Vanja Tepavcevic
@tepavcevicvanja.bsky.social
Neurobiologist.Oligodendrocytes/myelin/remyelination/energy metabolism.
Pinned
Monocarboxylate transporter 2 is required for the maintenance of myelin and axonal integrity by oligodendrocytes https://www.biorxiv.org/content/10.1101/2025.01.10.632306v1
Interested in #oligodendrocyte metabolism and/or #multiplesclerosis? Our paper is now at Biorxiv! We show that oligos express MCT2, the high affinity monocarboxylate transporter, well known for supplying neurons with astrocyte-derived lactate (astro-neuron lactate shuttle)👇
Reposted by Vanja Tepavcevic
Reminder that, as of the latest reports, Liam Ramos is still in prison in Texas - now for 5 days.
His parents are legal asylum seekers with no criminal record.
His parents are legal asylum seekers with no criminal record.
January 27, 2026 at 12:30 AM
Reminder that, as of the latest reports, Liam Ramos is still in prison in Texas - now for 5 days.
His parents are legal asylum seekers with no criminal record.
His parents are legal asylum seekers with no criminal record.
Reposted by Vanja Tepavcevic
Clonal CD8+ T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 27, 2026 at 2:15 PM
Clonal CD8+ T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Vanja Tepavcevic
Where does Aβ come from in Alzheimer’s disease? 🔍
In this review, we explore Aβ production and functions of APP processing in non-neuronal cells as well as how targeting non-neuronal Aβ could lead to a more holistic disease prevention/targeting.
link.springer.com/article/10.1...
In this review, we explore Aβ production and functions of APP processing in non-neuronal cells as well as how targeting non-neuronal Aβ could lead to a more holistic disease prevention/targeting.
link.springer.com/article/10.1...
A Question of Origins: Non-neuronal Sources of Amyloid-β - Neuroscience Bulletin
Amyloid-β (Aβ) plaques and neurofibrillary tau tangles are hallmarks of Alzheimer’s disease (AD). While the intracellular localization of tau tangles within neurons nominates them as the primary produ...
link.springer.com
January 20, 2026 at 1:25 PM
Where does Aβ come from in Alzheimer’s disease? 🔍
In this review, we explore Aβ production and functions of APP processing in non-neuronal cells as well as how targeting non-neuronal Aβ could lead to a more holistic disease prevention/targeting.
link.springer.com/article/10.1...
In this review, we explore Aβ production and functions of APP processing in non-neuronal cells as well as how targeting non-neuronal Aβ could lead to a more holistic disease prevention/targeting.
link.springer.com/article/10.1...
Reposted by Vanja Tepavcevic
📢Calling all @cam.ac.uk neuroscience students: Applications are still open to join our wonderful CamBRAIN team!🧠
This is a fantastic opportunity to get involved in the committee of one of the largest student neuro societies in the UK!
More details in the comments👇
Apply by 26/01: lnkd.in/eMZ3P286
This is a fantastic opportunity to get involved in the committee of one of the largest student neuro societies in the UK!
More details in the comments👇
Apply by 26/01: lnkd.in/eMZ3P286
January 20, 2026 at 4:50 PM
📢Calling all @cam.ac.uk neuroscience students: Applications are still open to join our wonderful CamBRAIN team!🧠
This is a fantastic opportunity to get involved in the committee of one of the largest student neuro societies in the UK!
More details in the comments👇
Apply by 26/01: lnkd.in/eMZ3P286
This is a fantastic opportunity to get involved in the committee of one of the largest student neuro societies in the UK!
More details in the comments👇
Apply by 26/01: lnkd.in/eMZ3P286
Reposted by Vanja Tepavcevic
Huntington’s disease: treatments are finally on the horizon after research breakthroughs theconversation.com/huntingtons-...
#Huntingtons #dementia #science #neuroscience #neurology
#Huntingtons #dementia #science #neuroscience #neurology
Huntington’s disease: treatments are finally on the horizon after research breakthroughs
Sadly, there is no cure for Huntington’s disease. But a couple new research papers suggests this may be about to change.
theconversation.com
January 16, 2026 at 2:18 AM
Huntington’s disease: treatments are finally on the horizon after research breakthroughs theconversation.com/huntingtons-...
