Bede Portz
@ysptsps.bsky.social
Biotech. Interests: oncology, transcription, RNA, small molecule drug discovery, RNA therapeutics, protein aggregation, phase transitions
Reposted by Bede Portz
I wrote a review of James Watson's obituary by CSHL: liorpachter.wordpress.com/2025/11/08/r...
Review of Cold Spring Harbor Laboratory’s Obituary for Dr. James Watson
James Watson, who described himself as “not a racist in a conventional way”, has died at the age of 97. Below is a review of an obituary for Dr. James Watson published by Cold Spring Ha…
liorpachter.wordpress.com
November 8, 2025 at 9:58 PM
I wrote a review of James Watson's obituary by CSHL: liorpachter.wordpress.com/2025/11/08/r...
Reposted by Bede Portz
The password to the Louvre’s video surveillance system was “Louvre,” according to a museum employee
Password to Louvre’s video surveillance system was 'Louvre', according to employee
According to an employee with knowledge of the system, the password to the Louvre's video surveillance system was simply "Louvre" at the time of the robbery last month.
abcnews.go.com
November 6, 2025 at 11:21 PM
The password to the Louvre’s video surveillance system was “Louvre,” according to a museum employee
Smoltz is a terrible announcer
November 2, 2025 at 3:52 AM
Smoltz is a terrible announcer
They dont give kids 100 grands or payday anymore we used to be a real country @triggerloop.bsky.social
November 1, 2025 at 1:21 AM
They dont give kids 100 grands or payday anymore we used to be a real country @triggerloop.bsky.social
Reposted by Bede Portz
1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
www.nature.com
October 28, 2025 at 4:02 PM
1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...
Abstract B105: Oral small molecule MYC condensate modulators (c-mods) induce robust anti-tumor responses in preclinical solid tumor models aacrjournals.org/mct/article/24… From my Dewpoint era. I lead this program from ideation to late lead optimization. I hope it advances to the clinic.
https://aacrjournals.org/mct/article/24…
October 23, 2025 at 2:41 AM
Abstract B105: Oral small molecule MYC condensate modulators (c-mods) induce robust anti-tumor responses in preclinical solid tumor models aacrjournals.org/mct/article/24… From my Dewpoint era. I lead this program from ideation to late lead optimization. I hope it advances to the clinic.
Reposted by Bede Portz
the Muppets have been real quiet since the Louvre heist
October 19, 2025 at 10:19 PM
the Muppets have been real quiet since the Louvre heist
From @retof.bsky.social @kevin-dean.bsky.social et al. As a big proponent of image-based high throughput phenotypic screening and AI-enabled hit calling this looks really cool www.biorxiv.org/content/10.1...
Multi-immersion Oblique Plane Microscope (miOPM): A reconfigurable platform for high-resolution Light-Sheet Fluorescence Microscopy
Light-Sheet Fluorescence Microscopy (LSFM) enables gentle, rapid, and efficient volumetric imaging of biological specimens. Despite its potential, LSFM has fragmented into multiple variants, each narr...
www.biorxiv.org
October 13, 2025 at 1:10 PM
From @retof.bsky.social @kevin-dean.bsky.social et al. As a big proponent of image-based high throughput phenotypic screening and AI-enabled hit calling this looks really cool www.biorxiv.org/content/10.1...
Reposted by Bede Portz
Humbled to announce that we received a New Innovator award. I thank the NIH’s civil servants for their hard work during a stressful funding cycle. I thank the leadership (and chair, Marc Diamond) at UTSW for betting on my lab’s high risk, high reward research. www.utsouthwestern.edu/newsroom/art...
UT Southwestern researcher receives NIH Director’s New Innovator Award
David Sanders, Ph.D., Assistant Professor in the Center for Alzheimer’s and Neurodegenerative Diseases and Molecular Biology at UT Southwestern Medical Center, has been awarded $2.4 million over five ...
www.utsouthwestern.edu
October 8, 2025 at 8:26 PM
Humbled to announce that we received a New Innovator award. I thank the NIH’s civil servants for their hard work during a stressful funding cycle. I thank the leadership (and chair, Marc Diamond) at UTSW for betting on my lab’s high risk, high reward research. www.utsouthwestern.edu/newsroom/art...
Reposted by Bede Portz
A strong quality for a good researcher is the ability to sometimes ignore small details, and sometimes delves into them with the greatest care, and more importantly to being able to switch wisely between the two modes.
October 7, 2025 at 5:55 PM
A strong quality for a good researcher is the ability to sometimes ignore small details, and sometimes delves into them with the greatest care, and more importantly to being able to switch wisely between the two modes.
