Sarah Shammas
@sarahshammas.bsky.social
Biophysicist who loves disordered proteins and transcription. PI at Univ of Oxford, UK. She/her.
Pinned
Why are transcription factors disordered? Come join us in Oxford as a postdoc and we'll find out together!
Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays!
biophysics
transcription
protein:DNA interactions
my.corehr.com/pls/uoxrecru...
Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays!
biophysics
transcription
protein:DNA interactions
my.corehr.com/pls/uoxrecru...
One week left to apply!
Why are transcription factors disordered? Come join us in Oxford as a postdoc and we'll find out together!
Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays!
biophysics
transcription
protein:DNA interactions
my.corehr.com/pls/uoxrecru...
Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays!
biophysics
transcription
protein:DNA interactions
my.corehr.com/pls/uoxrecru...
October 20, 2025 at 9:26 AM
One week left to apply!
Why are transcription factors disordered? Come join us in Oxford as a postdoc and we'll find out together!
Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays!
biophysics
transcription
protein:DNA interactions
my.corehr.com/pls/uoxrecru...
Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays!
biophysics
transcription
protein:DNA interactions
my.corehr.com/pls/uoxrecru...
October 1, 2025 at 4:30 PM
Why are transcription factors disordered? Come join us in Oxford as a postdoc and we'll find out together!
Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays!
biophysics
transcription
protein:DNA interactions
my.corehr.com/pls/uoxrecru...
Help publish 3 mature projects, AND develop cool new single molecule fluorescence binding assays!
biophysics
transcription
protein:DNA interactions
my.corehr.com/pls/uoxrecru...
Over 10% of human transcription factors are oligomeric. Stoichiometry might be dialled to modulate transcription. We show CREB searches in DNA mixtures as a dimer, and suggest this might be common amongst other members of the bZIP family which fold on binding DNA.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 8, 2025 at 9:36 AM
Over 10% of human transcription factors are oligomeric. Stoichiometry might be dialled to modulate transcription. We show CREB searches in DNA mixtures as a dimer, and suggest this might be common amongst other members of the bZIP family which fold on binding DNA.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
I'm excited to be invited alongside the fabulous Sonia Longhi to present at IDPseminars this Thursday. I will talk about some of our work with disordered DNA binding domains.
IDPSeminars is back with another seminar this week from @sarahshammas.bsky.social and @sonia-longhi.bsky.social!
Come hear about transcriptional regulation and viral pathogenesis!
Thursday June 5th!
PST 10 am EST 1 pm CET 7 pm!
Info: idpseminars.com
Signup form: forms.gle/3yCHeYvuuqLh...
Come hear about transcriptional regulation and viral pathogenesis!
Thursday June 5th!
PST 10 am EST 1 pm CET 7 pm!
Info: idpseminars.com
Signup form: forms.gle/3yCHeYvuuqLh...
June 3, 2025 at 7:32 PM
I'm excited to be invited alongside the fabulous Sonia Longhi to present at IDPseminars this Thursday. I will talk about some of our work with disordered DNA binding domains.
Reposted by Sarah Shammas
Just one stop. www.nature.com/articles/s41...
Engineering a genomically recoded organism with one stop codon - Nature
Ochre, a strain of Escherichia coli engineered to have a single stop codon, enables reassignment of four codons for non-degenerate functions, such as incorporation of non-standard amino acids into pro...
www.nature.com
February 7, 2025 at 7:44 AM
Just one stop. www.nature.com/articles/s41...
Reposted by Sarah Shammas
Announcing the Biophysics Week IDP Trainee Symposium on March 27 at 12pm CT hosted by @idpseminars.bsky.social & The BPS IDP Subgroup! Join via Zoom for talks by talented grad students & postdocs. Abstract submissions are open! See flyer for more details! #BiophysicsWeek @biophysicalsoc.bsky.social
February 7, 2025 at 6:08 PM
Announcing the Biophysics Week IDP Trainee Symposium on March 27 at 12pm CT hosted by @idpseminars.bsky.social & The BPS IDP Subgroup! Join via Zoom for talks by talented grad students & postdocs. Abstract submissions are open! See flyer for more details! #BiophysicsWeek @biophysicalsoc.bsky.social
Reposted by Sarah Shammas
Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin?
By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient!
#chromatin #3Dgenome #generegulation
www.science.org/doi/10.1126/...
👇
By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient!
