Anamika Avni
@anamikaavni.bsky.social
Postdoc fellow @LaskerKeren @ScrippsResearch| PhD graduate @SamratLabMohali @IiserMohali| Excited about IDPs & Biomolecular Condensates 🦠🧑🔬🔬she/her
Reposted by Anamika Avni
#LaskerAward winner Lucy Shapiro asked: How do living organisms translate information from a linear genetic code into three-dimensional structures?
And with that, she broke open a new field. 🧪
#Lasker2025 #systemsbiology
www.youtube.com/watch?v=vivR...
And with that, she broke open a new field. 🧪
#Lasker2025 #systemsbiology
www.youtube.com/watch?v=vivR...
From canvas to cell: a portrait of Lucy Shapiro
The 2025 Lasker~Koshland Special Achievement Award honors Lucy Shapiro, for a 55-year career in biomedical science—honored for discovering how bacteria coordinate their genetic logic in time and…
www.youtube.com
September 17, 2025 at 5:45 PM
#LaskerAward winner Lucy Shapiro asked: How do living organisms translate information from a linear genetic code into three-dimensional structures?
And with that, she broke open a new field. 🧪
#Lasker2025 #systemsbiology
www.youtube.com/watch?v=vivR...
And with that, she broke open a new field. 🧪
#Lasker2025 #systemsbiology
www.youtube.com/watch?v=vivR...
Reposted by Anamika Avni
Announcing the joint @idpseminars.bsky.social / BPS IDP Subgroup Trainee Symposium Speakers!
Join us on Mar 27, 12–2pm CST for 6 exciting talks focused on Intrinsically Disordered Proteins as part of #BophysicsWeek2025 with the @biophysicalsoc.bsky.social Sign up now using the QR code below!
Join us on Mar 27, 12–2pm CST for 6 exciting talks focused on Intrinsically Disordered Proteins as part of #BophysicsWeek2025 with the @biophysicalsoc.bsky.social Sign up now using the QR code below!
March 17, 2025 at 3:38 PM
Announcing the joint @idpseminars.bsky.social / BPS IDP Subgroup Trainee Symposium Speakers!
Join us on Mar 27, 12–2pm CST for 6 exciting talks focused on Intrinsically Disordered Proteins as part of #BophysicsWeek2025 with the @biophysicalsoc.bsky.social Sign up now using the QR code below!
Join us on Mar 27, 12–2pm CST for 6 exciting talks focused on Intrinsically Disordered Proteins as part of #BophysicsWeek2025 with the @biophysicalsoc.bsky.social Sign up now using the QR code below!
Reposted by Anamika Avni
Reposted by Anamika Avni
A new paper shows how LCD sequence patterns encode condensate dynamics and material properties.
🔹 Periodic repeats → Elasticity-dominated
🔹 Disordered sequences → Viscosity-dominated
🔹 Minimum sticker spacing is crucial for fluidity, preventing transitions to glassy states.
doi.org/10.1371/jour...
🔹 Periodic repeats → Elasticity-dominated
🔹 Disordered sequences → Viscosity-dominated
🔹 Minimum sticker spacing is crucial for fluidity, preventing transitions to glassy states.
doi.org/10.1371/jour...
February 24, 2025 at 1:38 AM
A new paper shows how LCD sequence patterns encode condensate dynamics and material properties.
🔹 Periodic repeats → Elasticity-dominated
🔹 Disordered sequences → Viscosity-dominated
🔹 Minimum sticker spacing is crucial for fluidity, preventing transitions to glassy states.
doi.org/10.1371/jour...
🔹 Periodic repeats → Elasticity-dominated
🔹 Disordered sequences → Viscosity-dominated
🔹 Minimum sticker spacing is crucial for fluidity, preventing transitions to glassy states.
doi.org/10.1371/jour...
Reposted by Anamika Avni
Happy to share the final program of the 2025 Intrinsically Disordered Proteins Subgroup Symposium at the Biophysical Society Meeting to be held in Los Angeles on February 15. Looking forward to seeing you all in less than a week @biophysicalsoc.bsky.social.
