Alejandro Adam
@aleadam.bsky.social
Cell and #vascular #biologist obsessed with transcriptional control of #inflammation
Associate professor at Albany Medical College in Upstate New York.
www.adamlabs.org
https://orcid.org/0000-0001-6285-7235
#AcademicSky #science #endothelium #shock
Associate professor at Albany Medical College in Upstate New York.
www.adamlabs.org
https://orcid.org/0000-0001-6285-7235
#AcademicSky #science #endothelium #shock
Reposted by Alejandro Adam
Trump joins a not-so-long list of people who have acquired someone else's Nobel medal, including... uh... Joseph Goebbels. www.nobelpeaceprize.org/press/press-...
January 16, 2026 at 7:23 PM
Trump joins a not-so-long list of people who have acquired someone else's Nobel medal, including... uh... Joseph Goebbels. www.nobelpeaceprize.org/press/press-...
Reposted by Alejandro Adam
ROV pilots filmed this giant phantom jelly, or Stygiomedusa gigantea, at 253 meters during an ROV descent to explore the Colorado-Rawson submarine canyon wall. #ArgentinianDeepSeeps
January 2, 2026 at 12:07 AM
ROV pilots filmed this giant phantom jelly, or Stygiomedusa gigantea, at 253 meters during an ROV descent to explore the Colorado-Rawson submarine canyon wall. #ArgentinianDeepSeeps
Reposted by Alejandro Adam
@governor.ny.gov we’re set on one goal in 2026: getting EBRI up & running so New Yorkers get the benefits ASAP after such a hard year for many.
EBRI is a transformative investment bringing new medicines & money that can solve other priorities in education, healthcare, transport for the long term.
EBRI is a transformative investment bringing new medicines & money that can solve other priorities in education, healthcare, transport for the long term.
a cartoon of spongebob reading a piece of paper with the words my new year 's resolutions above him
ALT: a cartoon of spongebob reading a piece of paper with the words my new year 's resolutions above him
media.tenor.com
December 31, 2025 at 5:33 PM
@governor.ny.gov we’re set on one goal in 2026: getting EBRI up & running so New Yorkers get the benefits ASAP after such a hard year for many.
EBRI is a transformative investment bringing new medicines & money that can solve other priorities in education, healthcare, transport for the long term.
EBRI is a transformative investment bringing new medicines & money that can solve other priorities in education, healthcare, transport for the long term.
Reposted by Alejandro Adam
As a doctor and scientist working to advance health, science, and economic growth in NY, I’m urging @governor.ny.gov to invest in the Empire Biomedical Research Institute to keep the state competitive, sustain jobs, and grow our life science economy.
@gothamist.com reports: tinyurl.com/5fab5k7u
@gothamist.com reports: tinyurl.com/5fab5k7u
NY medical schools press Gov. Hochul to put up billions for scientific research
The request comes amid continuing uncertainty over federal funding, with research and thousands of jobs on the line.
tinyurl.com
December 30, 2025 at 1:51 PM
As a doctor and scientist working to advance health, science, and economic growth in NY, I’m urging @governor.ny.gov to invest in the Empire Biomedical Research Institute to keep the state competitive, sustain jobs, and grow our life science economy.
@gothamist.com reports: tinyurl.com/5fab5k7u
@gothamist.com reports: tinyurl.com/5fab5k7u
Reposted by Alejandro Adam
Join us in Fort Myers to #connect, #share, and #learn from the leading #DiseaseResearchers at #Pathobiology2026! Submit your abstract and register to save by by January 20 pathobiology2026.asip.org
#DiseaseMechanisms #ASIP2026 #CareerDevelopment #PathobiologyResearch
#DiseaseMechanisms #ASIP2026 #CareerDevelopment #PathobiologyResearch
December 16, 2025 at 5:20 PM
Join us in Fort Myers to #connect, #share, and #learn from the leading #DiseaseResearchers at #Pathobiology2026! Submit your abstract and register to save by by January 20 pathobiology2026.asip.org
#DiseaseMechanisms #ASIP2026 #CareerDevelopment #PathobiologyResearch
#DiseaseMechanisms #ASIP2026 #CareerDevelopment #PathobiologyResearch
Reposted by Alejandro Adam
I stumbled across the 300th Episode of South Park, SHOTS!!!
One on the most funny/not funny things I have seen in a while.
It is about vaccinations and concerns about vaccine hesitancy and that vaccinations cause people to become "artistic".
www.youtube.com/watch?v=QZ40...
