Jerelle Joseph
@jerelleaj.bsky.social
Assistant Professor, Princeton University | biomolecular condensates + computer simulations | https://josephgroup.princeton.edu (she/her)
Pinned
Jerelle Joseph
@jerelleaj.bsky.social
· Jul 3
Prediction of Small-Molecule Partitioning into Biomolecular Condensates from Simulation
Predicting small-molecule partitioning into biomolecular condensates is the key to developing drugs that selectively target aberrant condensates. However, the molecular mechanisms underlying small-mol...
pubs.acs.org
Huge congratulations to @alinaemelianova.bsky.social Pablo and Daniel on their paper on small-molecule partitioning into condensates now published in JACS Au and selected as ACS Editor’s Choice!!! pubs.acs.org/doi/full/10....
Have not fully stopped but definitely way less now than before 💔
November 11, 2025 at 1:46 AM
Have not fully stopped but definitely way less now than before 💔
Reposted by Jerelle Joseph
Very insightful reconsideration what Stress Granules might actually be good for!
Going back to the fundamentals & questions arising from Susan Lindquist's and Nancy Kedersha's work.
Amazing talk & scholarship by @drummondlab.bsky.social!
youtu.be/caAPToh8v0Q
Going back to the fundamentals & questions arising from Susan Lindquist's and Nancy Kedersha's work.
Amazing talk & scholarship by @drummondlab.bsky.social!
youtu.be/caAPToh8v0Q
Physical Properties of the Cytoplasm Seminar Series #25 | Allan Drummond
YouTube video by Physical Properties of the Cytoplasm
youtu.be
October 9, 2025 at 12:39 PM
Very insightful reconsideration what Stress Granules might actually be good for!
Going back to the fundamentals & questions arising from Susan Lindquist's and Nancy Kedersha's work.
Amazing talk & scholarship by @drummondlab.bsky.social!
youtu.be/caAPToh8v0Q
Going back to the fundamentals & questions arising from Susan Lindquist's and Nancy Kedersha's work.
Amazing talk & scholarship by @drummondlab.bsky.social!
youtu.be/caAPToh8v0Q
Is there a way to directly connect microstructural dynamics of condensates to their mechanical response?
In his new pre-print, Pablo presents a “condensate Deborah number” that does just that!
www.biorxiv.org/content/10.1...
In his new pre-print, Pablo presents a “condensate Deborah number” that does just that!
www.biorxiv.org/content/10.1...
Biomolecular condensate viscoelasticity is dictated by the interplay between single-molecule shape memory and mesh reconfigurability
Biomolecular condensates are membraneless organelles that compartmentalize biological functions in living cells. Formed by the phase separation of biomolecules, condensates possess a wide range of mec...
www.biorxiv.org
October 7, 2025 at 11:32 PM
Is there a way to directly connect microstructural dynamics of condensates to their mechanical response?
In his new pre-print, Pablo presents a “condensate Deborah number” that does just that!
www.biorxiv.org/content/10.1...
In his new pre-print, Pablo presents a “condensate Deborah number” that does just that!
www.biorxiv.org/content/10.1...
Out now in #ACSMacroLett: we demonstrate how molecular charge asymmetry can control the size of condensates! Work done in collaboration with @zwickergroup.bsky.social!!
Theory led by Chengjie Luo and simulations by @nathanieldhess.bsky.social!!
pubs.acs.org/doi/10.1021/...
Theory led by Chengjie Luo and simulations by @nathanieldhess.bsky.social!!
pubs.acs.org/doi/10.1021/...
Theory of Condensate Size Control by Molecular Charge Asymmetry
Biomolecular condensates are complex droplets comprising diverse molecules that interact by various mechanisms. Condensation is often driven by short-range attraction, but net charges can also mediate...
pubs.acs.org
September 30, 2025 at 12:48 AM
Out now in #ACSMacroLett: we demonstrate how molecular charge asymmetry can control the size of condensates! Work done in collaboration with @zwickergroup.bsky.social!!
Theory led by Chengjie Luo and simulations by @nathanieldhess.bsky.social!!
pubs.acs.org/doi/10.1021/...
Theory led by Chengjie Luo and simulations by @nathanieldhess.bsky.social!!
pubs.acs.org/doi/10.1021/...
Out now in #SoftMatter, our work on linking single molecule features, microstructure, and macroscopic properties of condensates! Led by Daniel Tan, a former undergrad student who is now pursuing a PhD in Computational biophysics, Dilimulati Aierken and Pablo Garcia!
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
pubs.rsc.org
September 23, 2025 at 2:01 PM
Out now in #SoftMatter, our work on linking single molecule features, microstructure, and macroscopic properties of condensates! Led by Daniel Tan, a former undergrad student who is now pursuing a PhD in Computational biophysics, Dilimulati Aierken and Pablo Garcia!
