Tim Coorens
@timcoorens.bsky.social
Research Group Leader at EMBL-EBI | Former postdoc
at Broad Institute | Former PhD student at Sanger Institute | Lineage tracing, cancer genomics, human development
at Broad Institute | Former PhD student at Sanger Institute | Lineage tracing, cancer genomics, human development
Reposted by Tim Coorens
Welcome @timcoorens.bsky.social 🇳🇱, our new Research Group Leader.
Find out how Tim’s group is exploring using large-scale single-cell and spatial data to trace cell lineages, understand cancer origins, and uncover how mutations drive disease.
www.ebi.ac.uk/about/news/p...
🖥️🧬
Find out how Tim’s group is exploring using large-scale single-cell and spatial data to trace cell lineages, understand cancer origins, and uncover how mutations drive disease.
www.ebi.ac.uk/about/news/p...
🖥️🧬
Welcome: Tim Coorens
EMBL-EBI’s newest Research Group Leader is investigating how somatic mutations reveal the hidden histories of human cells.
www.ebi.ac.uk
August 12, 2025 at 9:04 AM
Welcome @timcoorens.bsky.social 🇳🇱, our new Research Group Leader.
Find out how Tim’s group is exploring using large-scale single-cell and spatial data to trace cell lineages, understand cancer origins, and uncover how mutations drive disease.
www.ebi.ac.uk/about/news/p...
🖥️🧬
Find out how Tim’s group is exploring using large-scale single-cell and spatial data to trace cell lineages, understand cancer origins, and uncover how mutations drive disease.
www.ebi.ac.uk/about/news/p...
🖥️🧬
The cells in our bodies constantly acquire mutations. But what are the patterns of mutations across tissues? How do mutations in normal cells lead to cancer and disease? These are questions we will tackle within the Somatic Mosaicism across Human Tissues (SMaHT) Network, now described in @nature.com
The Somatic Mosaicism across Human Tissues Network - Nature
The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.
www.nature.com
July 3, 2025 at 2:29 PM
The cells in our bodies constantly acquire mutations. But what are the patterns of mutations across tissues? How do mutations in normal cells lead to cancer and disease? These are questions we will tackle within the Somatic Mosaicism across Human Tissues (SMaHT) Network, now described in @nature.com
Reposted by Tim Coorens
Upcoming #CiMUSseminar on Monday ⤵️
🗣 Dr. @timcoorens.bsky.social from @ebi.embl.org :
🧪 "Somatic mutations across normal tissues: past, present, future"
📅 June 30, 1 PM
📍 Theatre room, CiMUS
#RedeCiGUS #FondosEuropeos
@mobilegenomes.bsky.social @usc.gal
🗣 Dr. @timcoorens.bsky.social from @ebi.embl.org :
🧪 "Somatic mutations across normal tissues: past, present, future"
📅 June 30, 1 PM
📍 Theatre room, CiMUS
#RedeCiGUS #FondosEuropeos
@mobilegenomes.bsky.social @usc.gal
June 27, 2025 at 8:24 AM
Upcoming #CiMUSseminar on Monday ⤵️
🗣 Dr. @timcoorens.bsky.social from @ebi.embl.org :
🧪 "Somatic mutations across normal tissues: past, present, future"
📅 June 30, 1 PM
📍 Theatre room, CiMUS
#RedeCiGUS #FondosEuropeos
@mobilegenomes.bsky.social @usc.gal
🗣 Dr. @timcoorens.bsky.social from @ebi.embl.org :
🧪 "Somatic mutations across normal tissues: past, present, future"
📅 June 30, 1 PM
📍 Theatre room, CiMUS
#RedeCiGUS #FondosEuropeos
@mobilegenomes.bsky.social @usc.gal
Reposted by Tim Coorens
🚨Chemo treatment upgrade!🚨
Check out our approach to modernise chemotherapy treatment published today in @natgenet.nature.com. From @cniostopcancer.bsky.social #TailorBio @cruk-ci.bsky.social www.nature.com/articles/s41... More details 👇
Check out our approach to modernise chemotherapy treatment published today in @natgenet.nature.com. From @cniostopcancer.bsky.social #TailorBio @cruk-ci.bsky.social www.nature.com/articles/s41... More details 👇
www.nature.com
June 23, 2025 at 9:03 AM
🚨Chemo treatment upgrade!🚨
Check out our approach to modernise chemotherapy treatment published today in @natgenet.nature.com. From @cniostopcancer.bsky.social #TailorBio @cruk-ci.bsky.social www.nature.com/articles/s41... More details 👇
Check out our approach to modernise chemotherapy treatment published today in @natgenet.nature.com. From @cniostopcancer.bsky.social #TailorBio @cruk-ci.bsky.social www.nature.com/articles/s41... More details 👇
Reposted by Tim Coorens
Social media grump Kamila has finally made it onto Bluesky!
