Agnese Loda
@agneseloda.bsky.social
Molecular Biologist, X-chromosome and gender equality lover exploring how the genome looks and works 🧬🧫👩🔬💥
MSCA fellow | Heard lab | EMBL
MSCA fellow | Heard lab | EMBL
Pinned
Escape from X inactivation is directly modulated by Xist noncoding RNA
Nature Cell Biology - The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape...
rdcu.be
Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
Great opportunity - wonderful team and research 👇👇👇👇!!
Do you want to play a key role in running a cutting-edge stem cell and embryology lab at reNEW @ucph.bsky.social ? We’re hiring a Lab Manager to support our team and help with stem cell and animal work. Apply before Feb. 1st : rb.gy/d5uf17
Academic employee for Research Group, Dept. of Biomedical Sciences, reNEW
rb.gy
December 17, 2025 at 7:50 PM
Great opportunity - wonderful team and research 👇👇👇👇!!
Reposted by Agnese Loda
Epigenetics Update - Escape from X inactivation is directly modulated by Xist noncoding RNA go.nature.com/49jeLH5
Edith Heard and Agnese Loda (EMBL) reporting in Nat Cell Biol
#Epigenetics #Xist #XInactivation #Chromatin
---
Perfect for cancer, immunology, and aging research; epigenometech.com
Edith Heard and Agnese Loda (EMBL) reporting in Nat Cell Biol
#Epigenetics #Xist #XInactivation #Chromatin
---
Perfect for cancer, immunology, and aging research; epigenometech.com
December 17, 2025 at 8:20 AM
Epigenetics Update - Escape from X inactivation is directly modulated by Xist noncoding RNA go.nature.com/49jeLH5
Edith Heard and Agnese Loda (EMBL) reporting in Nat Cell Biol
#Epigenetics #Xist #XInactivation #Chromatin
---
Perfect for cancer, immunology, and aging research; epigenometech.com
Edith Heard and Agnese Loda (EMBL) reporting in Nat Cell Biol
#Epigenetics #Xist #XInactivation #Chromatin
---
Perfect for cancer, immunology, and aging research; epigenometech.com
Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
Escape from X inactivation is directly modulated by Xist noncoding RNA
Nature Cell Biology - The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape...
rdcu.be
December 15, 2025 at 4:22 PM
Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.
Reposted by Agnese Loda
We are excited to share our new preprint:
SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids.
www.biorxiv.org/content/10.64898/2025.12.01.691499v1
SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids.
www.biorxiv.org/content/10.64898/2025.12.01.691499v1
December 3, 2025 at 6:53 PM
We are excited to share our new preprint:
SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids.
www.biorxiv.org/content/10.64898/2025.12.01.691499v1
SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids.
www.biorxiv.org/content/10.64898/2025.12.01.691499v1
Reposted by Agnese Loda
📣 SAVE THE DATE
Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social
Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social
November 17, 2025 at 11:39 AM
📣 SAVE THE DATE
Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social
Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social
Reposted by Agnese Loda
In this episode we talked with @pasquelab.bsky.social from KU Leuven about his work on the reprogramming of cell identity through epigenetic mechanisms, particularly during early development and cellular reprogramming. #epigenetics #podcast
Listen here: activemotif.com/podcasts-vin...
Listen here: activemotif.com/podcasts-vin...
October 31, 2025 at 8:01 AM
In this episode we talked with @pasquelab.bsky.social from KU Leuven about his work on the reprogramming of cell identity through epigenetic mechanisms, particularly during early development and cellular reprogramming. #epigenetics #podcast
Listen here: activemotif.com/podcasts-vin...
Listen here: activemotif.com/podcasts-vin...
Reposted by Agnese Loda
What is a promoter? And how does it work?
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
Enhancer-promoter compatibility is mediated by the promoter-proximal region
Gene promoters induce transcription in response to distal enhancers. How enhancers specifically activate their target promoter while bypassing other promoters remains unclear. Here, we find that the p...
www.biorxiv.org
October 16, 2025 at 3:06 PM
What is a promoter? And how does it work?
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
Reposted by Agnese Loda
Very excited to share an excellent review from @teresa-urli.bsky.social, published one week before her PhD defense! We did a deep dive into the fascinating biology of the variant Polycomb complex, PRC1.6 (1/5) journals.plos.org/plosgenetics...
Epigenetic relay: Polycomb-directed DNA methylation in mammalian development
In mammals, repression of germline-specific gene expression is essential for preserving somatic cell identity and preventing disease. Germline gene silencing is often dependent on the presence of prom...
journals.plos.org
September 15, 2025 at 7:04 PM
Very excited to share an excellent review from @teresa-urli.bsky.social, published one week before her PhD defense! We did a deep dive into the fascinating biology of the variant Polycomb complex, PRC1.6 (1/5) journals.plos.org/plosgenetics...
