Tanja Mittag
@tanjamittag.bsky.social
Phase separation and disordered proteins!
All comments/opinions are my own and are not representative of St. Jude.
All comments/opinions are my own and are not representative of St. Jude.
Pinned
Tanja Mittag
@tanjamittag.bsky.social
· Jul 9
New paper on transcription factor phase separation published from my colleague Aseem Ansari's and my lab: Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function authors.elsevier.com/sd/article/S...
Reposted by Tanja Mittag
Does targeting enzymes and substrates in a condensate lead to rate enhancement? No. Here, we investigate how the condensate environment can inhibit an enzyme reaction.
Spoiler: Mass-transport limitations. We find a strong correlation between diffusion and reaction rates.
doi.org/10.64898/202...
Spoiler: Mass-transport limitations. We find a strong correlation between diffusion and reaction rates.
doi.org/10.64898/202...
February 2, 2026 at 2:25 PM
Does targeting enzymes and substrates in a condensate lead to rate enhancement? No. Here, we investigate how the condensate environment can inhibit an enzyme reaction.
Spoiler: Mass-transport limitations. We find a strong correlation between diffusion and reaction rates.
doi.org/10.64898/202...
Spoiler: Mass-transport limitations. We find a strong correlation between diffusion and reaction rates.
doi.org/10.64898/202...
Reposted by Tanja Mittag
I am recruiting postdoctoral fellows to develop new research directions in the lab. We study transcriptional regulation through biomolecular condensates in development and disease, with an emphasis on first-principles and mechanistic discovery. Please repost or share with colleagues.
January 23, 2026 at 6:35 PM
I am recruiting postdoctoral fellows to develop new research directions in the lab. We study transcriptional regulation through biomolecular condensates in development and disease, with an emphasis on first-principles and mechanistic discovery. Please repost or share with colleagues.
Reposted by Tanja Mittag
Second preprint of the year in which @sarahgersing.bsky.social from @rhp-lab.bsky.social mapped the effects of >7500 variants in glucokinase (GCK) on the interaction with the glucokinase regulatory protein so that we now have a 3D GCK scan (abundance, interaction, activity)
doi.org/10.64898/202...
doi.org/10.64898/202...
January 18, 2026 at 6:14 PM
Second preprint of the year in which @sarahgersing.bsky.social from @rhp-lab.bsky.social mapped the effects of >7500 variants in glucokinase (GCK) on the interaction with the glucokinase regulatory protein so that we now have a 3D GCK scan (abundance, interaction, activity)
doi.org/10.64898/202...
doi.org/10.64898/202...
Reposted by Tanja Mittag
Are you a junior scientist working in theoretical biophysics? @zamakany.bsky.social and I are organizing another workshop this fall here at @hhmijanelia.bsky.social. Travel and the workshop expenses are all covered!
tinyurl.com/yc66fawc
tinyurl.com/yc66fawc
Junior Scientist Workshop on Theoretical Biophysics
Attendees will have the opportunity to present as well as learn from one another. They will give 20-minute talks on their own research questions, as well as in-depth 45-minute whiteboard tutorials on
tinyurl.com
January 9, 2026 at 5:33 PM
Are you a junior scientist working in theoretical biophysics? @zamakany.bsky.social and I are organizing another workshop this fall here at @hhmijanelia.bsky.social. Travel and the workshop expenses are all covered!
tinyurl.com/yc66fawc
tinyurl.com/yc66fawc
Reposted by Tanja Mittag
IDPSeminars is BACK THIS WEEK!
Talks from Andrea Soranno and @bokaizhulab.bsky.social on Thursday! 1 pm EST / 7 PM European time!
Sign up here: forms.gle/3yCHeYvuuqLh...
And check out the full Spring 2026 schedule at idpseminars.com!
Talks from Andrea Soranno and @bokaizhulab.bsky.social on Thursday! 1 pm EST / 7 PM European time!
Sign up here: forms.gle/3yCHeYvuuqLh...
And check out the full Spring 2026 schedule at idpseminars.com!
January 6, 2026 at 1:05 PM
IDPSeminars is BACK THIS WEEK!
Talks from Andrea Soranno and @bokaizhulab.bsky.social on Thursday! 1 pm EST / 7 PM European time!