#chromatin #3Dgenome #generegulation
www.science.org/doi/10.1126/...
👇
Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus
In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...
www.science.org
February 7, 2025 at 10:22 AM
Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin?
By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient!
#chromatin #3Dgenome #generegulation
www.science.org/doi/10.1126/...
👇
By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient!
#chromatin #3Dgenome #generegulation
www.science.org/doi/10.1126/...
👇
Reposted by Sarah Shammas
What happens to bacterial genomes when they're cloned into yeast? Do they transcribe, do they get silenced, do they get packaged away from the rest of the DNA? This cool study congrats to the Koszul lab team at Pasteur for this great work.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus
In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...
www.science.org
February 6, 2025 at 11:09 PM
What happens to bacterial genomes when they're cloned into yeast? Do they transcribe, do they get silenced, do they get packaged away from the rest of the DNA? This cool study congrats to the Koszul lab team at Pasteur for this great work.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Sarah Shammas
PhD opportunities (yes, plural!)
We will launch a center of excellence “Plat-PATH” with @bjornppedersen.bsky.social this summer. We have an opening for some PhD students to work on plant hormone transporter mechanism.
- Details and application link: tinyurl.com/44hf9zkd
Please repost 💚
We will launch a center of excellence “Plat-PATH” with @bjornppedersen.bsky.social this summer. We have an opening for some PhD students to work on plant hormone transporter mechanism.
- Details and application link: tinyurl.com/44hf9zkd
Please repost 💚
Structural and biophysical analysis of plant hormone transmembrane transport
tinyurl.com
January 14, 2025 at 10:53 AM
PhD opportunities (yes, plural!)
We will launch a center of excellence “Plat-PATH” with @bjornppedersen.bsky.social this summer. We have an opening for some PhD students to work on plant hormone transporter mechanism.
- Details and application link: tinyurl.com/44hf9zkd
Please repost 💚
We will launch a center of excellence “Plat-PATH” with @bjornppedersen.bsky.social this summer. We have an opening for some PhD students to work on plant hormone transporter mechanism.
- Details and application link: tinyurl.com/44hf9zkd
Please repost 💚
Reposted by Sarah Shammas
Attn. Intrinsically Disordered Proteins Subgroup members:
We are excited to host our IDP subgroup dinner on Feb 15 after the IDP symposium at a Mexican restaurant in Los Angeles: Sol Agave L.A. LIVE.
www.solagave.com/los-angeles
You can purchase a dinner ticket:
www.biophysics.org/store/produc...
We are excited to host our IDP subgroup dinner on Feb 15 after the IDP symposium at a Mexican restaurant in Los Angeles: Sol Agave L.A. LIVE.
www.solagave.com/los-angeles
You can purchase a dinner ticket:
www.biophysics.org/store/produc...
December 5, 2024 at 12:35 PM
Attn. Intrinsically Disordered Proteins Subgroup members:
We are excited to host our IDP subgroup dinner on Feb 15 after the IDP symposium at a Mexican restaurant in Los Angeles: Sol Agave L.A. LIVE.
www.solagave.com/los-angeles
You can purchase a dinner ticket:
www.biophysics.org/store/produc...
We are excited to host our IDP subgroup dinner on Feb 15 after the IDP symposium at a Mexican restaurant in Los Angeles: Sol Agave L.A. LIVE.
www.solagave.com/los-angeles
You can purchase a dinner ticket:
www.biophysics.org/store/produc...
Opportunity for postdocs in IDP related biophysics research! The deadline is coming up quite soon.
The deadline for the 2025 Intrinsically Disordered Protein (IDP) Subgroup Postdoctoral Awards is approaching (December 15, 2024). The award includes an oral presentation at the IDP symposium & an honorarium. Postdocs working in the IDP field are welcome to apply:
www.biophysics.org/awards-fundi...
www.biophysics.org/awards-fundi...
December 6, 2024 at 2:45 PM
Opportunity for postdocs in IDP related biophysics research! The deadline is coming up quite soon.
A paper to cite!
We did this crazy project where we tried to see if proteins could interact with their mirror image ligand. Seems impossible when proteins need to form 3D structures to interact. But what about if the interaction remains disordered???
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Stereochemistry in the disorder–order continuum of protein interactions - Nature
Studies on protein–protein interactions using proteins containing d- or l-amino acids show that stereoselectivity of binding varies with the degree of disorder within the complex.
www.nature.com
November 28, 2024 at 8:03 AM
A paper to cite!
