Siegenthaler Lab
@siegenthalerlab.bsky.social
Neuroscience, meninges, blood-brain barrier, cake (or cookies)
http://siegenthalerlabcu.weebly.com/
http://siegenthalerlabcu.weebly.com/
Last big grant of 2025 submitted today...Dr. Bones [channeling Slash here on Halloween] says it all for me. 💀🧠💰🎃
October 31, 2025 at 9:28 PM
Last big grant of 2025 submitted today...Dr. Bones [channeling Slash here on Halloween] says it all for me. 💀🧠💰🎃
Had our 1st joint lab fun activity with the Bonney Lab @stephaniebonney.bsky.social - a pumpkin painting party! 🎃 So creative!
Works well with our 4th floor Halloween activity of 'guess the 🧠 pumpkin's weight' ⚖️...🧠 pumpkin now has a vasculature complete w/ perivascular fibroblasts & macrophages!
Works well with our 4th floor Halloween activity of 'guess the 🧠 pumpkin's weight' ⚖️...🧠 pumpkin now has a vasculature complete w/ perivascular fibroblasts & macrophages!
October 28, 2025 at 7:24 PM
Had our 1st joint lab fun activity with the Bonney Lab @stephaniebonney.bsky.social - a pumpkin painting party! 🎃 So creative!
Works well with our 4th floor Halloween activity of 'guess the 🧠 pumpkin's weight' ⚖️...🧠 pumpkin now has a vasculature complete w/ perivascular fibroblasts & macrophages!
Works well with our 4th floor Halloween activity of 'guess the 🧠 pumpkin's weight' ⚖️...🧠 pumpkin now has a vasculature complete w/ perivascular fibroblasts & macrophages!
For all those who are WFH today, riding the struggle-bus through a mid-October, not-enough-time-left-in-the-year-and-things-feel/are-crappy Monday 🙋♀️...take a DEEP breath &, if possible, pet your animal...get a nice, deep scratch in!
October 20, 2025 at 5:21 PM
For all those who are WFH today, riding the struggle-bus through a mid-October, not-enough-time-left-in-the-year-and-things-feel/are-crappy Monday 🙋♀️...take a DEEP breath &, if possible, pet your animal...get a nice, deep scratch in!
My mood this morning...
Reviewing my 3mo science goals going into mid-October, ✅ boxes off & looking at this picture that accurately describes me ATM [the 'empty nester', me making a funny face, my boy walking out of the photo frame...from Coit Tower in SF this summer].
Reviewing my 3mo science goals going into mid-October, ✅ boxes off & looking at this picture that accurately describes me ATM [the 'empty nester', me making a funny face, my boy walking out of the photo frame...from Coit Tower in SF this summer].
October 11, 2025 at 12:56 PM
My mood this morning...
Reviewing my 3mo science goals going into mid-October, ✅ boxes off & looking at this picture that accurately describes me ATM [the 'empty nester', me making a funny face, my boy walking out of the photo frame...from Coit Tower in SF this summer].
Reviewing my 3mo science goals going into mid-October, ✅ boxes off & looking at this picture that accurately describes me ATM [the 'empty nester', me making a funny face, my boy walking out of the photo frame...from Coit Tower in SF this summer].
