Gaynor Ann Smith
@gaynorasmith.bsky.social
Neuroscience researcher - cell biologist - mitochondriac - fruit fly wrangler- studies neurodegenerative diseases. Senior Lecturer (Assistant Prof.) at Cardiff University.
Reposted by Gaynor Ann Smith
New preprint from our lab! ER geometry sets the tempo of neuronal bursting via Ca²⁺ store-refill—revealing selective neuronal vulnerability to ER-structure problems. Thread to follow.🧠⚡️
www.biorxiv.org/content/10.1...
#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv
www.biorxiv.org/content/10.1...
#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv
October 9, 2025 at 1:08 PM
New preprint from our lab! ER geometry sets the tempo of neuronal bursting via Ca²⁺ store-refill—revealing selective neuronal vulnerability to ER-structure problems. Thread to follow.🧠⚡️
www.biorxiv.org/content/10.1...
#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv
www.biorxiv.org/content/10.1...
#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv
Reposted by Gaynor Ann Smith
Amazing result from Huntington’s disease researchers from @cardiffunilib.bsky.social and @ucl.ac.uk and the wider HD team for getting to this monumental point! 👇🧬
healthandcareresearchwales.org/about/news/w...
healthandcareresearchwales.org/about/news/w...
Wales leads pioneering gene therapy trial shown to slow progression of Huntington’s disease
A Welsh research centre, funded by Health and Care Research Wales, is at the forefront of a major breakthrough in the treatment of Huntington’s Disease after playing a leading role in a global gene th...
healthandcareresearchwales.org
September 30, 2025 at 8:49 AM
Amazing result from Huntington’s disease researchers from @cardiffunilib.bsky.social and @ucl.ac.uk and the wider HD team for getting to this monumental point! 👇🧬
healthandcareresearchwales.org/about/news/w...
healthandcareresearchwales.org/about/news/w...
Amazing result from Huntington’s disease researchers from @cardiffunilib.bsky.social and @ucl.ac.uk and the wider HD team for getting to this monumental point! 👇🧬
healthandcareresearchwales.org/about/news/w...
healthandcareresearchwales.org/about/news/w...
Wales leads pioneering gene therapy trial shown to slow progression of Huntington’s disease
A Welsh research centre, funded by Health and Care Research Wales, is at the forefront of a major breakthrough in the treatment of Huntington’s Disease after playing a leading role in a global gene th...
healthandcareresearchwales.org
September 30, 2025 at 8:49 AM
Amazing result from Huntington’s disease researchers from @cardiffunilib.bsky.social and @ucl.ac.uk and the wider HD team for getting to this monumental point! 👇🧬
healthandcareresearchwales.org/about/news/w...
healthandcareresearchwales.org/about/news/w...
The Race Against Dementia 2025 Summit was a fantastic way to learn how to do things faster and more efficiently in dementia research @racingdementia 🧬🔬🚘 learning from experts from @f1tv.bsky.social and @portalmclarenbr.bsky.social
September 29, 2025 at 9:10 AM
The Race Against Dementia 2025 Summit was a fantastic way to learn how to do things faster and more efficiently in dementia research @racingdementia 🧬🔬🚘 learning from experts from @f1tv.bsky.social and @portalmclarenbr.bsky.social
A fully funded PhD opportunity as part of the @gw4biomeddtp.bsky.social program! Supervisors between @cardiffunilib.bsky.social and @brisunipress.bsky.social ⬇️ #Drosophila #Huntington’s #Mitochondria
gw4biomed.ac.uk/when-dna-bre...
gw4biomed.ac.uk/when-dna-bre...