Please check out my new perspective on metastasis evolution in @natrevcancer.nature.com if you need a reprieve from the news.
I tried my best to develop some new conceptual thoughts here, you be the judge whether I succeeded.
Please check out my new perspective on metastasis evolution in @natrevcancer.nature.com if you need a reprieve from the news.
I tried my best to develop some new conceptual thoughts here, you be the judge whether I succeeded.
🚨 PERSEPCTIVE
Naxerova explains how genetic analysis of primary tumors & metastases can distinguish competing metastasis models, arguing that quantifying whether metastasis occurs through nonrandom lineage selection could offer insights into metastasis biology.
📖 👇
Naxerova explains how genetic analysis of primary tumors & metastases can distinguish competing metastasis models, arguing that quantifying whether metastasis occurs through nonrandom lineage selection could offer insights into metastasis biology.
📖 👇
Evolutionary paths towards metastasis - Nature Reviews Cancer
In this Perspective, Kamila Naxerova discusses how genetic analyses of primary tumours and matched metastases can distinguish between competing metastasis evolution models, arguing that further insights into human metastasis biology could be enabled by a framework that rigorously quantifies whether metastases descend from a nonrandom selection of primary tumour lineages.
bit.ly
May 21, 2025 at 12:06 AM
Social media grump Kamila has finally made it onto Bluesky!
Please check out my new perspective on metastasis evolution in @natrevcancer.nature.com if you need a reprieve from the news.
I tried my best to develop some new conceptual thoughts here, you be the judge whether I succeeded.
Please check out my new perspective on metastasis evolution in @natrevcancer.nature.com if you need a reprieve from the news.
I tried my best to develop some new conceptual thoughts here, you be the judge whether I succeeded.
Reposted by Tim Coorens
If you’ve ever wondered about the statistical significance of differences among mutational signature profiles, check out our new Aggregate Mutation Spectrum Distance (AMSD) preprint co-led by Sam Hart and @alisonfeder.bsky.social with @nalcala.bsky.social www.biorxiv.org/cgi/content/...
A signature-agnostic test for differences between tumor mutation spectra reveals carcinogen and ancestry effects
Mutational signatures contain valuable information about the mutational processes shaping cancer genomes. However, despite dozens of tools to identify signatures in cancer samples, there is not an est...
www.biorxiv.org
May 20, 2025 at 4:58 PM
If you’ve ever wondered about the statistical significance of differences among mutational signature profiles, check out our new Aggregate Mutation Spectrum Distance (AMSD) preprint co-led by Sam Hart and @alisonfeder.bsky.social with @nalcala.bsky.social www.biorxiv.org/cgi/content/...
Reposted by Tim Coorens
Keeping you in the loop! ➰
Our Linktree includes all SMaHT websites and social media accounts for easy and consistent access.
Find all our social media accounts in one place:
linktr.ee/smahtnetwork
Our Linktree includes all SMaHT websites and social media accounts for easy and consistent access.
