jared toettcher
@toettch.bsky.social
Dad, bioengineer, climber, skier, surfer (in that order, more or less).
Chaotic good alignment, or so my lab tells me...
Chaotic good alignment, or so my lab tells me...
Reposted by jared toettcher
Today I'd like to honor the memory of my mentor and friend, Roger Tsien, born 1952 February 1. Today would have been Roger's 74th birthday.
Most know Roger for his 2008 Chemistry Nobel Prize with Shimomura and Chalfie. Roger made GFP into the versatile imaging method it is now.
Most know Roger for his 2008 Chemistry Nobel Prize with Shimomura and Chalfie. Roger made GFP into the versatile imaging method it is now.
February 1, 2026 at 10:51 PM
Today I'd like to honor the memory of my mentor and friend, Roger Tsien, born 1952 February 1. Today would have been Roger's 74th birthday.
Most know Roger for his 2008 Chemistry Nobel Prize with Shimomura and Chalfie. Roger made GFP into the versatile imaging method it is now.
Most know Roger for his 2008 Chemistry Nobel Prize with Shimomura and Chalfie. Roger made GFP into the versatile imaging method it is now.
Reposted by jared toettcher
Our new paper just out!
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
January 31, 2026 at 1:53 PM
Our new paper just out!
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Reposted by jared toettcher
Our research on magneto-sensitive fluorescent proteins and some of their applications has now been published!
Huge thank you to the many many people involved in making this happen. 🧪
www.nature.com/articles/s41...
Huge thank you to the many many people involved in making this happen. 🧪
www.nature.com/articles/s41...
Quantum spin resonance in engineered proteins for multimodal sensing - Nature
A recently developed class of magneto-sensitive fluorescent proteins are engineered to alter the properties of their response to magnetic fields and radio frequencies, enabling multimodal sensing of b...
www.nature.com
January 21, 2026 at 4:19 PM
Our research on magneto-sensitive fluorescent proteins and some of their applications has now been published!
Huge thank you to the many many people involved in making this happen. 🧪
www.nature.com/articles/s41...
Huge thank you to the many many people involved in making this happen. 🧪
www.nature.com/articles/s41...
Reposted by jared toettcher
Blog post: Just quit
Quitting projects in science is hard, but we should be doing a lot more of it.
open.substack.com/pub/arjunraj...
Quitting projects in science is hard, but we should be doing a lot more of it.
open.substack.com/pub/arjunraj...
Just quit
Quitting projects in science is hard, but we should be doing a lot more of it.
open.substack.com
December 30, 2025 at 3:02 PM
Blog post: Just quit
Quitting projects in science is hard, but we should be doing a lot more of it.
open.substack.com/pub/arjunraj...
Quitting projects in science is hard, but we should be doing a lot more of it.
open.substack.com/pub/arjunraj...
Reposted by jared toettcher
Here's another exciting doctoral project led by Research Group Leader Beatrice Ramm at the Friedrich Miescher Laboratory.
Check the list of other available projects on our website:
lnkd.in/gEMXNQY6
The application portal is open so apply now!
#PhD #IMPRS #graduateprogram #maxplanck
Check the list of other available projects on our website:
lnkd.in/gEMXNQY6
The application portal is open so apply now!
#PhD #IMPRS #graduateprogram #maxplanck
December 9, 2025 at 9:22 AM
Here's another exciting doctoral project led by Research Group Leader Beatrice Ramm at the Friedrich Miescher Laboratory.
Check the list of other available projects on our website:
lnkd.in/gEMXNQY6
The application portal is open so apply now!
#PhD #IMPRS #graduateprogram #maxplanck
Check the list of other available projects on our website:
lnkd.in/gEMXNQY6
The application portal is open so apply now!
#PhD #IMPRS #graduateprogram #maxplanck
Reposted by jared toettcher
Janelia is hiring! "Invent new imaging methods, molecular tools, or protein chemistry approaches"
www.janelia.org/content/lead...
www.janelia.org/content/lead...
Lead a lab at Janelia
www.janelia.org
December 8, 2025 at 8:41 PM
Janelia is hiring! "Invent new imaging methods, molecular tools, or protein chemistry approaches"
www.janelia.org/content/lead...
www.janelia.org/content/lead...
An elegant sprite!
November 27, 2025 at 2:02 AM
An elegant sprite!
Reposted by jared toettcher
So happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth!
#protistsonsky 🧵
#protistsonsky 🧵
November 25, 2025 at 8:41 PM
So happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth!