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
Now out in #ProteinScience! Work led by the talented 🥳🥳@ananyac2000.bsky.social
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
September 15, 2025 at 2:46 PM
Now out in #ProteinScience! Work led by the talented 🥳🥳@ananyac2000.bsky.social
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Who else gets nervous for the first lecture of the semester? It doesn’t matter how many times you’ve taught the course?!!! 😩#fallsemester
September 3, 2025 at 12:47 PM
Who else gets nervous for the first lecture of the semester? It doesn’t matter how many times you’ve taught the course?!!! 😩#fallsemester
On the cover of JACS Au! @alinaemelianova.bsky.social’s work with Pablo and Daniel on using atomistic and residue-resolution coarse-grained simulation to probe interactions between small molecules and biomolecular condensates!! Cover designed by D. Aierken w/ Alina! 1/
July 28, 2025 at 5:06 PM
On the cover of JACS Au! @alinaemelianova.bsky.social’s work with Pablo and Daniel on using atomistic and residue-resolution coarse-grained simulation to probe interactions between small molecules and biomolecular condensates!! Cover designed by D. Aierken w/ Alina! 1/
I second that!!! ♥️
So grateful to my co-coordinators, @zwickergroup.bsky.social, @jerelleaj.bsky.social, and Frank Jülicher, to all of the participants for sharing their knowledge and contributing to such open and stimulating discussions, and to everyone @kitp-ucsb.bsky.social for making our stay so comfortable. 🙏🙏🙏
July 14, 2025 at 10:12 PM
I second that!!! ♥️
Huge congratulations to @alinaemelianova.bsky.social Pablo and Daniel on their paper on small-molecule partitioning into condensates now published in JACS Au and selected as ACS Editor’s Choice!!! pubs.acs.org/doi/full/10....
Prediction of Small-Molecule Partitioning into Biomolecular Condensates from Simulation
Predicting small-molecule partitioning into biomolecular condensates is the key to developing drugs that selectively target aberrant condensates. However, the molecular mechanisms underlying small-mol...
pubs.acs.org
July 3, 2025 at 2:47 PM
Huge congratulations to @alinaemelianova.bsky.social Pablo and Daniel on their paper on small-molecule partitioning into condensates now published in JACS Au and selected as ACS Editor’s Choice!!! pubs.acs.org/doi/full/10....
Reposted by Jerelle Joseph
Can't say enough about the Condensates program at @kitp-ucsb.bsky.social. Invigorating discussions, fantastic facilities, and a beautiful location (a place I consider "home"). Thanks to @weber-lab.bsky.social, @jerelleaj.bsky.social, @zwickergroup.bsky.social, and Frank Julicher for organizing!
June 28, 2025 at 2:39 PM
Can't say enough about the Condensates program at @kitp-ucsb.bsky.social. Invigorating discussions, fantastic facilities, and a beautiful location (a place I consider "home"). Thanks to @weber-lab.bsky.social, @jerelleaj.bsky.social, @zwickergroup.bsky.social, and Frank Julicher for organizing!
Few more days left to nominate a rising star in bioengineering! Self-nominations are welcomed!
📣 Calling all Rising Stars in Biological Engineering. Nominate someone or self nominate: forms.gle/EszC1AvRFpfN...
forms.gle
June 23, 2025 at 4:42 AM
Few more days left to nominate a rising star in bioengineering! Self-nominations are welcomed!
“Biological Physics of Biomolecular Condensates: Bridging Theory and Experiment”
The conference associated with our #KITP program on condensates runs for the next three days. Looking forward to meeting everyone and the discussions!
www.kitp.ucsb.edu/activities/b...
The conference associated with our #KITP program on condensates runs for the next three days. Looking forward to meeting everyone and the discussions!
www.kitp.ucsb.edu/activities/b...
June 16, 2025 at 3:34 PM
“Biological Physics of Biomolecular Condensates: Bridging Theory and Experiment”
The conference associated with our #KITP program on condensates runs for the next three days. Looking forward to meeting everyone and the discussions!
www.kitp.ucsb.edu/activities/b...
The conference associated with our #KITP program on condensates runs for the next three days. Looking forward to meeting everyone and the discussions!
www.kitp.ucsb.edu/activities/b...
There’s nothing quite like #KITP! So grateful that we got the opportunity to put this on! The fun continues…🥰
@jerelleaj.bsky.social, master painter 👩🏽🎨 of the blackboard 👩🏽🏫, in action! 🤩 She is amazing at capturing the essence of our complex, meandering (and sometimes contentious) discussions @kitp-ucsb.bsky.social
June 14, 2025 at 11:42 PM
There’s nothing quite like #KITP! So grateful that we got the opportunity to put this on! The fun continues…🥰
This was a big week for the group! Our four seniors graduated and made us very proud. Ethan graduates as a Sachs Scholar, Ian secured several minors, Daniel won the MacCracken Senior Thesis Award from SEAS, and Caroline earned the highest awards in both CBE and Engineering!
May 29, 2025 at 8:52 PM
This was a big week for the group! Our four seniors graduated and made us very proud. Ethan graduates as a Sachs Scholar, Ian secured several minors, Daniel won the MacCracken Senior Thesis Award from SEAS, and Caroline earned the highest awards in both CBE and Engineering!
