Tony Southall
@tonysouthall.bsky.social
Reader (Associate Professor) at Imperial College London
Reposted by Tony Southall
Delighted that Ziqi Dong's PhD paper is out for all to read! Hypoxia is fundamental to normal development, and fascinating! Thanks to all of our co-authors including @jamesnathanlab.bsky.social @jellevda.bsky.social authors.elsevier.com/sd/article/S...
October 11, 2025 at 8:22 AM
Delighted that Ziqi Dong's PhD paper is out for all to read! Hypoxia is fundamental to normal development, and fascinating! Thanks to all of our co-authors including @jamesnathanlab.bsky.social @jellevda.bsky.social authors.elsevier.com/sd/article/S...
Reposted by Tony Southall
This is where the empty headed Flag shagging leads.
Race hate.
Race hate.
August 30, 2025 at 12:52 PM
This is where the empty headed Flag shagging leads.
Race hate.
Race hate.
Reposted by Tony Southall
A Drosophila single-cell 3D spatiotemporal multi-omics atlas unveils panoramic key regulators of cell-type differentiation: Cell
1/2
www.cell.com/cell/abstrac...
1/2
www.cell.com/cell/abstrac...
A Drosophila single-cell 3D spatiotemporal multi-omics atlas unveils panoramic key regulators of cell-type differentiation
This work introduces Flysta3D-v2, a 3D spatiotemporal multi-omics database that spans
Drosophila development from embryogenesis to metamorphosis. Through the integration
of multimodal data, we detail ...
www.cell.com
June 28, 2025 at 5:57 AM
A Drosophila single-cell 3D spatiotemporal multi-omics atlas unveils panoramic key regulators of cell-type differentiation: Cell
1/2
www.cell.com/cell/abstrac...
1/2
www.cell.com/cell/abstrac...
Reposted by Tony Southall
How 🆒 is this?!? www.cell.com/cell/abstrac...
A host organelle integrates stolen chloroplasts for animal photosynthesis
Sea slugs steal foreign chloroplasts and store them in specialized organelles that
facilitate photosynthesis and eventual digestion to mediate starvation resistance.
www.cell.com
June 25, 2025 at 8:05 PM
How 🆒 is this?!? www.cell.com/cell/abstrac...
Reposted by Tony Southall
That's not what we should be hearing. There is virtually no low-quality research that gets discussed at funding panels, or gets anywhere near being funded. The problem is that not enough high-quality research is funded.
Two senior @ukri.org figures this week have suggested unis could reduce how much research they do
“Concentrating on unique and high contributions & concentrating on less research, has the potential to bring the amount of activity into balance with research funding,” Steven Hill told #ARMA25
(1/2)
“Concentrating on unique and high contributions & concentrating on less research, has the potential to bring the amount of activity into balance with research funding,” Steven Hill told #ARMA25
(1/2)
Research England official: universities could do ‘less’ R&D - Research Professional News
Arma 2025: Director of research asks whether system should provide “disincentives for lower-quality research”
www.researchprofessionalnews.com
June 20, 2025 at 10:49 AM
That's not what we should be hearing. There is virtually no low-quality research that gets discussed at funding panels, or gets anywhere near being funded. The problem is that not enough high-quality research is funded.
Reposted by Tony Southall
I gave in! After students asking for it, I now made a simple figure design checklist.
To help all scientists w/o graphic skills create clear, accessible, and truthful charts!
-> Out in @nature Cell Biology: rdcu.be/erwl4
#DataVisualization #PhD #SciComm
Thx for review @bethcimini.bsky.social + 2
To help all scientists w/o graphic skills create clear, accessible, and truthful charts!
-> Out in @nature Cell Biology: rdcu.be/erwl4
#DataVisualization #PhD #SciComm
Thx for review @bethcimini.bsky.social + 2
A checklist for designing and improving the visualization of scientific data
Nature Cell Biology - Creating clear and engaging scientific figures is crucial to communicate complex data. In this Comment, I condense principles from design, visual perception and data...
rdcu.be
June 18, 2025 at 8:33 AM
I gave in! After students asking for it, I now made a simple figure design checklist.