Listening to the new Taylor Swift album & working on figures, sharing a 🤩 image for #FluorescenceFriday
[penetrating 🐭 cerebral arteriole at the pial surface, aSMA in yellow = smooth muscle cell, pan-laminin in cyan = basement membrane, fibroblast in magenta...squeezing in to cover that vessel 🫂)
[penetrating 🐭 cerebral arteriole at the pial surface, aSMA in yellow = smooth muscle cell, pan-laminin in cyan = basement membrane, fibroblast in magenta...squeezing in to cover that vessel 🫂)
October 3, 2025 at 12:42 PM
Listening to the new Taylor Swift album & working on figures, sharing a 🤩 image for #FluorescenceFriday
[penetrating 🐭 cerebral arteriole at the pial surface, aSMA in yellow = smooth muscle cell, pan-laminin in cyan = basement membrane, fibroblast in magenta...squeezing in to cover that vessel 🫂)
[penetrating 🐭 cerebral arteriole at the pial surface, aSMA in yellow = smooth muscle cell, pan-laminin in cyan = basement membrane, fibroblast in magenta...squeezing in to cover that vessel 🫂)
Had a 🤩 time in Freiburg 🇩🇪 for the CNS Wound Healing & Scarring meeting organized by Jae Lee @univmiami.bsky.social & Christian Schachtrup @uni-freiburg.de - amazing progress in this field! ⚡🧠🩹
Took a short trip to Basel & Luzern 🇨🇭 to finally connect with my Swiss roots...my ❤️ of ⛰️ & 🥾 is in my 🧬
Took a short trip to Basel & Luzern 🇨🇭 to finally connect with my Swiss roots...my ❤️ of ⛰️ & 🥾 is in my 🧬
October 1, 2025 at 12:29 PM
Had a 🤩 time in Freiburg 🇩🇪 for the CNS Wound Healing & Scarring meeting organized by Jae Lee @univmiami.bsky.social & Christian Schachtrup @uni-freiburg.de - amazing progress in this field! ⚡🧠🩹
Took a short trip to Basel & Luzern 🇨🇭 to finally connect with my Swiss roots...my ❤️ of ⛰️ & 🥾 is in my 🧬
Took a short trip to Basel & Luzern 🇨🇭 to finally connect with my Swiss roots...my ❤️ of ⛰️ & 🥾 is in my 🧬
We login with our university ID onto the imaging analysis computer & I always laugh being greeted by 'younger Julie' in my first faculty photo 😂
(**I am apparently am THAT kind of faculty that does not update their photo though I now understand why this happens...who has time for that?!?!)
(**I am apparently am THAT kind of faculty that does not update their photo though I now understand why this happens...who has time for that?!?!)
September 19, 2025 at 7:54 PM
We login with our university ID onto the imaging analysis computer & I always laugh being greeted by 'younger Julie' in my first faculty photo 😂
(**I am apparently am THAT kind of faculty that does not update their photo though I now understand why this happens...who has time for that?!?!)
(**I am apparently am THAT kind of faculty that does not update their photo though I now understand why this happens...who has time for that?!?!)
I ❤️ dahlias, the bigger the better!
Happy birthday! I hope you have a great day. 🌹🌸🌼
Happy birthday! I hope you have a great day. 🌹🌸🌼
September 1, 2025 at 1:08 PM
I ❤️ dahlias, the bigger the better!
Happy birthday! I hope you have a great day. 🌹🌸🌼
Happy birthday! I hope you have a great day. 🌹🌸🌼
It was a great day @cuanschutz.bsky.social for the @siegenthalerlab.bsky.social - our grad student Danae Mitchell gave an amazing talk & passed her comprehensive exam 🎉...& we celebrated after by holding puppies. Congrats Danae!
August 29, 2025 at 9:12 PM
It was a great day @cuanschutz.bsky.social for the @siegenthalerlab.bsky.social - our grad student Danae Mitchell gave an amazing talk & passed her comprehensive exam 🎉...& we celebrated after by holding puppies. Congrats Danae!
We were on the trails in Boulder bright & early this Sunday morning...Clark is one happy doggie (so are his humans!). 🐶+⛰️=😁
August 24, 2025 at 4:56 PM
We were on the trails in Boulder bright & early this Sunday morning...Clark is one happy doggie (so are his humans!). 🐶+⛰️=😁
Asking my #DevBio @socdevbio.bsky.social & #Neuroscience @sfn.org colleagues to join me in donating to the ABRCMS conference poster award fund. I am sure there will be 🤩 posters on these topics @ ABRCMS 2025 in Nov, let's make sure there is award $ to recognize their work! abrcms.org/donate/stude...
August 21, 2025 at 11:44 AM
Asking my #DevBio @socdevbio.bsky.social & #Neuroscience @sfn.org colleagues to join me in donating to the ABRCMS conference poster award fund. I am sure there will be 🤩 posters on these topics @ ABRCMS 2025 in Nov, let's make sure there is award $ to recognize their work! abrcms.org/donate/stude...
