Keren Lasker
@kerenlasker.bsky.social
Membraneless Organelles in Bacteria: Structure, Dynamics, Function, and Engineering. Assistant Professor @scripps.edu.
https://laskerlab.org/
https://laskerlab.org/
Pinned
Keren Lasker
@kerenlasker.bsky.social
· Dec 30
Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure
Biomolecular condensates play key roles in the spatiotemporal regulation of cellular processes. Yet, the relationship between atomic features and condensate function remains poorly understood. We stud...
www.biorxiv.org
1/ 🚨We’re thrilled to share our latest study:
"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟
www.biorxiv.org/content/10.1...
How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟
www.biorxiv.org/content/10.1...
How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
Reposted by Keren Lasker
Congratulations to Lucy Shapiro, 2025 #LaskerAward winner! – “for a 55-year career in biomedical science – honored for discovering how bacteria generate distinct daughter cells; and for exemplary leadership at the national level”
#Lasker2025 #LaskerLaureate #devbio 🧪
#Lasker2025 #LaskerLaureate #devbio 🧪
September 11, 2025 at 1:20 PM
Congratulations to Lucy Shapiro, 2025 #LaskerAward winner! – “for a 55-year career in biomedical science – honored for discovering how bacteria generate distinct daughter cells; and for exemplary leadership at the national level”
#Lasker2025 #LaskerLaureate #devbio 🧪
#Lasker2025 #LaskerLaureate #devbio 🧪
Over the moon to see my postdoc advisor, Prof. Lucy Shapiro, receive a Lasker Award—a brilliant salute to her decades of trail-blazing science, visionary leadership, and transformative mentorship. Congratulations!
Congratulations to this year’s #LaskerAward winners!
Basic: Dirk Görlich & Steven L. McKnight
Clinical: Michael J. Welsh, Jesús (Tito) González, & Paul A. Negulescu
Special Achievement: Lucy Shapiro
Laskerfoundation.org
#Lasker2025 #LaskerLaureate
Basic: Dirk Görlich & Steven L. McKnight
Clinical: Michael J. Welsh, Jesús (Tito) González, & Paul A. Negulescu
Special Achievement: Lucy Shapiro
Laskerfoundation.org
#Lasker2025 #LaskerLaureate
September 11, 2025 at 1:16 PM
Over the moon to see my postdoc advisor, Prof. Lucy Shapiro, receive a Lasker Award—a brilliant salute to her decades of trail-blazing science, visionary leadership, and transformative mentorship. Congratulations!
Reposted by Keren Lasker
Join us this Thursday, June 12, at 1PM for the first of our three summer virtual masterclasses — where seasoned PIs share how they transformed foundational science into VC-backed startups. 🔬🌟
🎟️ For more info, contact biotechsummit@scripps.edu.
🎟️ For more info, contact biotechsummit@scripps.edu.
June 10, 2025 at 5:05 PM
Join us this Thursday, June 12, at 1PM for the first of our three summer virtual masterclasses — where seasoned PIs share how they transformed foundational science into VC-backed startups. 🔬🌟
🎟️ For more info, contact biotechsummit@scripps.edu.
🎟️ For more info, contact biotechsummit@scripps.edu.
Reposted by Keren Lasker
🎉 Congratulations to Wolfgang Baumeister @maxplanck.de, awarded the 2025 #ShawPrize in Life Science & Medicine for pioneering work in cryo-ET!
Learn more 👉 europa.eu/!JBXDBG
#FrontierResearch #ERCSyG #CryoET #StructuralBiology #shawprize2025
Learn more 👉 europa.eu/!JBXDBG
#FrontierResearch #ERCSyG #CryoET #StructuralBiology #shawprize2025
ERC grantee wins the Shaw Prize in Life Science and Medicine
2025 Shaw Prize honours ERC-funded research in molecular imaging
europa.eu
May 28, 2025 at 7:49 AM
🎉 Congratulations to Wolfgang Baumeister @maxplanck.de, awarded the 2025 #ShawPrize in Life Science & Medicine for pioneering work in cryo-ET!
Learn more 👉 europa.eu/!JBXDBG
#FrontierResearch #ERCSyG #CryoET #StructuralBiology #shawprize2025
Learn more 👉 europa.eu/!JBXDBG
#FrontierResearch #ERCSyG #CryoET #StructuralBiology #shawprize2025
Reposted by Keren Lasker
Now published! Big congrats to first author @gginell.bsky.social
We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions.
www.science.org/doi/10.1126/...
We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions.
www.science.org/doi/10.1126/...
