Alejandro Adam
@aleadam.bsky.social
Cell and #vascular #biologist obsessed with transcriptional control of #inflammation
Associate professor at Albany Medical College in Upstate New York.
www.adamlabs.org
https://orcid.org/0000-0001-6285-7235
#AcademicSky #science #endothelium #shock
Associate professor at Albany Medical College in Upstate New York.
www.adamlabs.org
https://orcid.org/0000-0001-6285-7235
#AcademicSky #science #endothelium #shock
10/10 EC-specific deletion of STING or a global deletion of STAT1 not only block the interferon-like response, but decrease the severity of the response to LPS
November 4, 2025 at 12:47 AM
10/10 EC-specific deletion of STING or a global deletion of STAT1 not only block the interferon-like response, but decrease the severity of the response to LPS
9/10 The transcriptional response involves IRF1, through a mechanism we do not yet fully understand
November 4, 2025 at 12:47 AM
9/10 The transcriptional response involves IRF1, through a mechanism we do not yet fully understand
8/10 In parallel, IL-6 leads to mitochondrial dysfunction and mtDNA release that leads to cGAS/STING signaling
November 4, 2025 at 12:47 AM
8/10 In parallel, IL-6 leads to mitochondrial dysfunction and mtDNA release that leads to cGAS/STING signaling
7/10 Notably, this response does not require an autocrine IFN signaling, but is a direct transcriptional response to IL-6
November 4, 2025 at 12:47 AM
7/10 Notably, this response does not require an autocrine IFN signaling, but is a direct transcriptional response to IL-6
6/10 In vitro work showed that IL-6 leads to an IFN-like response that requires expression of STAT1, but not the canonical STAT3
November 4, 2025 at 12:47 AM
6/10 In vitro work showed that IL-6 leads to an IFN-like response that requires expression of STAT1, but not the canonical STAT3
5/10 This IFN signature was further increased by the deletion of the IL-6 signaling inhibitor SOCS3 in the endothelium
November 4, 2025 at 12:47 AM
5/10 This IFN signature was further increased by the deletion of the IL-6 signaling inhibitor SOCS3 in the endothelium
4/10 Analysis of the response to LPS suggested a strong interferon activation
November 4, 2025 at 12:47 AM
4/10 Analysis of the response to LPS suggested a strong interferon activation
3/10 This enables great enrichment of endothelial RNA
November 4, 2025 at 12:47 AM
3/10 This enables great enrichment of endothelial RNA
2/10 To better understand how endothelial cells respond to a cytokine storm, we performed endothelial-specific translating ribosome affinity purification (TRAP) on endotoxemic mice
November 4, 2025 at 12:47 AM
2/10 To better understand how endothelial cells respond to a cytokine storm, we performed endothelial-specific translating ribosome affinity purification (TRAP) on endotoxemic mice
1/10 Shock drives vascular dysfunction, with in turn leads to organ injury and potentially death, by inducing a ‘cytokine storm’. Chief among them, IL-6 is an excellent marker for septic shock severity and predicts for mortality
November 4, 2025 at 12:47 AM
1/10 Shock drives vascular dysfunction, with in turn leads to organ injury and potentially death, by inducing a ‘cytokine storm’. Chief among them, IL-6 is an excellent marker for septic shock severity and predicts for mortality
Rep Paul Tonko @reppaultonko.bsky.social standing up for science now!
March 7, 2025 at 5:43 PM
Rep Paul Tonko @reppaultonko.bsky.social standing up for science now!
Albany is happening now!
March 7, 2025 at 5:03 PM
Albany is happening now!
I hope to see you all at the NY State Capitol this Friday at 12:30!
standupforscience2025.org/local-event-...
standupforscience2025.org/local-event-...
March 4, 2025 at 10:25 PM
I hope to see you all at the NY State Capitol this Friday at 12:30!
standupforscience2025.org/local-event-...
standupforscience2025.org/local-event-...
We’re Standing Up for Science – because science is for everyone. Thank you Rep Paul Tonko @reppaultonko.bsky.social for joining us at the NY State Capitol at Albany!
#standupforscience2025 ・ #sciencenotsilence ・ #scienceforall #AcademicSky #science #ScienceSky 🧪
#standupforscience2025 ・ #sciencenotsilence ・ #scienceforall #AcademicSky #science #ScienceSky 🧪
March 1, 2025 at 7:31 PM
We’re Standing Up for Science – because science is for everyone. Thank you Rep Paul Tonko @reppaultonko.bsky.social for joining us at the NY State Capitol at Albany!
#standupforscience2025 ・ #sciencenotsilence ・ #scienceforall #AcademicSky #science #ScienceSky 🧪
#standupforscience2025 ・ #sciencenotsilence ・ #scienceforall #AcademicSky #science #ScienceSky 🧪
I used this book (2nd ed) as an undergrad in 1995 in Buenos Aires. One of the few books I kept and brought to my postdoc in New York.
The second part on proteins and regulation made me fall in love with signal transduction.
The second part on proteins and regulation made me fall in love with signal transduction.
December 18, 2024 at 3:37 PM
I used this book (2nd ed) as an undergrad in 1995 in Buenos Aires. One of the few books I kept and brought to my postdoc in New York.
The second part on proteins and regulation made me fall in love with signal transduction.
The second part on proteins and regulation made me fall in love with signal transduction.
I want to thank Kendra LaDuca, Nathaniel Lartey and Sally Davis. We had a fantastic time working the HCS Booth at ABRCMS2024, describing our #grants, travel #awards, and hands-on #course available for trainees at all levels: #undergraduate, #graduate and #postdoc
Find more: histochemicalsociety.org
Find more: histochemicalsociety.org
November 28, 2024 at 1:54 PM
I want to thank Kendra LaDuca, Nathaniel Lartey and Sally Davis. We had a fantastic time working the HCS Booth at ABRCMS2024, describing our #grants, travel #awards, and hands-on #course available for trainees at all levels: #undergraduate, #graduate and #postdoc
Find more: histochemicalsociety.org
Find more: histochemicalsociety.org
Lastly, we confirmed in vitro that many of the transcriptional changes can be a direct response of brain ECs to IL-6 stimulation.
November 24, 2024 at 5:38 PM
Lastly, we confirmed in vitro that many of the transcriptional changes can be a direct response of brain ECs to IL-6 stimulation.
Despite the transient nature of the transcriptional changes, we observed that mice that recovered from the endotoxemic shock showed mild, #sex-dependent #cognitive #impairment.
November 24, 2024 at 5:38 PM
Despite the transient nature of the transcriptional changes, we observed that mice that recovered from the endotoxemic shock showed mild, #sex-dependent #cognitive #impairment.
Notably, we found that the transcriptional response returns to baseline within days post-challenge, but reductions in gene expression regulating protein translation and respiratory electron transport remained.
November 24, 2024 at 5:38 PM
Notably, we found that the transcriptional response returns to baseline within days post-challenge, but reductions in gene expression regulating protein translation and respiratory electron transport remained.
Loss of endothelial SOCS3 promotes a drastic increase in the number of responsive genes, with little effect on the top changes induced by LPS.
November 24, 2024 at 5:38 PM
Loss of endothelial SOCS3 promotes a drastic increase in the number of responsive genes, with little effect on the top changes induced by LPS.
We tested #endothelial #transcription changes in #brain following a systemic endotoxin challenge. We found a strong correlation to whole brain changes but many EC-specific responses as well.
November 24, 2024 at 5:38 PM
We tested #endothelial #transcription changes in #brain following a systemic endotoxin challenge. We found a strong correlation to whole brain changes but many EC-specific responses as well.