To help all scientists w/o graphic skills create clear, accessible, and truthful charts!
-> Out in @nature Cell Biology: rdcu.be/erwl4
#DataVisualization #PhD #SciComm
Thx for review @bethcimini.bsky.social + 2
To help all scientists w/o graphic skills create clear, accessible, and truthful charts!
-> Out in @nature Cell Biology: rdcu.be/erwl4
#DataVisualization #PhD #SciComm
Thx for review @bethcimini.bsky.social + 2
Reposted by Tony Southall
Postdoc post in my lab from Autumn this year @lsiexeter.bsky.social @exeter.ac.uk
#Chromatin #StemCells #Enhancer #NeuralCrest #Transcription #CellFate
#NuRDIsTheWord
Apply and/or get in touch!
#Chromatin #StemCells #Enhancer #NeuralCrest #Transcription #CellFate
#NuRDIsTheWord
Apply and/or get in touch!
Looking for a Postdoc? A PDRA position is available in the LSI Exeter with Prof Brian Hendrich from September 2025. Do you have experience in mammalian stem cell culture and a solid understanding of molecular & biochemical lab techniques? Apply! Job Ref: Q05546 jobs.exeter.ac.uk/hrpr_webrecr...
Powered by MHR
jobs.exeter.ac.uk
June 11, 2025 at 10:10 AM
Postdoc post in my lab from Autumn this year @lsiexeter.bsky.social @exeter.ac.uk
#Chromatin #StemCells #Enhancer #NeuralCrest #Transcription #CellFate
#NuRDIsTheWord
Apply and/or get in touch!
#Chromatin #StemCells #Enhancer #NeuralCrest #Transcription #CellFate
#NuRDIsTheWord
Apply and/or get in touch!
Reposted by Tony Southall
✨️ Come join my lab! ✨️ I have an ARUK funded post doc position available for a talented ECR to work with Drosophila and human iPSC derived neurons.
krb-sjobs.brassring.com/TGnewUI/Sear...
krb-sjobs.brassring.com/TGnewUI/Sear...
Job Search | Cardiff University
Search for Internet job results.
krb-sjobs.brassring.com
June 11, 2025 at 10:35 AM
✨️ Come join my lab! ✨️ I have an ARUK funded post doc position available for a talented ECR to work with Drosophila and human iPSC derived neurons.
krb-sjobs.brassring.com/TGnewUI/Sear...
krb-sjobs.brassring.com/TGnewUI/Sear...
Reposted by Tony Southall
New paper from my group is out. We demonstrate that cranial neural crest (CNCC) induction requires the transcription factor SALL4 to physically recruit the BAF chromatin remodeller at CNCC-induction enhancers as early as at the neuroectodermal stage:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Neural crest induction requires SALL4-mediated BAF recruitment to lineage specific enhancers
Neural crest induction begins early during neural plate formation, requiring precise transcriptional control to activate lineage-specific enhancers. Here, we demonstrate that SALL4, a transcription fa...
www.biorxiv.org
June 10, 2025 at 7:25 PM
New paper from my group is out. We demonstrate that cranial neural crest (CNCC) induction requires the transcription factor SALL4 to physically recruit the BAF chromatin remodeller at CNCC-induction enhancers as early as at the neuroectodermal stage:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Tony Southall
Looking for a Postdoc? A PDRA position is available in the LSI Exeter with Prof Brian Hendrich from September 2025. Do you have experience in mammalian stem cell culture and a solid understanding of molecular & biochemical lab techniques? Apply! Job Ref: Q05546 jobs.exeter.ac.uk/hrpr_webrecr...
