Pinned
Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins. The MrTAC chimera recruits PRMT1 to a target protein for induced degradation in lysosomes. @albrechtlab.bsky.social @natureportfolio.bsky.social www.nature.com/articles/s41...
Dream come true to be featured on the cover!
Reposted by Lauren Albrecht
Renal Coenzyme A (CoA) Production Fuels Stem Cell Proliferation and Tumor Growth
Ting Miao, Ying Liu, Mujeeb Qadiri, John M. Asara, Yanhui Hu, Xiaomei Sun, Christian Dibble, Norbert Perrimon
bioRxiv 2025.08.08.669325; doi: doi.org/10.1101/2025...
Ting Miao, Ying Liu, Mujeeb Qadiri, John M. Asara, Yanhui Hu, Xiaomei Sun, Christian Dibble, Norbert Perrimon
bioRxiv 2025.08.08.669325; doi: doi.org/10.1101/2025...
Renal Coenzyme A (CoA) Production Fuels Stem Cell Proliferation and Tumor Growth
Coenzyme A (CoA), derived from Vitamin B5 (VB5), is essential for lipid metabolism, energy production, and cell proliferation. While the intracellular functions of CoA are well characterized, its tiss...
doi.org
August 12, 2025 at 10:57 AM
Renal Coenzyme A (CoA) Production Fuels Stem Cell Proliferation and Tumor Growth
Ting Miao, Ying Liu, Mujeeb Qadiri, John M. Asara, Yanhui Hu, Xiaomei Sun, Christian Dibble, Norbert Perrimon
bioRxiv 2025.08.08.669325; doi: doi.org/10.1101/2025...
Ting Miao, Ying Liu, Mujeeb Qadiri, John M. Asara, Yanhui Hu, Xiaomei Sun, Christian Dibble, Norbert Perrimon
bioRxiv 2025.08.08.669325; doi: doi.org/10.1101/2025...
Reposted by Lauren Albrecht
🥂Congratulations to Petropoulos & co for their new Open Access study in our journal (@naturecellbiology.bsky.social): single-cell #transcriptomics, spatial, functional and comparative analyses show that the guinea pig presents high similarity with early human #embryogenesis.
bit.ly/3RaRwWY
bit.ly/3RaRwWY
The guinea pig serves as an alternative model to study human preimplantation development - Nature Cell Biology
Petropoulos and colleagues perform single-cell transcriptomics, spatial, functional and comparative analyses, and show that the guinea pig presents high similarity with early human embryogenesis.
bit.ly
April 9, 2025 at 8:21 PM
🥂Congratulations to Petropoulos & co for their new Open Access study in our journal (@naturecellbiology.bsky.social): single-cell #transcriptomics, spatial, functional and comparative analyses show that the guinea pig presents high similarity with early human #embryogenesis.
bit.ly/3RaRwWY
bit.ly/3RaRwWY
Reposted by Lauren Albrecht
SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: “Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...
Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins
Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...
www.science.org
March 27, 2025 at 7:45 PM
SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: “Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...
Reposted by Lauren Albrecht
New work from Coon Lab (Wisconsin), @harperlabhms.bsky.social & Gygi Lab @harvardcellbio.bsky.social reports global proteomics/lipidomics of > 2 dozen Lysosomal Storage Disease mutant cells & reveals iron defects associated with mitochondrial defects in NPC2 mutants www.science.org/doi/10.1126/...
Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST
A nanoflow multiomic workflow reveals how lysosomal dysfunction disrupts autophagy and mitochondrial homeostasis in LSD mutants.
www.science.org
January 22, 2025 at 7:43 PM
New work from Coon Lab (Wisconsin), @harperlabhms.bsky.social & Gygi Lab @harvardcellbio.bsky.social reports global proteomics/lipidomics of > 2 dozen Lysosomal Storage Disease mutant cells & reveals iron defects associated with mitochondrial defects in NPC2 mutants www.science.org/doi/10.1126/...
Lipidome, proteome, LSD. What’s not to love??
In a new publication from CRN Team Harper found that select LSDs can cause problems with mitochondria. Specifically, these LSDs can interfere with the recycling of iron, which is important for mitochondria to function properly 🔬
🔗 Check out the full #publication: shorturl.at/HTPqW
🔗 Check out the full #publication: shorturl.at/HTPqW
February 26, 2025 at 7:48 AM
Lipidome, proteome, LSD. What’s not to love??
Reposted by Lauren Albrecht
Thank you Drs. Dan Klionsky and Dimitra Dialynaki for your commentary on our work: www.tandfonline.com/doi/epdf/10....
