Siegenthaler Lab
@siegenthalerlab.bsky.social
Neuroscience, meninges, blood-brain barrier, cake (or cookies)
http://siegenthalerlabcu.weebly.com/
http://siegenthalerlabcu.weebly.com/
Pinned
Hi Bluesky! I am Julie Siegenthaler, I am research faculty in Pediatrics at the University of Colorado, Anschutz Medical Campus in Aurora, Colorado USA - the @siegenthalerlab.bsky.social studies the meninges & brain vasculature & we ❤️ all CNS barriers...but the ones in the meninges are the best.
Reposted by Siegenthaler Lab
Online now: Transcription factor Maf promotes expression of repressor Zeb2 to drive microglia development in primitive hematopoiesis
Transcription factor Maf promotes expression of repressor Zeb2 to drive microglia development in primitive hematopoiesis
How distinct hematopoietic waves generate specialized macrophage lineages remains unclear. Chen et al. identify separate transcriptional pathways controlling macrophage development during primitive versus definitive hematopoiesis and identify Maf and Jun as key regulators of Zeb2 expression that drive microglia formation during primitive hematopoiesis, revealing a unique regulatory program for microglia development.
dlvr.it
December 26, 2025 at 3:48 PM
Online now: Transcription factor Maf promotes expression of repressor Zeb2 to drive microglia development in primitive hematopoiesis
Reposted by Siegenthaler Lab
We’re hiring! Join the Sivyer Lab at The University of Sydney as a Postdoctoral Research Fellow in Neurodegeneration within the Snow Vision Accelerator, a $50M initiative tackling glaucoma and optic nerve disease. iPSCs, electrophysiology, drug discovery, and gene therapy.
November 4, 2025 at 10:20 AM
We’re hiring! Join the Sivyer Lab at The University of Sydney as a Postdoctoral Research Fellow in Neurodegeneration within the Snow Vision Accelerator, a $50M initiative tackling glaucoma and optic nerve disease. iPSCs, electrophysiology, drug discovery, and gene therapy.
Reposted by Siegenthaler Lab
My kids and grandkids have returned to their homes.
Back to the real world.
I just emailed NIH Director Bhattacharya.
My last email of the year (I hope).
1/13
Back to the real world.
I just emailed NIH Director Bhattacharya.
My last email of the year (I hope).
1/13
December 27, 2025 at 12:54 AM
My kids and grandkids have returned to their homes.
Back to the real world.
I just emailed NIH Director Bhattacharya.
My last email of the year (I hope).
1/13
Back to the real world.
I just emailed NIH Director Bhattacharya.
My last email of the year (I hope).
1/13
Reposted by Siegenthaler Lab
Heroic Dog Saves Family Of 5 From Herb-Roasted Chicken https://theonion.com/heroic-dog-saves-family-of-5-from-herb-roasted-chicken/
December 26, 2025 at 9:15 PM
Heroic Dog Saves Family Of 5 From Herb-Roasted Chicken https://theonion.com/heroic-dog-saves-family-of-5-from-herb-roasted-chicken/
Reposted by Siegenthaler Lab
Make a Bond movie academic:
For Your Eyes Only: Two-Factor Authentication in Higher Ed
For Your Eyes Only: Two-Factor Authentication in Higher Ed
Make a Bond movie academic
Tomorrow Never Hires
Tomorrow Never Hires
Make a Bond Movie academic
Best, Russia
Best, Russia
December 26, 2025 at 7:29 PM
Make a Bond movie academic:
For Your Eyes Only: Two-Factor Authentication in Higher Ed
For Your Eyes Only: Two-Factor Authentication in Higher Ed
Reposted by Siegenthaler Lab
Inspired by her family, Channing Tate, PhD, has dedicated her career to serving the most vulnerable people in our 4th most read blog of 2025: https://bit.ly/4iZyGiD
@cumedicalschool.bsky.social
#ACCORDSInnovation #ACCORDSCommunity #HealthCareServicesResearch
@cumedicalschool.bsky.social
#ACCORDSInnovation #ACCORDSCommunity #HealthCareServicesResearch
CU Researcher Works to Improve Dementia and Hospice Care in Underserved Communities
Inspired by her family, Channing Tate, PhD, has dedicated her career to serving the most vulnerable people in our health care system.