Reposted by Agnese Loda
Open Team Leader position @embl.org to head & reshape our Genomics Core facility. Interested in providing & developing state-of-the art omics tech to a wide community? A very vibrant, dynamic place to work with fantastic colleagues. Closing Sept 30th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Team Leader – Genomics Core Facility and Method Development
Are you ready to lead a cutting-edge Genomics Core facility while developing state of the art genomics methods? Join us at EMBL! We are seeking talented scientists to develop and lead a cutting-edge G...
embl.wd103.myworkdayjobs.com
August 11, 2025 at 9:54 AM
Open Team Leader position @embl.org to head & reshape our Genomics Core facility. Interested in providing & developing state-of-the art omics tech to a wide community? A very vibrant, dynamic place to work with fantastic colleagues. Closing Sept 30th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Reposted by Agnese Loda
New work from @beckof.bsky.social and our lab's collaboration, with @alengronne.bsky.social! Multifaceted influence of transcription on yeast chromosome folding... loop extrusion of course but also active promoters making loops, bypassing centromeres boundaries
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
RNA Pol II-based regulations of chromosome folding
The spatial organization of eukaryotic genomes and its dynamics are of functional importance for gene expression, DNA replication, and segregation. St…
www.sciencedirect.com
August 11, 2025 at 12:32 PM
New work from @beckof.bsky.social and our lab's collaboration, with @alengronne.bsky.social! Multifaceted influence of transcription on yeast chromosome folding... loop extrusion of course but also active promoters making loops, bypassing centromeres boundaries
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Agnese Loda
Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social
June 27, 2025 at 3:07 PM
Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social
Reposted by Agnese Loda
We are looking for a research assistant to join our lab and support ongoing projects with genome engineering in mouse embryonic stem cells! Please get in touch if you are interested.
www.fmi.ch/education-ca...
www.fmi.ch/education-ca...
Friedrich Miescher Institute, open position
Friedrich Miescher Institute, open position
www.fmi.ch
June 26, 2025 at 3:04 PM
We are looking for a research assistant to join our lab and support ongoing projects with genome engineering in mouse embryonic stem cells! Please get in touch if you are interested.
www.fmi.ch/education-ca...
www.fmi.ch/education-ca...
Congratulations Juliane @julianeg.bsky.social 🥳🥳🥳🥳🥳 looking forward to see your lab in action 🤩🤩🤩!!
We are excited to officially welcome a new group leader at the MPI-IE in #Freiburg. 🎉
Dr Juliane Glaser 🥳 – she studies epigenetic mechanisms of embryonic development, with a focus on transposable elements. 👉 Interview: www.ie-freiburg.mpg.de/6043545/2025...
Welcome, @julianeg.bsky.social!
Dr Juliane Glaser 🥳 – she studies epigenetic mechanisms of embryonic development, with a focus on transposable elements. 👉 Interview: www.ie-freiburg.mpg.de/6043545/2025...
Welcome, @julianeg.bsky.social!
June 25, 2025 at 5:26 PM
Congratulations Juliane @julianeg.bsky.social 🥳🥳🥳🥳🥳 looking forward to see your lab in action 🤩🤩🤩!!
Reposted by Agnese Loda
Transitions in development – an interview with Jan Żylicz
We met with @jzylicz.bsky.social (reNEW @ucph.bsky.social) on Teams to learn more about working abroad, finding a good mentor and his career path so far:
journals.biologists.com/dev/article/...
We met with @jzylicz.bsky.social (reNEW @ucph.bsky.social) on Teams to learn more about working abroad, finding a good mentor and his career path so far:
journals.biologists.com/dev/article/...
June 17, 2025 at 8:51 AM
Transitions in development – an interview with Jan Żylicz
We met with @jzylicz.bsky.social (reNEW @ucph.bsky.social) on Teams to learn more about working abroad, finding a good mentor and his career path so far:
journals.biologists.com/dev/article/...
We met with @jzylicz.bsky.social (reNEW @ucph.bsky.social) on Teams to learn more about working abroad, finding a good mentor and his career path so far:
journals.biologists.com/dev/article/...
Reposted by Agnese Loda
We are looking to take on an intern at EMBL Rome, for anyone interested in CRISPR and Epigenetics training.
The traineeship is 3-12-months, in Rome (Italy), should start by July, and is supervised by the outstanding @steliostsagkris.bsky.social.
