Tim Frayling
@timfrayling.bsky.social
Human genetics, type 2 diabetes and obesity in today's environment. Cycling uphill. Team science. New shoots in Geneva & France, long roots in the UK & Exeter. https://www.unige.ch/medecine/gede/en/research-groups/timothy-frayling
Pinned
Tim Frayling
@timfrayling.bsky.social
· Sep 8
Projects - SPHN
Projects Implementation Projects The SPHN implementation projects aim at developing the core infrastructure which is required to make health-related data FAIR* at the national level. Using a top-down ...
sphn.ch
For more details about the Swiss personalised Health Network and the safe way trained researchers can work with data from multiple hospitals : sphn.ch/network/proj...
Rarely in the entire history of science, has QC been a topic of such passion, importance and impact. If only the French and Americans had adopted such rigor when they messed up the design of that multi billion $ telescope because one was using the metric system, the other the imperial system.
New paper on everyone’s favourite topic, QC!
We show why you should do genotype-level QC on your WGS data
www.biorxiv.org/content/10.1...
Very real quotes about this paper -
“The most exciting, mind-blowing paper of the year!”
“On a par with Fisher 1918”
“I read it every night. Just so beautiful”
We show why you should do genotype-level QC on your WGS data
www.biorxiv.org/content/10.1...
Very real quotes about this paper -
“The most exciting, mind-blowing paper of the year!”
“On a par with Fisher 1918”
“I read it every night. Just so beautiful”
Genotype-level quality control substantially reduces error rates in population-scale whole-genome sequencing
Population-scale whole-genome sequencing data will contain many individual-level genotype errors, even after allele-level quality control (QC). We establish the need for genotype-level QC using UK Bio...
www.biorxiv.org
November 8, 2025 at 3:35 PM
Rarely in the entire history of science, has QC been a topic of such passion, importance and impact. If only the French and Americans had adopted such rigor when they messed up the design of that multi billion $ telescope because one was using the metric system, the other the imperial system.
Now a nice series of papers using genetics to "uncouple" excess adiposity from its adverse metabolic effects. Here for metabolic traits www.nature.com/articles/s42..., here including non metabolic traits elifesciences.org/articles/72452 & here using partitioned PRS www.nature.com/articles/s41...
When more is not worse: Genetic subtypes of obesity challenge conventional risk paradigms
Emerging evidence challenges the view of obesity as a uniform metabolic risk. Spotlighting
the recent Nature Medicine study by Chami et al. this piece discusses how “uncoupling”
adiposity from its car...
www.cell.com
November 7, 2025 at 9:46 AM
Now a nice series of papers using genetics to "uncouple" excess adiposity from its adverse metabolic effects. Here for metabolic traits www.nature.com/articles/s42..., here including non metabolic traits elifesciences.org/articles/72452 & here using partitioned PRS www.nature.com/articles/s41...
Nearly two years in for our new common disease genetics and genomics team at the University of Geneva. Already lots to be proud of. Here is Lauric talking about his award from the local Diabetes charity. fr.linkedin.com/posts/fondat...
Découvrez l'un de nos trois chercheurs, Lauric Ferrat de l'UNIGE, qui explique son projet primé par notre Prix 2025 sur l'optimisation et la rentabilitédu dépistage du diabète de type 1 en...
Découvrez l'un de nos trois chercheurs, Lauric Ferrat de l'UNIGE, qui explique son projet primé par notre Prix 2025 sur l'optimisation et la rentabilitédu dépistage du diabète de type 1 en Suisse.
fr.linkedin.com
October 26, 2025 at 5:45 PM
Nearly two years in for our new common disease genetics and genomics team at the University of Geneva. Already lots to be proud of. Here is Lauric talking about his award from the local Diabetes charity. fr.linkedin.com/posts/fondat...
I’m learning more and more about the extremely impressive Swiss personalised Health Network and the trusted research environment infrastructure that enables researchers to safely access & Analyse data from multiple hospitals in Switzerland www.sib.swiss/news/sphn-is...
SPHN is a trusted partner between hospitals and private companies
A new collaboration framework allows private partners to transform sensitive Swiss health data into actionable insights while preserving patient privacy. The first pilot project examines risk factors ...
www.sib.swiss
October 26, 2025 at 4:10 PM
I’m learning more and more about the extremely impressive Swiss personalised Health Network and the trusted research environment infrastructure that enables researchers to safely access & Analyse data from multiple hospitals in Switzerland www.sib.swiss/news/sphn-is...
