Rob Patro
@robp.bsky.social
Associate Professor of CS @ University of Maryland. Proud Rust advocate! I ♥ science & compiled, statically-typed programming languages! Views are my own. Tech stack: https://github.com/rob-p/tech-stack.
I love Rust, but I think my biggest growing gripe is its current lack of reasonable compile-time capabilities. TIL that you can’t use an associated const of a trait as a const generic parameter. It counts as a const generic “expression” even though it’s just a value. WTH?!
December 27, 2025 at 4:04 AM
I love Rust, but I think my biggest growing gripe is its current lack of reasonable compile-time capabilities. TIL that you can’t use an associated const of a trait as a const generic parameter. It counts as a const generic “expression” even though it’s just a value. WTH?!
Reposted by Rob Patro
We're nearing the new year, so time for another Jan 1st Q&A! Ask questions at wewerewondering.com/event/01KDDA... — none too big or small. I'll get to as many as I can, and upload the recording after the fact. Stream starts 1/1/26 at 2:30p UTC @ youtube.com/live/g1ZgInF.... Hope to see you there ❤️
Q&A
Zero-setup, free tool for running live Q&A sessions, including question submission and voting.
wewerewondering.com
December 26, 2025 at 12:58 PM
We're nearing the new year, so time for another Jan 1st Q&A! Ask questions at wewerewondering.com/event/01KDDA... — none too big or small. I'll get to as many as I can, and upload the recording after the fact. Stream starts 1/1/26 at 2:30p UTC @ youtube.com/live/g1ZgInF.... Hope to see you there ❤️
Picture of M31 taken with our new telescope. This is so much better than any space photography I've ever done in the past it's not even funny. Interested to really learn to use this thing!
December 26, 2025 at 12:53 AM
Picture of M31 taken with our new telescope. This is so much better than any space photography I've ever done in the past it's not even funny. Interested to really learn to use this thing!
Christmas surprise; I fell and chipped my front tooth this morning. Luckily, the dentist was able to make an emergency visit. It was a small chip so it was filed down and looks alright. Not the best start ever to Christmas eve, but thanks to the kindness of the dentist, it will be OK.
December 24, 2025 at 4:39 PM
Christmas surprise; I fell and chipped my front tooth this morning. Luckily, the dentist was able to make an emergency visit. It was a small chip so it was filed down and looks alright. Not the best start ever to Christmas eve, but thanks to the kindness of the dentist, it will be OK.
Rust feature I wish existed; initialize const based on generic parameter:
```
fn foo<R: Bound>(r :R) {
...
const IS_IMPL: bool = TypeId::of::<R>() == TypeId::of::<ConcreteImpl>();
...
}
```
Why isn't this supported?
```
fn foo<R: Bound>(r :R) {
...
const IS_IMPL: bool = TypeId::of::<R>() == TypeId::of::<ConcreteImpl>();
...
}
```
Why isn't this supported?
December 24, 2025 at 2:49 PM
Rust feature I wish existed; initialize const based on generic parameter:
```
fn foo<R: Bound>(r :R) {
...
const IS_IMPL: bool = TypeId::of::<R>() == TypeId::of::<ConcreteImpl>();
...
}
```
Why isn't this supported?
```
fn foo<R: Bound>(r :R) {
...
const IS_IMPL: bool = TypeId::of::<R>() == TypeId::of::<ConcreteImpl>();
...
}
```
Why isn't this supported?
December 24, 2025 at 1:35 PM
Rust feature I wish existed; initialize const based on generic parameter:
```
fn foo<R: Bound>(r :R) {
...
const IS_IMPL: bool = TypeId::of::<R>() == TypeId::of::<ConcreteImpl>();
...
}
```
Why isn't this supported?
```
fn foo<R: Bound>(r :R) {
...
const IS_IMPL: bool = TypeId::of::<R>() == TypeId::of::<ConcreteImpl>();
...
}
```
Why isn't this supported?
Streisand effect, let's gooooo!!!
Oh, sweet summer CBS, when you hide something, it makes people really really really want it. Boss never learned the rules of journalism, or she might have known that.
High Quality version of the 60 Minutes segment on the CECOT that was cut but has now been leaked:
www.thereset.news/p/breaking-h...
www.thereset.news/p/breaking-h...
December 23, 2025 at 1:33 AM
Streisand effect, let's gooooo!!!
Nice! Somebody had to say it: www.justfuckinguseneovim.com
just fucking use neovim
www.justfuckinguseneovim.com
December 21, 2025 at 12:12 AM
Nice! Somebody had to say it: www.justfuckinguseneovim.com
Peter Theil knows about the antichrist!
December 19, 2025 at 4:16 PM
Peter Theil knows about the antichrist!