Reposted by Jerelle Joseph
@natsmb.nature.com has launched new content this month, namely Q&As. This interview with Dr. Joseph @jerelleaj.bsky.social www.nature.com/articles/s41... highlights what's great about these pieces. Get to learn about the scientist and their interesting work (consensates/computational biol)!
Jerelle Joseph: seeing biomolecular condensates with computation - Nature Structural & Molecular Biology
Jerelle Joseph is an assistant professor at the Department of Chemical and Biological Engineering and the Omenn–Darling Bioengineering Institute at Princeton University in New Jersey. We contacted Jer...
www.nature.com
May 27, 2025 at 12:38 PM
@natsmb.nature.com has launched new content this month, namely Q&As. This interview with Dr. Joseph @jerelleaj.bsky.social www.nature.com/articles/s41... highlights what's great about these pieces. Get to learn about the scientist and their interesting work (consensates/computational biol)!
See u all in Santa Barbara!!
It's finally here! After almost 3 years of planning, I'm thrilled to discover the literal and figurative blue skies @kitp-ucsb.bsky.social
@jerelleaj.bsky.social, @zwickergroup.bsky.social, Frank Jülicher and I will kick off our program on biomolecular condensates next week!
@jerelleaj.bsky.social, @zwickergroup.bsky.social, Frank Jülicher and I will kick off our program on biomolecular condensates next week!
May 21, 2025 at 11:31 PM
See u all in Santa Barbara!!
Thanks to @natsmb.nature.com for interviewing on our work: “seeing biomolecular condensates with computation”
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Jerelle Joseph: seeing biomolecular condensates with computation - Nature Structural & Molecular Biology
Jerelle Joseph is an assistant professor at the Department of Chemical and Biological Engineering and the Omenn–Darling Bioengineering Institute at Princeton University in New Jersey. We contacted Jer...
www.nature.com
May 16, 2025 at 7:43 PM
Thanks to @natsmb.nature.com for interviewing on our work: “seeing biomolecular condensates with computation”
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Yesterday was a great day to be at WashU!
May 14, 2025 at 12:09 PM
Yesterday was a great day to be at WashU!
Join our interdisciplinary team developing computational approaches to understand and engineer biomolecular condensates. We’re looking for a postdoc—please apply or share with interested persons! 👩🏽💻💧🧬
puwebp.princeton.edu/AcadHire/app...
puwebp.princeton.edu/AcadHire/app...
puwebp.princeton.edu
May 5, 2025 at 6:12 PM
Join our interdisciplinary team developing computational approaches to understand and engineer biomolecular condensates. We’re looking for a postdoc—please apply or share with interested persons! 👩🏽💻💧🧬
puwebp.princeton.edu/AcadHire/app...
puwebp.princeton.edu/AcadHire/app...
Congratulations to our 4 seniors (Dan, Ethan, Caroline and Ian) on defending their theses today in the #CBE poster session!! We’re so proud! They’re heading off to Rockefeller, Caltech, Fancy Industry job, and UCLA in the fall! 3/4 were the first 3 juniors in the group. *Cue the tears*😭😭
April 29, 2025 at 10:18 PM
Congratulations to our 4 seniors (Dan, Ethan, Caroline and Ian) on defending their theses today in the #CBE poster session!! We’re so proud! They’re heading off to Rockefeller, Caltech, Fancy Industry job, and UCLA in the fall! 3/4 were the first 3 juniors in the group. *Cue the tears*😭😭
📣 Calling all Rising Stars in Biological Engineering. Nominate someone or self nominate: forms.gle/EszC1AvRFpfN...
forms.gle
April 18, 2025 at 3:30 PM
📣 Calling all Rising Stars in Biological Engineering. Nominate someone or self nominate: forms.gle/EszC1AvRFpfN...
Had the best time at Duke over the last three days! Many many thanks to @gladfelterlab.bsky.social and the entire Center for Quantitative Living Systems for being such amazing hosts!
April 10, 2025 at 12:29 AM
Had the best time at Duke over the last three days! Many many thanks to @gladfelterlab.bsky.social and the entire Center for Quantitative Living Systems for being such amazing hosts!
The “social” network inside condensates is quite cliquey 🙃🙃
co-lead by undergrad student Daniel Tan w/ postdoc Dilimulati 🥳🥳🥳
Preprint out!! www.biorxiv.org/content/10.1...
co-lead by undergrad student Daniel Tan w/ postdoc Dilimulati 🥳🥳🥳
Preprint out!! www.biorxiv.org/content/10.1...
March 27, 2025 at 3:19 PM
The “social” network inside condensates is quite cliquey 🙃🙃
co-lead by undergrad student Daniel Tan w/ postdoc Dilimulati 🥳🥳🥳
Preprint out!! www.biorxiv.org/content/10.1...
co-lead by undergrad student Daniel Tan w/ postdoc Dilimulati 🥳🥳🥳
Preprint out!! www.biorxiv.org/content/10.1...
March 24, 2025 at 1:49 AM