Congratulations to our Liza Darrous for winning the women in data science award last week: tinyurl.com/lizaprize
Still buzzing from an incredible day at WiDS Belgium 2025 👩💻 ✨ !
Usually WiDS leaves me inspired by all the amazing women sharing their work on stage. This year, I had the chance to be on stage… | L...
Still buzzing from an incredible day at WiDS Belgium 2025 👩💻 ✨ !
Usually WiDS leaves me inspired by all the amazing women sharing their work on stage. This year, I had the chance to be on stage myse...
tinyurl.com
September 30, 2025 at 4:11 PM
Congratulations to our Liza Darrous for winning the women in data science award last week: tinyurl.com/lizaprize
thanks to @laraedw001.bsky.social for highlighting this micro.green-park.co.uk/hdrs/. I suggest whoever gets this position, pops over to Switzerland as the SPHN have achieved great things with consented data from 10% of the population available for study a few months after application & in a TRE
HDRS
micro.green-park.co.uk
September 8, 2025 at 6:56 PM
thanks to @laraedw001.bsky.social for highlighting this micro.green-park.co.uk/hdrs/. I suggest whoever gets this position, pops over to Switzerland as the SPHN have achieved great things with consented data from 10% of the population available for study a few months after application & in a TRE
Oh dear. Sad and presumably another lead statistician to be fired ? www.bbc.com/news/live/c5...
US economy adds fewer jobs than expected in August, confirming slowdown
After the previous month's release, Trump fired then-Bureau of Labor Statistics chief Erika McEntarfer.
www.bbc.com
September 5, 2025 at 2:53 PM
Oh dear. Sad and presumably another lead statistician to be fired ? www.bbc.com/news/live/c5...
Amazing study. A simple but important question affecting up to 50% of the population yet previously understudied . And an exemplar in the power of multi-modal data linkage. www.bristol.ac.uk/alspac/news/...
2025: Periods and GCSE results | Avon Longitudinal Study of Parents and Children | University of Bristol
www.bristol.ac.uk
August 20, 2025 at 8:02 PM
Amazing study. A simple but important question affecting up to 50% of the population yet previously understudied . And an exemplar in the power of multi-modal data linkage. www.bristol.ac.uk/alspac/news/...
Deadline 31/08. Join a friendly team in the heart of Europe. Build your research career in human genetics & genomics using data from millions of individuals to address important causes and consequences of disease. Apply here lnkd.in/dyZcgc-g More information on the team here: lnkd.in/dzZ2aU4Z
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
August 18, 2025 at 2:09 PM
Deadline 31/08. Join a friendly team in the heart of Europe. Build your research career in human genetics & genomics using data from millions of individuals to address important causes and consequences of disease. Apply here lnkd.in/dyZcgc-g More information on the team here: lnkd.in/dzZ2aU4Z
New position in Geneva jobs.unige.ch/www/wd_porta...
Maître assistant-e - Fonds National (6461)
jobs.unige.ch
August 18, 2025 at 8:50 AM
New position in Geneva jobs.unige.ch/www/wd_porta...
Reposted by Tim Frayling
Dirigée par @zkutalik.bsky.social et @rjhfmstr.bsky.social à la @fbm-unil.bsky.social, au @sib.swiss et à #unisanté, une nouvelle étude publiée dans @nature.com présente une méthode computationnelle innovante pour étudier ces effets liés à l’origine parentale.
🔗 www.nature.com/articles/s41...
🔗 www.nature.com/articles/s41...
Parent-of-origin effects on complex traits in up to 236,781 individuals - Nature
A novel multistep strategy reveals how parent-of-origin effects shape complex traits in large-scale biobanks.
www.nature.com
August 7, 2025 at 9:42 AM
Dirigée par @zkutalik.bsky.social et @rjhfmstr.bsky.social à la @fbm-unil.bsky.social, au @sib.swiss et à #unisanté, une nouvelle étude publiée dans @nature.com présente une méthode computationnelle innovante pour étudier ces effets liés à l’origine parentale.
🔗 www.nature.com/articles/s41...
🔗 www.nature.com/articles/s41...
Best of British : Black Sabbath’s Paranoid played by the Coldstream guards to commemorate Ozzy Osborne
August 2, 2025 at 3:17 PM
Best of British : Black Sabbath’s Paranoid played by the Coldstream guards to commemorate Ozzy Osborne
well done part I @erinltempleman.bsky.social
🚨Big news! Excited to share my first PhD paper!🎉
We validated & improved a T1D risk model using TrialNet data (originally from TEDDY), boosting accuracy 📈
bmcmedicine.biomedcentral.com/articles/10....
