Bede Portz
@ysptsps.bsky.social
Biotech. Interests: oncology, transcription, RNA, small molecule drug discovery, RNA therapeutics, protein aggregation, phase transitions
Reposted by Bede Portz
Happy to share Joey (Zhuoyi)'s review on technologies to map RBP:RNA and (especially) RBP-associated RNA:RNA interactions is now up at RNA! pubmed.ncbi.nlm.nih.gov/41535089
Progress and challenges in profiling protein-RNA and protein-associated RNA-RNA interactions - PubMed
RNA binding proteins (RBPs) play essential roles in post-transcriptional gene regulation by interacting with a wide range of RNA targets. In addition to regulating RNA processing via individual RBP-RNA interactions, there is a growing appreciation of the regulatory impact of protein-associated RNA-R …
pubmed.ncbi.nlm.nih.gov
January 18, 2026 at 3:29 AM
Happy to share Joey (Zhuoyi)'s review on technologies to map RBP:RNA and (especially) RBP-associated RNA:RNA interactions is now up at RNA! pubmed.ncbi.nlm.nih.gov/41535089
I want to pay (out of pocket) for an improved LLM over free ChatGPT. What model is the best for summarizing biology and biomedical literature, iterating on hypotheses, bioinformatics vibe coding, etc?
December 18, 2025 at 1:37 AM
I want to pay (out of pocket) for an improved LLM over free ChatGPT. What model is the best for summarizing biology and biomedical literature, iterating on hypotheses, bioinformatics vibe coding, etc?
Reposted by Bede Portz
This vaccine shows strong signal for reducing or delaying dementia! And who wants to get shingles? Get this vaccine!
“By 2020, only 10.8% of adults aged 50 and older had completed both doses of the recombinant zoster vaccine,with 14.1% receiving at least one.” www.managedhealthcareexecutive.com/view/low-upt...
Low uptake of shingles vaccine despite strong value proposition for older adults | Managed Healthcare Executive
By 2020, only 10.8% of adults aged 50 and older had completed both doses of the recombinant zoster vaccine,with 14.1% receiving at least one.
www.managedhealthcareexecutive.com
December 15, 2025 at 8:18 PM
This vaccine shows strong signal for reducing or delaying dementia! And who wants to get shingles? Get this vaccine!
Reposted by Bede Portz
I was in highschool when Colombine happened. I feel like that defines geriatric millennials as much as dial up internet. I remember a time we didn't fear school shootings.
December 15, 2025 at 3:52 AM
I was in highschool when Colombine happened. I feel like that defines geriatric millennials as much as dial up internet. I remember a time we didn't fear school shootings.
Reposted by Bede Portz
"It’s also, @georgwinter.bsky.social says, grounds for looking very closely at the proteome-wide effects of any compound in development, no matter its putative mechanism."
PREACH #biotech #chemsky
PREACH #biotech #chemsky
Biology strikes again: a whole lot of kinase active site inhibitors are also targeted kinase degraders. (Sometimes not even the same kinase!)
cen.acs.org/biological-c...
cen.acs.org/biological-c...
Kinase inhibitors can be targeted protein degraders too
Chemists think of the 2 modalities as different, but a large screen shows some small molecules can do both
cen.acs.org
December 9, 2025 at 4:40 PM
"It’s also, @georgwinter.bsky.social says, grounds for looking very closely at the proteome-wide effects of any compound in development, no matter its putative mechanism."
PREACH #biotech #chemsky
PREACH #biotech #chemsky
Reposted by Bede Portz
Online Now: Timing of transcription controls the selective translation of newly synthesized mRNAs during acute environmental stress Online now:
Timing of transcription controls the selective translation of newly synthesized mRNAs during acute environmental stress
Under stress, cells adapt their gene expression programs through changes in transcription and translation. It is unclear how cells determine which mRNAs are translated or repressed. Zedan et al. show that the timing of mRNA production alone determines the selectivity of translation, thereby coupling the processes of transcription and translation.
dlvr.it
November 27, 2025 at 8:15 PM
Online Now: Timing of transcription controls the selective translation of newly synthesized mRNAs during acute environmental stress Online now:
Reposted by Bede Portz
Oxidative phosphorylation complexes contain subunits encoded by both the nuclear and mitochondrial genomes. How do cells coordinate the synthesis and assembly of these complexes at the inner membrane? We teamed up with Martin Ott (@mitolab.bsky.social) to address this in two recent papers.
December 3, 2025 at 8:42 PM
Oxidative phosphorylation complexes contain subunits encoded by both the nuclear and mitochondrial genomes. How do cells coordinate the synthesis and assembly of these complexes at the inner membrane? We teamed up with Martin Ott (@mitolab.bsky.social) to address this in two recent papers.