February 9, 2025 at 12:57 PM
Happy to share the final program of the 2025 Intrinsically Disordered Proteins Subgroup Symposium at the Biophysical Society Meeting to be held in Los Angeles on February 15. Looking forward to seeing you all in less than a week @biophysicalsoc.bsky.social.
Reposted by Anamika Avni
Announcing the Biophysics Week IDP Trainee Symposium on March 27 at 12pm CT hosted by @idpseminars.bsky.social & The BPS IDP Subgroup! Join via Zoom for talks by talented grad students & postdocs. Abstract submissions are open! See flyer for more details! #BiophysicsWeek @biophysicalsoc.bsky.social
February 7, 2025 at 6:31 PM
Announcing the Biophysics Week IDP Trainee Symposium on March 27 at 12pm CT hosted by @idpseminars.bsky.social & The BPS IDP Subgroup! Join via Zoom for talks by talented grad students & postdocs. Abstract submissions are open! See flyer for more details! #BiophysicsWeek @biophysicalsoc.bsky.social
Reposted by Anamika Avni
Transthyretin’s structural asymmetry & “molecular breathing” drive its misfolding in ATTR—a discovery by Prof. Gabriel Lander (@landerlab.bsky.social) & Prof. Jeff Kelly, published in @naturesmb.bsky.social, that could inform new therapies for amyloid diseases.
Researchers illuminate new structures of a critical amyloid protein
www.scripps.edu
February 6, 2025 at 7:23 PM
Transthyretin’s structural asymmetry & “molecular breathing” drive its misfolding in ATTR—a discovery by Prof. Gabriel Lander (@landerlab.bsky.social) & Prof. Jeff Kelly, published in @naturesmb.bsky.social, that could inform new therapies for amyloid diseases.
Reposted by Anamika Avni
Multi-scale structure of chromatin condensates rationalizes phase separation and material properties https://www.biorxiv.org/content/10.1101/2025.01.17.633609v1
January 22, 2025 at 2:48 PM
Multi-scale structure of chromatin condensates rationalizes phase separation and material properties https://www.biorxiv.org/content/10.1101/2025.01.17.633609v1
Reposted by Anamika Avni
Just because it's a homo-oligomer, don't assume it's symmetric! @benjabsnt.bsky.social & collaborators used cryo-EM to study the transthyretin (TTR) tetramer (55 kDa), shedding light on its misfolding pathways linked to amyloid disease. Now in peer-reviewed form: www.nature.com/articles/s41...
January 22, 2025 at 4:45 PM
Just because it's a homo-oligomer, don't assume it's symmetric! @benjabsnt.bsky.social & collaborators used cryo-EM to study the transthyretin (TTR) tetramer (55 kDa), shedding light on its misfolding pathways linked to amyloid disease. Now in peer-reviewed form: www.nature.com/articles/s41...
Reposted by Anamika Avni
In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:
January 17, 2025 at 6:43 PM
In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:
Reposted by Anamika Avni
It's about time we have a conversation about the role of structured protein domains in form and function of bimolecular condensates. Proud of graduate student Nate Hess for taking the lead on synthesizing these ideas and identifying important gaps in the field!! www.sciencedirect.com/science/arti...
Structured protein domains enter the spotlight: modulators of biomolecular condensate form and function
Biomolecular condensates are membraneless organelles that concentrate proteins and nucleic acids. One of the primary components of condensates is mult…
www.sciencedirect.com
January 17, 2025 at 10:05 PM
It's about time we have a conversation about the role of structured protein domains in form and function of bimolecular condensates. Proud of graduate student Nate Hess for taking the lead on synthesizing these ideas and identifying important gaps in the field!! www.sciencedirect.com/science/arti...
Reposted by Anamika Avni
🔥🔥🔥🔥🔥🔥
🚨NEW PUBLICATION ALERT🚨: In a paper out now in
@science.org we describe a way to build synthetic phosphorylation circuits with customizable sense-and-response functions in human cells. Check it out at science.org/doi/10.1126/....
@science.org we describe a way to build synthetic phosphorylation circuits with customizable sense-and-response functions in human cells. Check it out at science.org/doi/10.1126/....