news.cuanschutz.edu
December 26, 2025 at 5:45 PM
Inspired by her family, Channing Tate, PhD, has dedicated her career to serving the most vulnerable people in our 4th most read blog of 2025: https://bit.ly/4iZyGiD
@cumedicalschool.bsky.social
#ACCORDSInnovation #ACCORDSCommunity #HealthCareServicesResearch
@cumedicalschool.bsky.social
#ACCORDSInnovation #ACCORDSCommunity #HealthCareServicesResearch
Reposted by Siegenthaler Lab
GLP-1s were a hot topic this year. Joseph Schacht, PhD, co-director of the Division of Addiction Science, Prevention, and Treatment, is investigating whether the pill form of Ozempic could help people with alcohol use disorder reduce their cravings to drink. https://bit.ly/44wI2w9
CU Researcher Studying Effects of GLP-1 Drugs on Alcohol Addiction
Joseph Schacht, PhD, of the CU School of Medicine, is investigating whether the pill form of Ozempic can curb alcohol cravings.
news.cuanschutz.edu
December 26, 2025 at 5:47 PM
GLP-1s were a hot topic this year. Joseph Schacht, PhD, co-director of the Division of Addiction Science, Prevention, and Treatment, is investigating whether the pill form of Ozempic could help people with alcohol use disorder reduce their cravings to drink. https://bit.ly/44wI2w9
Reposted by Siegenthaler Lab
Experimental evidence that students are more likely to contest grades when they are delivered by an evaluator with a female-sounding name.
"These findings suggest that women in evaluative positions face disproportionate resistance when delivering negative assessments."
"These findings suggest that women in evaluative positions face disproportionate resistance when delivering negative assessments."
December 24, 2025 at 11:21 PM
Experimental evidence that students are more likely to contest grades when they are delivered by an evaluator with a female-sounding name.
"These findings suggest that women in evaluative positions face disproportionate resistance when delivering negative assessments."
"These findings suggest that women in evaluative positions face disproportionate resistance when delivering negative assessments."
Reposted by Siegenthaler Lab
the last time a student pursued a grade grievance for one of my classes my dept chair was astounded at the meticulousness of the records I keep. This is why
Experimental evidence that students are more likely to contest grades when they are delivered by an evaluator with a female-sounding name.
"These findings suggest that women in evaluative positions face disproportionate resistance when delivering negative assessments."
"These findings suggest that women in evaluative positions face disproportionate resistance when delivering negative assessments."
December 26, 2025 at 12:41 PM
the last time a student pursued a grade grievance for one of my classes my dept chair was astounded at the meticulousness of the records I keep. This is why
Reposted by Siegenthaler Lab
Cat Clinging To Side Of Christmas Tree Admits That Was Extent Of Plan https://theonion.com/cat-clinging-to-side-of-christmas-tree-admits-that-was-1849899567/
December 26, 2025 at 3:00 PM
Cat Clinging To Side Of Christmas Tree Admits That Was Extent Of Plan https://theonion.com/cat-clinging-to-side-of-christmas-tree-admits-that-was-1849899567/
Reposted by Siegenthaler Lab
And I must give credit to people smarter than me i.e. @dacrotty.bsky.social who notes that any journal will very gladly publish a negative result as long as it is exciting enough. The bias against null results is really just another form of same old bias *for* perceived significance/impact.
Scooby Doo Fred Jones GIF
ALT: Scooby Doo Fred Jones GIF
media.tenor.com
December 26, 2025 at 2:42 PM
And I must give credit to people smarter than me i.e. @dacrotty.bsky.social who notes that any journal will very gladly publish a negative result as long as it is exciting enough. The bias against null results is really just another form of same old bias *for* perceived significance/impact.
