Claudèle Lemay-St-Denis
@claudele.bsky.social
Postdoc @haifaresearch.bsky.social w/ Rachel Kolodny | Biochem PhD from @umontreal.ca 🇨🇦 | Protein evolution 🧬 | Climate activist 🌍, vegan foodie 🍉 and hiking enthusiast 🏞 | she/her
How does catalysis emerge from non-catalytic domains?
In our new paper, we show that catalytic activity can arise without conserved active-site residues — through multimerization and electrostatic features instead.
A striking case of catalysis evolving from binding.
In our new paper, we show that catalytic activity can arise without conserved active-site residues — through multimerization and electrostatic features instead.
A striking case of catalysis evolving from binding.
@claudele.bsky.social et al. studied the fundamental question of how enzymatic activity emerges by focusing on type B dihydrofolate reductases, suggesting DfrB domains evolved rudimentary catalysis from a binding capacity.
🔗 doi.org/10.1093/molbev/msaf215
#evobio #molbio
🔗 doi.org/10.1093/molbev/msaf215
#evobio #molbio
From Binding to Catalysis: Emergence of a Rudimentary Enzyme Conferring Intrinsic Antibiotic Resistance
Abstract. How does enzymatic activity emerge? To shed light on this fundamental question, we study type B dihydrofolate reductases (DfrB), which were disco
doi.org
October 8, 2025 at 2:32 PM
How does catalysis emerge from non-catalytic domains?
In our new paper, we show that catalytic activity can arise without conserved active-site residues — through multimerization and electrostatic features instead.
A striking case of catalysis evolving from binding.
In our new paper, we show that catalytic activity can arise without conserved active-site residues — through multimerization and electrostatic features instead.
A striking case of catalysis evolving from binding.
Reposted by Claudèle Lemay-St-Denis
Night science is all about facilitating the import and export of ideas between scientists. Today at the workshop in Tel Aviv University we encouraged an open mind and an improvisational attitude to enthusiastically apply ‘night science’ thinking tools to our problems. 🙏 @judithberman11.bsky.social
March 24, 2025 at 1:44 PM
Night science is all about facilitating the import and export of ideas between scientists. Today at the workshop in Tel Aviv University we encouraged an open mind and an improvisational attitude to enthusiastically apply ‘night science’ thinking tools to our problems. 🙏 @judithberman11.bsky.social