer.com
January 6, 2026 at 6:33 PM
Need a bit of escapism? Not exactly Lord of the Rings, but in similar vein:
doi.org/10.1038/s443...
doi.org/10.1038/s443...
Reposted by Antoine Molaro
💥🥚 ANR-funded Assistant Engineer position open in our “Control & Dynamics of the Ovarian Cycle” group at IBDM Marseille 🇫🇷
Work on mouse lines + lab logistics + follicle culture/imaging 🔬
🗓️ Apply by 26 Jan: emploi.cnrs.fr/Offres/CDD/U...
Please share widely — especially with colleagues in France!
Work on mouse lines + lab logistics + follicle culture/imaging 🔬
🗓️ Apply by 26 Jan: emploi.cnrs.fr/Offres/CDD/U...
Please share widely — especially with colleagues in France!
January 6, 2026 at 8:13 AM
💥🥚 ANR-funded Assistant Engineer position open in our “Control & Dynamics of the Ovarian Cycle” group at IBDM Marseille 🇫🇷
Work on mouse lines + lab logistics + follicle culture/imaging 🔬
🗓️ Apply by 26 Jan: emploi.cnrs.fr/Offres/CDD/U...
Please share widely — especially with colleagues in France!
Work on mouse lines + lab logistics + follicle culture/imaging 🔬
🗓️ Apply by 26 Jan: emploi.cnrs.fr/Offres/CDD/U...
Please share widely — especially with colleagues in France!
Reposted by Antoine Molaro
New work from @miyapan.bsky.social and our team, bringing ant, bee, and wasp labs together. @chuanxinyu.bsky.social shows that the ANTSR locus we discovered in ants has determined sex for 150+ My across bees and stinging wasps 🐜🐝, despite virtually no sequence conservation 😮 doi.org/10.1073/pnas...
January 6, 2026 at 3:01 AM
New work from @miyapan.bsky.social and our team, bringing ant, bee, and wasp labs together. @chuanxinyu.bsky.social shows that the ANTSR locus we discovered in ants has determined sex for 150+ My across bees and stinging wasps 🐜🐝, despite virtually no sequence conservation 😮 doi.org/10.1073/pnas...
Reposted by Antoine Molaro
🧬 @science.org A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform | Science www.science.org/doi/10.1126/... @ckadoch.bsky.social @danafarber.bsky.social @harvardmed.bsky.social @broadinstitute.org @hhmi-science.bsky.social 🔬 #chromatin #transcription #cancer 🧫
A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform
Mammalian SWI/SNF chromatin remodeling complexes modulate DNA accessibility and gene expression; however, their genomic targeting mechanisms remain incompletely understood. Here, we identify SWIFT (SW...
www.science.org
January 1, 2026 at 7:53 PM
🧬 @science.org A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform | Science www.science.org/doi/10.1126/... @ckadoch.bsky.social @danafarber.bsky.social @harvardmed.bsky.social @broadinstitute.org @hhmi-science.bsky.social 🔬 #chromatin #transcription #cancer 🧫
Reposted by Antoine Molaro
Love this paper from @evahoermanseder.bsky.social and team; great to see it out. This is definitely "epigenetics" by any definition, but I wonder if it's premarking for activation or protecting against stable silence (i.e, DNAme), similar to Dppa2/4 targets in mammals www.nature.com/articles/s41...
Pre-marking chromatin with H3K4 methylation is required for accurate zygotic genome activation and development - Nature Communications
H3K4 methylation is required for defining active chromatin states in Xenopus embryos, ensuring faithful zygotic genome activation and successful embryonic development.
www.nature.com
December 24, 2025 at 12:02 PM
Love this paper from @evahoermanseder.bsky.social and team; great to see it out. This is definitely "epigenetics" by any definition, but I wonder if it's premarking for activation or protecting against stable silence (i.e, DNAme), similar to Dppa2/4 targets in mammals www.nature.com/articles/s41...
Reposted by Antoine Molaro
A human embryo implantation model from the @Rugg-Gunn Lab
*key for understanding the early extraembryonic-maternal interactions
Congrats to everyone involved! It’s been great to see this project develop. Huge credit to the @babrahaminst.bsky.social authors 🥂🍾
www.cell.com/cell/fulltex...
*key for understanding the early extraembryonic-maternal interactions
Congrats to everyone involved! It’s been great to see this project develop. Huge credit to the @babrahaminst.bsky.social authors 🥂🍾
www.cell.com/cell/fulltex...
December 24, 2025 at 8:45 AM
A human embryo implantation model from the @Rugg-Gunn Lab
*key for understanding the early extraembryonic-maternal interactions
Congrats to everyone involved! It’s been great to see this project develop. Huge credit to the @babrahaminst.bsky.social authors 🥂🍾
www.cell.com/cell/fulltex...
*key for understanding the early extraembryonic-maternal interactions
Congrats to everyone involved! It’s been great to see this project develop. Huge credit to the @babrahaminst.bsky.social authors 🥂🍾
www.cell.com/cell/fulltex...
Reposted by Antoine Molaro
My lab is hiring a postdoc (ERC funded)! If you're interested, get in touch!