#Huntingtons #dementia #science #neuroscience #neurology
#Huntingtons #dementia #science #neuroscience #neurology
Reposted by Vanja Tepavcevic
EBV is required for the development of multiple sclerosis, but it’s not known how a common virus leads to disease. 3 exciting new papers in @cellcellpress.bsky.social provide major insights into how this may occur:
January 13, 2026 at 4:55 PM
EBV is required for the development of multiple sclerosis, but it’s not known how a common virus leads to disease. 3 exciting new papers in @cellcellpress.bsky.social provide major insights into how this may occur:
Reposted by Vanja Tepavcevic
Extremely interesting research and thread!
⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...
Self-renewal of neuronal mitochondria through asymmetric division
Mitochondrial ATP production is essential for life. Mitochondrial function depends on the spatio-temporal coordination of nuclear and mitochondrial genome expression, yet how this coordination occurs ...
www.biorxiv.org
December 19, 2025 at 12:49 PM
Extremely interesting research and thread!
Reposted by Vanja Tepavcevic
🚨 REGISTRATION NOW OPEN – CAJAL CONFERENCE 2026
“Novel Insights Into Brain Energy Metabolism in Health and Disease”
📍 April 15–17, 2026 | Cádiz, Spain
🔔 SENC Fellowships available 🔔 20 slots for Oral Communications
👉🏻 Register here:
amconferences.eventsair.com/senc-cajal-c...
👇🏻 SPEAKERS
“Novel Insights Into Brain Energy Metabolism in Health and Disease”
📍 April 15–17, 2026 | Cádiz, Spain
🔔 SENC Fellowships available 🔔 20 slots for Oral Communications
👉🏻 Register here:
amconferences.eventsair.com/senc-cajal-c...
👇🏻 SPEAKERS
January 12, 2026 at 5:06 PM
🚨 REGISTRATION NOW OPEN – CAJAL CONFERENCE 2026
“Novel Insights Into Brain Energy Metabolism in Health and Disease”
📍 April 15–17, 2026 | Cádiz, Spain
🔔 SENC Fellowships available 🔔 20 slots for Oral Communications
👉🏻 Register here:
amconferences.eventsair.com/senc-cajal-c...
👇🏻 SPEAKERS
“Novel Insights Into Brain Energy Metabolism in Health and Disease”
📍 April 15–17, 2026 | Cádiz, Spain
🔔 SENC Fellowships available 🔔 20 slots for Oral Communications
👉🏻 Register here:
amconferences.eventsair.com/senc-cajal-c...
👇🏻 SPEAKERS
Reposted by Vanja Tepavcevic
The Cajal Conference 2026 on energy metabolism in health and disease in the wonderful city of Cadiz promises to be exceptional and exciting due to the impressive list of speakers. Registration with limited places is now open.
🚨 REGISTRATION NOW OPEN – CAJAL CONFERENCE 2026
“Novel Insights Into Brain Energy Metabolism in Health and Disease”
📍 April 15–17, 2026 | Cádiz, Spain
🔔 SENC Fellowships available 🔔 20 slots for Oral Communications
👉🏻 Register here:
amconferences.eventsair.com/senc-cajal-c...
👇🏻 SPEAKERS
“Novel Insights Into Brain Energy Metabolism in Health and Disease”
📍 April 15–17, 2026 | Cádiz, Spain
🔔 SENC Fellowships available 🔔 20 slots for Oral Communications
👉🏻 Register here:
amconferences.eventsair.com/senc-cajal-c...
👇🏻 SPEAKERS
January 12, 2026 at 6:44 PM
The Cajal Conference 2026 on energy metabolism in health and disease in the wonderful city of Cadiz promises to be exceptional and exciting due to the impressive list of speakers. Registration with limited places is now open.
