Sudipta Mukherjee
@sudimukherjee.bsky.social
Tissue mechanics and brain development @EBM @FAU Erlangen-Nuremberg
PhD @Franze lab @University of Cambridge
Masters @Sonawane lab @TIFR Mumbai
PhD @Franze lab @University of Cambridge
Masters @Sonawane lab @TIFR Mumbai
Pinned
Paper alert: Our study led by @evapillai.bsky.social and @sudimukherjee.bsky.social showing that mechanical properties of the #brain actively shape the molecular landscape during development and #axonpathfinding is finally out! www.nature.com/articles/s41... @pdncambridge.bsky.social @fau.de @MPZPM
Long-range chemical signalling in vivo is regulated by mechanical signals - Nature Materials
Tissue stiffness mediated by Piezo1 is shown to regulate the expression of diffusive guidance cues in the developing Xenopus laevis brain, revealing a crosstalk between mechanical signals and long-ran...
www.nature.com
Presenting our latest results!!
Glad to have been part of the team! Huge thanks to everyone especially @evapillai.bsky.social @niklasgampl.bsky.social and @franzelab.bsky.social !!!
#xenopus #mechanobiology
Glad to have been part of the team! Huge thanks to everyone especially @evapillai.bsky.social @niklasgampl.bsky.social and @franzelab.bsky.social !!!
#xenopus #mechanobiology
Reposted by Sudipta Mukherjee
A wonderful piece by @callimcflurry.bsky.social on how mechanosensitive PIEZO ion channels are being used to explore how our bodies rely on pressure sensing. It is a thoughtfully researched article, with perspectives from many colleagues across the field.
www.thetransmitter.org/interoceptio...
www.thetransmitter.org/interoceptio...
PIEZO channels are opening the study of mechanosensation in unexpected places
The force-activated ion channels underlie the senses of touch and proprioception. Now scientists are using them as a tool to explore molecular mechanisms at work in internal organs…
www.thetransmitter.org
January 30, 2026 at 5:36 PM
A wonderful piece by @callimcflurry.bsky.social on how mechanosensitive PIEZO ion channels are being used to explore how our bodies rely on pressure sensing. It is a thoughtfully researched article, with perspectives from many colleagues across the field.
www.thetransmitter.org/interoceptio...
www.thetransmitter.org/interoceptio...
Reposted by Sudipta Mukherjee
Congratulations🎉 @rashmi-priya.bsky.social !!
We are delighted to announce that @rashmi-priya.bsky.social from @crick.ac.uk has been awarded the 2026 Women in Cell Biology Early Career medal
You can read about Rashmi's prize-winning work on heart morphogenesis here:
bscb.org/wicb-early-c...
You can read about Rashmi's prize-winning work on heart morphogenesis here:
bscb.org/wicb-early-c...
January 22, 2026 at 10:04 AM
Congratulations🎉 @rashmi-priya.bsky.social !!
Reposted by Sudipta Mukherjee
During #brain development, axons grow along precise pathways. Scientists have now discovered that tissue stiffness & chemical signalling interact with each other.
👉 mpzpm.mpg.de/news/news-de...
@fau.de @embl.org @franzelab.bsky.social
#research #neuroscience
👉 mpzpm.mpg.de/news/news-de...
@fau.de @embl.org @franzelab.bsky.social
#research #neuroscience
January 20, 2026 at 9:24 AM
During #brain development, axons grow along precise pathways. Scientists have now discovered that tissue stiffness & chemical signalling interact with each other.
👉 mpzpm.mpg.de/news/news-de...
@fau.de @embl.org @franzelab.bsky.social
#research #neuroscience
👉 mpzpm.mpg.de/news/news-de...
@fau.de @embl.org @franzelab.bsky.social
#research #neuroscience
Reposted by Sudipta Mukherjee
🥳🥳🥳 Pretty fab start to 2026!!
Paper alert: Our study led by @evapillai.bsky.social and @sudimukherjee.bsky.social showing that mechanical properties of the #brain actively shape the molecular landscape during development and #axonpathfinding is finally out! www.nature.com/articles/s41... @pdncambridge.bsky.social @fau.de @MPZPM
Long-range chemical signalling in vivo is regulated by mechanical signals - Nature Materials
Tissue stiffness mediated by Piezo1 is shown to regulate the expression of diffusive guidance cues in the developing Xenopus laevis brain, revealing a crosstalk between mechanical signals and long-ran...
www.nature.com
January 19, 2026 at 4:51 PM
🥳🥳🥳 Pretty fab start to 2026!!