December 18, 2025 at 8:36 AM
My lab is hiring a postdoc (ERC funded)! If you're interested, get in touch!
Reposted by Antoine Molaro
A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An integrated view of the structure and function of the human 4D nucleome - Nature
The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitatin...
www.nature.com
December 17, 2025 at 8:59 PM
A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Antoine Molaro
Do you have an exciting new chromatin/transcription story that you'd like to share with the #FN community?
Fill out this form to be considered for a talk in our Jan-June 2026 schedule! forms.gle/TBi38UgYxPAB...
Please repost and share!
Fill out this form to be considered for a talk in our Jan-June 2026 schedule! forms.gle/TBi38UgYxPAB...
Please repost and share!
Application to speak in the Fragile Nucleosome series
Thank you for your interest in our seminar series!
We use a variety of different session formats but, in general, trainees can plan for a ~15 min talk + 5min Q/A and PIs can plan for a ~25min talk +...
forms.gle
November 24, 2025 at 1:50 PM
Do you have an exciting new chromatin/transcription story that you'd like to share with the #FN community?
Fill out this form to be considered for a talk in our Jan-June 2026 schedule! forms.gle/TBi38UgYxPAB...
Please repost and share!
Fill out this form to be considered for a talk in our Jan-June 2026 schedule! forms.gle/TBi38UgYxPAB...
Please repost and share!
Reposted by Antoine Molaro
If anyone has any ideas that they would like to work on in choanoflagellates or Nematostella (or both) then please reach out!
Attention scientists from all over the world🙃
The Call for Letters of Intent for #HFSPResearchGrants 2027 is now open! 🧪
Get your international & interdisciplinary team. It's time to put your bold research idea into practice!
🔗https://bit.ly/48VsGCG
📅 15 Dec 2025–26 Mar 2026
#sts #LifeSciences
The Call for Letters of Intent for #HFSPResearchGrants 2027 is now open! 🧪
Get your international & interdisciplinary team. It's time to put your bold research idea into practice!
🔗https://bit.ly/48VsGCG
📅 15 Dec 2025–26 Mar 2026
#sts #LifeSciences
December 16, 2025 at 10:13 AM
If anyone has any ideas that they would like to work on in choanoflagellates or Nematostella (or both) then please reach out!
Reposted by Antoine Molaro
Insights into natural neocentromere evolution from a cattle T2T X chromosome. #CattleGenome #T2T #HaplotypeResolvedGenome #Centromeres #Genomics @natcomms.nature.com 🧪🧬 🖥️
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 15, 2025 at 9:31 AM
Insights into natural neocentromere evolution from a cattle T2T X chromosome. #CattleGenome #T2T #HaplotypeResolvedGenome #Centromeres #Genomics @natcomms.nature.com 🧪🧬 🖥️
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Antoine Molaro
Permanent Research Group Leader Position, Crete, Greece: Interested to assume long-term responsibilities for the Biodiversity Computing Group www.biocomp.gr I have set up in Crete? Apply now via apella.minedu.gov.gr/en/node/5998 (PDF also in English) - for questions email to stamatak@ics.forth.gr
December 15, 2025 at 7:23 AM
Permanent Research Group Leader Position, Crete, Greece: Interested to assume long-term responsibilities for the Biodiversity Computing Group www.biocomp.gr I have set up in Crete? Apply now via apella.minedu.gov.gr/en/node/5998 (PDF also in English) - for questions email to stamatak@ics.forth.gr
Reposted by Antoine Molaro
New preprint from our lab: ‘Retroviral insertions contributed to the divergence of human and chimpanzee brains’. Very proud of this piece which took almost a decade to finish.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Retroviral insertions contributed to the divergence of human and chimpanzee brains
Over the past 5 to 7 million years, humans and chimpanzees have diverged in brain size, structural complexity, and cognitive abilities despite high conservation of protein-coding genes. Notably, the e...
www.biorxiv.org
December 14, 2025 at 8:16 PM
New preprint from our lab: ‘Retroviral insertions contributed to the divergence of human and chimpanzee brains’. Very proud of this piece which took almost a decade to finish.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Antoine Molaro
Fantastic #EvoChromo25. Wonderful iteration, learned a lot - and loved the Nirenberg gold Luger nucleosome prize ! Humor sun and outstanding and thought-provoking science.
December 13, 2025 at 2:37 PM
Fantastic #EvoChromo25. Wonderful iteration, learned a lot - and loved the Nirenberg gold Luger nucleosome prize ! Humor sun and outstanding and thought-provoking science.
Reposted by Antoine Molaro
Took us a bit, but proud of this published version. We now examine the genetic interaction of phosphorylation with oligomerization and where bulk and phospho-Swi6 localize. Wonder if chromatin affinity tuning to enable Suv39 H3K9me3 spreading is a conserved mechanism ?
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
December 12, 2025 at 11:37 PM
Took us a bit, but proud of this published version. We now examine the genetic interaction of phosphorylation with oligomerization and where bulk and phospho-Swi6 localize. Wonder if chromatin affinity tuning to enable Suv39 H3K9me3 spreading is a conserved mechanism ?