So question for single-cell peeps. It seems that ParseBio is even more locked-down than 10x! Is it the case that if I'm not a "registered" ParseBio customer, I can't even access their splitpipe software? Is there any archived version of splitpipe available?
December 17, 2025 at 6:46 PM
So question for single-cell peeps. It seems that ParseBio is even more locked-down than 10x! Is it the case that if I'm not a "registered" ParseBio customer, I can't even access their splitpipe software? Is there any archived version of splitpipe available?
Reposted by Rob Patro
💾 Prokka 1.15.6 is released!
This is the last major release of Prokka. But don't be sad, because @oschwengers.bsky.social already has an excellent replacement called Bakta you can migrate to.
#bioinformatics #microbiology #genomics
github.com/tseemann/pro...
This is the last major release of Prokka. But don't be sad, because @oschwengers.bsky.social already has an excellent replacement called Bakta you can migrate to.
#bioinformatics #microbiology #genomics
github.com/tseemann/pro...
Release Heading into the sunset · tseemann/prokka
The future
This is probably the last release of Prokka. I won't be making any code changes except bug fixes. I will update the databases occasionally. I strongly recommend you use Bakta by @oschwen...
github.com
December 15, 2025 at 9:09 PM
💾 Prokka 1.15.6 is released!
This is the last major release of Prokka. But don't be sad, because @oschwengers.bsky.social already has an excellent replacement called Bakta you can migrate to.
#bioinformatics #microbiology #genomics
github.com/tseemann/pro...
This is the last major release of Prokka. But don't be sad, because @oschwengers.bsky.social already has an excellent replacement called Bakta you can migrate to.
#bioinformatics #microbiology #genomics
github.com/tseemann/pro...
We relied on pyranges (v0) for a while in pyroe (which made splici/splicu transcriptomes for alevin-fry). It was nice to use, but many breaking changes eventually led us to rewrite what we needed in Rust in grangers (crates.io/crates/grang...). I'm happy to see v1 & that it's Rust-powered!
December 15, 2025 at 5:44 PM
We relied on pyranges (v0) for a while in pyroe (which made splici/splicu transcriptomes for alevin-fry). It was nice to use, but many breaking changes eventually led us to rewrite what we needed in Rust in grangers (crates.io/crates/grang...). I'm happy to see v1 & that it's Rust-powered!
I appreciate that the Rust compiler recognizes that I am not good at spelling ...
December 14, 2025 at 9:14 PM
I appreciate that the Rust compiler recognizes that I am not good at spelling ...
“The radio plays what they want ya to hear. Tell me it’s cool; I just don’t believe it.”
The corporate radio stations that have all been run by the same algorithms since the late 90s are now running ads saying “we’re 100% human” which is simply adorable.
December 14, 2025 at 2:03 PM
“The radio plays what they want ya to hear. Tell me it’s cool; I just don’t believe it.”
Yea, it's because Biden was actually attempting to govern the nation competently and legally. Trump, OTOH, is flagrantly breaking the law and doing everything he can to destroy the republic. 36% is an insanely high approval rating for someone actively trying to end the American experiment...
AP on Trump now, and Biden in June 2022.
For Trump, declining to 36 percent approval is “good news.”
For Biden, holding steady at 41% is “a source of concern.”
For Trump, declining to 36 percent approval is “good news.”
For Biden, holding steady at 41% is “a source of concern.”
December 12, 2025 at 3:47 PM
Yea, it's because Biden was actually attempting to govern the nation competently and legally. Trump, OTOH, is flagrantly breaking the law and doing everything he can to destroy the republic. 36% is an insanely high approval rating for someone actively trying to end the American experiment...
Reposted by Rob Patro
GPT-5.2 Lies About Reading your Documents blog.stephenturner.us/p/chatgpt-li...
GPT-5.2 Lies About Reading your Documents
"I did not sufficiently counterbalance that with skepticism and verification at the moment it mattered... I did not enforce the standard you expect: only claim access to evidence I can actually see"
blog.stephenturner.us
December 12, 2025 at 3:19 PM
GPT-5.2 Lies About Reading your Documents blog.stephenturner.us/p/chatgpt-li...
I am not all in on AI. Actually, I'm incredibly skeptical of the current AI hype. Nonetheless, I think eliminating the stats department is insanely foolish. It's like a microcosm of how the US itself is attempting STEM seppuku. U of N needs new leadership, immediately. Absolutely no confidence.
The University of Nebraska is closing their statistics department. Especially if you're all in on AI this is so short-sighted. It's like launching the first spacecraft into outer space and being like "welp time to close astrophysics and rocketry and only teach classes on buckling up your seat belts"
December 12, 2025 at 3:18 AM
I am not all in on AI. Actually, I'm incredibly skeptical of the current AI hype. Nonetheless, I think eliminating the stats department is insanely foolish. It's like a microcosm of how the US itself is attempting STEM seppuku. U of N needs new leadership, immediately. Absolutely no confidence.