Engineering synthetic phosphorylation signaling networks in human cells
Protein phosphorylation signaling networks have a central role in how cells sense and respond to their environment. We engineered artificial phosphorylation networks in which reversible enzymatic phos...
science.org
January 18, 2025 at 2:27 AM
🔥🔥🔥🔥🔥🔥
Reposted by Anamika Avni
Stunning fluorescence and EM imaging makes for a powerfully short title: "Passage of the HIV capsid cracks the nuclear pore". Just out in @cellcellpress.bsky.social: www.cell.com/cell/fulltex...
January 17, 2025 at 5:04 PM
Stunning fluorescence and EM imaging makes for a powerfully short title: "Passage of the HIV capsid cracks the nuclear pore". Just out in @cellcellpress.bsky.social: www.cell.com/cell/fulltex...
Reposted by Anamika Avni
New review / perspective with @albertilab-tud.bsky.social on our thoughts on condensate speciality and recruitment, focusing on interplay between site specific and chemically specific interactions
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Molecular determinants of condensate composition
Biomolecular condensates are non-stochiometric assemblies that organize cellular matter
in space and time. Despite much work, many questions remain regarding what determines
the recruitment and exclus...
www.cell.com
January 17, 2025 at 10:23 AM
New review / perspective with @albertilab-tud.bsky.social on our thoughts on condensate speciality and recruitment, focusing on interplay between site specific and chemically specific interactions
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Reposted by Anamika Avni
Protein production for cryoEM structure determination just got a lot cheaper - high resolution structure from half a plate of HEK cells with the "MIcro ISolation (MISO)" microfluidics-based approach. Congrats to the Brunner and Efremov labs in Brussels! www.biorxiv.org/content/10.1...
January 16, 2025 at 10:57 PM
Protein production for cryoEM structure determination just got a lot cheaper - high resolution structure from half a plate of HEK cells with the "MIcro ISolation (MISO)" microfluidics-based approach. Congrats to the Brunner and Efremov labs in Brussels! www.biorxiv.org/content/10.1...
Reposted by Anamika Avni
This is a textbook example (condensates are only just reaching textbooks!) of why condensates matter, and how they tend to work. Here these liquid-like blobs create a microenvironment in the nucleus of cancer cells within which chromatin sustains a conformation accessible to transcription...
Nature research paper: Targeting FOXM1 condensates reduces breast tumour growth and metastasis
https://go.nature.com/4g7BNC8
https://go.nature.com/4g7BNC8
Targeting FOXM1 condensates reduces breast tumour growth and metastasis - Nature
The transcription factor FOXM1 forms functional condensates, the formation of which can be targeted with a specific peptide to suppress breast cancer growth and metastasis.
go.nature.com
January 16, 2025 at 9:06 PM
This is a textbook example (condensates are only just reaching textbooks!) of why condensates matter, and how they tend to work. Here these liquid-like blobs create a microenvironment in the nucleus of cancer cells within which chromatin sustains a conformation accessible to transcription...
Reposted by Anamika Avni
Had a great time doing a long-form interview with Manthan!
Reflected on my journey through #Oxford, making #observations, #faculty applications, life as an #international researcher & more.
Check it out here and share your thoughts!
manthanmagazine.wordpress.com/2025/01/06/i...
🧠👩🏽🔬✨
Reflected on my journey through #Oxford, making #observations, #faculty applications, life as an #international researcher & more.
Check it out here and share your thoughts!
manthanmagazine.wordpress.com/2025/01/06/i...
🧠👩🏽🔬✨
January 8, 2025 at 1:50 AM
Had a great time doing a long-form interview with Manthan!
Reflected on my journey through #Oxford, making #observations, #faculty applications, life as an #international researcher & more.
Check it out here and share your thoughts!
manthanmagazine.wordpress.com/2025/01/06/i...
🧠👩🏽🔬✨
Reflected on my journey through #Oxford, making #observations, #faculty applications, life as an #international researcher & more.
Check it out here and share your thoughts!
manthanmagazine.wordpress.com/2025/01/06/i...