Identification of the mammalian VPS4A as a selective lipophagy receptor
www.tandfonline.com
January 5, 2025 at 9:13 PM
Thank you Drs. Dan Klionsky and Dimitra Dialynaki for your commentary on our work: www.tandfonline.com/doi/epdf/10....
So much fun sharing MrTAC with Keystone and seeing old friends and making new ones @fleurmferguson.bsky.social @stevenbanik.bsky.social @dannomura.bsky.social @danetteldaniels.bsky.social #lysosome #tpd
February 25, 2025 at 7:46 AM
So much fun sharing MrTAC with Keystone and seeing old friends and making new ones @fleurmferguson.bsky.social @stevenbanik.bsky.social @dannomura.bsky.social @danetteldaniels.bsky.social #lysosome #tpd
Thank you Brian !!
Congrats to my colleague, Prof. Albrecht @albrechtlab.bsky.social , who is a new Sloan Fellow! news.uci.edu/2025/02/20/u...
UC Irvine assistant professor Lauren Albrecht named 2025 Sloan Foundation Research Fellow
Accomplished early-career pharmaceutical scientist recognized as next-generation leader
news.uci.edu
February 21, 2025 at 5:35 AM
Thank you Brian !!
Honored to be a 2025 Sloan Research Fellow! #sloanfellow
🎉Congrats to the 126 early-career scientists who have been awarded a Sloan Research Fellowship this year! These exceptional scholars are drawn from 51 institutions across the US and Canada, and represent the next generation of groundbreaking researchers. sloan.org/fellowships/...
February 18, 2025 at 5:06 PM
Honored to be a 2025 Sloan Research Fellow! #sloanfellow
Reposted by Lauren Albrecht
Pondering a purge of pesky pathological proteins?
Honored to be giving a talk at Dana-Farber’s TPD seminar this Thursday 2/6 at 9am PST. dfci.zoom.us/webinar/regist… Come check out MrTAC Š @danafarber.bsky.social
February 5, 2025 at 5:54 AM
Pondering a purge of pesky pathological proteins?
Reposted by Lauren Albrecht
Oh no, they said “bias” in the title: AI-mediated desk rejection at NSF
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The role of ionic blockades in controlling the efficiency of energy recovery in forward bias bipolar membranes - Nature Energy
Bipolar membranes are increasingly being applied in a variety of electrochemical devices, yet understanding of how they operate in complex electrolyte environments is still limited. Here the authors o...
www.nature.com
February 4, 2025 at 4:41 AM
Oh no, they said “bias” in the title: AI-mediated desk rejection at NSF
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Honored to be giving a talk at Dana-Farber’s TPD seminar this Thursday 2/6 at 9am PST. dfci.zoom.us/webinar/regist… Come check out MrTAC Š @danafarber.bsky.social
February 5, 2025 at 12:00 AM
Honored to be giving a talk at Dana-Farber’s TPD seminar this Thursday 2/6 at 9am PST. dfci.zoom.us/webinar/regist… Come check out MrTAC Š @danafarber.bsky.social
Reposted by Lauren Albrecht
CRISPR screening in epithelial cells suggests that peroxisome-derived ether lipids alter cellular viability in response to lipotoxic stress. Fas-associated factor family member 2 (FAF2) appears to be a key regulator of this process. This is an interesting preprint!
www.biorxiv.org/content/bior...
www.biorxiv.org/content/bior...
www.biorxiv.org
December 20, 2024 at 3:57 PM
CRISPR screening in epithelial cells suggests that peroxisome-derived ether lipids alter cellular viability in response to lipotoxic stress. Fas-associated factor family member 2 (FAF2) appears to be a key regulator of this process. This is an interesting preprint!
www.biorxiv.org/content/bior...
www.biorxiv.org/content/bior...
Reposted by Lauren Albrecht
Protein Kinase C positively regulates peroxisome biogenesis by promoting peroxisome-endoplasmic reticulum interaction www.biorxiv.org/content/10.1...
Protein Kinase C positively regulates peroxisome biogenesis by promoting peroxisome-endoplasmic reticulum interaction
Peroxisomes carry out a diverse set of metabolic functions, including oxidation of very long-chained fatty acids, degradation of D-amino acids and hydrogen peroxide, and bile acid production. Many of ...
www.biorxiv.org
January 26, 2025 at 6:44 PM
Protein Kinase C positively regulates peroxisome biogenesis by promoting peroxisome-endoplasmic reticulum interaction www.biorxiv.org/content/10.1...