Try the web tool 👉 t1dpredictor.diabetesgenes.org
#T1D #RiskPrediction #PrecisionMedicine #TrialNet
We validated & improved a T1D risk model using TrialNet data (originally from TEDDY), boosting accuracy 📈
bmcmedicine.biomedcentral.com/articles/10....
Try the web tool 👉 t1dpredictor.diabetesgenes.org
#T1D #RiskPrediction #PrecisionMedicine #TrialNet
Development and recalibration of a multivariable type 1 diabetes prediction model for type 1 diabetes across multiple screening studies - BMC Medicine
Background Accurate type 1 diabetes prediction is important to facilitate screening for pre-clinical type 1 diabetes to enable potential early disease-modifying interventions and to reduce the risk of...
bmcmedicine.biomedcentral.com
August 1, 2025 at 9:41 AM
well done part I @erinltempleman.bsky.social
Which sports (and formats) come closest to test match cricket where no runs / points / goals / scores are being made but the tension and adrenaline levels are so high (for players and spectators alike )? www.espncricinfo.com/series/india...
3rd Test, Lord's, July 10 - 14, 2025, India tour of England (Ravindra Jadeja 61*, Shoaib Bashir 1/6, ENG vs IND live score, 3rd Test, day 4, Lord's, London, July 10 - 14, 2025
Check England vs India 3rd Test 2025 live cricket score from London. Get the live score updates and ball by ball commentary of ENG vs IND 3rd Test, 2025. Fastest scorecard and detailed analysis of the...
www.espncricinfo.com
July 14, 2025 at 5:32 PM
Which sports (and formats) come closest to test match cricket where no runs / points / goals / scores are being made but the tension and adrenaline levels are so high (for players and spectators alike )? www.espncricinfo.com/series/india...
Best wishes to this sports star Amanda Anismova. You don’t beat Anya Sabalenka in the semi finals of Wimbledon without being a superb tennis player : www.theguardian.com/sport/2025/j...
Iga Swiatek races to first Wimbledon title with 6-0, 6-0 thrashing of Anisimova
Iga Swiatek crushed Amanda Anisimova in the most one-sided Wimbledon final for 114 years, racing to a 6-0, 6-0 victory in only 57 minutes
www.theguardian.com
July 12, 2025 at 5:31 PM
Best wishes to this sports star Amanda Anismova. You don’t beat Anya Sabalenka in the semi finals of Wimbledon without being a superb tennis player : www.theguardian.com/sport/2025/j...
BBC radio 4´s more or less programme on obesity : www.bbc.co.uk/sounds/play/...
More or Less - Can drinking one less bottle of coke a day halve obesity? - BBC Sounds
Plus, the UK’s expensive electricity, church counts and babies in the City of London.
www.bbc.co.uk
July 9, 2025 at 7:19 PM
BBC radio 4´s more or less programme on obesity : www.bbc.co.uk/sounds/play/...
Wow. Amazing investigative journalism: observer.co.uk/news/nationa...
July 6, 2025 at 1:57 PM
Wow. Amazing investigative journalism: observer.co.uk/news/nationa...
Exciting, but wish the hype was dialled back. "This will enable identification & intervention for individuals at high risk of developing common diseases" probably better as "cheap once in lifetime test will nudge many people over & under certain thresholds for interventions.
The UK Govt just released its 10 year plan for the NHS and it is legitimately ambitious and exciting. Genomic population health features heavily... on the cover even! assets.publishing.service.gov.uk/media/686638...
July 5, 2025 at 7:49 AM
Exciting, but wish the hype was dialled back. "This will enable identification & intervention for individuals at high risk of developing common diseases" probably better as "cheap once in lifetime test will nudge many people over & under certain thresholds for interventions.
interesting non-personalised medicine experiment about to happen in UK. Supermarkets will be asked to report data on sales & incentivised to increase healthier food sales, in ways they choose, using their extensive longitudinal data on our purchasing behaviour www.independent.co.uk/news/uk/poli...
Supermarkets could face fines for failing healthy eating targets in obesity crackdown
Labour health secretary issues warning over future of health service ‘unless we curb the rising tide of cost and demand’ caused by obesity epidemic
www.independent.co.uk
June 29, 2025 at 8:40 AM
interesting non-personalised medicine experiment about to happen in UK. Supermarkets will be asked to report data on sales & incentivised to increase healthier food sales, in ways they choose, using their extensive longitudinal data on our purchasing behaviour www.independent.co.uk/news/uk/poli...