May 23, 2025 at 11:31 AM
Now published! Big congrats to first author @gginell.bsky.social
We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions.
www.science.org/doi/10.1126/...
We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions.
www.science.org/doi/10.1126/...
Reposted by Keren Lasker
In collaboration with the @lindorfflarsen.bsky.social group we release our map of degrons in >5,000 human cytosolic proteins with >99% coverage. A machine learning model trained on the data identifies missense variants forming degrons in exposed & disordered regions. Work led by @vvouts.bsky.social.
A complete map of human cytosolic degrons and their relevance for disease
Degrons are short protein segments that target proteins for degradation via the ubiquitin-proteasome system and thus ensure timely removal of signaling proteins and clearance of misfolded proteins fro...
www.biorxiv.org
May 15, 2025 at 11:56 AM
In collaboration with the @lindorfflarsen.bsky.social group we release our map of degrons in >5,000 human cytosolic proteins with >99% coverage. A machine learning model trained on the data identifies missense variants forming degrons in exposed & disordered regions. Work led by @vvouts.bsky.social.
Reposted by Keren Lasker
AlphaFold is amazing but gives you static structures 🧊
In a fantastic teamwork, @mcagiada.bsky.social and @emilthomasen.bsky.social developed AF2χ to generate conformational ensembles representing side-chain dynamics using AF2 💃
Code: github.com/KULL-Centre/...
Colab: github.com/matteo-cagia...
In a fantastic teamwork, @mcagiada.bsky.social and @emilthomasen.bsky.social developed AF2χ to generate conformational ensembles representing side-chain dynamics using AF2 💃
Code: github.com/KULL-Centre/...
Colab: github.com/matteo-cagia...
April 17, 2025 at 7:11 PM
AlphaFold is amazing but gives you static structures 🧊
In a fantastic teamwork, @mcagiada.bsky.social and @emilthomasen.bsky.social developed AF2χ to generate conformational ensembles representing side-chain dynamics using AF2 💃
Code: github.com/KULL-Centre/...
Colab: github.com/matteo-cagia...
In a fantastic teamwork, @mcagiada.bsky.social and @emilthomasen.bsky.social developed AF2χ to generate conformational ensembles representing side-chain dynamics using AF2 💃
Code: github.com/KULL-Centre/...
Colab: github.com/matteo-cagia...
Reposted by Keren Lasker
Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...
Tissue-like multicellular development triggered by mechanical compression in archaea
The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal mul...
www.science.org
April 3, 2025 at 6:24 PM
Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...
Reposted by Keren Lasker
Announcing the joint @idpseminars.bsky.social / BPS IDP Subgroup Trainee Symposium Speakers!
Join us on Mar 27, 12–2pm CST for 6 exciting talks focused on Intrinsically Disordered Proteins as part of #BophysicsWeek2025 with the @biophysicalsoc.bsky.social Sign up now using the QR code below!
Join us on Mar 27, 12–2pm CST for 6 exciting talks focused on Intrinsically Disordered Proteins as part of #BophysicsWeek2025 with the @biophysicalsoc.bsky.social Sign up now using the QR code below!
March 17, 2025 at 3:38 PM
Announcing the joint @idpseminars.bsky.social / BPS IDP Subgroup Trainee Symposium Speakers!
Join us on Mar 27, 12–2pm CST for 6 exciting talks focused on Intrinsically Disordered Proteins as part of #BophysicsWeek2025 with the @biophysicalsoc.bsky.social Sign up now using the QR code below!
Join us on Mar 27, 12–2pm CST for 6 exciting talks focused on Intrinsically Disordered Proteins as part of #BophysicsWeek2025 with the @biophysicalsoc.bsky.social Sign up now using the QR code below!
Reposted by Keren Lasker
This summer in beautiful Santa Barbara we will run a 3-day conference on “Biological Physics of Biomolecular Condensates: Bridging Theory and Experiment” June 16 to 18th. Register now: www.kitp.ucsb.edu/activities/b...
March 12, 2025 at 3:58 PM
This summer in beautiful Santa Barbara we will run a 3-day conference on “Biological Physics of Biomolecular Condensates: Bridging Theory and Experiment” June 16 to 18th. Register now: www.kitp.ucsb.edu/activities/b...
Reposted by Keren Lasker
Big health breakthrough: a protein from tardigrades can now protect human cells from radiation.
That’s going to lead to better cancer therapies.
That’s going to lead to better cancer therapies.
Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades - Nature Biomedical Engineering
Radiation-therapy-induced DNA damage in oral and rectal epithelial cells can be reduced via the nanoparticle-mediated local delivery of messenger RNA encoding for a damage-suppressor protein found in ...
www.nature.com
March 5, 2025 at 8:58 PM
Big health breakthrough: a protein from tardigrades can now protect human cells from radiation.