One on the most funny/not funny things I have seen in a while.
It is about vaccinations and concerns about vaccine hesitancy and that vaccinations cause people to become "artistic".
www.youtube.com/watch?v=QZ40...
Cartmans Mum gets a shot
YouTube video by Cat Uploader
www.youtube.com
December 11, 2025 at 4:22 PM
I stumbled across the 300th Episode of South Park, SHOTS!!!
One on the most funny/not funny things I have seen in a while.
It is about vaccinations and concerns about vaccine hesitancy and that vaccinations cause people to become "artistic".
www.youtube.com/watch?v=QZ40...
One on the most funny/not funny things I have seen in a while.
It is about vaccinations and concerns about vaccine hesitancy and that vaccinations cause people to become "artistic".
www.youtube.com/watch?v=QZ40...
Reposted by Alejandro Adam
Last week, ICE arrested and separated a father and son after a routine check-in. Six-year-old Yuanxin had just enrolled in the first grade at an elementary school in Astoria. Now he's in custody, alone. ICE won't say where. This cruelty serves no one. It must end.
December 2, 2025 at 9:16 PM
Last week, ICE arrested and separated a father and son after a routine check-in. Six-year-old Yuanxin had just enrolled in the first grade at an elementary school in Astoria. Now he's in custody, alone. ICE won't say where. This cruelty serves no one. It must end.
Reposted by Alejandro Adam
My wife has been HIV+ for 34 years. She’s alive today b/c work of activists who destigmatized the virus, pushed medical science to adapt & find ways to treat it, & advocated for gov health programs that helped fund her care. The current U.S. regime may want to go back in time, but we won’t let them.
December 2, 2025 at 1:27 AM
My wife has been HIV+ for 34 years. She’s alive today b/c work of activists who destigmatized the virus, pushed medical science to adapt & find ways to treat it, & advocated for gov health programs that helped fund her care. The current U.S. regime may want to go back in time, but we won’t let them.
Reposted by Alejandro Adam
Reposted by Alejandro Adam
December 2, 2025 at 8:48 AM
Reposted by Alejandro Adam
Since AI slop is again all over Scientific Reports, a thread on the economics of grey-zone publishing.
Why does slop keep getting published? What does it mean for science? How can we stop this?
Background readings:
Understand the strain: tinyurl.com/2b6wxx5r
Stop the drain: tinyurl.com/3jfscscy
Why does slop keep getting published? What does it mean for science? How can we stop this?
Background readings:
Understand the strain: tinyurl.com/2b6wxx5r
Stop the drain: tinyurl.com/3jfscscy
November 30, 2025 at 11:10 AM
Since AI slop is again all over Scientific Reports, a thread on the economics of grey-zone publishing.
Why does slop keep getting published? What does it mean for science? How can we stop this?
Background readings:
Understand the strain: tinyurl.com/2b6wxx5r
Stop the drain: tinyurl.com/3jfscscy
Why does slop keep getting published? What does it mean for science? How can we stop this?
Background readings:
Understand the strain: tinyurl.com/2b6wxx5r
Stop the drain: tinyurl.com/3jfscscy
Reposted by Alejandro Adam
Socialism is what they called public power.
Socialism is what they called social security.
Socialism is what they called the growth of free and independent labor organizations.
Socialism is their name for almost anything that helps all the people.
—Harry Truman, 1952
Socialism is what they called social security.
Socialism is what they called the growth of free and independent labor organizations.
Socialism is their name for almost anything that helps all the people.
—Harry Truman, 1952
November 21, 2025 at 5:15 PM
Socialism is what they called public power.
Socialism is what they called social security.
Socialism is what they called the growth of free and independent labor organizations.
Socialism is their name for almost anything that helps all the people.
—Harry Truman, 1952
Socialism is what they called social security.
Socialism is what they called the growth of free and independent labor organizations.
Socialism is their name for almost anything that helps all the people.
—Harry Truman, 1952
Reposted by Alejandro Adam
This team are searching for new "Asgard archaea" to sequence.
Let's talk about why these bacteria-like organisms are so fascinating, why they're named for Norse mythology, and why looking at them is unlocking a better understanding of our own genomes.
Once considered a type of oddball bacteria🦠...
Let's talk about why these bacteria-like organisms are so fascinating, why they're named for Norse mythology, and why looking at them is unlocking a better understanding of our own genomes.
Once considered a type of oddball bacteria🦠...