When DNA Breaks and Mitochondria Fail: Investigating Drivers of Huntington’s Disease - GW4 BioMed MRC DTP
Project Code MRCNMH26Ca Smith Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Huntington’s disease (HD) is a fatal inherited brain disorder with no ...
gw4biomed.ac.uk
September 4, 2025 at 1:10 PM
A fully funded PhD opportunity as part of the @gw4biomeddtp.bsky.social program! Supervisors between @cardiffunilib.bsky.social and @brisunipress.bsky.social ⬇️ #Drosophila #Huntington’s #Mitochondria
gw4biomed.ac.uk/when-dna-bre...
gw4biomed.ac.uk/when-dna-bre...
Thank you @rorycj.bsky.social for writing a fantastic article about your visit to the @ukdri.ac.uk labs @cardiffunilib.bsky.social
rorycellanjones.substack.com/p/dementia-r...
rorycellanjones.substack.com/p/dementia-r...
Dementia Research - meet the scientists
Big data, fruit flies and the battle against brain diseases
rorycellanjones.substack.com
July 12, 2025 at 10:11 AM
Thank you @rorycj.bsky.social for writing a fantastic article about your visit to the @ukdri.ac.uk labs @cardiffunilib.bsky.social
rorycellanjones.substack.com/p/dementia-r...
rorycellanjones.substack.com/p/dementia-r...
✨️ Come join my lab! ✨️ I have an ARUK funded post doc position available for a talented ECR to work with Drosophila and human iPSC derived neurons.
krb-sjobs.brassring.com/TGnewUI/Sear...
krb-sjobs.brassring.com/TGnewUI/Sear...
Job Search | Cardiff University
Search for Internet job results.
krb-sjobs.brassring.com
June 11, 2025 at 10:35 AM
✨️ Come join my lab! ✨️ I have an ARUK funded post doc position available for a talented ECR to work with Drosophila and human iPSC derived neurons.
krb-sjobs.brassring.com/TGnewUI/Sear...
krb-sjobs.brassring.com/TGnewUI/Sear...
Our latest pre-print about the conserved Alzheimer’s disease risk gene Wwox is now available! A lot of hard graft from Hannah Clarke and @danielmaddison.bsky.social and the rest of the team! #drosophila #mitochondria #dementia #Neurodegeneration #metabolism
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Alzheimer's disease risk gene Wwox protects against amyloid pathology through metabolic reprogramming
Genome wide association studies have identified multiple loci that mediate the risk of developing late-onset Alzheimer's Disease (LOAD). The gene WW-domain containing oxidoreductase (WWOX) has been id...
www.biorxiv.org
May 8, 2025 at 11:43 AM
Our latest pre-print about the conserved Alzheimer’s disease risk gene Wwox is now available! A lot of hard graft from Hannah Clarke and @danielmaddison.bsky.social and the rest of the team! #drosophila #mitochondria #dementia #Neurodegeneration #metabolism
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Gaynor Ann Smith
Summary:
(1) Baseline axonal SARM1 NADase activity may differ between people due to NMNAT2 differences
(2) This may confer risk of miscarriage and neurological disorders
(3) NR is safe in most people but there is some need for caution
link.springer.com/article/10.1...
Congratulations, Christina!
(1) Baseline axonal SARM1 NADase activity may differ between people due to NMNAT2 differences
(2) This may confer risk of miscarriage and neurological disorders
(3) NR is safe in most people but there is some need for caution
link.springer.com/article/10.1...
Congratulations, Christina!
November 24, 2024 at 12:18 PM
Summary:
(1) Baseline axonal SARM1 NADase activity may differ between people due to NMNAT2 differences
(2) This may confer risk of miscarriage and neurological disorders
(3) NR is safe in most people but there is some need for caution
link.springer.com/article/10.1...
Congratulations, Christina!
(1) Baseline axonal SARM1 NADase activity may differ between people due to NMNAT2 differences
(2) This may confer risk of miscarriage and neurological disorders
(3) NR is safe in most people but there is some need for caution
link.springer.com/article/10.1...
Congratulations, Christina!
Thanks for the warm welcome onto Bluesky!
November 23, 2024 at 12:12 PM
Thanks for the warm welcome onto Bluesky!