jared toettcher
@toettch.bsky.social
Dad, bioengineer, climber, skier, surfer (in that order, more or less).
Chaotic good alignment, or so my lab tells me...
Chaotic good alignment, or so my lab tells me...
There's lots more in the paper, but I just want to emphasize that an ideal switch:
- Should be easily adapted to respond to other kinases.
- Should easily "plug into" other target proteins.
Both are true! For example, here is a "phospho-nanobody" that binds actin only when ERK phosphorylates it :)
- Should be easily adapted to respond to other kinases.
- Should easily "plug into" other target proteins.
Both are true! For example, here is a "phospho-nanobody" that binds actin only when ERK phosphorylates it :)
April 21, 2025 at 4:08 PM
There's lots more in the paper, but I just want to emphasize that an ideal switch:
- Should be easily adapted to respond to other kinases.
- Should easily "plug into" other target proteins.
Both are true! For example, here is a "phospho-nanobody" that binds actin only when ERK phosphorylates it :)
- Should be easily adapted to respond to other kinases.
- Should easily "plug into" other target proteins.
Both are true! For example, here is a "phospho-nanobody" that binds actin only when ERK phosphorylates it :)