Presenting our latest results!!
Glad to have been part of the team! Huge thanks to everyone especially @evapillai.bsky.social @niklasgampl.bsky.social and @franzelab.bsky.social !!!
#xenopus #mechanobiology
Glad to have been part of the team! Huge thanks to everyone especially @evapillai.bsky.social @niklasgampl.bsky.social and @franzelab.bsky.social !!!
#xenopus #mechanobiology
Paper alert: Our study led by @evapillai.bsky.social and @sudimukherjee.bsky.social showing that mechanical properties of the #brain actively shape the molecular landscape during development and #axonpathfinding is finally out! www.nature.com/articles/s41... @pdncambridge.bsky.social @fau.de @MPZPM
Long-range chemical signalling in vivo is regulated by mechanical signals - Nature Materials
Tissue stiffness mediated by Piezo1 is shown to regulate the expression of diffusive guidance cues in the developing Xenopus laevis brain, revealing a crosstalk between mechanical signals and long-ran...
www.nature.com
January 19, 2026 at 6:13 PM
Presenting our latest results!!
Glad to have been part of the team! Huge thanks to everyone especially @evapillai.bsky.social @niklasgampl.bsky.social and @franzelab.bsky.social !!!
#xenopus #mechanobiology
Glad to have been part of the team! Huge thanks to everyone especially @evapillai.bsky.social @niklasgampl.bsky.social and @franzelab.bsky.social !!!
#xenopus #mechanobiology
Reposted by Sudipta Mukherjee
🚨Two fully-funded #PhD positions🚨
Join @slcuplants.bsky.social to help us explore intriguing fundamental plant development questions in a supportive, friendly institute with fantastic supervisors & exceptional support services 🌿🧬🔬
Find out more www.slcu.cam.ac.uk/PhD
Pls share
#plantscijobs
1/3🧵
Join @slcuplants.bsky.social to help us explore intriguing fundamental plant development questions in a supportive, friendly institute with fantastic supervisors & exceptional support services 🌿🧬🔬
Find out more www.slcu.cam.ac.uk/PhD
Pls share
#plantscijobs
1/3🧵
December 23, 2025 at 2:41 PM
🚨Two fully-funded #PhD positions🚨
Join @slcuplants.bsky.social to help us explore intriguing fundamental plant development questions in a supportive, friendly institute with fantastic supervisors & exceptional support services 🌿🧬🔬
Find out more www.slcu.cam.ac.uk/PhD
Pls share
#plantscijobs
1/3🧵
Join @slcuplants.bsky.social to help us explore intriguing fundamental plant development questions in a supportive, friendly institute with fantastic supervisors & exceptional support services 🌿🧬🔬
Find out more www.slcu.cam.ac.uk/PhD
Pls share
#plantscijobs
1/3🧵
Reposted by Sudipta Mukherjee
When a larval zebrafish twitches its tail, the vascular endothelium lights up with a calcium signal, mediated by Piezo1. We used to think mechanosensing in endothelial cells was about sensing blood flow, but at least in this case it's about sensing body motion.
November 14, 2025 at 8:34 PM
When a larval zebrafish twitches its tail, the vascular endothelium lights up with a calcium signal, mediated by Piezo1. We used to think mechanosensing in endothelial cells was about sensing blood flow, but at least in this case it's about sensing body motion.
Happy to have been part of such an amazing team of scientists! If you are curious about how stiffness regulates neuronal maturation, give this a read.
#xenopus #mechanobiology
#xenopus #mechanobiology
Environmental stiffness regulates neuronal
maturation via Piezo1-mediated transthyretin activity.
My main postdoc paper is finally online!
Thanks to all the co-authors, the entire Franze lab and the Káradóttir lab.
@franzelab.bsky.social
www.nature.com/articles/s41...
maturation via Piezo1-mediated transthyretin activity.
My main postdoc paper is finally online!
Thanks to all the co-authors, the entire Franze lab and the Káradóttir lab.
@franzelab.bsky.social
www.nature.com/articles/s41...