Reposted by Bede Portz
Been saying this for weeks, but this season is an exact copy of 2 years ago for the Eagles. A bad team with an awful OC masquerading as a good team for half the season until it all falls apart. They might win 2 games the rest of the year.
November 28, 2025 at 10:35 PM
Been saying this for weeks, but this season is an exact copy of 2 years ago for the Eagles. A bad team with an awful OC masquerading as a good team for half the season until it all falls apart. They might win 2 games the rest of the year.
Reposted by Bede Portz
New from the Butcher Lab—defining the RNA binding mechanism of TDP-43. Happy to have played a small part in this amazing work!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
TDP-43 controls RNA structure through high affinity lattice interactions
TDP-43 is an RNA binding protein implicated in neurodegenerative disease. TDP-43 binds to GU dinucleotide repeats, which are highly abundant sequences in human RNA. Here we show TDP- 43 has one of the...
www.biorxiv.org
November 29, 2025 at 12:14 AM
New from the Butcher Lab—defining the RNA binding mechanism of TDP-43. Happy to have played a small part in this amazing work!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Bede Portz
Anthony A. Hyman will become EMBL’s next Director General.
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
November 27, 2025 at 1:02 PM
Anthony A. Hyman will become EMBL’s next Director General.
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
AA but for ice cream near me
November 23, 2025 at 2:36 AM
AA but for ice cream near me
In Pulpits and Pews, Catholic Churches Urge Compassion for Immigrants www.nytimes.com/2025/11/16/u...
In Pulpits and Pews, Catholic Churches Urge Compassion for Immigrants
www.nytimes.com
November 17, 2025 at 12:37 PM
In Pulpits and Pews, Catholic Churches Urge Compassion for Immigrants www.nytimes.com/2025/11/16/u...
Dominos has stepped its game up.
November 16, 2025 at 4:10 AM
Dominos has stepped its game up.
Dominos has stepped its game up.
November 16, 2025 at 4:10 AM
Dominos has stepped its game up.
www.biorxiv.org/content/10.1... @rohitpappu68.bsky.social and Jim Shorter latest banger just dropped
Nuclear-import receptors remodel the dilute phase to suppress phase transitions of RNA-binding proteins with prion-like domains.
RNA-binding proteins (RBPs) with prion-like domains, including FUS, hnRNPA1, and hnRNPA2, assemble into functional, metastable condensates that organize ribostasis, but can also transition into self-t...
www.biorxiv.org
November 16, 2025 at 2:11 AM
www.biorxiv.org/content/10.1... @rohitpappu68.bsky.social and Jim Shorter latest banger just dropped
Reposted by Bede Portz
This work is now officially published
@natsmb.nature.com
with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...
@natsmb.nature.com
with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...
November 15, 2025 at 9:51 AM
This work is now officially published
@natsmb.nature.com
with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...
@natsmb.nature.com
with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...
Reposted by Bede Portz
CD-CODE 2.0 is now published in @narjournal.bsky.social 🤩
CD-CODE 2.0 stores #biomolecular #condensates and their #protein and nucleic acid components and now includes repository of 🦠 infectious condensates, 💊 condensate-modulating compounds, and 🩺 condensatopathies
👀 doi.org/10.1093/nar/...
CD-CODE 2.0 stores #biomolecular #condensates and their #protein and nucleic acid components and now includes repository of 🦠 infectious condensates, 💊 condensate-modulating compounds, and 🩺 condensatopathies
👀 doi.org/10.1093/nar/...
November 14, 2025 at 1:20 PM
CD-CODE 2.0 is now published in @narjournal.bsky.social 🤩
CD-CODE 2.0 stores #biomolecular #condensates and their #protein and nucleic acid components and now includes repository of 🦠 infectious condensates, 💊 condensate-modulating compounds, and 🩺 condensatopathies
👀 doi.org/10.1093/nar/...
CD-CODE 2.0 stores #biomolecular #condensates and their #protein and nucleic acid components and now includes repository of 🦠 infectious condensates, 💊 condensate-modulating compounds, and 🩺 condensatopathies
👀 doi.org/10.1093/nar/...
I wish adults could wear overalls.
November 13, 2025 at 2:05 AM
I wish adults could wear overalls.
Reposted by Bede Portz
I wrote a review of James Watson's obituary by CSHL: liorpachter.wordpress.com/2025/11/08/r...
Review of Cold Spring Harbor Laboratory’s Obituary for Dr. James Watson
James Watson, who described himself as “not a racist in a conventional way”, has died at the age of 97. Below is a review of an obituary for Dr. James Watson published by Cold Spring Ha…
liorpachter.wordpress.com
November 8, 2025 at 9:58 PM
I wrote a review of James Watson's obituary by CSHL: liorpachter.wordpress.com/2025/11/08/r...