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
Reposted by Antoine Molaro
@pravrutharaman.bsky.social got super intrigued about EZHIP/CATACOMB, previously identified as a histone H3K27M mimic of PRC2. You can read about her efforts here: www.biorxiv.org/content/10.6... We hope these analyses will help spur more analyses in this very cool gene! 1/
Dynamic evolution of EZHIP, an inhibitor of the Polycomb Repressive Complex 2 in mammals
The Polycomb Repressive Complex 2 (PRC2) is an ancient, conserved chromatin-interacting complex that controls gene expression, facilitating differentiation and cellular identity during development. It...
www.biorxiv.org
December 13, 2025 at 10:08 PM
@pravrutharaman.bsky.social got super intrigued about EZHIP/CATACOMB, previously identified as a histone H3K27M mimic of PRC2. You can read about her efforts here: www.biorxiv.org/content/10.6... We hope these analyses will help spur more analyses in this very cool gene! 1/
Reposted by Antoine Molaro
Please help! We are looking for tissue-specific RNA-seq datasets or pubs with both male and female individual gene expression data, not pooled, from animal species. If you know of any relevant resources, please drop a link in the comments or send me a DM. Also, please help spread the word - thanks!
December 5, 2025 at 3:20 PM
Please help! We are looking for tissue-specific RNA-seq datasets or pubs with both male and female individual gene expression data, not pooled, from animal species. If you know of any relevant resources, please drop a link in the comments or send me a DM. Also, please help spread the word - thanks!
So long #EvoChromo2025! I encourage you to mark your calendars as soon as the next one is announced. Special congrats to the Nirenberg prize recipients - including our very own @germainekaram.bsky.social
Here is a picture of Germaine receiving her Golden Luger from the hands of Nick Irwin. #ProudPI
Here is a picture of Germaine receiving her Golden Luger from the hands of Nick Irwin. #ProudPI
December 12, 2025 at 2:42 PM
So long #EvoChromo2025! I encourage you to mark your calendars as soon as the next one is announced. Special congrats to the Nirenberg prize recipients - including our very own @germainekaram.bsky.social
Here is a picture of Germaine receiving her Golden Luger from the hands of Nick Irwin. #ProudPI
Here is a picture of Germaine receiving her Golden Luger from the hands of Nick Irwin. #ProudPI
Reposted by Antoine Molaro
Have you ever wondered how new DNA methylation patterns are established?
Paradigm shift ahead! We discovered a new mode of DNA methylation targeting in plants that relies on transcription factors and sequence motifs rather than chromatin modifications to regulate the methylome. rdcu.be/eQ6L5
1/8
Paradigm shift ahead! We discovered a new mode of DNA methylation targeting in plants that relies on transcription factors and sequence motifs rather than chromatin modifications to regulate the methylome. rdcu.be/eQ6L5
1/8
December 11, 2025 at 9:56 PM
Have you ever wondered how new DNA methylation patterns are established?
Paradigm shift ahead! We discovered a new mode of DNA methylation targeting in plants that relies on transcription factors and sequence motifs rather than chromatin modifications to regulate the methylome. rdcu.be/eQ6L5
1/8
Paradigm shift ahead! We discovered a new mode of DNA methylation targeting in plants that relies on transcription factors and sequence motifs rather than chromatin modifications to regulate the methylome. rdcu.be/eQ6L5
1/8
Reposted by Antoine Molaro
Join our online seminar on December 16, 2025, at 16:00 UTC to celebrate the book release "The Paradox of the Organism". More info: https://internalconflictsstn.wordpress.com/ #conference
INTERNAL CONFLICTS AND ORGANISMAL ADAPTATION – ESEB Special Topic Network
INTERNAL CONFLICTS AND ORGANISMAL ADAPTATION – ESEB Special Topic Network
internalconflictsstn.wordpress.com
December 10, 2025 at 10:38 PM
Join our online seminar on December 16, 2025, at 16:00 UTC to celebrate the book release "The Paradox of the Organism". More info: https://internalconflictsstn.wordpress.com/ #conference
Reposted by Antoine Molaro
The Department of Genetics at the University of Cambridge is seeking a talented Postdoctoral Research Associate to work in the group of Dr Felipe Karam Teixeira (www.gen.cam.ac.uk/research-gro...)
➡️For Further details see the link www.cam.ac.uk/jobs/postdoc...
➡️For Further details see the link www.cam.ac.uk/jobs/postdoc...
Postdoctoral Research Associate (Fixed Term)
Applications are invited for a Postdoctoral Research Associate position to work in the group of Dr Felipe Karam Teixeira (https://www.gen.cam.ac.uk/research-groups/research-groups/karam-teixeira) in
www.cam.ac.uk
December 10, 2025 at 11:22 AM
The Department of Genetics at the University of Cambridge is seeking a talented Postdoctoral Research Associate to work in the group of Dr Felipe Karam Teixeira (www.gen.cam.ac.uk/research-gro...)
➡️For Further details see the link www.cam.ac.uk/jobs/postdoc...
➡️For Further details see the link www.cam.ac.uk/jobs/postdoc...