Alejandro Adam
@aleadam.bsky.social
Cell and #vascular #biologist obsessed with transcriptional control of #inflammation
Associate professor at Albany Medical College in Upstate New York.
www.adamlabs.org
https://orcid.org/0000-0001-6285-7235
#AcademicSky #science #endothelium #shock
Associate professor at Albany Medical College in Upstate New York.
www.adamlabs.org
https://orcid.org/0000-0001-6285-7235
#AcademicSky #science #endothelium #shock
Reposted by Alejandro Adam
Research in primate brains has been essential for the development of brain-computer interfaces and artificial neural networks. New funding and policy changes put future such advances at risk, write Cory Miller, @movshon.bsky.social and Doris Tsao.
#neuroskyence
bit.ly/47MXYLH
#neuroskyence
bit.ly/47MXYLH
Without monkeys, neuroscience has no future
Research in primate brains has been essential for the development of BCIs, ANNs. New funding and policy changes put future such advances at risk.
bit.ly
November 10, 2025 at 2:56 PM
Research in primate brains has been essential for the development of brain-computer interfaces and artificial neural networks. New funding and policy changes put future such advances at risk, write Cory Miller, @movshon.bsky.social and Doris Tsao.
#neuroskyence
bit.ly/47MXYLH
#neuroskyence
bit.ly/47MXYLH
Reposted by Alejandro Adam
Chuck Schumer Helps Pull Democrats Back From Brink Of Courage
November 10, 2025 at 5:02 AM
Chuck Schumer Helps Pull Democrats Back From Brink Of Courage
Reposted by Alejandro Adam
Dems. Snatching defeat from the jaws of victory
November 10, 2025 at 2:12 PM
Dems. Snatching defeat from the jaws of victory
Reposted by Alejandro Adam
Previously shared: Systemic shock can lead to vascular dysfunction and organ failure.
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA.
www.jci.org/articles/vie...
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA.
www.jci.org/articles/vie...
November 9, 2025 at 2:01 PM
Previously shared: Systemic shock can lead to vascular dysfunction and organ failure.
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA.
www.jci.org/articles/vie...
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA.
www.jci.org/articles/vie...
Reposted by Alejandro Adam
Vinculin is a simple adapter protein right? Wrong!
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
The mechanical response of vinculin
Vinculin buffers force via dynamic domain unfolding/refolding under physiological load and lacks a stable head-tail lock.
www.science.org
October 31, 2025 at 6:29 PM
Vinculin is a simple adapter protein right? Wrong!
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
Here's a quick thread with pics summarizing the paper. Many thanks for all the hard work at Albany Med and by our collaborator Pilar Alcaide!
Very proud of this work that is now out on JCI describing a new #signaling pathway downstream of the #cytokine IL-6 in the #endothelium with implications in #sepsis and #shock. Short thread with a summary coming later today.
For now just enjoy that gorgeous image taken by my student Fatma Awadalla!
For now just enjoy that gorgeous image taken by my student Fatma Awadalla!
Systemic shock can lead to vascular dysfunction and organ failure.
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA: www.jci.org/articles/vie...
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA: www.jci.org/articles/vie...
November 4, 2025 at 12:47 AM
Here's a quick thread with pics summarizing the paper. Many thanks for all the hard work at Albany Med and by our collaborator Pilar Alcaide!
Very proud of this work that is now out on JCI describing a new #signaling pathway downstream of the #cytokine IL-6 in the #endothelium with implications in #sepsis and #shock. Short thread with a summary coming later today.
For now just enjoy that gorgeous image taken by my student Fatma Awadalla!
For now just enjoy that gorgeous image taken by my student Fatma Awadalla!
Systemic shock can lead to vascular dysfunction and organ failure.
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA: www.jci.org/articles/vie...
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA: www.jci.org/articles/vie...
November 3, 2025 at 6:34 PM
Very proud of this work that is now out on JCI describing a new #signaling pathway downstream of the #cytokine IL-6 in the #endothelium with implications in #sepsis and #shock. Short thread with a summary coming later today.
For now just enjoy that gorgeous image taken by my student Fatma Awadalla!
For now just enjoy that gorgeous image taken by my student Fatma Awadalla!
Reposted by Alejandro Adam
New work from Daoud et al. shows that removal of YAP/TAZ from vascular smooth muscle cells triggers inflammation and immune activation- indicating these factors as essential in vascular health.#vascularbiology
sciencedirect.com/science/arti...
#CardioSky
sciencedirect.com/science/arti...