Reposted by Lauren Albrecht
"An early-life microbiota metabolite [peroxisome proliferator-activated receptor γ, or PPAR-γ] protects against obesity by regulating intestinal lipid metabolism [in mice]"
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
October 28, 2023 at 10:24 PM
"An early-life microbiota metabolite [peroxisome proliferator-activated receptor γ, or PPAR-γ] protects against obesity by regulating intestinal lipid metabolism [in mice]"
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Lauren Albrecht
... And if you want to know more, here's the featured Article: Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins ($) doi.org/10.1038/s415...
Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins - Nature Chemical Biology
Development of a targeted protein degradation platform, methylarginine targeting chimera (MrTAC), enables arginine methylation-driven degradation of intracellular proteins in lysosomes.
doi.org
December 19, 2024 at 11:27 AM
... And if you want to know more, here's the featured Article: Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins ($) doi.org/10.1038/s415...
Reposted by Lauren Albrecht
Our December issue has been out for a new weeks but it has quite a striking confocal microscopy image on the cover.
www.nature.com/nchembio/vol...
www.nature.com/nchembio/vol...
December 19, 2024 at 11:27 AM
Our December issue has been out for a new weeks but it has quite a striking confocal microscopy image on the cover.
www.nature.com/nchembio/vol...
www.nature.com/nchembio/vol...
Reposted by Lauren Albrecht
Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins. The MrTAC chimera recruits PRMT1 to a target protein for induced degradation in lysosomes. @albrechtlab.bsky.social @natureportfolio.bsky.social www.nature.com/articles/s41...
December 4, 2024 at 8:06 AM
Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins. The MrTAC chimera recruits PRMT1 to a target protein for induced degradation in lysosomes. @albrechtlab.bsky.social @natureportfolio.bsky.social www.nature.com/articles/s41...
Reposted by Lauren Albrecht
Loving #CellBio2024 and excited to present in micro session MONDAY 10:30 AM 28C microsession #MrTAC #lysosome #degrader #TPD #methylation
December 16, 2024 at 12:12 AM
Loving #CellBio2024 and excited to present in micro session MONDAY 10:30 AM 28C microsession #MrTAC #lysosome #degrader #TPD #methylation
Excited to attend ASCB #CellBio2024! The Albrecht lab will present on lysosomes, quality control, lipid / carbohydrate metabolism, and MrTAC TPD targeted degrader.
Please check out our lab's talks and posters:
Please check out our lab's talks and posters:
December 9, 2024 at 4:05 AM
Excited to attend ASCB #CellBio2024! The Albrecht lab will present on lysosomes, quality control, lipid / carbohydrate metabolism, and MrTAC TPD targeted degrader.
Please check out our lab's talks and posters:
Please check out our lab's talks and posters:
Reposted by Lauren Albrecht
A new #ScienceAdvances study demonstrates a vaccine for cancer immunotherapy that would speed up the efficiency of messenger RNA translation in cytoplasm—and effectively inhibited tumor growth. scim.ag/49qY0sY
mRNA compartmentalization via multimodule DNA nanostructure assembly augments the immunogenicity and efficacy of cancer mRNA vaccine
Intracellular DNA assembly for mRNA vaccine compartmentalization facilitates antigen expression and enhances adjuvant efficacy.
scim.ag
December 6, 2024 at 8:42 PM
A new #ScienceAdvances study demonstrates a vaccine for cancer immunotherapy that would speed up the efficiency of messenger RNA translation in cytoplasm—and effectively inhibited tumor growth. scim.ag/49qY0sY
Dream come true to be featured on the cover!
Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins. The MrTAC chimera recruits PRMT1 to a target protein for induced degradation in lysosomes. @albrechtlab.bsky.social @natureportfolio.bsky.social www.nature.com/articles/s41...
December 7, 2024 at 7:47 AM
Dream come true to be featured on the cover!
Thank you @haoyin.bsky.social !!
Do U know #MrDegron?😆
A protein arginine methyltransferase tags pyridoxal kinase, rate-limiting VitB6 enzyme, to #Lysosome #MicroAutophagy
A Wnt-responsive process😁
Does Wnt directly act on MrDegron or PDXK?
LAUREN ALBRECHT lab Sci Adv 2023
www.science.org/doi/10.1126/...
A protein arginine methyltransferase tags pyridoxal kinase, rate-limiting VitB6 enzyme, to #Lysosome #MicroAutophagy
A Wnt-responsive process😁
Does Wnt directly act on MrDegron or PDXK?
LAUREN ALBRECHT lab Sci Adv 2023
www.science.org/doi/10.1126/...
December 2, 2024 at 12:27 AM
Thank you @haoyin.bsky.social !!