Siegenthaler Lab
@siegenthalerlab.bsky.social
Neuroscience, meninges, blood-brain barrier, cake (or cookies)
http://siegenthalerlabcu.weebly.com/
http://siegenthalerlabcu.weebly.com/
Pinned
Hi Bluesky! I am Julie Siegenthaler, I am research faculty in Pediatrics at the University of Colorado, Anschutz Medical Campus in Aurora, Colorado USA - the @siegenthalerlab.bsky.social studies the meninges & brain vasculature & we ❤️ all CNS barriers...but the ones in the meninges are the best.
Reposted by Siegenthaler Lab
This is the easiest case for understanding gerrymandering. Salt Lake City, in the center of the state, is the only Dem leaning area in Utah. So GOPers divided the state into 4 districts, radiating out from SLC, cutting it into four quadrants, preventing the city from electing a Rep of their choice.
huge news from utah: judge strikes down GOP gerrymander, restores voter-approved map
www.democracydocket.com/news-alerts/...
www.democracydocket.com/news-alerts/...
Utah Judge Strikes Down GOP Gerrymander, Restores Voter-Approved Fair Map
Read more here.
www.democracydocket.com
November 11, 2025 at 2:59 PM
This is the easiest case for understanding gerrymandering. Salt Lake City, in the center of the state, is the only Dem leaning area in Utah. So GOPers divided the state into 4 districts, radiating out from SLC, cutting it into four quadrants, preventing the city from electing a Rep of their choice.
Reposted by Siegenthaler Lab
Ever wondered if analyzing your images by using intensity Z-projections impacts your data?
Happy to announce my guest article in Microscopy & Analysis on that topic. It's a very short read but worth for everyone dealing with image analysis!
buff.ly/KJ147tI
#Microscopy #ZProjection #ImageAnalysis
Happy to announce my guest article in Microscopy & Analysis on that topic. It's a very short read but worth for everyone dealing with image analysis!
buff.ly/KJ147tI
#Microscopy #ZProjection #ImageAnalysis
November 10, 2025 at 4:05 PM
Ever wondered if analyzing your images by using intensity Z-projections impacts your data?
Happy to announce my guest article in Microscopy & Analysis on that topic. It's a very short read but worth for everyone dealing with image analysis!
buff.ly/KJ147tI
#Microscopy #ZProjection #ImageAnalysis
Happy to announce my guest article in Microscopy & Analysis on that topic. It's a very short read but worth for everyone dealing with image analysis!
buff.ly/KJ147tI
#Microscopy #ZProjection #ImageAnalysis
Reposted by Siegenthaler Lab
Apolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes - Al‐Amin - 2025 - Alzheimer's & Dementia - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Apolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes
INTRODUCTION
The ε4 allele of the apolipoprotein E (APOE) gene is a risk factor for the development of Alzheimer's disease (AD). APOE4 isoform is associated with increased white matter lesions in hu.....
alz-journals.onlinelibrary.wiley.com
November 11, 2025 at 4:37 AM
Apolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes - Al‐Amin - 2025 - Alzheimer's & Dementia - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Siegenthaler Lab
This Veterans Day I want to acknowledge the Black veterans of WWII who fought fascism and nazism and came home to fight for civil rights and democracy here. New research shows Black veterans were critical in securing the voting rights currently under attack.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Homefront: Black Servicemembers and Black Voters in the Civil Rights Era
The role of Black World War II veterans in the Civil Rights Movement has been well documented, but the effect of Black military service on Black voting patterns remains unclear. Combining detailed in...
onlinelibrary.wiley.com
November 11, 2025 at 12:10 PM
This Veterans Day I want to acknowledge the Black veterans of WWII who fought fascism and nazism and came home to fight for civil rights and democracy here. New research shows Black veterans were critical in securing the voting rights currently under attack.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Siegenthaler Lab
Love being reminded to do this every year. It's a win/win all round
November 11, 2025 at 11:00 AM
Love being reminded to do this every year. It's a win/win all round
Reposted by Siegenthaler Lab
1st single-cell #SpatialTranscriptomics map of human coronary #Atherosclerosis published in peer-reviewed format🤠
CosMx 1k + GeoMx @brukerspatial
Immune cell-focused analysis
Use CosMx data to deconvolve GeoMx cell composition...😆
#EmboMolMed 2025
www.embopress.org/doi/full/10....