#protistsonsky 🧵
#protistsonsky 🧵
Reposted by jared toettcher
The lab’s first pre-print! We investigated how growth-inducing Erk activity waves are regulated in regenerating zebrafish scales. We discovered that Erk waves are followed by waves of expression of their own inhibitors, as predicted by excitable waves theory. tinyurl.com/26r2cmpj
November 20, 2025 at 6:11 PM
The lab’s first pre-print! We investigated how growth-inducing Erk activity waves are regulated in regenerating zebrafish scales. We discovered that Erk waves are followed by waves of expression of their own inhibitors, as predicted by excitable waves theory. tinyurl.com/26r2cmpj
Reminds me of a guy I knew in grad school who filled out his NCAA bracket based on amino acid hydrophilicity (ignoring non AA letters). D(u)KE always did well :)
November 11, 2025 at 12:43 AM
Reminds me of a guy I knew in grad school who filled out his NCAA bracket based on amino acid hydrophilicity (ignoring non AA letters). D(u)KE always did well :)
Reposted by jared toettcher
Domesticated animals have pulled our heavy carts and turned our large mills for centuries. But what about the opposite end of the spectrum—what if the wheel you want to turn is so small you can’t see it?
Turns out we can harness the power of bacteria to power the world’s smallest machines.
1/7 ⚛️🧪
Turns out we can harness the power of bacteria to power the world’s smallest machines.
1/7 ⚛️🧪
October 26, 2025 at 2:01 AM
Domesticated animals have pulled our heavy carts and turned our large mills for centuries. But what about the opposite end of the spectrum—what if the wheel you want to turn is so small you can’t see it?
Turns out we can harness the power of bacteria to power the world’s smallest machines.
1/7 ⚛️🧪
Turns out we can harness the power of bacteria to power the world’s smallest machines.
1/7 ⚛️🧪
Reposted by jared toettcher
Great Job - Great Colleagues - Great Science👍
Help us pick the next generation of @hhmi.org Investigators, Freeman Hrabowski Scholars, Hanna Gray Fellows, Gilliam Fellows
Relocation to DC is required, perfect for academic PIs looking for their next chapter
hhmi.wd1.myworkdayjobs.com/External/job...
Help us pick the next generation of @hhmi.org Investigators, Freeman Hrabowski Scholars, Hanna Gray Fellows, Gilliam Fellows
Relocation to DC is required, perfect for academic PIs looking for their next chapter
hhmi.wd1.myworkdayjobs.com/External/job...
Senior Director - Scientific Officer
Primary Work Address: 4000 Jones Bridge Road, Chevy Chase, MD, 20815 Current HHMI Employees, click here to apply via your Workday account. The Howard Hughes Medical Institute (HHMI) advances the disco...
hhmi.wd1.myworkdayjobs.com
October 9, 2025 at 9:48 PM
Great Job - Great Colleagues - Great Science👍
Help us pick the next generation of @hhmi.org Investigators, Freeman Hrabowski Scholars, Hanna Gray Fellows, Gilliam Fellows
Relocation to DC is required, perfect for academic PIs looking for their next chapter
hhmi.wd1.myworkdayjobs.com/External/job...
Help us pick the next generation of @hhmi.org Investigators, Freeman Hrabowski Scholars, Hanna Gray Fellows, Gilliam Fellows
Relocation to DC is required, perfect for academic PIs looking for their next chapter
hhmi.wd1.myworkdayjobs.com/External/job...
Reposted by jared toettcher
Want to get started with smart microscopy? 🧠🔬
Check out our online repository with implementations from labs and industry -- lots of practical tips and links to sample code! smartmicroscopy.github.io/implementati...
More details in the ✨updated preprint!✨
www.biorxiv.org/content/10.1...
Check out our online repository with implementations from labs and industry -- lots of practical tips and links to sample code! smartmicroscopy.github.io/implementati...
More details in the ✨updated preprint!✨
www.biorxiv.org/content/10.1...
October 1, 2025 at 9:43 AM
Want to get started with smart microscopy? 🧠🔬
Check out our online repository with implementations from labs and industry -- lots of practical tips and links to sample code! smartmicroscopy.github.io/implementati...
More details in the ✨updated preprint!✨
www.biorxiv.org/content/10.1...
Check out our online repository with implementations from labs and industry -- lots of practical tips and links to sample code! smartmicroscopy.github.io/implementati...
More details in the ✨updated preprint!✨
www.biorxiv.org/content/10.1...
Reposted by jared toettcher
🚀 Our new paper is out @natmethods.nature.com!
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
September 22, 2025 at 6:27 PM
🚀 Our new paper is out @natmethods.nature.com!