Environmental stiffness regulates neuronal maturation via Piezo1-mediated transthyretin activity - Nature Communications
How the environment regulates neuronal maturation during brain development is poorly understood. Here, Kreysing et al. identify brain stiffness as a key factor and determine a mechanotransduction path...
www.nature.com
November 7, 2025 at 4:53 PM
Happy to have been part of such an amazing team of scientists! If you are curious about how stiffness regulates neuronal maturation, give this a read.
#xenopus #mechanobiology
#xenopus #mechanobiology
An excellent opportunity to do your PhD in a fantastic lab with an incredible mentor!
The Chancellors Studentship is an excellent opportunity to do your PhD in the UK. If you are interested in doing your PhD at the interface between physics, neurobiology and mechanobiology, please get in touch.
warwick.ac.uk/services/dc/...
warwick.ac.uk/services/dc/...
Warwick PGR Scholarship Competitions
warwick.ac.uk
October 20, 2025 at 4:10 PM
An excellent opportunity to do your PhD in a fantastic lab with an incredible mentor!
Reposted by Sudipta Mukherjee
Zelda's Link: The role of gene activity-switching transcription factor Zelda in controlling tissue regeneration
📷 Anish Bose et al @rachelsmithbolton.bsky.social lab @uofillinois.bsky.social
in @science.org ScienceAdvances
➡️ bpod.org.uk/archive/2025... with
John Ankers
📷 Anish Bose et al @rachelsmithbolton.bsky.social lab @uofillinois.bsky.social
in @science.org ScienceAdvances
➡️ bpod.org.uk/archive/2025... with
John Ankers
August 3, 2025 at 12:08 PM
Zelda's Link: The role of gene activity-switching transcription factor Zelda in controlling tissue regeneration
📷 Anish Bose et al @rachelsmithbolton.bsky.social lab @uofillinois.bsky.social
in @science.org ScienceAdvances
➡️ bpod.org.uk/archive/2025... with
John Ankers
📷 Anish Bose et al @rachelsmithbolton.bsky.social lab @uofillinois.bsky.social
in @science.org ScienceAdvances
➡️ bpod.org.uk/archive/2025... with
John Ankers
Huge congratulations!!!
Huge congratulations to Anish Bose @anishbose.bsky.social for winning the Development talk award at the International Society for Regenerative Biology meeting!! Presented by Elly Tanaka.
August 16, 2025 at 9:39 AM
Huge congratulations!!!
Thanks,DionnHargreaves LabWoolner @dev-journal.bsky.social for highlighting our preprint! Curious how mechanical and chemical signaling guides axons or how frogs are excellent for this question? @franzelab.bsky.social @evapillai.bsky.social🐸🧠 check it out #xenopus #Devbio #mechanobiology
Thank you Dionn Hargreaves, Sarah Woolner & @dev-journal.bsky.social for highlighting our @sudimukherjee.bsky.social @franzelab.bsky.social preprint! Chuffed to see it engaged with through fresh eyes! 🙌
Interested in how mechanical & chemical signals shape tissue development? Give it a look!
🧠🐸⚙️
Interested in how mechanical & chemical signals shape tissue development? Give it a look!
🧠🐸⚙️
In preprints: unpicking chemical and mechanical crosstalk for axonal pathfinding
Dionn Hargreaves and Sarah Woolner @mcrcellmatrix.bsky.social discuss the #preprint from @evapillai.bsky.social @sudimukherjee.bsky.social @franzelab.bsky.social et al.
journals.biologists.com/dev/article/...
Dionn Hargreaves and Sarah Woolner @mcrcellmatrix.bsky.social discuss the #preprint from @evapillai.bsky.social @sudimukherjee.bsky.social @franzelab.bsky.social et al.
journals.biologists.com/dev/article/...
June 19, 2025 at 11:48 PM
Thanks,DionnHargreaves LabWoolner @dev-journal.bsky.social for highlighting our preprint! Curious how mechanical and chemical signaling guides axons or how frogs are excellent for this question? @franzelab.bsky.social @evapillai.bsky.social🐸🧠 check it out #xenopus #Devbio #mechanobiology
Reposted by Sudipta Mukherjee
So excited that our latest work is out! We have been working to understand how damaged tissue exits regeneration and returns to normal gene expression, and found a major role for the pioneer transcription factor Zelda in flies. Kudos to @anishbose.bsky.social @keatonschuster.bsky.social et al!