#CardioSky
YAP/TAZ deletion in vascular smooth muscle cells mirrors atherosclerosis-associated transcriptional programs
The transcriptional co-activators YAP (YAP1) and TAZ (WWTR1) are central regulators of vascular smooth muscle cell (VSMC) phenotype and vascular homeo…
sciencedirect.com
November 3, 2025 at 12:47 PM
New work from Daoud et al. shows that removal of YAP/TAZ from vascular smooth muscle cells triggers inflammation and immune activation- indicating these factors as essential in vascular health.#vascularbiology
sciencedirect.com/science/arti...
#CardioSky
sciencedirect.com/science/arti...
#CardioSky
Reposted by Alejandro Adam
The BICAR-ICU-2 trial just dropped!
RCT involving IV bicarb in metabolic acidosis among patients with mod-severe AKI
Bicarb didn't affect mortality but it reduced the need for dialysis & risk of bacteremia
VERY similar conclusions to BICAR-ICU-1
🧵 #1/
jamanetwork.com/journals/jam... #EMIMCC
RCT involving IV bicarb in metabolic acidosis among patients with mod-severe AKI
Bicarb didn't affect mortality but it reduced the need for dialysis & risk of bacteremia
VERY similar conclusions to BICAR-ICU-1
🧵 #1/
jamanetwork.com/journals/jam... #EMIMCC
October 29, 2025 at 2:59 PM
The BICAR-ICU-2 trial just dropped!
RCT involving IV bicarb in metabolic acidosis among patients with mod-severe AKI
Bicarb didn't affect mortality but it reduced the need for dialysis & risk of bacteremia
VERY similar conclusions to BICAR-ICU-1
🧵 #1/
jamanetwork.com/journals/jam... #EMIMCC
RCT involving IV bicarb in metabolic acidosis among patients with mod-severe AKI
Bicarb didn't affect mortality but it reduced the need for dialysis & risk of bacteremia
VERY similar conclusions to BICAR-ICU-1
🧵 #1/
jamanetwork.com/journals/jam... #EMIMCC
Reposted by Alejandro Adam
Stem cell research is opening new doors for treating age-related #MacularDegeneration (AMD), a leading cause of vision loss.
Join our co-founders, Drs. Jeffrey Stern and Sally Temple on @BrightFocus Foundation's Macular Chat on Wed, Oct 29.
Join our co-founders, Drs. Jeffrey Stern and Sally Temple on @BrightFocus Foundation's Macular Chat on Wed, Oct 29.
October 24, 2025 at 1:40 PM
Stem cell research is opening new doors for treating age-related #MacularDegeneration (AMD), a leading cause of vision loss.
Join our co-founders, Drs. Jeffrey Stern and Sally Temple on @BrightFocus Foundation's Macular Chat on Wed, Oct 29.
Join our co-founders, Drs. Jeffrey Stern and Sally Temple on @BrightFocus Foundation's Macular Chat on Wed, Oct 29.
Reposted by Alejandro Adam
Monty Python understood p-hacking
October 23, 2025 at 8:43 AM
Monty Python understood p-hacking
Reposted by Alejandro Adam
Today, I’m joining millions of Americans participating in No Kings rallies across the nation to reject Trump’s corruption and cruelty – and to stand up for democracy. Read more in my latest newsletter, and visit nokings.org to find a rally near you:
tonko.house.gov/news/email/s...
tonko.house.gov/news/email/s...
Representative Paul D. Tonko
tonko.house.gov
October 18, 2025 at 2:54 PM
Today, I’m joining millions of Americans participating in No Kings rallies across the nation to reject Trump’s corruption and cruelty – and to stand up for democracy. Read more in my latest newsletter, and visit nokings.org to find a rally near you:
tonko.house.gov/news/email/s...
tonko.house.gov/news/email/s...
Reposted by Alejandro Adam
New this month in JHC: "Expression of Glial Cell Line–derived Neurotrophic Factor and Its Receptors in Glioblastoma."
Click to read: bit.ly/3L1NIHz
#glioblastoma #immunohistochemistry #insituhybridization
Click to read: bit.ly/3L1NIHz
#glioblastoma #immunohistochemistry #insituhybridization
October 16, 2025 at 10:16 PM
New this month in JHC: "Expression of Glial Cell Line–derived Neurotrophic Factor and Its Receptors in Glioblastoma."
Click to read: bit.ly/3L1NIHz
#glioblastoma #immunohistochemistry #insituhybridization
Click to read: bit.ly/3L1NIHz
#glioblastoma #immunohistochemistry #insituhybridization
Reposted by Alejandro Adam
Add your name ✍ at www.nycures.org so Albany sees 10,000 scientists calling for the future of biomedical research to be built right here in New York.