Reposted by Siegenthaler Lab
From threats of violence to racially segregated restaurants to sundown towns, holiday travel required careful, deliberate planning from Black people. The Green Book project documents this history, and you can add your story as well: greenbookproject.osu.edu #GreenBookProject #CommunityMap #EconSky
December 26, 2025 at 2:05 PM
From threats of violence to racially segregated restaurants to sundown towns, holiday travel required careful, deliberate planning from Black people. The Green Book project documents this history, and you can add your story as well: greenbookproject.osu.edu #GreenBookProject #CommunityMap #EconSky
Reposted by Siegenthaler Lab
Our preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)
Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo
Enhancers control tissue-specific gene expression across metazoans. Although deep learning has enabled enhancer prediction and design in mammalian cell lines and invertebrate systems, it remains uncle...
www.biorxiv.org
December 24, 2025 at 3:06 PM
Our preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)
My doggo Clark 'asked' for a hike for his Christmas 🎁...who am I to refuse? I hope everyone is having a relaxing, joy-filled day! ❤️
December 25, 2025 at 9:58 PM
My doggo Clark 'asked' for a hike for his Christmas 🎁...who am I to refuse? I hope everyone is having a relaxing, joy-filled day! ❤️
Reposted by Siegenthaler Lab
Christmas Eve, 2025
Sitting in front of the fireplace with Alice the cat, reflecting upon a very bad, no good year.
So many people have suffered and are suffering this year. Let’s work to use whatever privilege and advantages we have to better life for everyone who has it harder than we do.
Sitting in front of the fireplace with Alice the cat, reflecting upon a very bad, no good year.
So many people have suffered and are suffering this year. Let’s work to use whatever privilege and advantages we have to better life for everyone who has it harder than we do.
December 24, 2025 at 11:15 PM
Christmas Eve, 2025
Sitting in front of the fireplace with Alice the cat, reflecting upon a very bad, no good year.
So many people have suffered and are suffering this year. Let’s work to use whatever privilege and advantages we have to better life for everyone who has it harder than we do.
Sitting in front of the fireplace with Alice the cat, reflecting upon a very bad, no good year.
So many people have suffered and are suffering this year. Let’s work to use whatever privilege and advantages we have to better life for everyone who has it harder than we do.
Reposted by Siegenthaler Lab
A Christmas present from us and the rest of the #OCTRON team to you: www.biorxiv.org/content/10.6... 🎁
December 25, 2025 at 9:51 AM
A Christmas present from us and the rest of the #OCTRON team to you: www.biorxiv.org/content/10.6... 🎁
Reposted by Siegenthaler Lab
Atlantic sturgeon is one of ~27 species in the sturgeon family Acipenseridae, a group whose looks haven’t changed much since the Cretaceous. They have bony plates (scutes) instead of scales, barbels by their mouths + heterocercal tails (one side larger than the other - like sharks) #25DaysofFishmas
December 25, 2025 at 2:03 PM
Atlantic sturgeon is one of ~27 species in the sturgeon family Acipenseridae, a group whose looks haven’t changed much since the Cretaceous. They have bony plates (scutes) instead of scales, barbels by their mouths + heterocercal tails (one side larger than the other - like sharks) #25DaysofFishmas
Reposted by Siegenthaler Lab
The big day is finally here - and with it, a very big fish!
Our #25DaysofFishmas road trip ends on the East Coast with the ancient-looking Atlantic Sturgeon (Acipenser oxyrinchus). Once close to becoming a Ghost of Fishmas Past, their ongoing recovery represents a possible brighter Fishmas Future
Our #25DaysofFishmas road trip ends on the East Coast with the ancient-looking Atlantic Sturgeon (Acipenser oxyrinchus). Once close to becoming a Ghost of Fishmas Past, their ongoing recovery represents a possible brighter Fishmas Future
December 25, 2025 at 2:01 PM
The big day is finally here - and with it, a very big fish!
Our #25DaysofFishmas road trip ends on the East Coast with the ancient-looking Atlantic Sturgeon (Acipenser oxyrinchus). Once close to becoming a Ghost of Fishmas Past, their ongoing recovery represents a possible brighter Fishmas Future
Our #25DaysofFishmas road trip ends on the East Coast with the ancient-looking Atlantic Sturgeon (Acipenser oxyrinchus). Once close to becoming a Ghost of Fishmas Past, their ongoing recovery represents a possible brighter Fishmas Future
Reposted by Siegenthaler Lab
Wishing all of our friends a very happy holiday season full of peace, love & happiness! Gracias Ignacio Gomez for this wonderful piece of art. #WeFeedYou
Deseándole a todos nuestros amigos unas felices fiestas llenas de amor, paz y felicidad! Gracias Ignacio Gómez por está increíble pieza de arte.
