Jose Jimenez
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jjimenez.bsky.social
Jose Jimenez
@jjimenez.bsky.social
Reader in Synthetic Biology at Imperial College London #synbio and evolution for health, the environment and the circular economy josejimenezlab.com
Pinned
Preprint alert!! Delighted to share Eve Nery's work exploring the evolutionary landscape of light-harvesting complexes. She found a new variant shifted to the red that allows purple bacteria to grow faster under high intensity light www.biorxiv.org/content/10.1...
Directed evolution and characterisation of light harvesting complexes with altered energy transfer dynamics in purple non-sulfur bacteria
Purple non-sulfur bacteria (PNSB) are metabolically versatile microorganisms that inhabit diverse environments taking advantage of a remarkably efficient photosynthetic machinery. In this work, we des...
www.biorxiv.org
Reposted by Jose Jimenez
What happens when you suddenly remove half of an essential enzyme from cells? 🤔

We watched in real-time as cells deploy multiple backup strategies to buffer against changes in RNA Pol II abundance.

Our lab's new preprint 👇

bit.ly/4pyPgax
Hierarchical buffering of cellular RNA polymerase II pools maintains transcriptional homeostasis
RNA polymerase II (Pol II) abundance and transcriptional output are coordinated across diverse conditions to maintain mRNA homeostasis. To determine whether Pol II acts as a limiting factor for transc...
bit.ly
January 15, 2026 at 5:25 AM
Reposted by Jose Jimenez
#CIBpapers

Researchers at the @cib-csic.bsky.social present a new bacterium capable of transforming plastic waste into high-value bioproducts

More info 🔗https://cib.csic.es/news/research/researchers-cib-margarita-salas-present-new-bacterium-capable-transforming-plastic
January 8, 2026 at 8:02 AM
New year resolution: develop the strength and technique to do ONE bloody muscle-up. Not a lot to ask. That at the back is the Bay of Cadiz. Not a bad place to start 2026. Happy New Year!!
January 1, 2026 at 10:08 AM
Really happy to see this paper out. It looks like Santa had us on the nice list!! Congrats to all authors, it's been such a joy to be involved!
December 26, 2025 at 11:04 AM
Reposted by Jose Jimenez
Manchester Institute of Biotechnology is looking for a new Professor. There are a few priority areas including microbial engineering (broadly defined, from pathways to cells to microbiomes). Closing 12 Jan.
Join us in the best city in the UK 😜
www.jobs.manchester.ac.uk/Job/JobDetai...
Professorial Appointment within the Manchester Institute of Biotechnology:Manchester Institute of Biotechnology
Applications are invited for a professorial appointment to be based in the Manchester Institute of Biotechnology (MIB) at the University of Manchester (UoM). The successful candidate will join a dynamic research environment at an exciting time and will help shape the institute research priorities and national/international profile. We are open to high quality applications from across the broad engineering biology and biotechnology landscape. Specific areas of interest include but are not limited to chemical biology of disease related proteins, natural product biosynthesis and enzyme discovery; structural biology and mechanistic enzymology; and microbial engineering.
www.jobs.manchester.ac.uk
December 20, 2025 at 12:21 PM
Reposted by Jose Jimenez
So you think your mammalian plasmids have nothing to fear from cloning and propagation in E.coli?
Quantitative profiling of millions of nucleotides by Tom Copeman will prove you wrong! Supervised with the amazing @proftomellis.bsky.social and AZ, now on BioRxiv:
doi.org/10.64898/202...
Quantitative profiling of millions of nucleotides reveals sequence-encoded interactions that govern plasmid propagation
Plasmids are central to modern biotechnology, especially therapeutic development, yet their propagation in Escherichia coli remains difficult to predict. Although expression-induced burden is well und...
doi.org
December 17, 2025 at 8:19 AM
Reposted by Jose Jimenez
- Using novel genomic tools to understand the evolution of Acinetobacter baumannii pathogenicity in clinical environments

Supervisors: David Grainger, Katie Hopkins, Jessica Blair, Willem van Schaik

www.findaphd.com/phds/project...

