Daniel E. Weeks
@statgendan.bsky.social
Statistical geneticist. Professor of Human Genetics and Biostatistics at the University of Pittsburgh. Assiduously meticulous.
Reposted by Daniel E. Weeks
Reflections on the I-squared index for measuring inconsistency in meta-analysis. Julian P. T. Higgins, José A. López-López. Research Synthesis Methods. bit.ly/48Xsjce
Reflections on the I-squared index for measuring inconsistency in meta-analysis | Research Synthesis Methods | Cambridge Core
Reflections on the I-squared index for measuring inconsistency in meta-analysis
bit.ly
December 30, 2025 at 2:37 AM
Reflections on the I-squared index for measuring inconsistency in meta-analysis. Julian P. T. Higgins, José A. López-López. Research Synthesis Methods. bit.ly/48Xsjce
Reposted by Daniel E. Weeks
Do transcriptional activators work on any promoter? Our data says no. 🙅♂️
Despite driving ~2/3 of mammalian genes, CpG island (CGI) promoters have remained a puzzle. We identified >50 activators that are exclusively compatible with this promoter class. 🧬
Despite driving ~2/3 of mammalian genes, CpG island (CGI) promoters have remained a puzzle. We identified >50 activators that are exclusively compatible with this promoter class. 🧬
December 29, 2025 at 7:30 PM
Do transcriptional activators work on any promoter? Our data says no. 🙅♂️
Despite driving ~2/3 of mammalian genes, CpG island (CGI) promoters have remained a puzzle. We identified >50 activators that are exclusively compatible with this promoter class. 🧬
Despite driving ~2/3 of mammalian genes, CpG island (CGI) promoters have remained a puzzle. We identified >50 activators that are exclusively compatible with this promoter class. 🧬
Reposted by Daniel E. Weeks
New preprint 👇
Does diagnostic misclassification in EHR-based psychiatry GWAS suppress genetic discovery?
We use simulations and FinnGen data to expand the SuperControl framework and propose a new ML approach (PRISMA) to boost signal discovery.
Led by Lisa Eick & Zhiyu Yang!
Does diagnostic misclassification in EHR-based psychiatry GWAS suppress genetic discovery?
We use simulations and FinnGen data to expand the SuperControl framework and propose a new ML approach (PRISMA) to boost signal discovery.
Led by Lisa Eick & Zhiyu Yang!
December 29, 2025 at 2:51 PM
New preprint 👇
Does diagnostic misclassification in EHR-based psychiatry GWAS suppress genetic discovery?
We use simulations and FinnGen data to expand the SuperControl framework and propose a new ML approach (PRISMA) to boost signal discovery.
Led by Lisa Eick & Zhiyu Yang!
Does diagnostic misclassification in EHR-based psychiatry GWAS suppress genetic discovery?
We use simulations and FinnGen data to expand the SuperControl framework and propose a new ML approach (PRISMA) to boost signal discovery.
Led by Lisa Eick & Zhiyu Yang!
Reposted by Daniel E. Weeks
{toggle} does one thing: adds a button to hide code output in #quarto docs.
Took two versions to do that one thing well. Now it works everywhere... tabsets, callouts, nested containers, you name it.
📚 quarto.thecoatlessprofessor.com/toggle/
🐙 github.com/coatless-qua...
Took two versions to do that one thing well. Now it works everywhere... tabsets, callouts, nested containers, you name it.
📚 quarto.thecoatlessprofessor.com/toggle/
🐙 github.com/coatless-qua...
December 29, 2025 at 6:48 AM
{toggle} does one thing: adds a button to hide code output in #quarto docs.
Took two versions to do that one thing well. Now it works everywhere... tabsets, callouts, nested containers, you name it.
📚 quarto.thecoatlessprofessor.com/toggle/
🐙 github.com/coatless-qua...
Took two versions to do that one thing well. Now it works everywhere... tabsets, callouts, nested containers, you name it.
📚 quarto.thecoatlessprofessor.com/toggle/
🐙 github.com/coatless-qua...
Reposted by Daniel E. Weeks
I'm working on some figures for a book to illustrate the foundation of quantitative genetics (as confirmed by GWAS a century later).
Mendel showed discrete inheritance in peas (left figure, 1860s).
Fisher showed that many such Mendelian effects yield continuous traits (right figure, 1918).
Mendel showed discrete inheritance in peas (left figure, 1860s).