Our first email to members goes out soon—introducing the statewide biomedical institute we’re proposing and how you can help power it forward.
Our first email to members goes out soon—introducing the statewide biomedical institute we’re proposing and how you can help power it forward.
October 15, 2025 at 12:55 PM
Add your name ✍ at www.nycures.org so Albany sees 10,000 scientists calling for the future of biomedical research to be built right here in New York.
Our first email to members goes out soon—introducing the statewide biomedical institute we’re proposing and how you can help power it forward.
Our first email to members goes out soon—introducing the statewide biomedical institute we’re proposing and how you can help power it forward.
Impressive demonstration of how a leukocyte separates the two ECs to squeeze by.
Time to update my TEM lecture slides!
Time to update my TEM lecture slides!
Excellent #postLight uploaded by @fadelvalle.bsky.social!
He revisits work from Werner van der Meer & colleagues originally posted as a preprint and now published in @cp-cellreports.bsky.social
postLight: prelights.biologists.com/highlights/l...
He revisits work from Werner van der Meer & colleagues originally posted as a preprint and now published in @cp-cellreports.bsky.social
postLight: prelights.biologists.com/highlights/l...
October 6, 2025 at 6:13 PM
Impressive demonstration of how a leukocyte separates the two ECs to squeeze by.
Time to update my TEM lecture slides!
Time to update my TEM lecture slides!
Reposted by Alejandro Adam
Staff members at the NIH seem to have done the impossible: spend the agency's $48 billion budget.
“Everyone has been rallying together to clean up the mess, but it’s a mess that did not need to be made,” an NIH program officer told me.
www.nature.com/articles/d41...
“Everyone has been rallying together to clean up the mess, but it’s a mess that did not need to be made,” an NIH program officer told me.
www.nature.com/articles/d41...
NIH races to spend its 2025 grant money — but fewer projects win funding
Despite political obstacles, officials are on track to disburse all of the research funds allocated to US biomedical behemoth.
www.nature.com
September 30, 2025 at 3:32 PM
Staff members at the NIH seem to have done the impossible: spend the agency's $48 billion budget.
“Everyone has been rallying together to clean up the mess, but it’s a mess that did not need to be made,” an NIH program officer told me.
www.nature.com/articles/d41...
“Everyone has been rallying together to clean up the mess, but it’s a mess that did not need to be made,” an NIH program officer told me.
www.nature.com/articles/d41...
@gabbyfredman.bsky.social
EPA+DHA may be considered as part of the management of patients with NYHA functional class II-IV HF, irrespective of etiology or LVEF.
EPA+DHA may be considered as part of the management of patients with NYHA functional class II-IV HF, irrespective of etiology or LVEF.
A long-awaited consensus statement on inflammation and heart disease
"We have thus entered an era when the evidence linking inflammation with ASCVD is no longer exploratory but is
compelling and clinically actionable."
@jaccjournals.bsky.social open-access
www.jacc.org/doi/10.1016/...
"We have thus entered an era when the evidence linking inflammation with ASCVD is no longer exploratory but is
compelling and clinically actionable."
@jaccjournals.bsky.social open-access
www.jacc.org/doi/10.1016/...
September 29, 2025 at 5:26 PM
@gabbyfredman.bsky.social
EPA+DHA may be considered as part of the management of patients with NYHA functional class II-IV HF, irrespective of etiology or LVEF.
EPA+DHA may be considered as part of the management of patients with NYHA functional class II-IV HF, irrespective of etiology or LVEF.
Reposted by Alejandro Adam
New vascular seminars coming up @evborg.bsky.social
September 25, 2025 at 2:39 PM
New vascular seminars coming up @evborg.bsky.social
Reposted by Alejandro Adam
Trump Administration Attempts To Link Autism To Tylenol
https://theonion.com/trump-administration-attempts-to-link-autism-to-tylenol/
https://theonion.com/trump-administration-attempts-to-link-autism-to-tylenol/
September 24, 2025 at 8:30 PM
Trump Administration Attempts To Link Autism To Tylenol
https://theonion.com/trump-administration-attempts-to-link-autism-to-tylenol/
https://theonion.com/trump-administration-attempts-to-link-autism-to-tylenol/
Reposted by Alejandro Adam
David Baltimore passed away this weekend. A pioneer of molecular virology who won the Nobel prize in medicine & physiology for his discovery of viral reverse transcriptase. This essay he wrote in 2018 reflecting of his 60yr career in science is a great read.
