Reposted by Alejandro Melero
Extremely grateful to @hfspo.bsky.social and super excited to set this project in motion together with the incredibly talented @ritamateus.bsky.social and @vmonje.bsky.social Zebrafish hide a secret: lipid membranes shaping the crystals behind their stunning structural colors. How? Stay tuned! #HFSP
🥳Congratulations to the 104 pioneering scientists from 30 nations awarded 2025 #HFSPResearchGrants! 🎉Your frontier research is shaping the future of #LifeSciences! 🌍🔬🧪
🏆 Meet the awardees & their projects: www.hfsp.org/bookletRG202...
#ScienceDiplomacy #HFSP #FrontierScience #sts
🏆 Meet the awardees & their projects: www.hfsp.org/bookletRG202...
#ScienceDiplomacy #HFSP #FrontierScience #sts
April 2, 2025 at 1:32 PM
Extremely grateful to @hfspo.bsky.social and super excited to set this project in motion together with the incredibly talented @ritamateus.bsky.social and @vmonje.bsky.social Zebrafish hide a secret: lipid membranes shaping the crystals behind their stunning structural colors. How? Stay tuned! #HFSP
Reposted by Alejandro Melero
Next, work from the Etienne Herzog, @davip-bdx.bsky.social and @fronzeslab.bsky.social using cryo-CLEM and cryo-ET of cortico-striatal dopaminergic synaptosomes to delineate the architecture of non-synaptic modulation: www.biorxiv.org/content/10.1...
February 9, 2025 at 11:23 AM
Next, work from the Etienne Herzog, @davip-bdx.bsky.social and @fronzeslab.bsky.social using cryo-CLEM and cryo-ET of cortico-striatal dopaminergic synaptosomes to delineate the architecture of non-synaptic modulation: www.biorxiv.org/content/10.1...
This goes beyond my wildest imaginations! Congratulations to @mathilda95.bsky.social @nadlerlab.bsky.social and all the authors! Such a big step forward for membrane biology.
It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density, which usually isn’t attainable. Lipid-CLEM brought to you by @mathilda95.bsky.social changes that.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 3, 2025 at 9:46 PM
This goes beyond my wildest imaginations! Congratulations to @mathilda95.bsky.social @nadlerlab.bsky.social and all the authors! Such a big step forward for membrane biology.
Reposted by Alejandro Melero
Looking for a PostDoc? Exciting science and great city! Join us @albertpol.bsky.social @albertherms.bsky.social in @idibaps.bsky.social Barcelona to work in an @ercresearch.bsky.social funded project to study how lipid droplets attract and kill bacteria. www.clinicbarcelona.org/uploads/medi...
February 2, 2025 at 11:08 AM
Looking for a PostDoc? Exciting science and great city! Join us @albertpol.bsky.social @albertherms.bsky.social in @idibaps.bsky.social Barcelona to work in an @ercresearch.bsky.social funded project to study how lipid droplets attract and kill bacteria. www.clinicbarcelona.org/uploads/medi...
Reposted by Alejandro Melero
Check it out, is finally out!!
How does tRNA-modifier #Elongator stabilize microtubules during asymmetric cell division?
Vicente Planelles Herrero @deriverylab.bsky.social et al find subcomplexes binding to microtubule ends & tubulin dimers, & enriching microtubules with polyglutamylated tubulin
www.embopress.org/doi/full/10....
Vicente Planelles Herrero @deriverylab.bsky.social et al find subcomplexes binding to microtubule ends & tubulin dimers, & enriching microtubules with polyglutamylated tubulin
www.embopress.org/doi/full/10....
January 16, 2025 at 10:44 AM
Check it out, is finally out!!
Reposted by Alejandro Melero
Exciting news! #MembraneTrafficking online seminars with @felixmendu.bsky.social @franbottanelli.bsky.social and me are back!
Check the spectacular Jan-April 2025 lineup.
Details (Zoom links, calendar invites) on the mailing list, Slack group & website: felixcampelo.wixsite.com/membranetraf...
Check the spectacular Jan-April 2025 lineup.
Details (Zoom links, calendar invites) on the mailing list, Slack group & website: felixcampelo.wixsite.com/membranetraf...
January 15, 2025 at 7:59 PM
Exciting news! #MembraneTrafficking online seminars with @felixmendu.bsky.social @franbottanelli.bsky.social and me are back!