Find all our social media accounts in one place:
linktr.ee/smahtnetwork
SMaHT Network | Instagram, Facebook | Linktree
Aiming to transform our understanding of somatic mosaicism.
linktr.ee
May 16, 2025 at 3:29 PM
Keeping you in the loop! ➰
Our Linktree includes all SMaHT websites and social media accounts for easy and consistent access.
Find all our social media accounts in one place:
linktr.ee/smahtnetwork
Our Linktree includes all SMaHT websites and social media accounts for easy and consistent access.
Find all our social media accounts in one place:
linktr.ee/smahtnetwork
Reposted by Tim Coorens
Thrilled to see my #MITS25 talk brought to life by the brilliant 🎨 @atjcagan.bsky.social! Dive into the stellar science from @g-agarwal.bsky.social & co - fresh on bioRxiv: www.biorxiv.org/content/10.1...
#Genomics #SomaticEvolution
#Genomics #SomaticEvolution
May 1, 2025 at 7:10 PM
Thrilled to see my #MITS25 talk brought to life by the brilliant 🎨 @atjcagan.bsky.social! Dive into the stellar science from @g-agarwal.bsky.social & co - fresh on bioRxiv: www.biorxiv.org/content/10.1...
#Genomics #SomaticEvolution
#Genomics #SomaticEvolution
Reposted by Tim Coorens
Read ‘The somatic mutation landscape of normal gastric epithelium’ from @sangerinstitute.bsky.social, @broadinstitute.org, The University of Hong Kong & others in @nature.com ⤵️
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The somatic mutation landscape of normal gastric epithelium - Nature
Whole-gene sequencing of microdissected gastric glands from individuals with and without gastric cancer reveals distinct patterns of somatic mutations and provides insights into influen...
www.nature.com
March 20, 2025 at 12:10 PM
Read ‘The somatic mutation landscape of normal gastric epithelium’ from @sangerinstitute.bsky.social, @broadinstitute.org, The University of Hong Kong & others in @nature.com ⤵️
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The stomach is an organ unique in its function, environment and exposures. How does this affect the mutations that normal cells in the stomach acquire? What does this reveal about the origins of stomach cancer? These questions and more in our @nature.com paper:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The somatic mutation landscape of normal gastric epithelium - Nature
Whole-gene sequencing of microdissected gastric glands from individuals with and without gastric cancer reveals distinct patterns of somatic mutations and provides insights into influen...
www.nature.com
March 20, 2025 at 2:59 PM
The stomach is an organ unique in its function, environment and exposures. How does this affect the mutations that normal cells in the stomach acquire? What does this reveal about the origins of stomach cancer? These questions and more in our @nature.com paper:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Tim Coorens
Excited to share our new preprint demonstrating somatic rescue mutations in a genetic liver disease! [1/12]
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency - Nature Genetics
The expansion of clones with distinct SERPINA1 somatic mutants in the livers of alpha-1 antitrypsin deficiency (A1AT) patients is consistent with convergent evolution. These variants interfere with th...
www.nature.com
March 12, 2025 at 5:29 PM
Excited to share our new preprint demonstrating somatic rescue mutations in a genetic liver disease! [1/12]
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Tim Coorens
@timcoorens.bsky.social diving into the Bostonian wing of the SMaHT program (a.k.a. 'wicked SMaHT), detailing new sequencing solution for ultra high accuracy duplex sequencing, essential for detecting somatic variation #AGBTgm
February 24, 2025 at 4:23 PM
@timcoorens.bsky.social diving into the Bostonian wing of the SMaHT program (a.k.a. 'wicked SMaHT), detailing new sequencing solution for ultra high accuracy duplex sequencing, essential for detecting somatic variation #AGBTgm
Reposted by Tim Coorens
Awesome talk by @timcoorens.bsky.social on the detection and interpretation of somatic mutations. Now hiring postdocs! #AGBT25 | #AGBTGM
February 24, 2025 at 4:23 PM
Awesome talk by @timcoorens.bsky.social on the detection and interpretation of somatic mutations. Now hiring postdocs! #AGBT25 | #AGBTGM
Reposted by Tim Coorens
First large-scale analysis of chemical toxicity in primary human hepatocytes!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Cell Painting for cytotoxicity and mode-of-action analysis in primary human hepatocytes
High-throughput, human-relevant approaches for predicting chemical toxicity are urgently needed for better decision-making in human health. Here, we apply image-based profiling (the Cell Painting assa...
