Kamila Naxerova
@naxerova.bsky.social
Naxerova lab at @HMSGenetics. We study somatic evolution and cancer genetics.
Reposted by Kamila Naxerova
New @natgenet.nature.com paper from the brilliant @eszterlakatos.bsky.social presents evidence that chromatin alterations disrupt antigen presentation & neoantigens in colorectal cancer. Also that immune escape is part of the "Big Bang", at the outset of CRC growth. www.nature.com/articles/s41...
Epigenetically driven and early immune evasion in colorectal cancer evolution - Nature Genetics
This study nominates immune escape as an early event in colorectal cancer and shows how this can be driven through both genetic and epigenetic changes.
www.nature.com
November 5, 2025 at 4:36 PM
New @natgenet.nature.com paper from the brilliant @eszterlakatos.bsky.social presents evidence that chromatin alterations disrupt antigen presentation & neoantigens in colorectal cancer. Also that immune escape is part of the "Big Bang", at the outset of CRC growth. www.nature.com/articles/s41...
Reposted by Kamila Naxerova
The exciting next instalment of Mutations in Time and Space... Open for registration now
Explore the origins, patterns and consequences of mutations across biological systems! #MITS26
🗓️ Conference dates: 13-15 April 2026
Participate in expert-led knowledge exchange on how genome evolution shapes human health and ageing 🧬
Check out our exciting speakers ➡️ bit.ly/4hmbnyr
#Genomics
🗓️ Conference dates: 13-15 April 2026
Participate in expert-led knowledge exchange on how genome evolution shapes human health and ageing 🧬
Check out our exciting speakers ➡️ bit.ly/4hmbnyr
#Genomics
November 4, 2025 at 10:28 AM
The exciting next instalment of Mutations in Time and Space... Open for registration now
Reposted by Kamila Naxerova
WEEKEND LISTEN
This year, the Trump admin threw everything it had at the nation's oldest and richest university
3 Harvard profs tell the story of what they saw
@naxerova.bsky.social
@ryanenos.bsky.social & Kit Parker
www.wnycstudios.org/podcasts/otm...
This year, the Trump admin threw everything it had at the nation's oldest and richest university
3 Harvard profs tell the story of what they saw
@naxerova.bsky.social
@ryanenos.bsky.social & Kit Parker
www.wnycstudios.org/podcasts/otm...
S2 - Episode 1: The Harvard Plan | On the Media | WNYC Studios
The Harvard Plan - our collaboration with the Boston Globe, is back! In episode one, we hear what unfolded at Harvard from Donald Trump’s inauguration to convocation 2025. Three main ...
www.wnycstudios.org
November 1, 2025 at 1:25 PM
WEEKEND LISTEN
This year, the Trump admin threw everything it had at the nation's oldest and richest university
3 Harvard profs tell the story of what they saw
@naxerova.bsky.social
@ryanenos.bsky.social & Kit Parker
www.wnycstudios.org/podcasts/otm...
This year, the Trump admin threw everything it had at the nation's oldest and richest university
3 Harvard profs tell the story of what they saw
@naxerova.bsky.social
@ryanenos.bsky.social & Kit Parker
www.wnycstudios.org/podcasts/otm...
Reposted by Kamila Naxerova
Big, beautiful trees!!
SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.
www.biorxiv.org/content/10.1...
SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.
www.biorxiv.org/content/10.1...
October 14, 2025 at 2:37 PM
Big, beautiful trees!!
SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.
www.biorxiv.org/content/10.1...
SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life.
www.biorxiv.org/content/10.1...
Reposted by Kamila Naxerova
We have two fantastically well-funded #PhD studentships available through the @evomg-dn.bsky.social #EU doctoral network (led by brilliant @mirimiam.bsky.social, @crg.eu). These enable students to move to the UK and come and work with us @icr.ac.uk to exploit #cancer #evolution for patient benefit.
October 14, 2025 at 8:21 PM
We have two fantastically well-funded #PhD studentships available through the @evomg-dn.bsky.social #EU doctoral network (led by brilliant @mirimiam.bsky.social, @crg.eu). These enable students to move to the UK and come and work with us @icr.ac.uk to exploit #cancer #evolution for patient benefit.
Reposted by Kamila Naxerova
🚨 New paper alert!
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder - Nature
Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.
www.nature.com
October 8, 2025 at 4:44 PM
🚨 New paper alert!
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Sex and smoking bias in the selection of somatic mutations in human bladder
www.nature.com/articles/s41...
by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
Reposted by Kamila Naxerova
Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...
Somatic mutation and selection at population scale - Nature
A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.
www.nature.com
October 8, 2025 at 4:31 PM
Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...
Reposted by Kamila Naxerova
Very excited to see this work in press! I think there is a reason to believe that this is a common means of stabilizing large-effect polymorphisms in general and might be an important reason for why diploidy is so common. news.stanford.edu/stories/2025...