Sign up here: forms.gle/3yCHeYvuuqLh...
And check out the full Spring 2026 schedule at idpseminars.com!
Talks from Andrea Soranno and @bokaizhulab.bsky.social on Thursday! 1 pm EST / 7 PM European time!
Sign up here: forms.gle/3yCHeYvuuqLh...
And check out the full Spring 2026 schedule at idpseminars.com!
Reposted by Tanja Mittag
Nuclear speckle associated RRM-containing proteins are block copolymers. They make size-limited, ordered microphases, tens of nm in size comprising tens of molecules. Speckles are likely clusters or emulsions of distinct microphases and not macrophases www.sciencedirect.com/science/arti...
Nuclear speckle proteins form intrinsic and MALAT1-dependent microphases
Pre-mRNA processing components in nuclear speckles encompass one or more folded RNA recognition motifs (RRMs) and disordered regions with specific seq…
www.sciencedirect.com
December 19, 2025 at 7:14 PM
Nuclear speckle associated RRM-containing proteins are block copolymers. They make size-limited, ordered microphases, tens of nm in size comprising tens of molecules. Speckles are likely clusters or emulsions of distinct microphases and not macrophases www.sciencedirect.com/science/arti...
Reposted by Tanja Mittag
🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle.
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
December 16, 2025 at 12:05 PM
🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle.
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
Led by superb PhD student Carol Gao.
www.biorxiv.org/content/10.1...
Implications for drug tolerance/resistance, and includes one big surprise🫧.👇
Reposted by Tanja Mittag
Hey that’s us 🎉
#Quantum computing is moving from theoretical promise toward more evidence-driven, quantitatively grounded pathways — and these teams are leading the way! 🖥️ We’re thrilled to announce the seven XPRIZE #QuantumApplications Finalist teams. Learn more here. xprize.org/news/xprize-...
#QuantumComputing
#QuantumComputing
December 10, 2025 at 10:34 PM
Hey that’s us 🎉
Reposted by Tanja Mittag
Our review on Integrative modelling of biomolecular dynamics 💃 is now live at COSB
We discuss approaches to integrate computational methods with time-dependent & time-resolved experiments to study protein dynamics
With @dariagusew.bsky.social & Carl G. Henning Hansen
doi.org/10.1016/j.sb...
We discuss approaches to integrate computational methods with time-dependent & time-resolved experiments to study protein dynamics
With @dariagusew.bsky.social & Carl G. Henning Hansen
doi.org/10.1016/j.sb...
December 9, 2025 at 10:13 PM
Our review on Integrative modelling of biomolecular dynamics 💃 is now live at COSB
We discuss approaches to integrate computational methods with time-dependent & time-resolved experiments to study protein dynamics
With @dariagusew.bsky.social & Carl G. Henning Hansen
doi.org/10.1016/j.sb...
We discuss approaches to integrate computational methods with time-dependent & time-resolved experiments to study protein dynamics
With @dariagusew.bsky.social & Carl G. Henning Hansen
doi.org/10.1016/j.sb...
Reposted by Tanja Mittag
Iowa State Dept of Molecular Biology is hiring for biomolecular solution NMR facility staff #NMRchat #Chemjobs #Chemsky
(I am NOT the hiring manager for this position, but I will refer any questions you have to the appropriate person.) isu.wd1.myworkdayjobs.com/IowaStateJob...
(I am NOT the hiring manager for this position, but I will refer any questions you have to the appropriate person.) isu.wd1.myworkdayjobs.com/IowaStateJob...
Biomolecular NMR Facility Manager
Position Title: Biomolecular NMR Facility Manager Job Group: Professional & Scientific Required Minimum Qualifications: Bachelor’s degree and 5 years of related experience Preferred Qualifications...
isu.wd1.myworkdayjobs.com
December 5, 2025 at 1:51 PM
Iowa State Dept of Molecular Biology is hiring for biomolecular solution NMR facility staff #NMRchat #Chemjobs #Chemsky
(I am NOT the hiring manager for this position, but I will refer any questions you have to the appropriate person.) isu.wd1.myworkdayjobs.com/IowaStateJob...
