Jeremy Schmit
@schmitbiophysics.bsky.social
Statistical mechanics & biophysics theorist. Emergent properties in biomolecules. Systems biology curious. Father, former athlete. Kansas State University Physics. Occasional appearance of Legos.
Reposted by Jeremy Schmit
Out now in #SoftMatter, our work on linking single molecule features, microstructure, and macroscopic properties of condensates! Led by Daniel Tan, a former undergrad student who is now pursuing a PhD in Computational biophysics, Dilimulati Aierken and Pablo Garcia!
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
pubs.rsc.org
September 23, 2025 at 2:01 PM
Out now in #SoftMatter, our work on linking single molecule features, microstructure, and macroscopic properties of condensates! Led by Daniel Tan, a former undergrad student who is now pursuing a PhD in Computational biophysics, Dilimulati Aierken and Pablo Garcia!
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
Reposted by Jeremy Schmit
Excited to share our paper:
“Historical and Experimental Evidence that Inherent Properties Are Overweighted in Early Scientific Explanation”
I’m grateful to Zach Horne & my dear advisor @andreicimpian.bsky.social to let me be part of this project, it was a great experience!
doi.org/10.1073/pnas...
“Historical and Experimental Evidence that Inherent Properties Are Overweighted in Early Scientific Explanation”
I’m grateful to Zach Horne & my dear advisor @andreicimpian.bsky.social to let me be part of this project, it was a great experience!
doi.org/10.1073/pnas...
Historical and experimental evidence that inherent properties are overweighted in early scientific explanation | PNAS
Scientific explanation is one of the most sophisticated forms of human reasoning.
Nevertheless, here we hypothesize that scientific explanation is ...
doi.org
September 23, 2025 at 3:35 PM
Excited to share our paper:
“Historical and Experimental Evidence that Inherent Properties Are Overweighted in Early Scientific Explanation”
I’m grateful to Zach Horne & my dear advisor @andreicimpian.bsky.social to let me be part of this project, it was a great experience!
doi.org/10.1073/pnas...
“Historical and Experimental Evidence that Inherent Properties Are Overweighted in Early Scientific Explanation”
I’m grateful to Zach Horne & my dear advisor @andreicimpian.bsky.social to let me be part of this project, it was a great experience!
doi.org/10.1073/pnas...
Reposted by Jeremy Schmit
Biomolecular phase boundaries are described by a solubility product that accounts for variable stoichiometry and soluble oligomers https://www.biorxiv.org/content/10.1101/2025.08.27.672390v1
August 29, 2025 at 11:50 PM
Biomolecular phase boundaries are described by a solubility product that accounts for variable stoichiometry and soluble oligomers https://www.biorxiv.org/content/10.1101/2025.08.27.672390v1
"What does this curved line mean?"
Like palm reading for your phase boundary.
Plus, when is your condensate actually an oligomer (or vice versa)?
A new preprint from the Schmit Group, in collaboration with Jonathon Ditlev, Les Loew, and @ani-chattaraj.bsky.social
www.biorxiv.org/content/10.1...
Like palm reading for your phase boundary.
Plus, when is your condensate actually an oligomer (or vice versa)?
A new preprint from the Schmit Group, in collaboration with Jonathon Ditlev, Les Loew, and @ani-chattaraj.bsky.social
www.biorxiv.org/content/10.1...
Biomolecular phase boundaries are described by a solubility product that accounts for variable stoichiometry and soluble oligomers
The solubility product is a rigorous description of the phase boundary for salt precipitation and has also been used to qualitatively describe the condensation of biomolecules. Here we present a deriv...
www.biorxiv.org
September 2, 2025 at 1:32 PM
"What does this curved line mean?"
Like palm reading for your phase boundary.
Plus, when is your condensate actually an oligomer (or vice versa)?
A new preprint from the Schmit Group, in collaboration with Jonathon Ditlev, Les Loew, and @ani-chattaraj.bsky.social
www.biorxiv.org/content/10.1...
Like palm reading for your phase boundary.
Plus, when is your condensate actually an oligomer (or vice versa)?
A new preprint from the Schmit Group, in collaboration with Jonathon Ditlev, Les Loew, and @ani-chattaraj.bsky.social
www.biorxiv.org/content/10.1...
Can't say enough about the Condensates program at @kitp-ucsb.bsky.social. Invigorating discussions, fantastic facilities, and a beautiful location (a place I consider "home"). Thanks to @weber-lab.bsky.social, @jerelleaj.bsky.social, @zwickergroup.bsky.social, and Frank Julicher for organizing!