September 15, 2025 at 5:24 PM
Very excited to see this work in press! I think there is a reason to believe that this is a common means of stabilizing large-effect polymorphisms in general and might be an important reason for why diploidy is so common. news.stanford.edu/stories/2025...
Reposted by Kamila Naxerova
Welcome @timcoorens.bsky.social 🇳🇱, our new Research Group Leader.
Find out how Tim’s group is exploring using large-scale single-cell and spatial data to trace cell lineages, understand cancer origins, and uncover how mutations drive disease.
www.ebi.ac.uk/about/news/p...
🖥️🧬
Find out how Tim’s group is exploring using large-scale single-cell and spatial data to trace cell lineages, understand cancer origins, and uncover how mutations drive disease.
www.ebi.ac.uk/about/news/p...
🖥️🧬
Welcome: Tim Coorens
EMBL-EBI’s newest Research Group Leader is investigating how somatic mutations reveal the hidden histories of human cells.
www.ebi.ac.uk
August 12, 2025 at 9:04 AM
Welcome @timcoorens.bsky.social 🇳🇱, our new Research Group Leader.
Find out how Tim’s group is exploring using large-scale single-cell and spatial data to trace cell lineages, understand cancer origins, and uncover how mutations drive disease.
www.ebi.ac.uk/about/news/p...
🖥️🧬
Find out how Tim’s group is exploring using large-scale single-cell and spatial data to trace cell lineages, understand cancer origins, and uncover how mutations drive disease.
www.ebi.ac.uk/about/news/p...
🖥️🧬
Reposted by Kamila Naxerova
August 8, 2025 at 10:42 AM
Thank you for thinking of us. It’s been a rough ride. My lab lost two R01s, and as painful as that is for us, we are just one drop in a big bucket of terminations. HMS is doing everything they can to help us in the short term, but we need long term solutions - please keep up the conversation.
I still can’t believe that all NIH grants to my colleagues at Harvard and Harvard Medical School have been nullified. And that, as a nation, we’re somehow okay with this illegal, arbitrary, and petty act. Just think of the consequences: scientists, students, and patients will all suffer.
July 18, 2025 at 1:25 PM
Thank you for thinking of us. It’s been a rough ride. My lab lost two R01s, and as painful as that is for us, we are just one drop in a big bucket of terminations. HMS is doing everything they can to help us in the short term, but we need long term solutions - please keep up the conversation.
Reposted by Kamila Naxerova
Today is my last day at the @uoe-igc.bsky.social in Edinburgh, as I'm starting my own lab in Munich as part of the German Cancer Consortium (DKTK), DKFZ and the LMU. I'll continue to focus on DNA damage and mutagenesis to determine their role in somatic evolution and disease.
July 18, 2025 at 8:44 AM
Today is my last day at the @uoe-igc.bsky.social in Edinburgh, as I'm starting my own lab in Munich as part of the German Cancer Consortium (DKTK), DKFZ and the LMU. I'll continue to focus on DNA damage and mutagenesis to determine their role in somatic evolution and disease.
Very cool!
Consistently, Tbx3 KO protected against, and overexpression worsened fatty liver. This is because Tbx3 KO resulted in more VLDL-triglyceride secretion, which moves lipids from the liver to the rest of the body. Consequently, mice suffered from high blood triglyceride levels. 7/8
July 12, 2025 at 6:37 PM
Very cool!
Reposted by Kamila Naxerova
Introducing 2 new papers from my lab on somatic mutations in liver disease. The 1st is about a mutated gene that leads to improved clone fitness and organismal health (CIDEB). The 2nd is about a mutated gene that leads to improved clone fitness but worse overall health (TBX3). 1/8
July 12, 2025 at 5:04 PM
Introducing 2 new papers from my lab on somatic mutations in liver disease. The 1st is about a mutated gene that leads to improved clone fitness and organismal health (CIDEB). The 2nd is about a mutated gene that leads to improved clone fitness but worse overall health (TBX3). 1/8
Reposted by Kamila Naxerova
The cells in our bodies constantly acquire mutations. But what are the patterns of mutations across tissues? How do mutations in normal cells lead to cancer and disease? These are questions we will tackle within the Somatic Mosaicism across Human Tissues (SMaHT) Network, now described in @nature.com
The Somatic Mosaicism across Human Tissues Network - Nature
The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.
www.nature.com
July 3, 2025 at 2:29 PM
The cells in our bodies constantly acquire mutations. But what are the patterns of mutations across tissues? How do mutations in normal cells lead to cancer and disease? These are questions we will tackle within the Somatic Mosaicism across Human Tissues (SMaHT) Network, now described in @nature.com
Reposted by Kamila Naxerova
Delighted to share our latest on longitudinal methylation dynamics preceding cancer. Epigenetic signs of AML appear in blood DECADES before Dx.
👉 Early cancer detection
👉 Methylation drivers
👉 Epimutation rates
👉 CpG lineage tracing
www.biorxiv.org/content/10.1...
👉 Early cancer detection
👉 Methylation drivers
👉 Epimutation rates
👉 CpG lineage tracing
www.biorxiv.org/content/10.1...