(I am NOT the hiring manager for this position, but I will refer any questions you have to the appropriate person.) isu.wd1.myworkdayjobs.com/IowaStateJob...
Reposted by Tanja Mittag
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
November 19, 2025 at 9:16 PM
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
Reposted by Tanja Mittag
Help me spread the word about an opening for the Furino Chair in Bioengineering in the Department of Bioengineering at McGill University. We seek candidates focused on developing biotherapeutic approaches to cancer, including but not limited to mRNA vaccines, CAR-T, and immunotherapy. (1/3)
November 12, 2025 at 6:05 PM
Help me spread the word about an opening for the Furino Chair in Bioengineering in the Department of Bioengineering at McGill University. We seek candidates focused on developing biotherapeutic approaches to cancer, including but not limited to mRNA vaccines, CAR-T, and immunotherapy. (1/3)
Reposted by Tanja Mittag
Re-boosting! The Dept. of Microbiology 🧫 at the University of Tennessee is hiring two 9-month faculty! Come join a vibrant and growing department located in the foothills of the Smoky Mountains! #microsky
Come join us in Knoxville!
The Dept. of Microbiology 🧫🦠 at the University of Tennessee is hiring 2 Assistant Professors (tenure track, 9-month appt.).
Microbial Drivers of Chronic Disease: apply.interfolio.com/173153Quantitative Microbe-Plant-Environment Interactions: apply.interfolio.com/173345
The Dept. of Microbiology 🧫🦠 at the University of Tennessee is hiring 2 Assistant Professors (tenure track, 9-month appt.).
Microbial Drivers of Chronic Disease: apply.interfolio.com/173153Quantitative Microbe-Plant-Environment Interactions: apply.interfolio.com/173345
November 6, 2025 at 1:07 PM
Re-boosting! The Dept. of Microbiology 🧫 at the University of Tennessee is hiring two 9-month faculty! Come join a vibrant and growing department located in the foothills of the Smoky Mountains! #microsky
Reposted by Tanja Mittag
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
October 31, 2025 at 9:24 AM
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
Reposted by Tanja Mittag
We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
October 20, 2025 at 11:26 AM
We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
Reposted by Tanja Mittag
During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!
apply.interfolio.com/174756
apply.interfolio.com/174756
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 14, 2025 at 5:35 PM
During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!
apply.interfolio.com/174756
apply.interfolio.com/174756
Reposted by Tanja Mittag
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
www.nature.com/naturecareer...
Please repost!
www.nature.com/naturecareer...
Please repost!
August 28, 2025 at 6:34 AM
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
www.nature.com/naturecareer...
Please repost!
www.nature.com/naturecareer...
Please repost!
Reposted by Tanja Mittag
🚨The 2026 IDP GRC Program is LIVE! 📣
Check it out: www.grc.org/intrinsicall...
We’ve got an incredible speaker lineup! 🌟
Over the next few weeks, we’ll be highlighting some of them and giving you a sneak peek at the exciting topics they’ll be covering. Stay tuned!
Check it out: www.grc.org/intrinsicall...
We’ve got an incredible speaker lineup! 🌟
Over the next few weeks, we’ll be highlighting some of them and giving you a sneak peek at the exciting topics they’ll be covering. Stay tuned!
2026 Intrinsically Disordered Proteins Conference GRC
The 2026 Gordon Research Conference on Intrinsically Disordered Proteins will be held in Les Diablerets, Vaud (fr) Switzerland. Apply today to reserve your spot.
www.grc.org
October 7, 2025 at 3:17 PM
🚨The 2026 IDP GRC Program is LIVE! 📣
Check it out: www.grc.org/intrinsicall...
We’ve got an incredible speaker lineup! 🌟
Over the next few weeks, we’ll be highlighting some of them and giving you a sneak peek at the exciting topics they’ll be covering. Stay tuned!
Check it out: www.grc.org/intrinsicall...
We’ve got an incredible speaker lineup! 🌟
Over the next few weeks, we’ll be highlighting some of them and giving you a sneak peek at the exciting topics they’ll be covering. Stay tuned!
Reposted by Tanja Mittag
Open faculty position!
We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa
We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa
August 26, 2025 at 5:03 PM
Open faculty position!
