Excited to share our paper identifying that bat coronavirus HKU5 uses ACE2 from its native bat host and American mink as a receptor. This highlights farmed mink has a high risk intermediate host for HKU5-like viruses.https://www.nature.com/articles/s41467-025-61583-7 Great collab. with the NIH VRC

Our @natrevimmunol.bsky.social review with @abhishekgarglab.bsky.social, @deadoc80.bsky.social and Kellie Smith is out!

We attempt to integrate the data on CD8 T cell dysfunction into a new framework of hypofunctionality in cancer and chronic infections!

www.nature.com/articles/s41...

'Here, we developed a probe that can fluorogenically label mouse gut microbiota in situ after gavage, and the use of two-photon microscopy enabled us to directly visualize the bacteria translocated into blood vessels and liver in real-time.'
#Immunology #Immunosky
www.pnas.org/doi/10.1073/...

'However, how the ∼500 million enteric neurons that reside in the GI tract sense and respond to force remains unknown. Herein, we establish that the mechanosensor Piezo1 is functionally expressed in cholinergic enteric neurons.'
#Immunology
www.cell.com/cell/abstrac...

Hey fellow Drosophila researchers - if you haven't heard, the UMGC is offering ultra low-cost genome sequencing! See here to learn more: z.umn.edu/UMGC-MOSS #Dros25

First authors Madeline Churchill and Ankit Pandeya @nkeet50.bsky.social from @rauchlab.bsky.social show that tuft cells, known for their role in anti-parasite defenses, can also contribute to anti-bacterial responses in the small intestine. rupress.org/jem/article/...

#InfectiousDisease

Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA.

Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...

A tour de force review of the connections between between the nervous and immune systems
www.nature.com/articles/s41...

YES. Need to say this loudly and often! This 2.46x is also the short-term ROI. Long-term ROI (more difficult to estimate) may ~10x. Highest for any gov't spending. And the source of discoveries necessary for all new drugs (industry important too but without NIH funded science there's no foundation)

If anyone has had an NIH grant cancelled and is willing to talk to a science journalist, please DM me and I will connect you.

“Host-derived and dietary fucose mediate IgA recognition of gut microbiota, and this interaction facilitates the translocation of commensals to PPs and alters the immune landscape of PPs with increased germinal centre B cells and IgA-secreting antigen-specific B cells”
www.nature.com/articles/s41...

Kazachstania pintolopesii, a fungal symbiont transmitted by free-living mice, induces type 2 immunity to enhance resistance to helminth infections or aggravate gastrointestinal allergy
www.nature.com/articles/s41...

#InterferonPower! Elewaut, @obenaufa.bsky.social &co show @ Nature that inflammatory monocytes can acquire MHC-class I from tumor cells & locally activate CD8 T cells, given that the capacity of the tumor to shut down type I #IFNs & upreg PGE2 is reverted! www.nature.com/articles/s41...

Antibiotic treatment of pregnant mice reduces the amount of breast milk antibodies (SIgA) and alters the neonatal fecal microbiota, making neonatal mice more susceptible to sepsis
www.cell.com/cell-host-mi...