Check the spectacular Jan-April 2025 lineup.
Details (Zoom links, calendar invites) on the mailing list, Slack group & website: felixcampelo.wixsite.com/membranetraf...
Check the spectacular Jan-April 2025 lineup.
Details (Zoom links, calendar invites) on the mailing list, Slack group & website: felixcampelo.wixsite.com/membranetraf...
Reposted by Alejandro Melero
Time to share our organelle proteome paper
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/
1/3 🧪
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/
1/3 🧪
January 14, 2025 at 4:03 PM
Time to share our organelle proteome paper
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/
1/3 🧪
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/
1/3 🧪
Reposted by Alejandro Melero
Any #SpatialTranscriptomics people out there interested in studying #microglial development?
We need a collaborator based in the Americas or Asia to apply for a #HSPF grant
www.hfsp.org/funding/hfsp...
We need a collaborator based in the Americas or Asia to apply for a #HSPF grant
www.hfsp.org/funding/hfsp...
Research Grants | Human Frontier Science Program
www.hfsp.org
January 15, 2025 at 11:38 AM
Any #SpatialTranscriptomics people out there interested in studying #microglial development?
We need a collaborator based in the Americas or Asia to apply for a #HSPF grant
www.hfsp.org/funding/hfsp...
We need a collaborator based in the Americas or Asia to apply for a #HSPF grant
www.hfsp.org/funding/hfsp...
Reposted by Alejandro Melero
"A study of federally funded research projects in the United States estimated that principal investigators spend on average about 45% of their time on administrative activities related to applying for and managing projects rather than conducting active research"
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
January 4, 2025 at 1:26 PM
"A study of federally funded research projects in the United States estimated that principal investigators spend on average about 45% of their time on administrative activities related to applying for and managing projects rather than conducting active research"
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Alejandro Melero
Happy to share our Perspective on #microglia #pruning and help to answer the questions of whether they are hunters or gatherers of brain #synapses 🧠🧪
#neuroskyence
nature.com/articles/s4159…
#neuroskyence
nature.com/articles/s4159…
December 11, 2024 at 3:37 PM
Happy to share our Perspective on #microglia #pruning and help to answer the questions of whether they are hunters or gatherers of brain #synapses 🧠🧪
#neuroskyence
nature.com/articles/s4159…
#neuroskyence
nature.com/articles/s4159…
Reposted by Alejandro Melero
Postdoc position available in the Röper lab at the University of Cambridge @PDN_Cambridge!
Join us and discover the role that control of cytoskeletal dynamics, crosstalk and cell adhesion play in the formation of the nephron tube in human renal organoids!
jobs.cam.ac.uk/job/48947/
Join us and discover the role that control of cytoskeletal dynamics, crosstalk and cell adhesion play in the formation of the nephron tube in human renal organoids!
jobs.cam.ac.uk/job/48947/
November 14, 2024 at 12:59 AM
Postdoc position available in the Röper lab at the University of Cambridge @PDN_Cambridge!
Join us and discover the role that control of cytoskeletal dynamics, crosstalk and cell adhesion play in the formation of the nephron tube in human renal organoids!
jobs.cam.ac.uk/job/48947/
Join us and discover the role that control of cytoskeletal dynamics, crosstalk and cell adhesion play in the formation of the nephron tube in human renal organoids!
jobs.cam.ac.uk/job/48947/
Reposted by Alejandro Melero
Kicking off here with some old but gold movies showing ER-lysosome interactions triggered by blue-light excitation of the light-sensitive protein eMags. A shining example of how light can control cellular dynamics! 💡🧫✨
November 30, 2024 at 2:39 AM
Kicking off here with some old but gold movies showing ER-lysosome interactions triggered by blue-light excitation of the light-sensitive protein eMags. A shining example of how light can control cellular dynamics! 💡🧫✨
Reposted by Alejandro Melero
Stunning paper by Anne Simonsen's lab, identifying BEACH domain-containing proteins as membrane coat proteins involved in endosomal sorting: rupress.org/jcb/article-...
Read also @franbottanelli.bsky.social's beauty on ARF1 directing cargo maturation into RE!(www.nature.com/articles/s41...)