Reposted by Tim Frayling
Lausanne Comp Bio Symposium 2025 (cbiosymposium.unil.ch)
🗓 Abstract deadline 30 June (𝟑 𝐝𝐚𝐲𝐬 𝐭𝐨 𝐠𝐨!!!)
🎤 Oral presentation notifications: 7 July
✅ Early Bird registration deadline: 11 July
💰 Registration fee for non-PI: 150 CHF
🗓 Abstract deadline 30 June (𝟑 𝐝𝐚𝐲𝐬 𝐭𝐨 𝐠𝐨!!!)
🎤 Oral presentation notifications: 7 July
✅ Early Bird registration deadline: 11 July
💰 Registration fee for non-PI: 150 CHF
June 27, 2025 at 10:00 AM
Lausanne Comp Bio Symposium 2025 (cbiosymposium.unil.ch)
🗓 Abstract deadline 30 June (𝟑 𝐝𝐚𝐲𝐬 𝐭𝐨 𝐠𝐨!!!)
🎤 Oral presentation notifications: 7 July
✅ Early Bird registration deadline: 11 July
💰 Registration fee for non-PI: 150 CHF
🗓 Abstract deadline 30 June (𝟑 𝐝𝐚𝐲𝐬 𝐭𝐨 𝐠𝐨!!!)
🎤 Oral presentation notifications: 7 July
✅ Early Bird registration deadline: 11 July
💰 Registration fee for non-PI: 150 CHF
Danny Boyle « The idea that we have a broadcaster that is part of our national identity but is also trusted around the world and that can’t be bought, can’t be subsumed into Meta or whatever, feels really precious » www.theguardian.com/film/ng-inte...
‘You’d never make Slumdog today’: Danny Boyle on risks, regrets and returning to the undead
In 28 Years Later, zombies maraud over a Britain broken by more than Brexit. Its director discusses cultural baggage, catastrophising – and why his kids’ generation is an ‘upgrade’
www.theguardian.com
June 20, 2025 at 7:21 PM
Danny Boyle « The idea that we have a broadcaster that is part of our national identity but is also trusted around the world and that can’t be bought, can’t be subsumed into Meta or whatever, feels really precious » www.theguardian.com/film/ng-inte...
I have just heard from a US visitor from San Diego. She discussed PhD students in her lab. US citizens of chinese and african ancestry. One a military veteran. Both have received knocks on the door with officials asking them for their birth certificates.
June 19, 2025 at 2:00 PM
I have just heard from a US visitor from San Diego. She discussed PhD students in her lab. US citizens of chinese and african ancestry. One a military veteran. Both have received knocks on the door with officials asking them for their birth certificates.
Mike’s on his next trip after we were lucky enough to host him in Geneva for a few hours . It was great to hear his measured and inspiring take on polygenic risk scores .
Heading to Shanghai tomorrow for a few days for a meeting (and first time to China). If you had 24 hours free there, what would you do? Any once in a lifetime / only in Shanghai experiences?
June 19, 2025 at 1:21 PM
Mike’s on his next trip after we were lucky enough to host him in Geneva for a few hours . It was great to hear his measured and inspiring take on polygenic risk scores .
there's that big gap between MAF 0.01 and 0.001 again...
A Review in Nature Reviews Genetics discusses how genomic advances have enhanced our understanding of schizophrenia, bipolar disorder and major depressive disorder, which could address limitations in diagnostic frameworks and future treatment strategies. go.nature.com/44bKTuy 🧬 🧪
June 14, 2025 at 9:00 AM
there's that big gap between MAF 0.01 and 0.001 again...
Reposted by Tim Frayling
In the latest update to the 23andMe, Anne Wojcicki (i.e., not REGN) won the bidding war.
www.wsj.com/tech/biotech...
www.wsj.com/tech/biotech...
Exclusive | Anne Wojcicki Wins Bidding for 23andMe
Regeneron is backing away from buying the DNA-testing company after a nonprofit controlled by co-founder Wojcicki made a higher bid.
www.wsj.com
June 13, 2025 at 9:15 PM
In the latest update to the 23andMe, Anne Wojcicki (i.e., not REGN) won the bidding war.
www.wsj.com/tech/biotech...
www.wsj.com/tech/biotech...