CosMx 1k + GeoMx @brukerspatial
Immune cell-focused analysis
Use CosMx data to deconvolve GeoMx cell composition...😆
#EmboMolMed 2025
www.embopress.org/doi/full/10....
November 11, 2025 at 12:15 PM
1st single-cell #SpatialTranscriptomics map of human coronary #Atherosclerosis published in peer-reviewed format🤠
CosMx 1k + GeoMx @brukerspatial
Immune cell-focused analysis
Use CosMx data to deconvolve GeoMx cell composition...😆
#EmboMolMed 2025
www.embopress.org/doi/full/10....
CosMx 1k + GeoMx @brukerspatial
Immune cell-focused analysis
Use CosMx data to deconvolve GeoMx cell composition...😆
#EmboMolMed 2025
www.embopress.org/doi/full/10....
Reposted by Siegenthaler Lab
My book 'The Tree of Life' is published in the USA and Canada today.
Available as book, on kindle and as audio.
I would be really grateful for reposts.
www.amazon.com/Tree-Life-So...
www.amazon.ca/Tree-Life-So...
Available as book, on kindle and as audio.
I would be really grateful for reposts.
www.amazon.com/Tree-Life-So...
www.amazon.ca/Tree-Life-So...
November 11, 2025 at 12:01 PM
My book 'The Tree of Life' is published in the USA and Canada today.
Available as book, on kindle and as audio.
I would be really grateful for reposts.
www.amazon.com/Tree-Life-So...
www.amazon.ca/Tree-Life-So...
Available as book, on kindle and as audio.
I would be really grateful for reposts.
www.amazon.com/Tree-Life-So...
www.amazon.ca/Tree-Life-So...
Reposted by Siegenthaler Lab
Oh, I love this. A new species of sea anemone was discovered recently that parks itself on top of a hermit crab shell like a hat. It seems to feed partly off the crab's faeces, but it also excretes a hard shell that extends the crab's home. In return, it's carried around the seafloor like a king.
November 10, 2025 at 9:57 PM
Oh, I love this. A new species of sea anemone was discovered recently that parks itself on top of a hermit crab shell like a hat. It seems to feed partly off the crab's faeces, but it also excretes a hard shell that extends the crab's home. In return, it's carried around the seafloor like a king.
Reposted by Siegenthaler Lab
“A.L.S. is such an isolating disease, constantly stripping away pieces of you that make you you,” Ms. Brous said. “You’re always having to ask someone else to be your arms and legs and your driver, and it’s easier to say, ‘It’s easier if I stay home.’ But that isolation will eat you alive.”
The Young Women Grappling With an ‘Old Man’s Disease’
www.nytimes.com
November 11, 2025 at 12:19 PM
“A.L.S. is such an isolating disease, constantly stripping away pieces of you that make you you,” Ms. Brous said. “You’re always having to ask someone else to be your arms and legs and your driver, and it’s easier to say, ‘It’s easier if I stay home.’ But that isolation will eat you alive.”
Reposted by Siegenthaler Lab
How does foxg1 impact pineal gland development? What are the implications for FOXG1 syndrome?
Lewis Hill, masters student, investigates this in #zebrafish. His image shows in-situ HCR + immuno in foxg1,Gal4;UAS,GFP zebrafish at 24hpf revealing foxg1 mRNA/protein with pineal markers aanat2 & exorh.
Lewis Hill, masters student, investigates this in #zebrafish. His image shows in-situ HCR + immuno in foxg1,Gal4;UAS,GFP zebrafish at 24hpf revealing foxg1 mRNA/protein with pineal markers aanat2 & exorh.
July 29, 2025 at 4:23 PM
How does foxg1 impact pineal gland development? What are the implications for FOXG1 syndrome?
Lewis Hill, masters student, investigates this in #zebrafish. His image shows in-situ HCR + immuno in foxg1,Gal4;UAS,GFP zebrafish at 24hpf revealing foxg1 mRNA/protein with pineal markers aanat2 & exorh.