July 3, 2025 at 8:47 PM
Delighted to share our latest on longitudinal methylation dynamics preceding cancer. Epigenetic signs of AML appear in blood DECADES before Dx.
👉 Early cancer detection
👉 Methylation drivers
👉 Epimutation rates
👉 CpG lineage tracing
www.biorxiv.org/content/10.1...
👉 Early cancer detection
👉 Methylation drivers
👉 Epimutation rates
👉 CpG lineage tracing
www.biorxiv.org/content/10.1...
Reposted by Kamila Naxerova
We are recruiting students who are thinking of applying to Biology PhD programs this fall to apply for the Stanford Biology Preview Program. Please spread the word!
Applying to Biology PhD programs this year? Let us help!
At BPP, we aim to support students from all backgrounds through the grad school application process. Learn more about grad student life and receive 1-on-1 feedback on your application materials!
Apply here: forms.gle/EvTyUWXFMRSL...
At BPP, we aim to support students from all backgrounds through the grad school application process. Learn more about grad student life and receive 1-on-1 feedback on your application materials!
Apply here: forms.gle/EvTyUWXFMRSL...
June 27, 2025 at 4:52 PM
We are recruiting students who are thinking of applying to Biology PhD programs this fall to apply for the Stanford Biology Preview Program. Please spread the word!
Reposted by Kamila Naxerova
To what extent is cancer development deterministic and predictable..?
Does the germline genome affect that predictability...?
Preprint: www.biorxiv.org/content/10.1...
Does the germline genome affect that predictability...?
Preprint: www.biorxiv.org/content/10.1...
January 15, 2025 at 7:32 PM
To what extent is cancer development deterministic and predictable..?
Does the germline genome affect that predictability...?
Preprint: www.biorxiv.org/content/10.1...
Does the germline genome affect that predictability...?
Preprint: www.biorxiv.org/content/10.1...
Reposted by Kamila Naxerova
🚨 Looking for postdocs!
I'm starting my lab at UT Southwestern this September.
If you're interested in:
🧬 Somatic & germline mutagenesis
🐭 Evolution of mutation processes
🧠 Adjacent areas like Mendelian genomics & population genetics—please consider joining.
Formal ad coming soon. DM me!
I'm starting my lab at UT Southwestern this September.
If you're interested in:
🧬 Somatic & germline mutagenesis
🐭 Evolution of mutation processes
🧠 Adjacent areas like Mendelian genomics & population genetics—please consider joining.
Formal ad coming soon. DM me!
June 4, 2025 at 4:09 AM
🚨 Looking for postdocs!
I'm starting my lab at UT Southwestern this September.
If you're interested in:
🧬 Somatic & germline mutagenesis
🐭 Evolution of mutation processes
🧠 Adjacent areas like Mendelian genomics & population genetics—please consider joining.
Formal ad coming soon. DM me!
I'm starting my lab at UT Southwestern this September.
If you're interested in:
🧬 Somatic & germline mutagenesis
🐭 Evolution of mutation processes
🧠 Adjacent areas like Mendelian genomics & population genetics—please consider joining.
Formal ad coming soon. DM me!
Social media grump Kamila has finally made it onto Bluesky!
Please check out my new perspective on metastasis evolution in @natrevcancer.nature.com if you need a reprieve from the news.
I tried my best to develop some new conceptual thoughts here, you be the judge whether I succeeded.
Please check out my new perspective on metastasis evolution in @natrevcancer.nature.com if you need a reprieve from the news.
I tried my best to develop some new conceptual thoughts here, you be the judge whether I succeeded.
🚨 PERSEPCTIVE
Naxerova explains how genetic analysis of primary tumors & metastases can distinguish competing metastasis models, arguing that quantifying whether metastasis occurs through nonrandom lineage selection could offer insights into metastasis biology.
📖 👇
Naxerova explains how genetic analysis of primary tumors & metastases can distinguish competing metastasis models, arguing that quantifying whether metastasis occurs through nonrandom lineage selection could offer insights into metastasis biology.
📖 👇
Evolutionary paths towards metastasis - Nature Reviews Cancer
In this Perspective, Kamila Naxerova discusses how genetic analyses of primary tumours and matched metastases can distinguish between competing metastasis evolution models, arguing that further insights into human metastasis biology could be enabled by a framework that rigorously quantifies whether metastases descend from a nonrandom selection of primary tumour lineages.
bit.ly
May 21, 2025 at 12:06 AM
Social media grump Kamila has finally made it onto Bluesky!
Please check out my new perspective on metastasis evolution in @natrevcancer.nature.com if you need a reprieve from the news.
I tried my best to develop some new conceptual thoughts here, you be the judge whether I succeeded.
Please check out my new perspective on metastasis evolution in @natrevcancer.nature.com if you need a reprieve from the news.
I tried my best to develop some new conceptual thoughts here, you be the judge whether I succeeded.
Reposted by Kamila Naxerova