That’s going to lead to better cancer therapies.
That’s going to lead to better cancer therapies.
Reposted by Keren Lasker
New Preprint ‼️ Work led by the incredible @ananyac2000.bsky.social 💃🏽💃🏽 Mpipi-T is finally here!!! 🥳🥳 👇🏽👇🏽
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
March 6, 2025 at 10:10 PM
New Preprint ‼️ Work led by the incredible @ananyac2000.bsky.social 💃🏽💃🏽 Mpipi-T is finally here!!! 🥳🥳 👇🏽👇🏽
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Keren Lasker
MBoC #CallForPapers: Special Issue on Biomolecular Condensates
Submit to be considered by lead editors:
Amy Gladfelter, University of North Carolina
Jeffrey B. Woodruff, UT Southwestern Medical Center
Huaiying Zhang, Carnegie Mellon University
www.molbiolcell.org/biomolecular... #CellBiology
Submit to be considered by lead editors:
Amy Gladfelter, University of North Carolina
Jeffrey B. Woodruff, UT Southwestern Medical Center
Huaiying Zhang, Carnegie Mellon University
www.molbiolcell.org/biomolecular... #CellBiology
March 4, 2025 at 4:49 PM
MBoC #CallForPapers: Special Issue on Biomolecular Condensates
Submit to be considered by lead editors:
Amy Gladfelter, University of North Carolina
Jeffrey B. Woodruff, UT Southwestern Medical Center
Huaiying Zhang, Carnegie Mellon University
www.molbiolcell.org/biomolecular... #CellBiology
Submit to be considered by lead editors:
Amy Gladfelter, University of North Carolina
Jeffrey B. Woodruff, UT Southwestern Medical Center
Huaiying Zhang, Carnegie Mellon University
www.molbiolcell.org/biomolecular... #CellBiology
Reposted by Keren Lasker
From MBoC
AI: A transformative opportunity in cell biology, by Sandra Schmid, Chan Zuckerberg Biohub Network, et al.
doi.org/10.1091/mbc.... #CellBiology
AI: A transformative opportunity in cell biology, by Sandra Schmid, Chan Zuckerberg Biohub Network, et al.
doi.org/10.1091/mbc.... #CellBiology
AI: A transformative opportunity in cell biology | Molecular Biology of the Cell
The success of artificial intelligence (AI) algorithms in predicting protein structure and more recently, protein interactions, demonstrates the power and potential of machine learning and AI for adva...
doi.org
March 3, 2025 at 2:33 PM
From MBoC
AI: A transformative opportunity in cell biology, by Sandra Schmid, Chan Zuckerberg Biohub Network, et al.
doi.org/10.1091/mbc.... #CellBiology
AI: A transformative opportunity in cell biology, by Sandra Schmid, Chan Zuckerberg Biohub Network, et al.
doi.org/10.1091/mbc.... #CellBiology
Reposted by Keren Lasker
Reposted by Keren Lasker
Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA.
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry
Mammalian cells present RNA-binding proteins on the cell surface that form clustered
domains containing glycoRNAs.
www.cell.com
February 27, 2025 at 3:48 PM
Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA.
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
Reposted by Keren Lasker
First senior-author paper is out today in the Journal of Microscopy! 🧪🔬
We present the first 3D printed microscope where both the optics & frame are entirely 3D printed - a low-cost, accessible, and reproducible tool for histological imaging!
onlinelibrary.wiley.com/doi/full/10.1111/jmi.13398
We present the first 3D printed microscope where both the optics & frame are entirely 3D printed - a low-cost, accessible, and reproducible tool for histological imaging!
onlinelibrary.wiley.com/doi/full/10.1111/jmi.13398
February 25, 2025 at 12:07 PM
First senior-author paper is out today in the Journal of Microscopy! 🧪🔬
We present the first 3D printed microscope where both the optics & frame are entirely 3D printed - a low-cost, accessible, and reproducible tool for histological imaging!
onlinelibrary.wiley.com/doi/full/10.1111/jmi.13398
We present the first 3D printed microscope where both the optics & frame are entirely 3D printed - a low-cost, accessible, and reproducible tool for histological imaging!
onlinelibrary.wiley.com/doi/full/10.1111/jmi.13398
Reposted by Keren Lasker
In a new op-ed for the @sandiegouniontribune.com, Scripps Research President and CEO Pete Schultz discusses how proposed changes to federal science funding could have unintended consequences for biomedical research, innovation, and the broader life sciences ecosystem in San Diego.