Powered by MHR
jobs.exeter.ac.uk
June 9, 2025 at 2:01 PM
Looking for a Postdoc? A PDRA position is available in the LSI Exeter with Prof Brian Hendrich from September 2025. Do you have experience in mammalian stem cell culture and a solid understanding of molecular & biochemical lab techniques? Apply! Job Ref: Q05546 jobs.exeter.ac.uk/hrpr_webrecr...
Reposted by Tony Southall
No question, we need to keep FlyBase alive in the present to ensure there's a future.
June 7, 2025 at 3:58 PM
No question, we need to keep FlyBase alive in the present to ensure there's a future.
Reposted by Tony Southall
European Fly PIs: please respond to the email we sent out yesterday and help save FlyBase!
We currently have a call for support that has gone out to European labs, to support FlyBase-UK. We are asking our colleagues from labs in the US and other countries to wait for a similar call to them that will go out in the near future, to support the US sites. We thank you for your patience.
URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
June 4, 2025 at 7:22 AM
European Fly PIs: please respond to the email we sent out yesterday and help save FlyBase!
Reposted by Tony Southall
We are recruiting!! Exciting opportunity to join our team as a Postdoctoral Researcher in the Dept. of Life Sciences at Imperial College as part of the amazing Preventing Plastic Pollution Engineering Biology Hub (P3EB). More information and how to apply here: www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
May 30, 2025 at 10:05 AM
We are recruiting!! Exciting opportunity to join our team as a Postdoctoral Researcher in the Dept. of Life Sciences at Imperial College as part of the amazing Preventing Plastic Pollution Engineering Biology Hub (P3EB). More information and how to apply here: www.imperial.ac.uk/jobs/search-...
Reposted by Tony Southall
UK universities are in the top 3 in global reputation. But they are losing money, cutting programmes, and laying off staff.
International students are the safety net—and it’s being pulled away.
International students are the safety net—and it’s being pulled away.
Will the government’s immigration plans be good for our universities?
The Immigration White Paper aims to reduce international student numbers. But universities need them. Can the circle be squared?
eastangliabylines.co.uk
May 29, 2025 at 5:48 PM
UK universities are in the top 3 in global reputation. But they are losing money, cutting programmes, and laying off staff.
International students are the safety net—and it’s being pulled away.
International students are the safety net—and it’s being pulled away.
Reposted by Tony Southall
Excited to introduce evoCAST: a platform for efficient, programmable gene integration in human cells. This work, a close collab between my PhD lab (Liu group) and @sternberglab.bsky.social, has been such a fun journey to help lead. Huge thanks to all contributors!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase
Programmable gene integration in human cells has the potential to enable mutation-agnostic treatments for loss-of-function genetic diseases and facilitate many applications in the life sciences. CRISP...
www.science.org
May 15, 2025 at 7:06 PM
Excited to introduce evoCAST: a platform for efficient, programmable gene integration in human cells. This work, a close collab between my PhD lab (Liu group) and @sternberglab.bsky.social, has been such a fun journey to help lead. Huge thanks to all contributors!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Tony Southall
Am I a stranger now?
Many have asked ourselves this in the past 24 hours, not only because of where we are from, but because of what the UK is becoming.
You don't defeat Faragism by validating its anti-immigrant rhetoric.
Solidarity with the UK's migrants!
www.theguardian.com/politics/202...
Many have asked ourselves this in the past 24 hours, not only because of where we are from, but because of what the UK is becoming.
You don't defeat Faragism by validating its anti-immigrant rhetoric.
Solidarity with the UK's migrants!
www.theguardian.com/politics/202...
Starmer accused of echoing far right with ‘island of strangers’ speech
Prime minister’s immigration speech was likened by MPs to rhetoric of Enoch Powell
www.theguardian.com
May 13, 2025 at 8:29 AM
Am I a stranger now?
Many have asked ourselves this in the past 24 hours, not only because of where we are from, but because of what the UK is becoming.