Reposted by Vanja Tepavcevic
Mitochondrial transfer from glia to neurons protects against peripheral neuropathy @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 7, 2026 at 6:54 PM
Mitochondrial transfer from glia to neurons protects against peripheral neuropathy @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Glial progenitor cells, including OPCs, with IDH mutations (rather than neural stem cells) may be the cellular starting point for the development of IDH-mutant glioma. Science www.science.org/doi/10.1126/...
IDH-mutant gliomas arise from glial progenitor cells harboring the initial driver mutation
Identifying the cell of origin that harbors an initial driver mutation is key to understanding tumor evolution and for the development of new treatments. For isocitrate dehydrogenase (IDH)–mutant glio...
www.science.org
January 10, 2026 at 8:43 PM
Glial progenitor cells, including OPCs, with IDH mutations (rather than neural stem cells) may be the cellular starting point for the development of IDH-mutant glioma. Science www.science.org/doi/10.1126/...
Reposted by Vanja Tepavcevic
We identified how mechanical forces shape myelin development. The TMEM63A channel in oligodendrocytes converts physical cues into molecular signals that control myelin growth.
Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...
Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...
Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry
Dereddi, Djannatian, and colleagues show that oligodendrocytes use mechanical cues
to measure axon size. The stretch-activated channel TMEM63A converts membrane tension
into calcium signals, which cal...
www.cell.com
January 2, 2026 at 3:55 PM
We identified how mechanical forces shape myelin development. The TMEM63A channel in oligodendrocytes converts physical cues into molecular signals that control myelin growth.
Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...
Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...
How is myelin remodelled without compromising myelin integrity???
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
December 16, 2025 at 12:52 PM
How is myelin remodelled without compromising myelin integrity???
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Vanja Tepavcevic
Comprehensive study looking at the genomic effects of chemotherapy on normal tissues.
Somatic evolution following cancer treatment in normal tissue | Nature
www.nature.com/articles/s41...
Somatic evolution following cancer treatment in normal tissue | Nature
www.nature.com/articles/s41...
Somatic evolution following cancer treatment in normal tissue - Nature
High-depth sequencing of non-cancerous tissue from patients with metastatic cancer reveals single-base mutational signatures of alcohol, smoking and cancer treatments, and reveals how exogenous factor...
www.nature.com
December 11, 2025 at 4:07 PM
Comprehensive study looking at the genomic effects of chemotherapy on normal tissues.
Somatic evolution following cancer treatment in normal tissue | Nature
www.nature.com/articles/s41...
Somatic evolution following cancer treatment in normal tissue | Nature
www.nature.com/articles/s41...
Reposted by Vanja Tepavcevic
Textbooks said neurons don’t burn fatty acids for energy🤔. Our study delivers the first in vivo demonstration that fatty acid oxidation in defined memory neurons fuels memory formation.
Closing chapter of my PhD 🥳, out today in Nature Metabolism💥 @natmetabolism.nature.com
Closing chapter of my PhD 🥳, out today in Nature Metabolism💥 @natmetabolism.nature.com
Neuronal fatty acid oxidation fuels memory after intensive learning in Drosophila - Nature Metabolism
Neurons are shown to use fatty acid β-oxidation as a fuel source for memory formation upon intensive learning in Drosophila, challenging the view that neurons are unable to use fatty acids for energy ...
www.nature.com
December 10, 2025 at 11:13 AM
Textbooks said neurons don’t burn fatty acids for energy🤔. Our study delivers the first in vivo demonstration that fatty acid oxidation in defined memory neurons fuels memory formation.
Closing chapter of my PhD 🥳, out today in Nature Metabolism💥 @natmetabolism.nature.com
Closing chapter of my PhD 🥳, out today in Nature Metabolism💥 @natmetabolism.nature.com
Super congratulations to Sarah Moyon @neurosarah.bsky.social on this well-deserved achievement!!!
Super exciting news for the #OligOld team 🤩😱: our project Epiglia has been awarded an #ERCCog!
Ready to dive into the epigenetics of oligodendroglial cells in Alzheimer for the next 5 years with our amazing group and collaborators @inp-marseille.bsky.social @univ-amu.fr
Ready to dive into the epigenetics of oligodendroglial cells in Alzheimer for the next 5 years with our amazing group and collaborators @inp-marseille.bsky.social @univ-amu.fr
The results of the ERC Consolidator Grant call have been announced! 📣
349 researchers have been selected for funding. Congratulations to all! #ERCCogG!