The pioneer transcription factor Zelda controls the exit from regeneration and restoration of patterning in Drosophila
The pioneer factor Zelda activates a specific set of developmental and structural genes to end tissue regeneration.
www.science.org
June 14, 2025 at 12:47 AM
So excited that our latest work is out! We have been working to understand how damaged tissue exits regeneration and returns to normal gene expression, and found a major role for the pioneer transcription factor Zelda in flies. Kudos to @anishbose.bsky.social @keatonschuster.bsky.social et al!
Reposted by Sudipta Mukherjee
Experimental embryology postdoc available in my lab at the @biology.ox.ac.uk @ox.ac.uk working on the evolution of vertebral counts. Reach out if you’re passionate about EvoDevo, enjoy lab work and microscopy and are into or could get into cichlid fishes. Deadline on the 16th June. Please share!
May 19, 2025 at 4:10 PM
Experimental embryology postdoc available in my lab at the @biology.ox.ac.uk @ox.ac.uk working on the evolution of vertebral counts. Reach out if you’re passionate about EvoDevo, enjoy lab work and microscopy and are into or could get into cichlid fishes. Deadline on the 16th June. Please share!
Reposted by Sudipta Mukherjee
For an update on a set of recent preprints using gastruloids to investigate the interplay between morphogenesis, gene expression and physical parameters, on the robustness of patterning:
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
In preprints: exploring developmental robustness and timing with gastruloids
How developmental processes are coordinated in time and space to ensure the robust formation of complex, functional patterns during embryogenesis remains an outstanding question. Investigating this in...
journals.biologists.com
May 19, 2025 at 8:11 AM
For an update on a set of recent preprints using gastruloids to investigate the interplay between morphogenesis, gene expression and physical parameters, on the robustness of patterning:
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
Reposted by Sudipta Mukherjee
🤩🤩 Check out this selection of amazing images on the Node! #devbio
thenode.biologists.com/grs-developm...
thenode.biologists.com/grs-developm...
May 15, 2025 at 8:47 AM
🤩🤩 Check out this selection of amazing images on the Node! #devbio
thenode.biologists.com/grs-developm...
thenode.biologists.com/grs-developm...
Reposted by Sudipta Mukherjee
Want to engage with the #mechanobiology community? Why not join this group? Just drop me a DM and I´ll add you.
go.bsky.app/G5cQqYT
go.bsky.app/G5cQqYT
November 13, 2024 at 1:59 PM
Want to engage with the #mechanobiology community? Why not join this group? Just drop me a DM and I´ll add you.
go.bsky.app/G5cQqYT
go.bsky.app/G5cQqYT
Reposted by Sudipta Mukherjee
High impact, small size.
We welcome papers that address findings from a single set of experiments, or that are substantial enough to stand alone in 1,500 words or fewer.
Find out more 👇
We welcome papers that address findings from a single set of experiments, or that are substantial enough to stand alone in 1,500 words or fewer.
Find out more 👇
eLife Latest: Publish in a format that fits
Alongside Research Articles, eLife also publishes scientific discoveries in the form of Tools and Resources papers, Research Advances and Short Reports.
elifesciences.org
April 26, 2025 at 1:59 PM
High impact, small size.
We welcome papers that address findings from a single set of experiments, or that are substantial enough to stand alone in 1,500 words or fewer.
Find out more 👇
We welcome papers that address findings from a single set of experiments, or that are substantial enough to stand alone in 1,500 words or fewer.
Find out more 👇
Reposted by Sudipta Mukherjee
“Our comprehensive atlas serves as a valuable resource to the cardiovascular and regeneration scientific communities and their ongoing efforts to understand the molecular and cellular mechanisms underlying vertebrate heart regeneration.”
New work from Ying Su Lab 🇨🇳
🔗 www.nature.com/articles/s41...
New work from Ying Su Lab 🇨🇳
🔗 www.nature.com/articles/s41...
An organ-wide spatiotemporal transcriptomic and cellular atlas of the regenerating zebrafish heart - Nature Communications
Adult zebrafish possess the ability to regenerate injured hearts through a complex orchestration of molecular and cellular activities. Here, the authors present a single cell and spatially-resolved at...
www.nature.com
April 22, 2025 at 4:35 AM
“Our comprehensive atlas serves as a valuable resource to the cardiovascular and regeneration scientific communities and their ongoing efforts to understand the molecular and cellular mechanisms underlying vertebrate heart regeneration.”