Fisher showed that many such Mendelian effects yield continuous traits (right figure, 1918).
December 28, 2025 at 4:39 PM
I'm working on some figures for a book to illustrate the foundation of quantitative genetics (as confirmed by GWAS a century later).
Mendel showed discrete inheritance in peas (left figure, 1860s).
Fisher showed that many such Mendelian effects yield continuous traits (right figure, 1918).
Mendel showed discrete inheritance in peas (left figure, 1860s).
Fisher showed that many such Mendelian effects yield continuous traits (right figure, 1918).
Reposted by Daniel E. Weeks
Every research project starts with a question and ends with a folder called “final_FINAL_reallyfinal2”
December 29, 2025 at 10:26 AM
Every research project starts with a question and ends with a folder called “final_FINAL_reallyfinal2”
Reposted by Daniel E. Weeks
Kangaroos have a remarkable ability to speed up without burning extra energy.
Clever posture changes let their tendons store and return extra elastic energy, acting like natural springs and keeping the metabolic cost almost flat even at higher speeds.
buff.ly/JGx98pe
Clever posture changes let their tendons store and return extra elastic energy, acting like natural springs and keeping the metabolic cost almost flat even at higher speeds.
buff.ly/JGx98pe
December 29, 2025 at 11:44 AM
Kangaroos have a remarkable ability to speed up without burning extra energy.
Clever posture changes let their tendons store and return extra elastic energy, acting like natural springs and keeping the metabolic cost almost flat even at higher speeds.
buff.ly/JGx98pe
Clever posture changes let their tendons store and return extra elastic energy, acting like natural springs and keeping the metabolic cost almost flat even at higher speeds.
buff.ly/JGx98pe
Reposted by Daniel E. Weeks
It has a name now 😜
Many thanks to Ken for agreeing to put his good name to my...artwork. The image is in the public domain (CC 0), but citations to the linked documents are warmly welcomed.
✅ zenodo.org/records/1808...
✅ pubmed.ncbi.nlm.nih.gov/24452418/
Many thanks to Ken for agreeing to put his good name to my...artwork. The image is in the public domain (CC 0), but citations to the linked documents are warmly welcomed.
✅ zenodo.org/records/1808...
✅ pubmed.ncbi.nlm.nih.gov/24452418/
December 29, 2025 at 11:19 AM
It has a name now 😜
Many thanks to Ken for agreeing to put his good name to my...artwork. The image is in the public domain (CC 0), but citations to the linked documents are warmly welcomed.
✅ zenodo.org/records/1808...
✅ pubmed.ncbi.nlm.nih.gov/24452418/
Many thanks to Ken for agreeing to put his good name to my...artwork. The image is in the public domain (CC 0), but citations to the linked documents are warmly welcomed.
✅ zenodo.org/records/1808...
✅ pubmed.ncbi.nlm.nih.gov/24452418/
Reposted by Daniel E. Weeks
You called? Check out Box 1 in this paper: journals.sagepub.com/doi/10.1177/...
December 29, 2025 at 11:36 AM
You called? Check out Box 1 in this paper: journals.sagepub.com/doi/10.1177/...
“The literature review found that 37 of 92 studies (40.2%) using MIMIC to predict same-admission outcomes included ICD codes as features, even though both MIMIC publications and documentation clearly state that ICD codes are derived after discharge.”
This prognostic study of the MIMIC-IV database suggests that using ICD codes as features in same-admission prediction models may be a severe methodological flaw associated with inflated performance metrics. ja.ma/3Ydx3nP
December 27, 2025 at 8:24 PM
“The literature review found that 37 of 92 studies (40.2%) using MIMIC to predict same-admission outcomes included ICD codes as features, even though both MIMIC publications and documentation clearly state that ICD codes are derived after discharge.”
Reposted by Daniel E. Weeks
Do you think #genomics models are becoming overly complex but lack reproducibility? You are not alone!
In the December issue of #G3journal, Réka Howard and Alex Lipka argue that the focus should be on #reproducibility when it comes to genomics prediction.
In the December issue of #G3journal, Réka Howard and Alex Lipka argue that the focus should be on #reproducibility when it comes to genomics prediction.
Genomic selection and reproducibility: are complex models distracting us from true scientific validity in the presence of genotype-by-environment interaction?