👉 buff.ly/uu62uFV
#FrontierResearch #EUfunded #HorizonEurope
@scienceinnovation.ec.europa.eu
349 researchers have been selected for funding. Congratulations to all! #ERCCogG!
👉 buff.ly/uu62uFV
#FrontierResearch #EUfunded #HorizonEurope
@scienceinnovation.ec.europa.eu
December 10, 2025 at 5:35 PM
Super congratulations to Sarah Moyon @neurosarah.bsky.social on this well-deserved achievement!!!
Reposted by Vanja Tepavcevic
Super exciting news for the #OligOld team 🤩😱: our project Epiglia has been awarded an #ERCCog!
Ready to dive into the epigenetics of oligodendroglial cells in Alzheimer for the next 5 years with our amazing group and collaborators @inp-marseille.bsky.social @univ-amu.fr
Ready to dive into the epigenetics of oligodendroglial cells in Alzheimer for the next 5 years with our amazing group and collaborators @inp-marseille.bsky.social @univ-amu.fr
The results of the ERC Consolidator Grant call have been announced! 📣
349 researchers have been selected for funding. Congratulations to all! #ERCCogG!
👉 buff.ly/uu62uFV
#FrontierResearch #EUfunded #HorizonEurope
@scienceinnovation.ec.europa.eu
349 researchers have been selected for funding. Congratulations to all! #ERCCogG!
👉 buff.ly/uu62uFV
#FrontierResearch #EUfunded #HorizonEurope
@scienceinnovation.ec.europa.eu
December 9, 2025 at 5:45 PM
Super exciting news for the #OligOld team 🤩😱: our project Epiglia has been awarded an #ERCCog!
Ready to dive into the epigenetics of oligodendroglial cells in Alzheimer for the next 5 years with our amazing group and collaborators @inp-marseille.bsky.social @univ-amu.fr
Ready to dive into the epigenetics of oligodendroglial cells in Alzheimer for the next 5 years with our amazing group and collaborators @inp-marseille.bsky.social @univ-amu.fr
Reposted by Vanja Tepavcevic
Longitudinal proteomic profiling of cerebrospinal fluid in untreated multiple sclerosis defines evolving disease biology
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Longitudinal proteomic profiling of cerebrospinal fluid in untreated multiple sclerosis defines evolving disease biology - Nature Communications
Longitudinal cerebrospinal fluid proteomics in multiple sclerosis uncovers dynamic antiviral immune activity, sex-based differences in damage and repair, and evolving myeloid-stromal cell interactions...
www.nature.com
December 7, 2025 at 9:56 PM
Longitudinal proteomic profiling of cerebrospinal fluid in untreated multiple sclerosis defines evolving disease biology
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Vanja Tepavcevic
Poor heart health in middle age linked to dementia in old age – new study theconversation.com/poor-heart-h...
#Alzheimers #dementia #health #wellness
#Alzheimers #dementia #health #wellness
Poor heart health in middle age linked to dementia in old age – new study
A 25-year study reveals that silent heart damage in your 50s can predict dementia risk decades later.
theconversation.com
November 12, 2025 at 1:04 PM
Poor heart health in middle age linked to dementia in old age – new study theconversation.com/poor-heart-h...
#Alzheimers #dementia #health #wellness
#Alzheimers #dementia #health #wellness
Reposted by Vanja Tepavcevic
Looking forward to presenting our work on oligodendrocyte dysfunction in a rare neurodegenerative movement disorder X-linked Dystonia Parkinsonism. Come say hi if you're around on Tuesday, Nov 18 between 1-5 pm! @sfn.org #SfN2025 #SfN25
@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below.