Lewis Hill, masters student, investigates this in #zebrafish. His image shows in-situ HCR + immuno in foxg1,Gal4;UAS,GFP zebrafish at 24hpf revealing foxg1 mRNA/protein with pineal markers aanat2 & exorh.
Reposted by Siegenthaler Lab
Talking about impostor syndrome.....
I'll be a teacher in the EMBO "Hack your Microscope" together with some of the very best researchers in the field.
5.5 days of hacking and microscope/fluidics shenanigans in Portugal.
You can apply here: meetings.embo.org/event/26-mic... #EMBOmicroscope
I'll be a teacher in the EMBO "Hack your Microscope" together with some of the very best researchers in the field.
5.5 days of hacking and microscope/fluidics shenanigans in Portugal.
You can apply here: meetings.embo.org/event/26-mic... #EMBOmicroscope
Hack your microscope
Recent advances in open-source microscopy have made high-resolution, customizable imaging systems more accessible, allowing researchers to overcome the constraints of traditional commercial solutions…
meetings.embo.org
November 11, 2025 at 11:39 AM
Talking about impostor syndrome.....
I'll be a teacher in the EMBO "Hack your Microscope" together with some of the very best researchers in the field.
5.5 days of hacking and microscope/fluidics shenanigans in Portugal.
You can apply here: meetings.embo.org/event/26-mic... #EMBOmicroscope
I'll be a teacher in the EMBO "Hack your Microscope" together with some of the very best researchers in the field.
5.5 days of hacking and microscope/fluidics shenanigans in Portugal.
You can apply here: meetings.embo.org/event/26-mic... #EMBOmicroscope
Reposted by Siegenthaler Lab
Hydra (Hydra vulgaris) ✨Small but mighty! Hydra can regenerate its entire body, even its head 🧠 A classic model for regeneration, stem cell dynamics, and body axis patterning 📸 Image by Daniel Bressan de Andrade #ModelMonday #DevBio #Regeneration
November 11, 2025 at 2:28 AM
Hydra (Hydra vulgaris) ✨Small but mighty! Hydra can regenerate its entire body, even its head 🧠 A classic model for regeneration, stem cell dynamics, and body axis patterning 📸 Image by Daniel Bressan de Andrade #ModelMonday #DevBio #Regeneration
Reposted by Siegenthaler Lab
This is Oakley. He has an injury that requires physical therapy and at-home massages. Luckily, his cat sibling River has been training his whole life for this. 14/10 for both
November 10, 2025 at 11:58 PM
This is Oakley. He has an injury that requires physical therapy and at-home massages. Luckily, his cat sibling River has been training his whole life for this. 14/10 for both
Reposted by Siegenthaler Lab
With much gratitude to everyone who supported the wonderful #STAMPS summer course at the MBL, I share that STAMPS will not be offered in 2026.
💔😿
💔😿
November 11, 2025 at 1:05 AM
With much gratitude to everyone who supported the wonderful #STAMPS summer course at the MBL, I share that STAMPS will not be offered in 2026.
💔😿
💔😿
Reposted by Siegenthaler Lab
PSA for people with NIH grant periods starting January 1st (including most NIGMS MIRAs): your RPPR is due Saturday, but they haven’t sent out the usual automated reminders, presumably due to the shutdown
November 11, 2025 at 1:20 AM
PSA for people with NIH grant periods starting January 1st (including most NIGMS MIRAs): your RPPR is due Saturday, but they haven’t sent out the usual automated reminders, presumably due to the shutdown
Reposted by Siegenthaler Lab
(bonus)
thanks to the amazing @droligo.bsky.social and @amygleichman.bsky.social the social aspects of glial biology will be strongly represented.
(thanks also to @plasmidsaurus.bsky.social & Avantor for supporting our community!)
thanks to the amazing @droligo.bsky.social and @amygleichman.bsky.social the social aspects of glial biology will be strongly represented.
(thanks also to @plasmidsaurus.bsky.social & Avantor for supporting our community!)
November 10, 2025 at 4:43 PM
(bonus)
thanks to the amazing @droligo.bsky.social and @amygleichman.bsky.social the social aspects of glial biology will be strongly represented.
(thanks also to @plasmidsaurus.bsky.social & Avantor for supporting our community!)
thanks to the amazing @droligo.bsky.social and @amygleichman.bsky.social the social aspects of glial biology will be strongly represented.