Read also @franbottanelli.bsky.social's beauty on ARF1 directing cargo maturation into RE!(www.nature.com/articles/s41...)
rupress.org
November 29, 2024 at 10:00 PM
Stunning paper by Anne Simonsen's lab, identifying BEACH domain-containing proteins as membrane coat proteins involved in endosomal sorting: rupress.org/jcb/article-...
Read also @franbottanelli.bsky.social's beauty on ARF1 directing cargo maturation into RE!(www.nature.com/articles/s41...)
Read also @franbottanelli.bsky.social's beauty on ARF1 directing cargo maturation into RE!(www.nature.com/articles/s41...)
Reposted by Alejandro Melero
A fun journey of full-length EGFR with Dan Leahy and
@edwardmarcotte.bsky.social at UT Austin @utaustin.bsky.social. See below:
Structure and organization of full-length Epidermal Growth Factor Receptor in extracellular vesicles by cryo-electron tomography www.biorxiv.org/content/10.1...
@edwardmarcotte.bsky.social at UT Austin @utaustin.bsky.social. See below:
Structure and organization of full-length Epidermal Growth Factor Receptor in extracellular vesicles by cryo-electron tomography www.biorxiv.org/content/10.1...
November 29, 2024 at 6:15 AM
A fun journey of full-length EGFR with Dan Leahy and
@edwardmarcotte.bsky.social at UT Austin @utaustin.bsky.social. See below:
Structure and organization of full-length Epidermal Growth Factor Receptor in extracellular vesicles by cryo-electron tomography www.biorxiv.org/content/10.1...
@edwardmarcotte.bsky.social at UT Austin @utaustin.bsky.social. See below:
Structure and organization of full-length Epidermal Growth Factor Receptor in extracellular vesicles by cryo-electron tomography www.biorxiv.org/content/10.1...
Reposted by Alejandro Melero
Reposted by Alejandro Melero
- Imaging interorganelle contacts at a glance
- Reviews on machine learning, synchrotron X-ray imaging, fluorescence polarisation microscopy and imaging cell-cell junctions
- An Editorial from FocalPlane
journals.biologists.com/jcs/issue/13...
- Reviews on machine learning, synchrotron X-ray imaging, fluorescence polarisation microscopy and imaging cell-cell junctions
- An Editorial from FocalPlane
journals.biologists.com/jcs/issue/13...
November 15, 2024 at 12:47 PM
- Imaging interorganelle contacts at a glance
- Reviews on machine learning, synchrotron X-ray imaging, fluorescence polarisation microscopy and imaging cell-cell junctions
- An Editorial from FocalPlane
journals.biologists.com/jcs/issue/13...
- Reviews on machine learning, synchrotron X-ray imaging, fluorescence polarisation microscopy and imaging cell-cell junctions
- An Editorial from FocalPlane
journals.biologists.com/jcs/issue/13...
Reposted by Alejandro Melero
Characterizing heterogeneity in amyloid formation processes pubmed.ncbi.nlm.nih.gov/39566372/
November 21, 2024 at 10:45 PM
Characterizing heterogeneity in amyloid formation processes pubmed.ncbi.nlm.nih.gov/39566372/
Reposted by Alejandro Melero
Finally this cool story by @brfalcon.bsky.social is out! 😍😍
November 21, 2024 at 8:10 PM
Finally this cool story by @brfalcon.bsky.social is out! 😍😍
Reposted by Alejandro Melero
My latest paper, deep proteomic analysis of mouse and human microglia: www.cell.com/cell-reports...
Deep proteomic analysis of microglia reveals fundamental biological differences between model systems
Lloyd et al. generated a comprehensive microglia proteome database, identifying over
11,000 proteins. Fundamental differences between ex vivo and in vitro microglia associated
with protein synthesis, ...
www.cell.com
November 13, 2024 at 9:24 AM
My latest paper, deep proteomic analysis of mouse and human microglia: www.cell.com/cell-reports...
Reposted by Alejandro Melero
How do organelles fit together inside a crowded cell? Answering this question requires a way to image many organelles in a whole cell at high resolution with high throughput. Our new preprint shows how to do this in yeast using soft x-ray tomography
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 21, 2024 at 7:47 PM
How do organelles fit together inside a crowded cell? Answering this question requires a way to image many organelles in a whole cell at high resolution with high throughput. Our new preprint shows how to do this in yeast using soft x-ray tomography
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...