You don't defeat Faragism by validating its anti-immigrant rhetoric.
Solidarity with the UK's migrants!
www.theguardian.com/politics/202...
Many have asked ourselves this in the past 24 hours, not only because of where we are from, but because of what the UK is becoming.
You don't defeat Faragism by validating its anti-immigrant rhetoric.
Solidarity with the UK's migrants!
www.theguardian.com/politics/202...
Reposted by Tony Southall
This is insane. Labour is making the very same mistake the Tories made but in a more catastrophic way. A left-leaning party adopting an ultra-right fascist agenda: what could go wrong?
'Every area of the immigration system - work, family and study - will be tightened up', says PM Keir Starmer
- Skill requirements raised to degree level
- English language requirements increased
- Pathway to citizenship increased from five years to 10
- Skill requirements raised to degree level
- English language requirements increased
- Pathway to citizenship increased from five years to 10
May 12, 2025 at 9:41 AM
This is insane. Labour is making the very same mistake the Tories made but in a more catastrophic way. A left-leaning party adopting an ultra-right fascist agenda: what could go wrong?
Reposted by Tony Southall
Finally! (remember the famous 2022 ASCB poster and Twitter discussion) www.biorxiv.org/content/10.1...
Enhanced axonal transport in large vertebrates: KIF5A adaptations in giraffes and pythons
Efficient axonal transport is essential for neuronal function, particularly in species with exceptionally long axons. The Kinesin-1 motor protein KIF5A plays a key role in this process, but whether an...
www.biorxiv.org
May 5, 2025 at 5:05 PM
Finally! (remember the famous 2022 ASCB poster and Twitter discussion) www.biorxiv.org/content/10.1...
Reposted by Tony Southall
Opportunity alert! It's also not in the USA.
My dept in London at Imperial (Bioengineering) is recruiting a group leader at Professor level 🧑🎓 Please RT. It's a great place with world-class expertise in all sorts of biomedical & biological engineering topics like synthetic biology. It's also not in the USA. www.imperial.ac.uk/jobs/search-...
May 2, 2025 at 3:25 PM
Opportunity alert! It's also not in the USA.
Reposted by Tony Southall
New lab paper out! 😀
We describe a new benchtop technique to isolate microRNAs from various cell types in a complex tissue (like the developing CNS). This is a fruitful collab with the Cremer lab from @ibdm.bsky.social journals.plos.org/plosgenetics... 1/n 🧵
We describe a new benchtop technique to isolate microRNAs from various cell types in a complex tissue (like the developing CNS). This is a fruitful collab with the Cremer lab from @ibdm.bsky.social journals.plos.org/plosgenetics... 1/n 🧵
In vivo AGO-APP identifies a module of microRNAs cooperatively preserving neural progenitors
Author summary MicroRNAs (miRNAs) are small RNAs that silence messenger RNAs (mRNAs) by binding to partially complementary sequences. They play a crucial role in cell type specification during develop...
journals.plos.org
April 30, 2025 at 4:50 PM
New lab paper out! 😀
We describe a new benchtop technique to isolate microRNAs from various cell types in a complex tissue (like the developing CNS). This is a fruitful collab with the Cremer lab from @ibdm.bsky.social journals.plos.org/plosgenetics... 1/n 🧵
We describe a new benchtop technique to isolate microRNAs from various cell types in a complex tissue (like the developing CNS). This is a fruitful collab with the Cremer lab from @ibdm.bsky.social journals.plos.org/plosgenetics... 1/n 🧵
Reposted by Tony Southall
New paper/gene drive from the lab! Dropped by NComms on Friday evening on World Malaria Day of all times - without a word of warning….
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A suppression-modification gene drive for malaria control targeting the ultra-conserved RNA gene mir-184 - Nature Communications
Here, the authors describe a highly efficient gene drive targeting the non-coding miR-184 gene. Disruption of the miR-184 gene by the gene drive reduces mosquito lifespan and interferes with survival ...
www.nature.com
April 28, 2025 at 8:27 AM
New paper/gene drive from the lab! Dropped by NComms on Friday evening on World Malaria Day of all times - without a word of warning….