Genomic selection is poised to remain an exemplary plant breeding tool if reproducibility is maximized. Defined as the consistency of results when using th
buff.ly
December 27, 2025 at 5:02 PM
Do you think #genomics models are becoming overly complex but lack reproducibility? You are not alone!
In the December issue of #G3journal, Réka Howard and Alex Lipka argue that the focus should be on #reproducibility when it comes to genomics prediction.
In the December issue of #G3journal, Réka Howard and Alex Lipka argue that the focus should be on #reproducibility when it comes to genomics prediction.
“Before CGI & screens, there was the zoetrope: a cylinder, drawings, and visual persistence creating movement. Science and art in their purest form. Today, it reminds us that innovation isn't always about more technology, but about imagination, rhythm, and the human craft to tell stories with soul.”
🎞️ Antes del CGI y las pantallas, ya existía el zoótropo: un cilindro, dibujos y persistencia visual creando movimiento. Ciencia y arte en estado puro. Hoy nos recuerda que innovar no siempre es más tecnología, sino imaginación, ritmo y oficio humano para contar historias con alma.
December 27, 2025 at 2:55 PM
“Before CGI & screens, there was the zoetrope: a cylinder, drawings, and visual persistence creating movement. Science and art in their purest form. Today, it reminds us that innovation isn't always about more technology, but about imagination, rhythm, and the human craft to tell stories with soul.”
Interesting to search for works with “Genetics” in the title in Anthropic Works List Lookup to see what was stolen and ingested.
#Genetics #AI #Anthropic
secure.anthropiccopyrightsettlement.com/lookup
#Genetics #AI #Anthropic
secure.anthropiccopyrightsettlement.com/lookup
Submit a Claim
secure.anthropiccopyrightsettlement.com
December 26, 2025 at 12:50 PM
Interesting to search for works with “Genetics” in the title in Anthropic Works List Lookup to see what was stolen and ingested.
#Genetics #AI #Anthropic
secure.anthropiccopyrightsettlement.com/lookup
#Genetics #AI #Anthropic
secure.anthropiccopyrightsettlement.com/lookup
Reposted by Daniel E. Weeks
Congrats @jeffgroh.bsky.social et al. Some avocado trees open female-phase flowers in the morning & then male in afternoon. Others show complementary pattern (m->f), to synchronize pollination of two types. Jeff show this to be a >45Mya polymorphism at a transcription factor across 100s of species.
Balanced polymorphism in a floral transcription factor underlies an ancient rhythm of daily sex alternation in avocado https://www.biorxiv.org/content/10.64898/2025.12.22.695989v1
December 25, 2025 at 6:47 PM
Congrats @jeffgroh.bsky.social et al. Some avocado trees open female-phase flowers in the morning & then male in afternoon. Others show complementary pattern (m->f), to synchronize pollination of two types. Jeff show this to be a >45Mya polymorphism at a transcription factor across 100s of species.
Reposted by Daniel E. Weeks
For the interdisciplinary scientists at the Max Planck Society's little known North Pole Institute of Christmas Studies, this is always an especially busy time of year.
Exclusive report by @tomgauld.bsky.social:
Exclusive report by @tomgauld.bsky.social:
December 24, 2025 at 10:15 PM
For the interdisciplinary scientists at the Max Planck Society's little known North Pole Institute of Christmas Studies, this is always an especially busy time of year.
Exclusive report by @tomgauld.bsky.social:
Exclusive report by @tomgauld.bsky.social:
Reposted by Daniel E. Weeks
Please, I beg you to title your comment "Recent discoveries on the acquisition of the highest levels of statistical fallacy"
December 21, 2025 at 7:22 PM
Please, I beg you to title your comment "Recent discoveries on the acquisition of the highest levels of statistical fallacy"
Reposted by Daniel E. Weeks
Ever wondered why the earliest sunset / latest sunrise comes days away the shortest day of the year? Here is a _fabulous_ explanation. And it is presented in the style of the internet of my adolescence. ❤️
larry.denenberg.com/earliest-sun...
larry.denenberg.com/earliest-sun...
Why doesn't the earliest sunset occur on the shortest day?
Learn why
the earliest sunset and latest sunrise do not fall on the shortest day.
larry.denenberg.com
December 24, 2025 at 10:59 AM
Ever wondered why the earliest sunset / latest sunrise comes days away the shortest day of the year? Here is a _fabulous_ explanation. And it is presented in the style of the internet of my adolescence. ❤️
larry.denenberg.com/earliest-sun...
larry.denenberg.com/earliest-sun...