#job #internship; see info below...
The traineeship is 3-12-months, in Rome (Italy), should start by July, and is supervised by the outstanding @steliostsagkris.bsky.social.
#job #internship; see info below...
May 15, 2025 at 7:38 AM
We are looking to take on an intern at EMBL Rome, for anyone interested in CRISPR and Epigenetics training.
The traineeship is 3-12-months, in Rome (Italy), should start by July, and is supervised by the outstanding @steliostsagkris.bsky.social.
#job #internship; see info below...
The traineeship is 3-12-months, in Rome (Italy), should start by July, and is supervised by the outstanding @steliostsagkris.bsky.social.
#job #internship; see info below...
Reposted by Agnese Loda
EMBL’s departing director general, Edith Heard, reflects on her legacy at Europe’s life science institute as she prepares for new leadership challenges at the Francis Crick Institute (@crick.ac.uk) .
Read more: www.embl.org/news/people-...
Read more: www.embl.org/news/people-...
Edith Heard: what I’ve learned | EMBL
As EMBL’s fifth Director General departs for a new role as Crick Institute CEO, she reflects on EMBL and lessons learned through the years.
www.embl.org
May 14, 2025 at 1:14 PM
EMBL’s departing director general, Edith Heard, reflects on her legacy at Europe’s life science institute as she prepares for new leadership challenges at the Francis Crick Institute (@crick.ac.uk) .
Read more: www.embl.org/news/people-...
Read more: www.embl.org/news/people-...
Reposted by Agnese Loda
I’m incredibly proud to share the results of our lab’s first project, leading to the exciting discovery – Aging promotes reactivation of the Barr body at distal chromosome regions – now published in @nataging.nature.com!
🔗 tinyurl.com/3jkzzy7d
🔗 tinyurl.com/3jkzzy7d
May 2, 2025 at 7:57 PM
I’m incredibly proud to share the results of our lab’s first project, leading to the exciting discovery – Aging promotes reactivation of the Barr body at distal chromosome regions – now published in @nataging.nature.com!
🔗 tinyurl.com/3jkzzy7d
🔗 tinyurl.com/3jkzzy7d
Well done Jan and team! Such a beautiful work 👏👏👏🤩🤩🤩
Can metabolism regulate more than bioenergetics during human development? Our new study says YES! We show that metabolism influences cell fate choice in human naïve pluripotent stem cells, histone acetylation, and trophectoderm maturation. rb.gy/spqr9j
@natcellbio.nature.com
@natcellbio.nature.com
α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells - Nature Cell Biology
Van Nerum et al. show that dimethyl α-ketoglutarate enhances the production and functional maturation of human trophectoderm-like cells from embryonic stem cells by regulating histone acetyltransferas...
rb.gy
April 25, 2025 at 10:03 AM
Well done Jan and team! Such a beautiful work 👏👏👏🤩🤩🤩
Reposted by Agnese Loda
Happy to share the latest story from @arnaudkr.bsky.social's lab @embl.org! With @guidobarzaghi.bsky.social, we used Single Molecule Footprinting to quantify how often chromatin is accessible at enhancers after TF and chromatin environment changes! Check our preprint bit.ly/3XQMFxN + thread ⬇️ 1/11
April 8, 2025 at 1:52 PM
Happy to share the latest story from @arnaudkr.bsky.social's lab @embl.org! With @guidobarzaghi.bsky.social, we used Single Molecule Footprinting to quantify how often chromatin is accessible at enhancers after TF and chromatin environment changes! Check our preprint bit.ly/3XQMFxN + thread ⬇️ 1/11
Reposted by Agnese Loda
Looking for a PhD in sunny Barcelona? ☀️🔬
Our team is hiring a PhD student for the @hologen.bsky.social project!
📅 Deadline: Apr 20
⚠️ READ THE MOBILITY RULE FOR THIS POSITION
🔁 Please, spread the word
All the info here 👉 www.cnag.eu/jobs/phd-stu...
#PhDlife #Genomics #HoloGen #Barcelona
Our team is hiring a PhD student for the @hologen.bsky.social project!
📅 Deadline: Apr 20
⚠️ READ THE MOBILITY RULE FOR THIS POSITION
🔁 Please, spread the word
All the info here 👉 www.cnag.eu/jobs/phd-stu...
