Broder Schmidt
@hbschmidt.bsky.social
Practitioner of the dark art of biochemistry 🧙♂️
In vivo | in vitro | in silico
https://broderschmidt.com
In vivo | in vitro | in silico
https://broderschmidt.com
Ever wondered how mammalian cells sense osmotic stress? There's gotta be a signaling pathway, right?
We propose a *one-component system*: NFAT5, the transcription factor that executes the osmoprotective response, is also the stress sensor!
www.science.org/doi/full/10....
We propose a *one-component system*: NFAT5, the transcription factor that executes the osmoprotective response, is also the stress sensor!
www.science.org/doi/full/10....
Direct ionic stress sensing and mitigation by the transcription factor NFAT5
Intracellular ionic strength is sensed and regulated by a prion-like domain in a transcription factor.
www.science.org
February 25, 2025 at 2:49 PM
Ever wondered how mammalian cells sense osmotic stress? There's gotta be a signaling pathway, right?
We propose a *one-component system*: NFAT5, the transcription factor that executes the osmoprotective response, is also the stress sensor!
www.science.org/doi/full/10....
We propose a *one-component system*: NFAT5, the transcription factor that executes the osmoprotective response, is also the stress sensor!
www.science.org/doi/full/10....
Reposted by Broder Schmidt
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
February 8, 2025 at 9:21 PM
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
Quick poll: what year is the below abstract from?
„Our results indicate that protein sequences contain not only a folding code, but also a previously unrecognized code governing their distribution to diverse subcellular compartments.“
„Our results indicate that protein sequences contain not only a folding code, but also a previously unrecognized code governing their distribution to diverse subcellular compartments.“
February 7, 2025 at 4:36 PM
Quick poll: what year is the below abstract from?
„Our results indicate that protein sequences contain not only a folding code, but also a previously unrecognized code governing their distribution to diverse subcellular compartments.“
„Our results indicate that protein sequences contain not only a folding code, but also a previously unrecognized code governing their distribution to diverse subcellular compartments.“
Reposted by Broder Schmidt
Dunno what they have planned, but a devastated NIH will destroy universities and academic science (on the heels of significant COVID impacts) but will also destroy biotech and cede US leadership in this sector to China and elsewhere very very quickly.
January 23, 2025 at 1:58 AM
Dunno what they have planned, but a devastated NIH will destroy universities and academic science (on the heels of significant COVID impacts) but will also destroy biotech and cede US leadership in this sector to China and elsewhere very very quickly.
Reposted by Broder Schmidt
The Dept. of Biochem. & Biophys. @ WashU is running its summer undergrad research program!
Rising seniors who have not had the opportunity to do bona fide research but are interested in this are strongly encouraged to apply
Deadline: Jan 31st
Details: biochem.wustl.edu/resources/in...
Pls share!
Rising seniors who have not had the opportunity to do bona fide research but are interested in this are strongly encouraged to apply
Deadline: Jan 31st
Details: biochem.wustl.edu/resources/in...
Pls share!
Summer Undergraduate Research Group Experience Program (SURGE) – Department of Biochemistry and Molecular Biophysics
biochem.wustl.edu
January 13, 2025 at 1:36 PM
The Dept. of Biochem. & Biophys. @ WashU is running its summer undergrad research program!
Rising seniors who have not had the opportunity to do bona fide research but are interested in this are strongly encouraged to apply
Deadline: Jan 31st
Details: biochem.wustl.edu/resources/in...
Pls share!
Rising seniors who have not had the opportunity to do bona fide research but are interested in this are strongly encouraged to apply
Deadline: Jan 31st
Details: biochem.wustl.edu/resources/in...
Pls share!
Reposted by Broder Schmidt
Proud to share our work spear-headed by PhD student Tommy Sroka with major contributions by #xenopus expert Kerstin Feistel.
Our iAPEX #ProximityLabeling method for #MassSpec based subcellular #proteomics works by locally generating H2O2 using a D-amino acid oxidase that activates APEX2 in situ.
Our iAPEX #ProximityLabeling method for #MassSpec based subcellular #proteomics works by locally generating H2O2 using a D-amino acid oxidase that activates APEX2 in situ.
iAPEX: Improved APEX-based proximity labeling for subcellular proteomics using an enzymatic reaction cascade
Ascorbate peroxidase (APEX) is a versatile labeling enzyme used for live-cell proteomics at high spatial and temporal resolution. However, toxicity of its substrate hydrogen peroxide and background la...
www.biorxiv.org
January 11, 2025 at 7:51 PM
Proud to share our work spear-headed by PhD student Tommy Sroka with major contributions by #xenopus expert Kerstin Feistel.
Our iAPEX #ProximityLabeling method for #MassSpec based subcellular #proteomics works by locally generating H2O2 using a D-amino acid oxidase that activates APEX2 in situ.
Our iAPEX #ProximityLabeling method for #MassSpec based subcellular #proteomics works by locally generating H2O2 using a D-amino acid oxidase that activates APEX2 in situ.
Found some old drawings I had to do for my undergrad in Molecular & Cellular Biology. @dadrummond.bsky.social may particularly appreciate this one, although I’m not nearly the artist he is.
December 13, 2024 at 11:17 AM
Found some old drawings I had to do for my undergrad in Molecular & Cellular Biology. @dadrummond.bsky.social may particularly appreciate this one, although I’m not nearly the artist he is.
@boeynaemssteven.bsky.social New night science project?
Did much of the basic tool kit for multicellular development, possibly even animal development, arose early in eukaryote evolution?
The Acrasis kona genome and developmental transcriptomes reveal deep origins of eukaryotic multicellular pathways.
www.nature.com/articles/s41...
The Acrasis kona genome and developmental transcriptomes reveal deep origins of eukaryotic multicellular pathways.
www.nature.com/articles/s41...
The Acrasis kona genome and developmental transcriptomes reveal deep origins of eukaryotic multicellular pathways - Nature Communications
Acrasis kona is a solitary amoeba which builds a multicellular fruiting body, despite being a distant relative of other multicellular eukaryotes. This study analysed A. kona’s genome and developmental...
www.nature.com
November 28, 2024 at 1:54 AM
@boeynaemssteven.bsky.social New night science project?