This is the most scathing teaching review
“Did I learn anything from this class? Sure! How NOT to teach
algorithms; and something about algorithms, in the hardest, most
onerous, time-tested manner: ON MY OWN.”
Makes the ones I’ve received a bit less painful.
www.larry.denenberg.com/cs124-eval
“Did I learn anything from this class? Sure! How NOT to teach
algorithms; and something about algorithms, in the hardest, most
onerous, time-tested manner: ON MY OWN.”
Makes the ones I’ve received a bit less painful.
www.larry.denenberg.com/cs124-eval
www.larry.denenberg.com
December 24, 2025 at 11:48 AM
This is the most scathing teaching review
“Did I learn anything from this class? Sure! How NOT to teach
algorithms; and something about algorithms, in the hardest, most
onerous, time-tested manner: ON MY OWN.”
Makes the ones I’ve received a bit less painful.
www.larry.denenberg.com/cs124-eval
“Did I learn anything from this class? Sure! How NOT to teach
algorithms; and something about algorithms, in the hardest, most
onerous, time-tested manner: ON MY OWN.”
Makes the ones I’ve received a bit less painful.
www.larry.denenberg.com/cs124-eval
Reposted by Daniel E. Weeks
Consumer PSA:
A lot of stores will advertise an Xmas tree,
but the package actually *contains* a Ymas tree.
DON'T BE FOOLED.
A lot of stores will advertise an Xmas tree,
but the package actually *contains* a Ymas tree.
DON'T BE FOOLED.
December 23, 2025 at 6:36 PM
Consumer PSA:
A lot of stores will advertise an Xmas tree,
but the package actually *contains* a Ymas tree.
DON'T BE FOOLED.
A lot of stores will advertise an Xmas tree,
but the package actually *contains* a Ymas tree.
DON'T BE FOOLED.
Reposted by Daniel E. Weeks
Writing Genres:
First draft: Horror
Abstract: Action thriller
Hypothesis section: Fantasy
Results section: Tragedy
Limitations section: True crime
Implications section: Satire
Grant application: Science fiction
First draft: Horror
Abstract: Action thriller
Hypothesis section: Fantasy
Results section: Tragedy
Limitations section: True crime
Implications section: Satire
Grant application: Science fiction
December 22, 2025 at 3:30 AM
Writing Genres:
First draft: Horror
Abstract: Action thriller
Hypothesis section: Fantasy
Results section: Tragedy
Limitations section: True crime
Implications section: Satire
Grant application: Science fiction
First draft: Horror
Abstract: Action thriller
Hypothesis section: Fantasy
Results section: Tragedy
Limitations section: True crime
Implications section: Satire
Grant application: Science fiction
Reposted by Daniel E. Weeks
Apologies if you see this again but I am still looking for postdoc positions in psychiatric genetics! I am currently a postdoc at Mount Sinai, I have a PhD in genetic epi from King’s, and have experience in psychosis, ADHD, and autism, including postpartum psychosis!
December 23, 2025 at 1:18 PM
Apologies if you see this again but I am still looking for postdoc positions in psychiatric genetics! I am currently a postdoc at Mount Sinai, I have a PhD in genetic epi from King’s, and have experience in psychosis, ADHD, and autism, including postpartum psychosis!
Reposted by Daniel E. Weeks
In the December issue of #GENETICS, @jeremyjberg.bsky.social et al. introduce an evolutionary model of complex disease susceptibility, identifying how diseases are shaped by selection acting on other pleiotropically related traits. buff.ly/QTZPpYQ
December 22, 2025 at 11:01 PM
In the December issue of #GENETICS, @jeremyjberg.bsky.social et al. introduce an evolutionary model of complex disease susceptibility, identifying how diseases are shaped by selection acting on other pleiotropically related traits. buff.ly/QTZPpYQ
Reposted by Daniel E. Weeks
December 21, 2025 at 3:22 PM
Reposted by Daniel E. Weeks
I agree, and for those who don't want to check the link here it is: Messor ibericus, an ant that lays individuals from two distinct species. In this life cycle, females must clone males of another species because they require their sperm to produce the worker caste.
December 22, 2025 at 1:20 AM
I agree, and for those who don't want to check the link here it is: Messor ibericus, an ant that lays individuals from two distinct species. In this life cycle, females must clone males of another species because they require their sperm to produce the worker caste.