#PhDlife #Genomics #HoloGen #Barcelona
PhD Student - Structural Genomics Team (HoloGen Project) | CNAG, Centro Nacional de Análisis Genómico
MPORTANT MOBILITY RULE FOR THIS POSITION The MSCA mobility rule applies to this position: the applicant must not have resided or carried out their main activity (e.g., studies, work, research) in Spai...
www.cnag.eu
March 29, 2025 at 11:02 AM
Looking for a PhD in sunny Barcelona? ☀️🔬
Our team is hiring a PhD student for the @hologen.bsky.social project!
📅 Deadline: Apr 20
⚠️ READ THE MOBILITY RULE FOR THIS POSITION
🔁 Please, spread the word
All the info here 👉 www.cnag.eu/jobs/phd-stu...
#PhDlife #Genomics #HoloGen #Barcelona
Our team is hiring a PhD student for the @hologen.bsky.social project!
📅 Deadline: Apr 20
⚠️ READ THE MOBILITY RULE FOR THIS POSITION
🔁 Please, spread the word
All the info here 👉 www.cnag.eu/jobs/phd-stu...
#PhDlife #Genomics #HoloGen #Barcelona
Reposted by Agnese Loda
I am super proud to share the first Andergassen Lab preprint! Here, we introduce a new framework to decode the non-coding genome, led by the outstanding work of
@hasenbeint.bsky.social and co-authors Sarah Hölzl, Stefan Engelhardt @tum.de👇🧵
@hasenbeint.bsky.social and co-authors Sarah Hölzl, Stefan Engelhardt @tum.de👇🧵
March 6, 2025 at 11:40 AM
I am super proud to share the first Andergassen Lab preprint! Here, we introduce a new framework to decode the non-coding genome, led by the outstanding work of
@hasenbeint.bsky.social and co-authors Sarah Hölzl, Stefan Engelhardt @tum.de👇🧵
@hasenbeint.bsky.social and co-authors Sarah Hölzl, Stefan Engelhardt @tum.de👇🧵
Reposted by Agnese Loda
Excited to share our recent review on extraembryonic mesoderm development, just published in Development!
"Extra embryonic mesoderm during development and in in vitro models."
journals.biologists.com/dev/article/...
"Extra embryonic mesoderm during development and in in vitro models."
journals.biologists.com/dev/article/...
March 15, 2025 at 2:17 PM
Excited to share our recent review on extraembryonic mesoderm development, just published in Development!
"Extra embryonic mesoderm during development and in in vitro models."
journals.biologists.com/dev/article/...
"Extra embryonic mesoderm during development and in in vitro models."
journals.biologists.com/dev/article/...
Reposted by Agnese Loda
🚨New preprint from @bonevlab.bsky.social 🚨: What are the key epigenetic mechanisms that drive species-specific gene regulation during primate neurogenesis - and how do they contribute to the evolution of the human neocortex?
Here’s what we discovered 👇
www.biorxiv.org/content/10.1...
Here’s what we discovered 👇
www.biorxiv.org/content/10.1...
3D Epigenome Evolution Underlies Divergent Gene Regulatory Programs in Primate Neural Development
The expansion of the neocortex is a hallmark of human evolution and is closely linked to neural stem cell biology. Yet, the epigenetic mechanisms driving divergent gene regulation during primate neuro...
www.biorxiv.org
March 13, 2025 at 9:59 AM
🚨New preprint from @bonevlab.bsky.social 🚨: What are the key epigenetic mechanisms that drive species-specific gene regulation during primate neurogenesis - and how do they contribute to the evolution of the human neocortex?
Here’s what we discovered 👇
www.biorxiv.org/content/10.1...
Here’s what we discovered 👇
www.biorxiv.org/content/10.1...
Reposted by Agnese Loda
PUBLIC RESEARCH!! ✊🧪 @standupforscifr.bsky.social @sufs-paris-rp.bsky.social @standupforscience.bsky.social
March 7, 2025 at 2:21 PM
PUBLIC RESEARCH!! ✊🧪 @standupforscifr.bsky.social @sufs-paris-rp.bsky.social @standupforscience.bsky.social
My first post here to share this beautiful work that I’m so happy to see out this week! Congratulations @maudborensztein.bsky.social and the entire team 💥
I am thrilled to share our latest work, released today 🤩
www-nature-com.insb.bib.cnrs.fr/articles/s41...
It results from years of hard work by the team and long-time collaborators, with special thanks to PhD student Clara Roidor and collaborator Laurène Syx.
www-nature-com.insb.bib.cnrs.fr/articles/s41...
It results from years of hard work by the team and long-time collaborators, with special thanks to PhD student Clara Roidor and collaborator Laurène Syx.
January 22, 2025 at 9:41 AM
My first post here to share this beautiful work that I’m so happy to see out this week! Congratulations @maudborensztein.bsky.social and the entire team 💥