OMG.... samtools collate is taking *FOREVER*. WTH?
December 11, 2025 at 7:57 PM
OMG.... samtools collate is taking *FOREVER*. WTH?
Reposted by Rob Patro
Rust 1.92.0 has been released! 🌈 🦀
This version adds RwLockWriteGuard::downgrade(), adds Location::file_as_c_str(), improves diagnostic and validation for various attributes, no longer warns for unused Result<(), Infallible>, and more!
Check out the announcement: blog.rust-lang.org/2025/12/11/R...
This version adds RwLockWriteGuard::downgrade(), adds Location::file_as_c_str(), improves diagnostic and validation for various attributes, no longer warns for unused Result<(), Infallible>, and more!
Check out the announcement: blog.rust-lang.org/2025/12/11/R...
Announcing Rust 1.92.0 | Rust Blog
Empowering everyone to build reliable and efficient software.
blog.rust-lang.org
December 11, 2025 at 3:34 PM
Rust 1.92.0 has been released! 🌈 🦀
This version adds RwLockWriteGuard::downgrade(), adds Location::file_as_c_str(), improves diagnostic and validation for various attributes, no longer warns for unused Result<(), Infallible>, and more!
Check out the announcement: blog.rust-lang.org/2025/12/11/R...
This version adds RwLockWriteGuard::downgrade(), adds Location::file_as_c_str(), improves diagnostic and validation for various attributes, no longer warns for unused Result<(), Infallible>, and more!
Check out the announcement: blog.rust-lang.org/2025/12/11/R...
Reposted by Rob Patro
My first Rust toy tool (just for learning purposes)!!!
The performance (both time and memory) is good!
Rust is hard to learn, and I still need more practice!
github.com/shenwei356/f...
The performance (both time and memory) is good!
Rust is hard to learn, and I still need more practice!
github.com/shenwei356/f...
December 11, 2025 at 12:32 PM
My first Rust toy tool (just for learning purposes)!!!
The performance (both time and memory) is good!
Rust is hard to learn, and I still need more practice!
github.com/shenwei356/f...
The performance (both time and memory) is good!
Rust is hard to learn, and I still need more practice!
github.com/shenwei356/f...
Reposted by Rob Patro
If you ever need to fuzzy search some DNA, sassy is your tool.
Please spread the word; I think many people just outside my own circle could benefit from this :)
cc @rickbitloo.bsky.social
github.com/RagnarGrootK...
Please spread the word; I think many people just outside my own circle could benefit from this :)
cc @rickbitloo.bsky.social
github.com/RagnarGrootK...
December 10, 2025 at 3:50 PM
If you ever need to fuzzy search some DNA, sassy is your tool.
Please spread the word; I think many people just outside my own circle could benefit from this :)
cc @rickbitloo.bsky.social
github.com/RagnarGrootK...
Please spread the word; I think many people just outside my own circle could benefit from this :)
cc @rickbitloo.bsky.social
github.com/RagnarGrootK...
Reposted by Rob Patro
The 12th edition of the 2-days workshop “Data Structures in Bioinformatics” (DSB) will take place in Venice (Italy) on February 18-19th, 2026: dsb-meeting.github.io/DSB2026/
DSB 2026 Venice - February 18-19
Workshop Data Structures in Bioinformatics
dsb-meeting.github.io
December 10, 2025 at 2:29 PM
The 12th edition of the 2-days workshop “Data Structures in Bioinformatics” (DSB) will take place in Venice (Italy) on February 18-19th, 2026: dsb-meeting.github.io/DSB2026/
Brown to Panda Nano conversion #2 now underway!
December 9, 2025 at 3:29 PM
Brown to Panda Nano conversion #2 now underway!
Reposted by Rob Patro
🧬Explore the latest from Bioinformatics Advances: “Ish: SIMD and GPU accelerated local and semi-global alignment as a CLI filtering tool.”
Read the full paper here: https://doi.org/10.1093/bioadv/vbaf292
Author: @ducktapeprogrammer.bsky.social
Read the full paper here: https://doi.org/10.1093/bioadv/vbaf292
Author: @ducktapeprogrammer.bsky.social
December 9, 2025 at 10:01 AM
🧬Explore the latest from Bioinformatics Advances: “Ish: SIMD and GPU accelerated local and semi-global alignment as a CLI filtering tool.”
Read the full paper here: https://doi.org/10.1093/bioadv/vbaf292
Author: @ducktapeprogrammer.bsky.social
Read the full paper here: https://doi.org/10.1093/bioadv/vbaf292
Author: @ducktapeprogrammer.bsky.social