Deseándole a todos nuestros amigos unas felices fiestas llenas de amor, paz y felicidad! Gracias Ignacio Gómez por está increíble pieza de arte.
December 25, 2025 at 1:01 PM
Wishing all of our friends a very happy holiday season full of peace, love & happiness! Gracias Ignacio Gomez for this wonderful piece of art. #WeFeedYou
Deseándole a todos nuestros amigos unas felices fiestas llenas de amor, paz y felicidad! Gracias Ignacio Gómez por está increíble pieza de arte.
Deseándole a todos nuestros amigos unas felices fiestas llenas de amor, paz y felicidad! Gracias Ignacio Gómez por está increíble pieza de arte.
Reposted by Siegenthaler Lab
This is your brain on Ritalin. Got your attention? Stimulant medications like Ritalin (methylphenidate) do, but not in the way you might think. They don't act directly on the brain’s attention systems! Find out what's really happening in @cellpress.bsky.social. doi.org/10.1016/j.ce...
December 24, 2025 at 4:46 PM
This is your brain on Ritalin. Got your attention? Stimulant medications like Ritalin (methylphenidate) do, but not in the way you might think. They don't act directly on the brain’s attention systems! Find out what's really happening in @cellpress.bsky.social. doi.org/10.1016/j.ce...
Reposted by Siegenthaler Lab
I’ve been teaching medical students stimulants treat hyperactivity by “stimulating” the brain’s attention systems, but it turns out I was wrong. Stimulants mimicked the effects of getting more sleep and anticipated reward, not attention.
December 24, 2025 at 4:46 PM
I’ve been teaching medical students stimulants treat hyperactivity by “stimulating” the brain’s attention systems, but it turns out I was wrong. Stimulants mimicked the effects of getting more sleep and anticipated reward, not attention.
Reposted by Siegenthaler Lab
Do you love quantifying animal behavior as much as we do? We have just the tool for you! Presenting #OCTRON - a pipeline that helps you create rich annotation data and enables training of custom segmentation models. Have a look, particularly if you work with non-model / invertebrate organisms!
December 23, 2025 at 7:52 PM
Do you love quantifying animal behavior as much as we do? We have just the tool for you! Presenting #OCTRON - a pipeline that helps you create rich annotation data and enables training of custom segmentation models. Have a look, particularly if you work with non-model / invertebrate organisms!
Reposted by Siegenthaler Lab
My first ever paper as a xmas present! 🎄
Check out this amazing pipeline created by @octoscience.bsky.social to track squishy animals 🐙
Very happy I could contribute to this, #OCTRON works great on my gossamer worms!
👇
Check out this amazing pipeline created by @octoscience.bsky.social to track squishy animals 🐙
Very happy I could contribute to this, #OCTRON works great on my gossamer worms!
👇
Do you love quantifying animal behavior as much as we do? We have just the tool for you! Presenting #OCTRON - a pipeline that helps you create rich annotation data and enables training of custom segmentation models. Have a look, particularly if you work with non-model / invertebrate organisms!
December 25, 2025 at 12:55 PM
My first ever paper as a xmas present! 🎄
Check out this amazing pipeline created by @octoscience.bsky.social to track squishy animals 🐙
Very happy I could contribute to this, #OCTRON works great on my gossamer worms!
👇
Check out this amazing pipeline created by @octoscience.bsky.social to track squishy animals 🐙
Very happy I could contribute to this, #OCTRON works great on my gossamer worms!
👇
Reposted by Siegenthaler Lab
Last day of #ArtAdventCalendar, I guess? Here's a brand new brain in ink on yupo #sciart
December 24, 2025 at 6:13 PM
Last day of #ArtAdventCalendar, I guess? Here's a brand new brain in ink on yupo #sciart
Reposted by Siegenthaler Lab
If anyone still needs to get a gift for your family, we are still scheduling fundraiser charters for 2026. Up to 15 total guests join us for a day of shark research, and you get to help us catch, tag, measure, and sample sharks.
DM me if you’re interested.
DM me if you’re interested.
December 24, 2025 at 7:37 PM
If anyone still needs to get a gift for your family, we are still scheduling fundraiser charters for 2026. Up to 15 total guests join us for a day of shark research, and you get to help us catch, tag, measure, and sample sharks.
DM me if you’re interested.
DM me if you’re interested.