#AsgardArchaea team, led by @archaeal.bsky.social fr @texasscience.bsky.social — sequencing the DNA collected fr mouth of Rio de la Plata to the continental shelf of Uruguay to detect Asgards, a group of single-celled organisms & our closest microbial relatives on the tree of life. bit.ly/3MdniTH
November 21, 2025 at 1:25 PM
This team are searching for new "Asgard archaea" to sequence.
Let's talk about why these bacteria-like organisms are so fascinating, why they're named for Norse mythology, and why looking at them is unlocking a better understanding of our own genomes.
Once considered a type of oddball bacteria🦠...
Let's talk about why these bacteria-like organisms are so fascinating, why they're named for Norse mythology, and why looking at them is unlocking a better understanding of our own genomes.
Once considered a type of oddball bacteria🦠...
Reposted by Alejandro Adam
So, I have read articles written by people who claim that the entire concept of modern medicine is bad, because "artificially" saving people's lives has put a stop to human evolution by letting genetically inferior people breed. Great that those folks are in charge of the CDC now.
EXCLUSIVE: CDC to end all monkey studies. Decision handed down by recent college grad and former DOGE employee who is now deputy chief of staff at the agency. Animals were being used in studies of HIV prevention. Some may be euthanized. My latest for @science.org
Exclusive: CDC to end all monkey research
Studies related to HIV and other infectious diseases will be phased out, sources say; fate of the agency's animals remains unclear
www.science.org
November 21, 2025 at 2:50 PM
So, I have read articles written by people who claim that the entire concept of modern medicine is bad, because "artificially" saving people's lives has put a stop to human evolution by letting genetically inferior people breed. Great that those folks are in charge of the CDC now.
Congratulations Margarida Barroso @barroso8.bsky.social for receiving the Carpenter Ranch Award from @histochemicalsoc.bsky.social ! So well deserved!
November 17, 2025 at 6:11 PM
Congratulations Margarida Barroso @barroso8.bsky.social for receiving the Carpenter Ranch Award from @histochemicalsoc.bsky.social ! So well deserved!
Reposted by Alejandro Adam
I wanted to share probably the most important sermon I’ve given and it’s while I’m being arrested. It’s torture pure and simple what happens at #Broadview. I’m ok, though I was thrown to the ground and choked with my pectoral cross. A review of the video shows I was peaceful - did I deserve this?
November 15, 2025 at 5:57 AM
I wanted to share probably the most important sermon I’ve given and it’s while I’m being arrested. It’s torture pure and simple what happens at #Broadview. I’m ok, though I was thrown to the ground and choked with my pectoral cross. A review of the video shows I was peaceful - did I deserve this?
Reposted by Alejandro Adam
Research in primate brains has been essential for the development of brain-computer interfaces and artificial neural networks. New funding and policy changes put future such advances at risk, write Cory Miller, @movshon.bsky.social and Doris Tsao.
#neuroskyence
bit.ly/47MXYLH
#neuroskyence
bit.ly/47MXYLH
Without monkeys, neuroscience has no future
Research in primate brains has been essential for the development of BCIs, ANNs. New funding and policy changes put future such advances at risk.
bit.ly
November 10, 2025 at 2:56 PM
Research in primate brains has been essential for the development of brain-computer interfaces and artificial neural networks. New funding and policy changes put future such advances at risk, write Cory Miller, @movshon.bsky.social and Doris Tsao.
#neuroskyence
bit.ly/47MXYLH
#neuroskyence
bit.ly/47MXYLH
Reposted by Alejandro Adam
Chuck Schumer Helps Pull Democrats Back From Brink Of Courage
November 10, 2025 at 5:02 AM
Chuck Schumer Helps Pull Democrats Back From Brink Of Courage
Reposted by Alejandro Adam
Dems. Snatching defeat from the jaws of victory
November 10, 2025 at 2:12 PM
Dems. Snatching defeat from the jaws of victory
Reposted by Alejandro Adam
Previously shared: Systemic shock can lead to vascular dysfunction and organ failure.
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA.
www.jci.org/articles/vie...
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA.
www.jci.org/articles/vie...
November 9, 2025 at 2:01 PM
Previously shared: Systemic shock can lead to vascular dysfunction and organ failure.
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA.
www.jci.org/articles/vie...
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA.
www.jci.org/articles/vie...
Reposted by Alejandro Adam
Vinculin is a simple adapter protein right? Wrong!