June 28, 2025 at 2:39 PM
Can't say enough about the Condensates program at @kitp-ucsb.bsky.social. Invigorating discussions, fantastic facilities, and a beautiful location (a place I consider "home"). Thanks to @weber-lab.bsky.social, @jerelleaj.bsky.social, @zwickergroup.bsky.social, and Frank Julicher for organizing!
Reposted by Jeremy Schmit
What nanometer structure-function relationships exist in your favorite condensate? We hope you will try to measure it! Congrats to Kris, @evdokiiap.bsky.social, Abby, Archish, Gandhar, and @schmitbiophysics.bsky.social . 4/4
February 28, 2025 at 12:55 PM
What nanometer structure-function relationships exist in your favorite condensate? We hope you will try to measure it! Congrats to Kris, @evdokiiap.bsky.social, Abby, Archish, Gandhar, and @schmitbiophysics.bsky.social . 4/4
Reposted by Jeremy Schmit
In lab’s #FIRSTPREPRINT, we present methods to measure nanometer-scale organization around & between specific proteins in condensates in live cells. We uncover unexpected heterogeneity for a liquid-like phase with local meshwork spanning 10-50nm, stemming from ribosome biogenesis in the nucleolus.
February 28, 2025 at 12:52 PM
In lab’s #FIRSTPREPRINT, we present methods to measure nanometer-scale organization around & between specific proteins in condensates in live cells. We uncover unexpected heterogeneity for a liquid-like phase with local meshwork spanning 10-50nm, stemming from ribosome biogenesis in the nucleolus.
Reposted by Jeremy Schmit
Here is a thread on a paper we published on Dec 30th: doi.org/10.1038/s414... In this collaborative work, we looked at the structure of proteins behind Huntington’s disease. HD is an inherited neurodegenerative disease, with patients having a mutated form of the huntingtin gene. (1/..)
Integrative determination of atomic structure of mutant huntingtin exon 1 fibrils implicated in Huntington disease - Nature Communications
An integrated structural biology approach encompassing solid-state NMR and molecular dynamics simulations was implemented to obtain an atomic view of the ordered polyglutamine core and fuzzy coat of t...
doi.org
January 19, 2025 at 6:54 PM
Here is a thread on a paper we published on Dec 30th: doi.org/10.1038/s414... In this collaborative work, we looked at the structure of proteins behind Huntington’s disease. HD is an inherited neurodegenerative disease, with patients having a mutated form of the huntingtin gene. (1/..)
Hoping the demise of the clock app drives me to discover more cool science here.
January 19, 2025 at 2:50 PM
Hoping the demise of the clock app drives me to discover more cool science here.
When the turkey is supposed to be the centerpiece but your 12yo steals your thunder.
November 28, 2024 at 10:40 PM
When the turkey is supposed to be the centerpiece but your 12yo steals your thunder.
Reposted by Jeremy Schmit
Cutting NIH funding to improve federal cash flow is like cutting the wings off an airplane to make it lighter.
Research funded by NIH generated $2.46 in economic activity for every $1 of funding in 2023 [a total of $92.9 billion]
www.fiercebiotech.com/research/rep...
www.fiercebiotech.com/research/rep...
Report: Every dollar of NIH research funding doubles in economic returns
Research funded by the National Institutes of Health (NIH) generated $2.46 in economic activity for every $1 of funding in 2023, a total of $92.9 billion, according to an
www.fiercebiotech.com
November 18, 2024 at 5:42 PM
Cutting NIH funding to improve federal cash flow is like cutting the wings off an airplane to make it lighter.
Shopping for summer 2025 conferences. Pitch me your favorites in:
Biological LLPS
Amyloids
Self-assembly
Soft condensed matter Physics
Chromatin
Systems biology
Other???
Biological LLPS
Amyloids
Self-assembly
Soft condensed matter Physics
Chromatin
Systems biology
Other???
November 19, 2024 at 12:47 PM
Shopping for summer 2025 conferences. Pitch me your favorites in:
Biological LLPS
Amyloids
Self-assembly
Soft condensed matter Physics
Chromatin
Systems biology
Other???
Biological LLPS
Amyloids
Self-assembly
Soft condensed matter Physics
Chromatin
Systems biology
Other???
Reposted by Jeremy Schmit
Excited to find this place and find all the people from the biophysics and LLPS community are already here! I'd like to link up with the soft condensed matter community too. Any suggestions?
November 17, 2024 at 10:01 PM
Excited to find this place and find all the people from the biophysics and LLPS community are already here! I'd like to link up with the soft condensed matter community too. Any suggestions?