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
Sixty Years of Discovery | Annual Reviews
Each of us is a story. Mine is a story of doing science for 60 years, and I am honored to be asked to tell it. Even though this autobiography was written for the Annual Review of Immunology, I have ch...
www.annualreviews.org
September 8, 2025 at 1:43 AM
David Baltimore passed away this weekend. A pioneer of molecular virology who won the Nobel prize in medicine & physiology for his discovery of viral reverse transcriptase. This essay he wrote in 2018 reflecting of his 60yr career in science is a great read.
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
Just signed it!
www.standupforscience.net/rfk-impeachm...
www.standupforscience.net/rfk-impeachm...
Sign the IMPEACH RFK Citizens' Petition to Congress — STAND UP FOR SCIENCE
Join with us to sign our Citizens' Petition to the US Congress to choose the people over Trump and Impeach RFK Jr Now!
www.standupforscience.net
September 4, 2025 at 5:46 PM
Just signed it!
www.standupforscience.net/rfk-impeachm...
www.standupforscience.net/rfk-impeachm...
Reposted by Alejandro Adam
Double the discovery, double the momentum 🚀
Europe doubles down on research competitiveness with a major boost to #HorizonEurope:
€95.5 billion foreseen for 2021-2027
💰💰💰💰💰💰💰💰💰
€175 billion proposed for 2028-2034
💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰
Europe doubles down on research competitiveness with a major boost to #HorizonEurope:
€95.5 billion foreseen for 2021-2027
💰💰💰💰💰💰💰💰💰
€175 billion proposed for 2028-2034
💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰
August 5, 2025 at 6:55 AM
Double the discovery, double the momentum 🚀
Europe doubles down on research competitiveness with a major boost to #HorizonEurope:
€95.5 billion foreseen for 2021-2027
💰💰💰💰💰💰💰💰💰
€175 billion proposed for 2028-2034
💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰
Europe doubles down on research competitiveness with a major boost to #HorizonEurope:
€95.5 billion foreseen for 2021-2027
💰💰💰💰💰💰💰💰💰
€175 billion proposed for 2028-2034
💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰💰
Reposted by Alejandro Adam
open.substack.com/pub/clauswil... this is very true and highly under appreciated. Not just for a PhD but any high level accomplishment.
August 27, 2025 at 2:59 AM
open.substack.com/pub/clauswil... this is very true and highly under appreciated. Not just for a PhD but any high level accomplishment.
Reposted by Alejandro Adam
The Journal of Histochemistry and Cytochemistry, the Histochemical Society’s flagship journal for 70 years, is seeking manuscript submissions!
To learn more & submit: journals.sagepub.com/author-instr...
#callforpapers #histochemistry #immunohistochemistry #microscopy
To learn more & submit: journals.sagepub.com/author-instr...
#callforpapers #histochemistry #immunohistochemistry #microscopy
August 25, 2025 at 9:25 PM
The Journal of Histochemistry and Cytochemistry, the Histochemical Society’s flagship journal for 70 years, is seeking manuscript submissions!
To learn more & submit: journals.sagepub.com/author-instr...
#callforpapers #histochemistry #immunohistochemistry #microscopy
To learn more & submit: journals.sagepub.com/author-instr...
#callforpapers #histochemistry #immunohistochemistry #microscopy
Reposted by Alejandro Adam
ICYMI: Vasculopathy occurs early in systemic sclerosis, but intervention strategies are lacking.
Colin Jamora & team reveal ANGPTL2 as an inducer of vasculopathy that drives cutaneous fibrogenesis in mice—mirroring SSc—and present a therapeutic approach: UAS03.
buff.ly/xNYvnRj
Colin Jamora & team reveal ANGPTL2 as an inducer of vasculopathy that drives cutaneous fibrogenesis in mice—mirroring SSc—and present a therapeutic approach: UAS03.
buff.ly/xNYvnRj
August 10, 2025 at 3:33 PM
ICYMI: Vasculopathy occurs early in systemic sclerosis, but intervention strategies are lacking.
Colin Jamora & team reveal ANGPTL2 as an inducer of vasculopathy that drives cutaneous fibrogenesis in mice—mirroring SSc—and present a therapeutic approach: UAS03.
buff.ly/xNYvnRj
Colin Jamora & team reveal ANGPTL2 as an inducer of vasculopathy that drives cutaneous fibrogenesis in mice—mirroring SSc—and present a therapeutic approach: UAS03.
buff.ly/xNYvnRj