🧠👩🏽🔬✨
Reposted by Anamika Avni
Many of you already know about my battle with an autoimmune disease that started shortly after I got COVID in 2022. Here's a summary from a science/health blog aimed at battling disinformation. 🧪😷🧠
Separate from my story, there is a lot of other useful health content!
www.youcanknowthings.com
Separate from my story, there is a lot of other useful health content!
www.youcanknowthings.com
You Can Know Things
A blog about science in a world of untrue facts.
www.youcanknowthings.com
January 7, 2025 at 2:41 PM
Many of you already know about my battle with an autoimmune disease that started shortly after I got COVID in 2022. Here's a summary from a science/health blog aimed at battling disinformation. 🧪😷🧠
Separate from my story, there is a lot of other useful health content!
www.youcanknowthings.com
Separate from my story, there is a lot of other useful health content!
www.youcanknowthings.com
Reposted by Anamika Avni
Reposted by Anamika Avni
Deeply saddened by the news of Fraser Stoddart’s passing. Here is a piece I wrote on the occasion of his 2016 @nobelprize.bsky.social at ACSCentSci.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Design, Synthesis, Action! Molecular Machines Take the 2016 Nobel Prize in Chemistry
pubs.acs.org
December 31, 2024 at 11:05 PM
Deeply saddened by the news of Fraser Stoddart’s passing. Here is a piece I wrote on the occasion of his 2016 @nobelprize.bsky.social at ACSCentSci.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Reposted by Anamika Avni
Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 23, 2024 at 5:49 PM
Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Anamika Avni
1/ 🚨We’re thrilled to share our latest study:
"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟
www.biorxiv.org/content/10.1...
How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟
www.biorxiv.org/content/10.1...
How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure
Biomolecular condensates play key roles in the spatiotemporal regulation of cellular processes. Yet, the relationship between atomic features and condensate function remains poorly understood. We stud...
www.biorxiv.org
December 30, 2024 at 9:01 PM
1/ 🚨We’re thrilled to share our latest study:
"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟
www.biorxiv.org/content/10.1...
How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟
www.biorxiv.org/content/10.1...
How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
Reposted by Anamika Avni
Excited to share our preprint, work by Anthony Gurunian, showing that #condensates can induce localized potentials in membranes + an analytical framework, with important biological implications, collaboration with @kerenlasker
biorxiv.org/cgi/content/...
biorxiv.org/cgi/content/...
Biomolecular Condensates can Induce Local Membrane Potentials
Biomolecular condensates are a ubiquitous component of cells, known for their ability to selectively partition and compartmentalize biomolecules without the need for a lipid membrane. Nevertheless, co...
biorxiv.org
December 29, 2024 at 9:02 AM
Excited to share our preprint, work by Anthony Gurunian, showing that #condensates can induce localized potentials in membranes + an analytical framework, with important biological implications, collaboration with @kerenlasker
biorxiv.org/cgi/content/...
biorxiv.org/cgi/content/...
Reposted by Anamika Avni
Mahamid and Woodruff labs use cryo-ET to look at mitotic centrosomes: Stunned to see the pericentriolar matrix taking shape, and what seem to be ‚S size’ gamma-tubulin complex oligomers capping the end of 11-pf microtubules.
www.cell.com/developmenta...
www.cell.com/developmenta...
Molecular architectures of centrosomes in C. elegans embryos visualized by cryo-electron tomography
Tollervey et al. use cryo-electron tomography to capture 3D snapshots of centrosomes at molecular resolution in their near-native state inside embryonic C. elegans cells in different stages of cell division. They characterize structural features of centrioles during their assembly and of a disordered matrix that nucleates and organizes mitotic spindle microtubules.
www.cell.com
December 25, 2024 at 1:00 PM
Mahamid and Woodruff labs use cryo-ET to look at mitotic centrosomes: Stunned to see the pericentriolar matrix taking shape, and what seem to be ‚S size’ gamma-tubulin complex oligomers capping the end of 11-pf microtubules.
www.cell.com/developmenta...
www.cell.com/developmenta...