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
November 10, 2025 at 11:09 PM
Reposted by Vanja Tepavcevic
Local #mRNAtranslation in polarized cells is well studied in neurons but what about #microglia? This study shows that #inflammation enhances microglial #RNA localization & translation via RNA-binding protein IMP1/ZBP1, regulating morphology, motility & phagocytosis @plosbiology.org 🧪 plos.io/486ZLMS
November 11, 2025 at 9:48 AM
Local #mRNAtranslation in polarized cells is well studied in neurons but what about #microglia? This study shows that #inflammation enhances microglial #RNA localization & translation via RNA-binding protein IMP1/ZBP1, regulating morphology, motility & phagocytosis @plosbiology.org 🧪 plos.io/486ZLMS
Reposted by Vanja Tepavcevic
📢 Interested in #lipidomics and #dementia? Join us tomorrow 👇
🚨Join our next @DEMONNetworkUK #Genetics and #Omics joint with #Biomarkers meeting on THURSDAY 6th November at 2.30 PM (UK Time). Delighted to have Asger Wretlind as invited speaker – “Unsaturated #Lipid Deficits: A #Female Specific #Alzheimer's Signature”
Join the network or DM for more info!
Join the network or DM for more info!
November 5, 2025 at 9:47 PM
📢 Interested in #lipidomics and #dementia? Join us tomorrow 👇
Reposted by Vanja Tepavcevic
Últimos días para presentar candidaturas al Comité Científico Técnico de la @AgEInves.
📅 Plazo hasta el 10 de noviembre
ℹ️ Procedimiento y detalles: www.aei.gob.es/sobre-aei/or...
#Últimallamada #ComitéCientíficoTécnico #EvaluaciónCientífica
📅 Plazo hasta el 10 de noviembre
ℹ️ Procedimiento y detalles: www.aei.gob.es/sobre-aei/or...
#Últimallamada #ComitéCientíficoTécnico #EvaluaciónCientífica
November 5, 2025 at 10:50 AM
Últimos días para presentar candidaturas al Comité Científico Técnico de la @AgEInves.
📅 Plazo hasta el 10 de noviembre
ℹ️ Procedimiento y detalles: www.aei.gob.es/sobre-aei/or...
#Últimallamada #ComitéCientíficoTécnico #EvaluaciónCientífica
📅 Plazo hasta el 10 de noviembre
ℹ️ Procedimiento y detalles: www.aei.gob.es/sobre-aei/or...
#Últimallamada #ComitéCientíficoTécnico #EvaluaciónCientífica
Reposted by Vanja Tepavcevic
Join us at the last IBRO Connect of 2025 during #SfN2025. Connect with fellow #neuroscientists & join us in celebrating this year’s achievements in a fun atmosphere!
17 Nov | 19:00–21:00 PST at Venue 808, San Diego
Limited seats: https://ibro.org/event/ibro-connect-networking-event-in-san-diego/
17 Nov | 19:00–21:00 PST at Venue 808, San Diego
Limited seats: https://ibro.org/event/ibro-connect-networking-event-in-san-diego/
November 5, 2025 at 8:00 AM
Join us at the last IBRO Connect of 2025 during #SfN2025. Connect with fellow #neuroscientists & join us in celebrating this year’s achievements in a fun atmosphere!
17 Nov | 19:00–21:00 PST at Venue 808, San Diego
Limited seats: https://ibro.org/event/ibro-connect-networking-event-in-san-diego/
17 Nov | 19:00–21:00 PST at Venue 808, San Diego
Limited seats: https://ibro.org/event/ibro-connect-networking-event-in-san-diego/
Reposted by Vanja Tepavcevic
Thrilled to publish our new study on #mitochondrial ROS coming from complex III, revealing this key site in #astrocytes 🎯as a crucial immunometabolic signal transducer🤯 and potential therapeutic target for #dementia #FTD 💊 rdcu.be/eOc0m 👈💪 Great commentary by H. Pan and F. Yin🤩! tinyurl.com/4hdytw4c
November 4, 2025 at 6:30 PM
Thrilled to publish our new study on #mitochondrial ROS coming from complex III, revealing this key site in #astrocytes 🎯as a crucial immunometabolic signal transducer🤯 and potential therapeutic target for #dementia #FTD 💊 rdcu.be/eOc0m 👈💪 Great commentary by H. Pan and F. Yin🤩! tinyurl.com/4hdytw4c