We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa
We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa
Reposted by Tanja Mittag
🚨🚨The GRC on Intrinsically Disordered Proteins #IDPs is back!! 🍝🧵🏔️Join us for cutting-edge IDP science, great discussions, and mountain views 🌄🍝
📅 June 21-26, 2026 | Les Diablerets, Switzerland
👉 Details & registration: grc.org/intrinsicall...
📅 June 21-26, 2026 | Les Diablerets, Switzerland
👉 Details & registration: grc.org/intrinsicall...
2026 Intrinsically Disordered Proteins Conference GRC
The 2026 Gordon Research Conference on Intrinsically Disordered Proteins will be held in Les Diablerets, Vaud (fr) Switzerland. Apply today to reserve your spot.
grc.org
October 2, 2025 at 3:21 PM
🚨🚨The GRC on Intrinsically Disordered Proteins #IDPs is back!! 🍝🧵🏔️Join us for cutting-edge IDP science, great discussions, and mountain views 🌄🍝
📅 June 21-26, 2026 | Les Diablerets, Switzerland
👉 Details & registration: grc.org/intrinsicall...
📅 June 21-26, 2026 | Les Diablerets, Switzerland
👉 Details & registration: grc.org/intrinsicall...
Reposted by Tanja Mittag
Why are transcription factors disordered? Come join us in Oxford as a postdoc and we'll find out together!
Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays!
biophysics
transcription
protein:DNA interactions
my.corehr.com/pls/uoxrecru...
Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays!
biophysics
transcription
protein:DNA interactions
my.corehr.com/pls/uoxrecru...
October 1, 2025 at 4:30 PM
Why are transcription factors disordered? Come join us in Oxford as a postdoc and we'll find out together!
Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays!
biophysics
transcription
protein:DNA interactions
my.corehr.com/pls/uoxrecru...
Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays!
biophysics
transcription
protein:DNA interactions
my.corehr.com/pls/uoxrecru...
Reposted by Tanja Mittag
Come work with me. Excellent startup package. su.varbi.com/en/what:job/...
Assistant Professor in Data-driven cell and molecular biology
At Stockholm University the Department of Biochemistry and Biophysics (DBB) and the Department of Molecular Biosciences, The Wenner-Gren Institute (MBW) are looking to fill one position as DDLS fellow
su.varbi.com
September 30, 2025 at 7:43 AM
Come work with me. Excellent startup package. su.varbi.com/en/what:job/...
Reposted by Tanja Mittag
We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...
biochem.weill.cornell.edu/join-our-fac...
Join our Faculty | Department of Biochemistry & Biophysics
Call for applications:We invite applications for a tenure-track Assistant Professor position in the newly established Department of Biochemistry and Biophysics. We are conducting an open search for ou...
biochem.weill.cornell.edu
September 29, 2025 at 7:58 PM
We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22.
biochem.weill.cornell.edu/join-our-fac...
biochem.weill.cornell.edu/join-our-fac...
Reposted by Tanja Mittag
We are looking for a new colleague to join the vibrant and fast-growing biophysics community at CMU and in Pittsburgh! The City of Bridges also offers a unique combination of affordability, innovative ecosystems, and rich cultures. Please spread the word!
I am super excited to announce that we have a tenure-track faculty position in biophysics open in the Department of Physics at Carnegie Mellon! 🧪
Interfolio link: apply.interfolio.com/174360
PLEASE, share widely across the blue skies!
Let me briefly explain what we're looking for:
1/10
Interfolio link: apply.interfolio.com/174360
PLEASE, share widely across the blue skies!
Let me briefly explain what we're looking for:
1/10
September 29, 2025 at 9:10 PM
We are looking for a new colleague to join the vibrant and fast-growing biophysics community at CMU and in Pittsburgh! The City of Bridges also offers a unique combination of affordability, innovative ecosystems, and rich cultures. Please spread the word!
Reposted by Tanja Mittag
Feeling awed and a bit starstruck that @science.org chose to run a book review on #LabworkToLeadership!!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Leading a lab, and all it entails
A chemist offers actionable leadership advice to principal investigators
www.science.org
August 15, 2025 at 7:29 PM
Feeling awed and a bit starstruck that @science.org chose to run a book review on #LabworkToLeadership!!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...