Opinion: Science funding cuts are based on flawed logic. Here’s the truth.
Earlier this month, the National Institutes of Health issued supplemental guidance indicating it would immediately impose a 15% cap on indirect costs for research grants, an unprecedented and abrup…
www.sandiegouniontribune.com
February 26, 2025 at 4:28 PM
In a new op-ed for the @sandiegouniontribune.com, Scripps Research President and CEO Pete Schultz discusses how proposed changes to federal science funding could have unintended consequences for biomedical research, innovation, and the broader life sciences ecosystem in San Diego.
Reposted by Keren Lasker
Ever wondered how mammalian cells sense osmotic stress? There's gotta be a signaling pathway, right?
We propose a *one-component system*: NFAT5, the transcription factor that executes the osmoprotective response, is also the stress sensor!
www.science.org/doi/full/10....
We propose a *one-component system*: NFAT5, the transcription factor that executes the osmoprotective response, is also the stress sensor!
www.science.org/doi/full/10....
Direct ionic stress sensing and mitigation by the transcription factor NFAT5
Intracellular ionic strength is sensed and regulated by a prion-like domain in a transcription factor.
www.science.org
February 25, 2025 at 2:49 PM
Ever wondered how mammalian cells sense osmotic stress? There's gotta be a signaling pathway, right?
We propose a *one-component system*: NFAT5, the transcription factor that executes the osmoprotective response, is also the stress sensor!
www.science.org/doi/full/10....
We propose a *one-component system*: NFAT5, the transcription factor that executes the osmoprotective response, is also the stress sensor!
www.science.org/doi/full/10....
🎉🎉 Kudos to @bornanovak.bsky.social , Jeff, Ryan, and @alexholehouse.bsky.social —this breakthrough work paves the way for exciting new frontiers in disordered protein research! 🌟✨
Excited to announce the newest member of the flock - STARLING (conSTruction of intrinsicAlly disoRdered proteins ensembles efficientLy vIa multi-dimeNsional Generative models).
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 15, 2025 at 11:50 PM
🎉🎉 Kudos to @bornanovak.bsky.social , Jeff, Ryan, and @alexholehouse.bsky.social —this breakthrough work paves the way for exciting new frontiers in disordered protein research! 🌟✨
Part 2 is starting soon! 🤩
February 15, 2025 at 6:22 PM
Part 2 is starting soon! 🤩
Part I of BIV subgroup starts in an hour (8:30 am PT)
Join us!
Join us!
February 15, 2025 at 3:39 PM
Part I of BIV subgroup starts in an hour (8:30 am PT)
Join us!
Join us!
🚀 Join us at #BPS2025 tomorrow at 8:30 AM for a spectacular lineup of cutting-edge methods & biology in Biopolymers In Vivo! 🧪🔬
🧠 AI & IDP phase behavior | 🌱 Protein thermosensing | ❄️ Cryo-EM
🧬 GTPase activity | 🛠️ Engineered condensates | 🤖 Deep learning | 💧 Phase separation
🧠 AI & IDP phase behavior | 🌱 Protein thermosensing | ❄️ Cryo-EM
🧬 GTPase activity | 🛠️ Engineered condensates | 🤖 Deep learning | 💧 Phase separation
February 15, 2025 at 12:05 AM
🚀 Join us at #BPS2025 tomorrow at 8:30 AM for a spectacular lineup of cutting-edge methods & biology in Biopolymers In Vivo! 🧪🔬
🧠 AI & IDP phase behavior | 🌱 Protein thermosensing | ❄️ Cryo-EM
🧬 GTPase activity | 🛠️ Engineered condensates | 🤖 Deep learning | 💧 Phase separation
🧠 AI & IDP phase behavior | 🌱 Protein thermosensing | ❄️ Cryo-EM
🧬 GTPase activity | 🛠️ Engineered condensates | 🤖 Deep learning | 💧 Phase separation
Reposted by Keren Lasker
Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5
February 12, 2025 at 4:20 PM
Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5
Reposted by Keren Lasker
🎉🧪New perspective paper! Single-point missense mutations are common in disordered regions but are often overlooked👀. We analyzed thousands of IDR point mutations associated with human congenital diseases to show that many can significantly change local IDR ensemble structure!
shorturl.at/iIbLX
shorturl.at/iIbLX
February 7, 2025 at 7:55 PM
🎉🧪New perspective paper! Single-point missense mutations are common in disordered regions but are often overlooked👀. We analyzed thousands of IDR point mutations associated with human congenital diseases to show that many can significantly change local IDR ensemble structure!
shorturl.at/iIbLX
shorturl.at/iIbLX