(thanks also to @plasmidsaurus.bsky.social & Avantor for supporting our community!)
Reposted by Siegenthaler Lab
@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below.
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
November 10, 2025 at 4:43 PM
@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below.
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Reposted by Siegenthaler Lab
Having no reason to hire qualified faculty is a feature, not a bug.
www.texastribune.org/2025/11/10/t...
www.texastribune.org/2025/11/10/t...
November 10, 2025 at 11:07 PM
Having no reason to hire qualified faculty is a feature, not a bug.
www.texastribune.org/2025/11/10/t...
www.texastribune.org/2025/11/10/t...
Reposted by Siegenthaler Lab
Looking forward to presenting our work on oligodendrocyte dysfunction in a rare neurodegenerative movement disorder X-linked Dystonia Parkinsonism. Come say hi if you're around on Tuesday, Nov 18 between 1-5 pm! @sfn.org #SfN2025 #SfN25
@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below.
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
November 10, 2025 at 11:09 PM
Reposted by Siegenthaler Lab
We're very excited to welcome Dr. @sumrubayin.bsky.social from the @gurdoninstitute.bsky.social onto the next episode of the podcast! 🎉
Her lab studies the mouse #cerebellum to better understand the regulation of #neural stem cell behavior. 🧠
Her lab studies the mouse #cerebellum to better understand the regulation of #neural stem cell behavior. 🧠
November 10, 2025 at 9:46 PM
We're very excited to welcome Dr. @sumrubayin.bsky.social from the @gurdoninstitute.bsky.social onto the next episode of the podcast! 🎉
Her lab studies the mouse #cerebellum to better understand the regulation of #neural stem cell behavior. 🧠
Her lab studies the mouse #cerebellum to better understand the regulation of #neural stem cell behavior. 🧠
Reposted by Siegenthaler Lab
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
November 10, 2025 at 1:26 PM
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Reposted by Siegenthaler Lab
Kyle Kingsbury is not a journalist. He is not an op-ed writer.
He is a computer safety researcher.
And he has written one of the most compelling, comprehensive accounts of the ongoing hell in Chicago that you could possibly imagine.
In under 1600 words.
aphyr.com/posts/397-i-...
He is a computer safety researcher.
And he has written one of the most compelling, comprehensive accounts of the ongoing hell in Chicago that you could possibly imagine.
In under 1600 words.
aphyr.com/posts/397-i-...
November 9, 2025 at 8:49 PM
Kyle Kingsbury is not a journalist. He is not an op-ed writer.
He is a computer safety researcher.
And he has written one of the most compelling, comprehensive accounts of the ongoing hell in Chicago that you could possibly imagine.
In under 1600 words.
aphyr.com/posts/397-i-...
He is a computer safety researcher.
And he has written one of the most compelling, comprehensive accounts of the ongoing hell in Chicago that you could possibly imagine.
In under 1600 words.
aphyr.com/posts/397-i-...
Reposted by Siegenthaler Lab
Modelling human adult V-SVZ niche assembly and ependymal cell generation in brain organoids | EMBO reports www.embopress.org/doi/full/10....
Modelling human adult V-SVZ niche assembly and ependymal cell generation in brain organoids | EMBO reports
imageimageHuman progenitors are programmed into ependymal cells in brain organoids via GEMC1
and MCIDAS expression. This strategy recapitulates hallmarks of the adult human V-SVZ
niche, providing a pl...
www.embopress.org
November 10, 2025 at 12:22 PM
Modelling human adult V-SVZ niche assembly and ependymal cell generation in brain organoids | EMBO reports www.embopress.org/doi/full/10....
Reposted by Siegenthaler Lab
Discover CellSNVReg: a vast resource of SNVs affecting gene regulation in single-cell and spatial omics. Explore at CellSNVReg online! PMID:41171131, Nucleic Acids Res 2025, @NAR_Open https://doi.org/10.1093/nar/gkaf1076 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://doi.org/10.1093/nar/gkaf1076
No description available
doi.org
November 10, 2025 at 12:10 PM
Reposted by Siegenthaler Lab
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
November 10, 2025 at 11:11 AM
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...