www.biorxiv.org
February 3, 2025 at 12:32 PM
First large-scale analysis of chemical toxicity in primary human hepatocytes!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Tim Coorens
Building on our discovery of #LesionSegregation, @mikespencerchapman.bsky.social and colleagues from @sangerinstitute.bsky.social find that some DNA lesions can persist in humans for months or years!
"Prolonged persistence of mutagenic DNA lesions in somatic cells"
www.nature.com/articles/s41...
"Prolonged persistence of mutagenic DNA lesions in somatic cells"
www.nature.com/articles/s41...
Prolonged persistence of mutagenic DNA lesions in somatic cells - Nature
Persistent DNA lesions can occur throughout the human lifespan and can remain in the genome of affected cells for several years and generate a substantial proportion of the mutational burden.
www.nature.com
January 15, 2025 at 5:21 PM
Building on our discovery of #LesionSegregation, @mikespencerchapman.bsky.social and colleagues from @sangerinstitute.bsky.social find that some DNA lesions can persist in humans for months or years!
"Prolonged persistence of mutagenic DNA lesions in somatic cells"
www.nature.com/articles/s41...
"Prolonged persistence of mutagenic DNA lesions in somatic cells"
www.nature.com/articles/s41...
Our new perspective article describing the human and non-human primate developmental GTEx projects is now out in
@nature.com! We outline the scope, vision, opportunities and challenges of these projects here:
www.nature.com/articles/s41...
The human and non-human primate developmental GTEx projects - Nature
The developmental Genotype-Tissue Expression (dGTEx) projects will catalogue and integrate gene expression, regulation and genetics data across 120 human donors from birth to adulthood with developmen...
www.nature.com
January 15, 2025 at 4:40 PM
Our new perspective article describing the human and non-human primate developmental GTEx projects is now out in
@nature.com! We outline the scope, vision, opportunities and challenges of these projects here:
www.nature.com/articles/s41...
The abstract deadline for "Mutations in Time and Space 2025" is in a week! Please register here: broadinstitute.swoogo.com/mits2025
January 10, 2025 at 2:53 PM
The abstract deadline for "Mutations in Time and Space 2025" is in a week! Please register here: broadinstitute.swoogo.com/mits2025
Spread the word! Registration for the "Mutations in Time and Space" conference is open. The meeting is all about the origins, patterns, and consequences of mutations across cells, individuals, populations, species. Abstract submission deadline is Jan 17th broadinstitute.swoogo.com/mits2025/597...
December 6, 2024 at 2:29 PM
Spread the word! Registration for the "Mutations in Time and Space" conference is open. The meeting is all about the origins, patterns, and consequences of mutations across cells, individuals, populations, species. Abstract submission deadline is Jan 17th broadinstitute.swoogo.com/mits2025/597...
Reposted by Tim Coorens
Let's build a starter pack for childhood cancer research.
Please send a message to be added! 🎗️
go.bsky.app/Tpd9QnM
Please send a message to be added! 🎗️
go.bsky.app/Tpd9QnM
November 24, 2024 at 3:27 PM
Let's build a starter pack for childhood cancer research.
Please send a message to be added! 🎗️
go.bsky.app/Tpd9QnM
Please send a message to be added! 🎗️
go.bsky.app/Tpd9QnM