(4/7)
Using novel genomic tools to understand the evolution of Acinetobacter baumannii pathogenicity in clinical environments at University of Birmingham on FindAPhD.com
PhD Project - Using novel genomic tools to understand the evolution of Acinetobacter baumannii pathogenicity in clinical environments at University of Birmingham, listed on FindAPhD.com
www.findaphd.com
December 16, 2025 at 6:55 PM
As the year comes close to an end, just wanted to thank all team members for making my everyday better. Really proud of this talented and selfless group of scientists!!
December 16, 2025 at 9:24 AM
Reposted by Jose Jimenez
We're advertising for a bacteriology technician and a post-doc to work on AI-guided antibiotic development as part of a large multidisciplinary Fleming Initiative project:
www.imperial.ac.uk/jobs/search-...

www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
December 3, 2025 at 7:23 AM
Reposted by Jose Jimenez
Our paper is out! Analysis of 30K+ genomes revealed that CPR bacteria assemble their ribosomes in unconventional ways, and that these assembly processes appear to have co-evolved with ribosome structure. doi.org/10.1093/molb... #Ribosome #Evolution #Patescibacteria #MBE
November 24, 2025 at 1:15 PM
Just found this definition in the gov.uk webpage that thought might be useful for some. Btw, someone between 14 and 18 years old is sometimes called a Young Person, but is still legally a child.
November 14, 2025 at 8:52 PM
The scariest thing I have seen this Halloween
October 31, 2025 at 7:05 PM
Reposted by Jose Jimenez
The Wallace Lab is expanding in 2026, with five new Postdoctoral Research Associate positions now open. If you're passionate about engineering biology for sustainability, we'd love to hear from you! 🧬 ♻️

Deadline: 12th November 2025, details below ⬇️
October 29, 2025 at 12:34 PM
Reposted by Jose Jimenez
1 week left to apply for a postdoctoral position in my group to lead the experimental component of a 5 year BBSRC project on synthetic microbial communities

www.ucl.ac.uk/work-at-ucl/...
October 20, 2025 at 9:49 AM
Reposted by Jose Jimenez
Oct. 23, 6pm at UCL 🥳! Excited for:

🧬 Dirk Benzinger (Briscoe Lab)
Dissecting and engineering cellular signal processing with synthetic biology and optogenetics

🌍 Brooke Wain (Jimenez Lab)
Biocatalytic recycling of plastic: industrial viability and limitations
events.humanitix.com/london-synbi...
London SynBio Network 11
London SynBio afterwork talks and networking event on Thursday 23rd of September
events.humanitix.com
October 16, 2025 at 11:05 AM
This is how Castilla La Mancha will conquer the world: blending tradition and empathy. I'd recommend all world leaders to complete a couple of grape harvests (vendimia) to develop thoughtful leadership. Great mix of cardio and strength exercise too!
www.theguardian.com/world/2025/o...
‘It’s a question of humanity’: how a small Spanish town made headlines over its immigration stance
Mayor explains why Villamalea unanimously backed call to regularise undocumented migrants – across party lines
www.theguardian.com
October 11, 2025 at 2:33 PM
New preprint this time through a fantastic collaboration with @jorgebarriuso.bsky.social and team. We have discovered the genetic basis behind the remarkable ability of Pseudomonas putida JM37 to use the PET #plastic monomer ethylene glycol as a growth substrate! www.biorxiv.org/content/10.1...
Pseudomonas putida JM37 as a novel bacterial chassis for ethylene glycol upcycling
Ethylene glycol (EG), one of the main monomers of polyethylene terephthalate (PET), is an attractive target for microbial upcycling. Despite this interest, there is a limited number of described organ...
www.biorxiv.org
October 8, 2025 at 8:48 AM
Reposted by Jose Jimenez
Independent research fellowships leading to tenured positions at the John Innes Centre.

Repost = nice. Thank you very much!!!
Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.

Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.

Find out more: www.jic.ac.uk/training-car...
Independent Research Fellowships Leading to Tenured Faculty Positions | John Innes Centre
The John Innes Centre (JIC), is a world leading centre of excellence in plant and microbial sciences based on the Norwich Research Park, UK. We are inviting applications from outstanding researchers…
www.jic.ac.uk
October 3, 2025 at 4:06 PM
Reposted by Jose Jimenez
Mapping the evolution of computationally designed protein binders [new]
Evolve comp. mini-protein binders *in vivo*. Maps seq-affinity.
October 6, 2025 at 3:15 AM
Reposted by Jose Jimenez
Microbial stem cells support productivity in dedicated factory cells in an asymmetrically dividing E. coli system
doi.org/10.1101/2025...
October 6, 2025 at 7:03 AM
Preprint alert!! Delighted to share Eve Nery's work exploring the evolutionary landscape of light-harvesting complexes. She found a new variant shifted to the red that allows purple bacteria to grow faster under high intensity light www.biorxiv.org/content/10.1...
Directed evolution and characterisation of light harvesting complexes with altered energy transfer dynamics in purple non-sulfur bacteria
Purple non-sulfur bacteria (PNSB) are metabolically versatile microorganisms that inhabit diverse environments taking advantage of a remarkably efficient photosynthetic machinery. In this work, we des...
www.biorxiv.org
October 3, 2025 at 7:07 AM