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Reposted by jared toettcher
SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N
September 17, 2025 at 5:20 PM
SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N
Congrats, Daniel!
September 11, 2025 at 1:07 AM
Congrats, Daniel!
Reposted by jared toettcher
Out in @science.org! We found that the intestine doesn’t just push out cells when crowded. Instead, cells are in a mechanical tug-of-war, and weaker ones are extruded. A new view of how our gut keeps its balance and stays healthy.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Epithelial tension controls intestinal cell extrusion
Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...
www.science.org
September 6, 2025 at 9:28 AM
Out in @science.org! We found that the intestine doesn’t just push out cells when crowded. Instead, cells are in a mechanical tug-of-war, and weaker ones are extruded. A new view of how our gut keeps its balance and stays healthy.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by jared toettcher
Very excited to be co-organizing this meeting next February. Fellow collective behavior enthusiasts, this one is for you!
✨ How do bird flocks form or diseases emerge?
Join the brand-new EMBO | EMBL Symposium #EESCollectivity and explore how collective behaviours arise from fundamental principles across biological systems 🧬🦠🐒
💻 s.embl.org/ees26-01-bl
✒️ Submit your abstract by 18 Nov
Join the brand-new EMBO | EMBL Symposium #EESCollectivity and explore how collective behaviours arise from fundamental principles across biological systems 🧬🦠🐒
💻 s.embl.org/ees26-01-bl
✒️ Submit your abstract by 18 Nov
August 21, 2025 at 12:04 PM
Very excited to be co-organizing this meeting next February. Fellow collective behavior enthusiasts, this one is for you!
Check out those figure making skills! She should do Illustrator tutorials.
August 23, 2025 at 7:27 PM
Check out those figure making skills! She should do Illustrator tutorials.
On kid number 3 (kid 1 born in my last year as a postdoc) and this has been my weekend schedule for the better part of a decade :)
August 23, 2025 at 6:27 PM
On kid number 3 (kid 1 born in my last year as a postdoc) and this has been my weekend schedule for the better part of a decade :)
Reposted by jared toettcher
Latest paper elifesciences.org/articles/107... closes an important cycle in our efforts to study regeneration: week-long recordings allow us to observe the behaviour of cells during the entire course of regeneration in a crustacean leg – bright objects in movie are fluorescent nuclei of cells. 1/6
August 8, 2025 at 5:39 PM
Latest paper elifesciences.org/articles/107... closes an important cycle in our efforts to study regeneration: week-long recordings allow us to observe the behaviour of cells during the entire course of regeneration in a crustacean leg – bright objects in movie are fluorescent nuclei of cells. 1/6
Reposted by jared toettcher
🤩Wow huge opportunity alert!
EMBL Cell Biology and Biophysics department is searching for a new director. A major position to lead this field in Europe and beyond.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Head of the Cell Biology and Biophysics Unit
The European Molecular Biology Laboratory (EMBL) is Europe’s flagship life sciences organisation, and one of the world’s leading research institutions. An intergovernmental organisation of 29 Member S...
embl.wd103.myworkdayjobs.com
July 29, 2025 at 4:30 PM
🤩Wow huge opportunity alert!
And for your Friday afternoon, some in vivo ERK and RTK biosensor eye candy :)
pYtags - our in vivo biosensors for receptor tyrosine kinases - in all their beauty on the cover of Cell Reports! Read more here: www.cell.com/cell-reports...
July 22, 2025 at 9:16 PM
And for your Friday afternoon, some in vivo ERK and RTK biosensor eye candy :)
Reposted by jared toettcher
NIH will only accept six applications per PI per calendar year. drugmonkey.wordpress.com/2025/07/17/n...
NIH will only accept six applications per PI per calendar year.
NIH has issued NOT-OD-25-132 Supporting Fairness and Originality in NIH Research Applications which informs us that NIH will only accept six new, renewal, resubmission, or revision applications fro…
drugmonkey.wordpress.com
July 17, 2025 at 5:44 PM
NIH will only accept six applications per PI per calendar year. drugmonkey.wordpress.com/2025/07/17/n...
Reposted by jared toettcher
I was explaining to my Ukrainian colleague the phrase ‘There’s no such thing as a free lunch’. She told me the equivalent in Ukrainian is ‘The only free cheese is in the mousetrap’ - which is so much better
July 16, 2025 at 6:39 AM
I was explaining to my Ukrainian colleague the phrase ‘There’s no such thing as a free lunch’. She told me the equivalent in Ukrainian is ‘The only free cheese is in the mousetrap’ - which is so much better