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
The mechanical response of vinculin
Vinculin buffers force via dynamic domain unfolding/refolding under physiological load and lacks a stable head-tail lock.
www.science.org
October 31, 2025 at 6:29 PM
Vinculin is a simple adapter protein right? Wrong!
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
That’s been the prevailing view for the 46 years since it was discovered.
Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains.
www.science.org/doi/10.1126/...
Here's a quick thread with pics summarizing the paper. Many thanks for all the hard work at Albany Med and by our collaborator Pilar Alcaide!
Very proud of this work that is now out on JCI describing a new #signaling pathway downstream of the #cytokine IL-6 in the #endothelium with implications in #sepsis and #shock. Short thread with a summary coming later today.
For now just enjoy that gorgeous image taken by my student Fatma Awadalla!
For now just enjoy that gorgeous image taken by my student Fatma Awadalla!
Systemic shock can lead to vascular dysfunction and organ failure.
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA: www.jci.org/articles/vie...
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA: www.jci.org/articles/vie...
November 4, 2025 at 12:47 AM
Here's a quick thread with pics summarizing the paper. Many thanks for all the hard work at Albany Med and by our collaborator Pilar Alcaide!
Very proud of this work that is now out on JCI describing a new #signaling pathway downstream of the #cytokine IL-6 in the #endothelium with implications in #sepsis and #shock. Short thread with a summary coming later today.
For now just enjoy that gorgeous image taken by my student Fatma Awadalla!
For now just enjoy that gorgeous image taken by my student Fatma Awadalla!
Systemic shock can lead to vascular dysfunction and organ failure.
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA: www.jci.org/articles/vie...
This issue’s cover features work by Alejandro P. Adam @aleadam.bsky.social showing inflammatory cytokines drives endothelial stress via cytoplasmic DNA: www.jci.org/articles/vie...
November 3, 2025 at 6:34 PM
Very proud of this work that is now out on JCI describing a new #signaling pathway downstream of the #cytokine IL-6 in the #endothelium with implications in #sepsis and #shock. Short thread with a summary coming later today.
For now just enjoy that gorgeous image taken by my student Fatma Awadalla!
For now just enjoy that gorgeous image taken by my student Fatma Awadalla!
Reposted by Alejandro Adam
New work from Daoud et al. shows that removal of YAP/TAZ from vascular smooth muscle cells triggers inflammation and immune activation- indicating these factors as essential in vascular health.#vascularbiology
sciencedirect.com/science/arti...
#CardioSky
sciencedirect.com/science/arti...
#CardioSky
YAP/TAZ deletion in vascular smooth muscle cells mirrors atherosclerosis-associated transcriptional programs
The transcriptional co-activators YAP (YAP1) and TAZ (WWTR1) are central regulators of vascular smooth muscle cell (VSMC) phenotype and vascular homeo…
sciencedirect.com
November 3, 2025 at 12:47 PM
New work from Daoud et al. shows that removal of YAP/TAZ from vascular smooth muscle cells triggers inflammation and immune activation- indicating these factors as essential in vascular health.#vascularbiology
sciencedirect.com/science/arti...
#CardioSky
sciencedirect.com/science/arti...
#CardioSky
Reposted by Alejandro Adam
The BICAR-ICU-2 trial just dropped!
RCT involving IV bicarb in metabolic acidosis among patients with mod-severe AKI
Bicarb didn't affect mortality but it reduced the need for dialysis & risk of bacteremia
VERY similar conclusions to BICAR-ICU-1
🧵 #1/
jamanetwork.com/journals/jam... #EMIMCC
RCT involving IV bicarb in metabolic acidosis among patients with mod-severe AKI
Bicarb didn't affect mortality but it reduced the need for dialysis & risk of bacteremia
VERY similar conclusions to BICAR-ICU-1
🧵 #1/
jamanetwork.com/journals/jam... #EMIMCC
October 29, 2025 at 2:59 PM
The BICAR-ICU-2 trial just dropped!
RCT involving IV bicarb in metabolic acidosis among patients with mod-severe AKI
Bicarb didn't affect mortality but it reduced the need for dialysis & risk of bacteremia
VERY similar conclusions to BICAR-ICU-1
🧵 #1/
jamanetwork.com/journals/jam... #EMIMCC
RCT involving IV bicarb in metabolic acidosis among patients with mod-severe AKI
Bicarb didn't affect mortality but it reduced the need for dialysis & risk of bacteremia
VERY similar conclusions to BICAR-ICU-1
🧵 #1/
jamanetwork.com/journals/jam... #EMIMCC