Harrison Bader battling through injury he got facing Nitro in the joust. #GoPhils #Phillies #americangladiator
October 7, 2025 at 1:13 AM
Harrison Bader battling through injury he got facing Nitro in the joust. #GoPhils #Phillies #americangladiator
Reposted by Bede Portz
Happy to participate in Pittsburgh SCADaddle 5K for SCAD research. SCAD is the kind of heart attack that mostly affects healthy women >40 without traditional risk factors. Can be associated with peri or postpartum and commonly SCAD patients also suffer migraines @scadalliance.bsky.social
October 5, 2025 at 7:01 PM
Happy to participate in Pittsburgh SCADaddle 5K for SCAD research. SCAD is the kind of heart attack that mostly affects healthy women >40 without traditional risk factors. Can be associated with peri or postpartum and commonly SCAD patients also suffer migraines @scadalliance.bsky.social
Turned this game on against my better judgement only to see PSU mismanage (charitable) the clock and bungle the play calling, Allar to take the most Allar sack, and for us to give ball to UCLA to score. All while announcers excoriate us.
October 4, 2025 at 9:04 PM
Turned this game on against my better judgement only to see PSU mismanage (charitable) the clock and bungle the play calling, Allar to take the most Allar sack, and for us to give ball to UCLA to score. All while announcers excoriate us.
Reposted by Bede Portz
My rock climbing gym has paper copies of Cell and Neuron, and I ran into a buddy there working on a drug discovery paper while his kid climbed. #Boston #NorthShore
October 4, 2025 at 7:03 PM
My rock climbing gym has paper copies of Cell and Neuron, and I ran into a buddy there working on a drug discovery paper while his kid climbed. #Boston #NorthShore
Reposted by Bede Portz
Today I am so pleased to present our work on how chromatin remodelers affect mesoscale chromatin organization.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes
Adenosine triphosphate (ATP)–dependent chromatin remodeling enzymes mobilize nucleosomes, but how such mobilization affects chromatin condensation is unclear. We investigate effects of two major remod...
www.science.org
October 2, 2025 at 10:55 PM
Today I am so pleased to present our work on how chromatin remodelers affect mesoscale chromatin organization.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Bede Portz
Also needs to be said that (as some folks know) our software packages are named after birds, so while I was away, the lab filled my office with birds... ...but honestly... *very* tastefully.
Will stay for the foreseeable future!
Will stay for the foreseeable future!
October 2, 2025 at 4:00 PM
Also needs to be said that (as some folks know) our software packages are named after birds, so while I was away, the lab filled my office with birds... ...but honestly... *very* tastefully.
Will stay for the foreseeable future!
Will stay for the foreseeable future!
If we take just a lil bit of Tylenol or maybe make a slightly less potent analog would that be like a vaccine that prevents autism?
September 24, 2025 at 1:30 AM
If we take just a lil bit of Tylenol or maybe make a slightly less potent analog would that be like a vaccine that prevents autism?
Reposted by Bede Portz
Still trying to figure out what MAHA hates more: women or vaccines.
I still can't get over the suggestion for pregnant women to 'tough it out' spoken by the softest man that has ever lived.
September 23, 2025 at 11:01 AM
Still trying to figure out what MAHA hates more: women or vaccines.
Reposted by Bede Portz
I know antifa isn't a real organization because I don't get 40 texts a week from them asking for donations.
September 22, 2025 at 11:21 PM
I know antifa isn't a real organization because I don't get 40 texts a week from them asking for donations.
Go birds 🦅 unbelievable
September 21, 2025 at 8:09 PM
Go birds 🦅 unbelievable
Major Medical Prizes Given to Cell Biology and Cystic Fibrosis Pioneers www.nytimes.com/2025/09/11/h...
Major Medical Prizes Given to Cell Biology and Cystic Fibrosis Pioneers
www.nytimes.com
September 11, 2025 at 2:44 PM
Major Medical Prizes Given to Cell Biology and Cystic Fibrosis Pioneers www.nytimes.com/2025/09/11/h...
Reposted by Bede Portz
Our new pre-print from the Greenberg and Churchman labs shows that activity-dependent modulation of RNA stability is a major, and underappreciated, mechanism of gene regulation in neurons. Tutorial below! www.biorxiv.org/content/10.1... (1/11)
HuD controls widespread RNA stability to drive neuronal activity-dependent responses
Neuronal activity shapes brain development and refines synaptic connectivity in part through dynamic changes in gene expression. While activity-regulated transcriptional programs have been extensively...
www.biorxiv.org
September 9, 2025 at 2:41 PM
Our new pre-print from the Greenberg and Churchman labs shows that activity-dependent modulation of RNA stability is a major, and underappreciated, mechanism of gene regulation in neurons. Tutorial below! www.biorxiv.org/content/10.1... (1/11)