Alejandro Adam
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aleadam.bsky.social
Alejandro Adam
@aleadam.bsky.social
Cell and #vascular #biologist obsessed with transcriptional control of #inflammation
Associate professor at Albany Medical College in Upstate New York.
www.adamlabs.org
https://orcid.org/0000-0001-6285-7235
#AcademicSky #science #endothelium #shock
10/10 EC-specific deletion of STING or a global deletion of STAT1 not only block the interferon-like response, but decrease the severity of the response to LPS
November 4, 2025 at 12:47 AM
9/10 The transcriptional response involves IRF1, through a mechanism we do not yet fully understand
November 4, 2025 at 12:47 AM
8/10 In parallel, IL-6 leads to mitochondrial dysfunction and mtDNA release that leads to cGAS/STING signaling
November 4, 2025 at 12:47 AM
7/10 Notably, this response does not require an autocrine IFN signaling, but is a direct transcriptional response to IL-6
November 4, 2025 at 12:47 AM
6/10 In vitro work showed that IL-6 leads to an IFN-like response that requires expression of STAT1, but not the canonical STAT3
November 4, 2025 at 12:47 AM
5/10 This IFN signature was further increased by the deletion of the IL-6 signaling inhibitor SOCS3 in the endothelium
November 4, 2025 at 12:47 AM
4/10 Analysis of the response to LPS suggested a strong interferon activation
November 4, 2025 at 12:47 AM
3/10 This enables great enrichment of endothelial RNA
November 4, 2025 at 12:47 AM
2/10 To better understand how endothelial cells respond to a cytokine storm, we performed endothelial-specific translating ribosome affinity purification (TRAP) on endotoxemic mice
November 4, 2025 at 12:47 AM
1/10 Shock drives vascular dysfunction, with in turn leads to organ injury and potentially death, by inducing a ‘cytokine storm’. Chief among them, IL-6 is an excellent marker for septic shock severity and predicts for mortality
November 4, 2025 at 12:47 AM
Rep Paul Tonko @reppaultonko.bsky.social standing up for science now!
March 7, 2025 at 5:43 PM
Albany is happening now!
March 7, 2025 at 5:03 PM
I hope to see you all at the NY State Capitol this Friday at 12:30!
standupforscience2025.org/local-event-...
March 4, 2025 at 10:25 PM
We’re Standing Up for Science – because science is for everyone. Thank you Rep Paul Tonko @reppaultonko.bsky.social for joining us at the NY State Capitol at Albany!
#standupforscience2025#sciencenotsilence#scienceforall #AcademicSky #science #ScienceSky 🧪
March 1, 2025 at 7:31 PM
I used this book (2nd ed) as an undergrad in 1995 in Buenos Aires. One of the few books I kept and brought to my postdoc in New York.
The second part on proteins and regulation made me fall in love with signal transduction.
December 18, 2024 at 3:37 PM
I want to thank Kendra LaDuca, Nathaniel Lartey and Sally Davis. We had a fantastic time working the HCS Booth at ABRCMS2024, describing our #grants, travel #awards, and hands-on #course available for trainees at all levels: #undergraduate, #graduate and #postdoc
Find more: histochemicalsociety.org
November 28, 2024 at 1:54 PM
Lastly, we confirmed in vitro that many of the transcriptional changes can be a direct response of brain ECs to IL-6 stimulation.
November 24, 2024 at 5:38 PM
Despite the transient nature of the transcriptional changes, we observed that mice that recovered from the endotoxemic shock showed mild, #sex-dependent #cognitive #impairment.
November 24, 2024 at 5:38 PM
Notably, we found that the transcriptional response returns to baseline within days post-challenge, but reductions in gene expression regulating protein translation and respiratory electron transport remained.
November 24, 2024 at 5:38 PM
Loss of endothelial SOCS3 promotes a drastic increase in the number of responsive genes, with little effect on the top changes induced by LPS.
November 24, 2024 at 5:38 PM
We tested #endothelial #transcription changes in #brain following a systemic endotoxin challenge. We found a strong correlation to whole brain changes but many EC-specific responses as well.
November 24, 2024 at 5:38 PM