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New preprint! We have discovered that the splicing factor Sex lethal (Sxl - well known for its role in sex determination) binds to chromatin and regulates tRNA synthesis in neurons by interacting with RNA Pol III! Highlighting Sxl as a novel modulator of neuronal homeostasis. tinyurl.com/s44s2z95
Sex-lethal is recruited to chromatin to promote neuronal tRNA synthesis in males through RNA Polymerase III regulation
The RNA-binding protein Sex-lethal (Sxl) is classically known as a master regulator of sex determination and mRNA splicing in Drosophila melanogaster. However, this role is not conserved across specie...
tinyurl.com
April 26, 2025 at 9:36 AM
New preprint! We have discovered that the splicing factor Sex lethal (Sxl - well known for its role in sex determination) binds to chromatin and regulates tRNA synthesis in neurons by interacting with RNA Pol III! Highlighting Sxl as a novel modulator of neuronal homeostasis. tinyurl.com/s44s2z95
Reposted by Tony Southall
Despite there being mounting evidence of Brexit being a monumental exercise only in self-harm…
We continue down this ridiculous road because politicians are too scared to re-open the debate.
We continue down this ridiculous road because politicians are too scared to re-open the debate.
April 21, 2025 at 8:58 AM
Despite there being mounting evidence of Brexit being a monumental exercise only in self-harm…
We continue down this ridiculous road because politicians are too scared to re-open the debate.
We continue down this ridiculous road because politicians are too scared to re-open the debate.
Reposted by Tony Southall
New preprint from my group! Here we studied the contribution of a subset of human- and hominoid-specific transposons (SVA, LTR5HS) to the evolution of human craniofacial development. We specifically focussed on cranial neural crest (CNCC) formation and migration 1/n
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Human-specific transposable elements shaped the evolution of craniofacial development through regulation of neural crest migration
Craniofacial development and neural crest specification are evolutionarily conserved processes, yet subtle modifications to their gene regulatory networks drive species-specific craniofacial diversity...
www.biorxiv.org
April 7, 2025 at 1:26 PM
New preprint from my group! Here we studied the contribution of a subset of human- and hominoid-specific transposons (SVA, LTR5HS) to the evolution of human craniofacial development. We specifically focussed on cranial neural crest (CNCC) formation and migration 1/n
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Tony Southall
Funded PhD Studentship available in my lab at @lsiexeter.bsky.social.
Want to study how chromatin remodellers act on enhancers to facilitate cell fate decisions in human pluripotent cells? Want to work and live in a lively city by the sea? Get in touch/Apply!
lsi.exeter.ac.uk/groups/hendr...
Want to study how chromatin remodellers act on enhancers to facilitate cell fate decisions in human pluripotent cells? Want to work and live in a lively city by the sea? Get in touch/Apply!
lsi.exeter.ac.uk/groups/hendr...
Hendrich Group - Starting Sept 2025 - Living Systems Institute - University of Exeter
Opportunity for LSI PHD studentship – starting in September 2025 or January 2026 PhD Studentship applications will open on 1st...
lsi.exeter.ac.uk
April 12, 2025 at 12:58 PM
Funded PhD Studentship available in my lab at @lsiexeter.bsky.social.
Want to study how chromatin remodellers act on enhancers to facilitate cell fate decisions in human pluripotent cells? Want to work and live in a lively city by the sea? Get in touch/Apply!
lsi.exeter.ac.uk/groups/hendr...
Want to study how chromatin remodellers act on enhancers to facilitate cell fate decisions in human pluripotent cells? Want to work and live in a lively city by the sea? Get in touch/Apply!
lsi.exeter.ac.uk/groups/hendr...