Reposted by Sarah Shammas
If you are a PhD student and like protein disorder (or want to learn more), Birthe Kragelund @bbkrage.bsky.social and Kristian Strømgaard are organizing a PhD course on How IDPs work 🧶🧬🧪 Note the cost if you are not at a Danish university.
Details: phdcourses.ku.dk/DetailKursus...
Details: phdcourses.ku.dk/DetailKursus...
November 25, 2024 at 4:13 PM
If you are a PhD student and like protein disorder (or want to learn more), Birthe Kragelund @bbkrage.bsky.social and Kristian Strømgaard are organizing a PhD course on How IDPs work 🧶🧬🧪 Note the cost if you are not at a Danish university.
Details: phdcourses.ku.dk/DetailKursus...
Details: phdcourses.ku.dk/DetailKursus...
Reposted by Sarah Shammas
Reposted by Sarah Shammas
We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how:
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
Action Intent Links | Bluesky
Authors, websites, and apps can use action intent links to implement "Share on Bluesky" buttons, or similar in-app actions. Logged-in users will be directed to the corresponding action view in the Blu...
docs.bsky.app
November 18, 2024 at 2:48 PM
We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how:
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
Reposted by Sarah Shammas
My first post on Blue Sky - moving over !
For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...
For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...
EMBL Jobs
We offer a wide range of challenging scientific and non-scientific positions at all of our European locations and encourage applications from international candidates at all career levels.
www.embl.org
November 18, 2024 at 5:28 PM
My first post on Blue Sky - moving over !
For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...
For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...
Reposted by Sarah Shammas
New collaborative work in collaboration with the labs of Robert Best & Tanja Mittag driven by Ben Schuler.
Identifying Sequence Effects on Chain Dimensions of Disordered Proteins by Integrating Experiments and Simulations.
pubs.acs.org/doi/10.1021/...
Identifying Sequence Effects on Chain Dimensions of Disordered Proteins by Integrating Experiments and Simulations.
pubs.acs.org/doi/10.1021/...
Identifying Sequence Effects on Chain Dimensions of Disordered Proteins by Integrating Experiments and Simulations
It has become increasingly evident that the conformational distributions of intrinsically disordered proteins or regions are strongly dependent on their amino acid compositions and sequence. To facili...
pubs.acs.org
November 15, 2024 at 4:56 PM
New collaborative work in collaboration with the labs of Robert Best & Tanja Mittag driven by Ben Schuler.
Identifying Sequence Effects on Chain Dimensions of Disordered Proteins by Integrating Experiments and Simulations.
pubs.acs.org/doi/10.1021/...
Identifying Sequence Effects on Chain Dimensions of Disordered Proteins by Integrating Experiments and Simulations.
pubs.acs.org/doi/10.1021/...
Reposted by Sarah Shammas
BONUS! If IDPs are your jam, check out an ever-expanding starter pack!
go.bsky.app/J23B51L
go.bsky.app/J23B51L
November 10, 2024 at 7:38 PM
BONUS! If IDPs are your jam, check out an ever-expanding starter pack!
go.bsky.app/J23B51L
go.bsky.app/J23B51L
Reposted by Sarah Shammas
Register for the upcoming JUST-B Seminar on Nov. 19th at 11am PST / 2pm EST to learn about the science of two amazing PhD students❗️❗️❗️
Register here: biophysics.org/store/products…
@blackinx.bsky.social
Register here: biophysics.org/store/products…
@blackinx.bsky.social
November 14, 2024 at 3:37 PM
Register for the upcoming JUST-B Seminar on Nov. 19th at 11am PST / 2pm EST to learn about the science of two amazing PhD students❗️❗️❗️
Register here: biophysics.org/store/products…
@blackinx.bsky.social
Register here: biophysics.org/store/products…
@blackinx.bsky.social
Reposted by Sarah Shammas
Download our database of 313 different postdoctoral fellowships.
For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).
Download our database here: research.jhu.edu/rdt/funding-...
For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).
Download our database here: research.jhu.edu/rdt/funding-...
November 16, 2024 at 7:05 PM
Download our database of 313 different postdoctoral fellowships.
For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).
Download our database here: research.jhu.edu/rdt/funding-...
For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship).
Download our database here: research.jhu.edu/rdt/funding-...