New work from Ying Su Lab 🇨🇳
🔗 www.nature.com/articles/s41...
New work from Ying Su Lab 🇨🇳
🔗 www.nature.com/articles/s41...
Reposted by Sudipta Mukherjee
“Together, our results establish this optogenetic toolkit as a potent experimental platform to rapidly, directly, and adjustably activate FGF, BMP, and Nodal signaling in zebrafish embryos.”
New work from @leanneiannucci.bsky.social & @katwrog.bsky.social 🔥
New work from @leanneiannucci.bsky.social & @katwrog.bsky.social 🔥
An optogenetic toolkit for robust activation of FGF, BMP, and Nodal signaling in zebrafish https://www.biorxiv.org/content/10.1101/2025.04.17.649426v1
April 20, 2025 at 4:51 AM
“Together, our results establish this optogenetic toolkit as a potent experimental platform to rapidly, directly, and adjustably activate FGF, BMP, and Nodal signaling in zebrafish embryos.”
New work from @leanneiannucci.bsky.social & @katwrog.bsky.social 🔥
New work from @leanneiannucci.bsky.social & @katwrog.bsky.social 🔥
Reposted by Sudipta Mukherjee
Are material phase transitions more than simple regulators of tissue deformability? Check our latest work uncovering that rigidity transitions can trigger cell polarity! Congratulations to @laura-rustarazo.bsky.social , @crisp-c.bsky.social and Adrián for leading this work!
🎉 Excited to share our new work: “Adhesion-driven tissue rigidification triggers epithelial cell polarity”, now on @biorxivpreprint.bsky.social !
A huge thank you to @nicolettapetridou.bsky.social, Bernat, @crisp-c.bsky.social, Adrián, and everyone involved! 🙌
🧵⤵️
A huge thank you to @nicolettapetridou.bsky.social, Bernat, @crisp-c.bsky.social, Adrián, and everyone involved! 🙌
🧵⤵️
March 27, 2025 at 2:31 PM
Are material phase transitions more than simple regulators of tissue deformability? Check our latest work uncovering that rigidity transitions can trigger cell polarity! Congratulations to @laura-rustarazo.bsky.social , @crisp-c.bsky.social and Adrián for leading this work!
Reposted by Sudipta Mukherjee
Nervous system of a five-day-old zebrafish larva. Credit to Dr. Nathan Martin of @plavickilab.bsky.social. #ZebrafishZunday 🧪
March 23, 2025 at 8:14 AM
Nervous system of a five-day-old zebrafish larva. Credit to Dr. Nathan Martin of @plavickilab.bsky.social. #ZebrafishZunday 🧪
Reposted by Sudipta Mukherjee
Proteins that allow water to move in and out of cells help shape the development of new blood vessels.
buff.ly/Sl19tgH
buff.ly/Sl19tgH
March 22, 2025 at 2:59 PM
Proteins that allow water to move in and out of cells help shape the development of new blood vessels.
buff.ly/Sl19tgH
buff.ly/Sl19tgH
Reposted by Sudipta Mukherjee
Hyaluronic acid deposition & a soft ECM promote digit regeneration in mice. 🐁
@jontytownson.bsky.social covers the first #preprint from the @storerlab.bsky.social delving into the importance of the ECM in wound regeneration in mice.
#preLight ⬇️ 👀
prelights.biologists.com/highlights/h...
@jontytownson.bsky.social covers the first #preprint from the @storerlab.bsky.social delving into the importance of the ECM in wound regeneration in mice.
#preLight ⬇️ 👀
prelights.biologists.com/highlights/h...
Hyaluronic Acid and Emergent Tissue Mechanics Orchestrate Digit Tip Regeneration - preLights
Mui and team show hyaluronic acid deposition and a soft ECM promote digit regeneration in mice.
prelights.biologists.com
March 21, 2025 at 12:32 PM
Hyaluronic acid deposition & a soft ECM promote digit regeneration in mice. 🐁
@jontytownson.bsky.social covers the first #preprint from the @storerlab.bsky.social delving into the importance of the ECM in wound regeneration in mice.
#preLight ⬇️ 👀
prelights.biologists.com/highlights/h...
@jontytownson.bsky.social covers the first #preprint from the @storerlab.bsky.social delving into the importance of the ECM in wound regeneration in mice.
#preLight ⬇️ 👀
prelights.biologists.com/highlights/h...