The experiment didn't work as expected yet the data is still beautiful, so I got that going for me. 😜
And I spy with my little eye a mitotic figure... #MicroscopyMonday
And I spy with my little eye a mitotic figure... #MicroscopyMonday
August 18, 2025 at 10:49 PM
The experiment didn't work as expected yet the data is still beautiful, so I got that going for me. 😜
And I spy with my little eye a mitotic figure... #MicroscopyMonday
And I spy with my little eye a mitotic figure... #MicroscopyMonday
Clark has a had a rough couple weeks...'mom' has been too busy writing grants to hike ⛰️...he was bit by another dog on a walk [required a vet visit & staples 🥴]...BUT 'mom's' grant is submitted, wound is healed & it's a GREAT day for a long hike....made perfect with a dip in the creek at the end. ❤️
August 10, 2025 at 5:08 PM
Clark has a had a rough couple weeks...'mom' has been too busy writing grants to hike ⛰️...he was bit by another dog on a walk [required a vet visit & staples 🥴]...BUT 'mom's' grant is submitted, wound is healed & it's a GREAT day for a long hike....made perfect with a dip in the creek at the end. ❤️
Pretty certain running a lab is mostly about making signs to avoid inconveniences & minor catastrophes. 😊
August 10, 2025 at 2:34 AM
Pretty certain running a lab is mostly about making signs to avoid inconveniences & minor catastrophes. 😊
Submitting a R01 grant today...different R01 submitted in April has study section tomorrow....
*cue me humming, head-nodding along to Cindi Lauper's "Girls just want to have fun"...changing the last word to "funding"...because that's all we really want. Seriously.
*cue me humming, head-nodding along to Cindi Lauper's "Girls just want to have fun"...changing the last word to "funding"...because that's all we really want. Seriously.
August 6, 2025 at 11:54 PM
Submitting a R01 grant today...different R01 submitted in April has study section tomorrow....
*cue me humming, head-nodding along to Cindi Lauper's "Girls just want to have fun"...changing the last word to "funding"...because that's all we really want. Seriously.
*cue me humming, head-nodding along to Cindi Lauper's "Girls just want to have fun"...changing the last word to "funding"...because that's all we really want. Seriously.
Grant due in >2 weeks = Saturday morning grant writing.
Made far easier with a lovely view of bluebird Colorado skies, a freshly mowed lawn (courtesy of my boy) & ☕. 🌞⛰️👩💻🧠🔬🐭
Made far easier with a lovely view of bluebird Colorado skies, a freshly mowed lawn (courtesy of my boy) & ☕. 🌞⛰️👩💻🧠🔬🐭
July 26, 2025 at 2:15 PM
Grant due in >2 weeks = Saturday morning grant writing.
Made far easier with a lovely view of bluebird Colorado skies, a freshly mowed lawn (courtesy of my boy) & ☕. 🌞⛰️👩💻🧠🔬🐭
Made far easier with a lovely view of bluebird Colorado skies, a freshly mowed lawn (courtesy of my boy) & ☕. 🌞⛰️👩💻🧠🔬🐭
I am inspired by my colleagues, trainees & staff in the Dept of Pediatrics, Section of Dev Bio @cudevbio.bsky.social - studying genetic & environmental causes of congenital disorders, developmental origins of infertility, pediatric 🧠 cancer, intellectual disability & type 1 diabetes 🐭🧫🐟🧬🫀🧪👩🏻🔬👨🏽🔬
July 17, 2025 at 6:15 PM
I am inspired by my colleagues, trainees & staff in the Dept of Pediatrics, Section of Dev Bio @cudevbio.bsky.social - studying genetic & environmental causes of congenital disorders, developmental origins of infertility, pediatric 🧠 cancer, intellectual disability & type 1 diabetes 🐭🧫🐟🧬🫀🧪👩🏻🔬👨🏽🔬
Bassem Hassan @bassemh.bsky.social, Corey Harwell & yours truly are co-chairs for 2026 Neural Development #GRC August 2-7, 2026 in Newport, RI 🇺🇸 - if you are interested in updates on the conference & to hear about our 🤩 line-up of speakers...follow @neuraldevgrc.bsky.social!
🧠🪰🐭🐙🐸🦎🧒🏻🧫🧪🧠
🧠🪰🐭🐙🐸🦎🧒🏻🧫🧪🧠
July 14, 2025 at 8:28 PM
Bassem Hassan @bassemh.bsky.social, Corey Harwell & yours truly are co-chairs for 2026 Neural Development #GRC August 2-7, 2026 in Newport, RI 🇺🇸 - if you are interested in updates on the conference & to hear about our 🤩 line-up of speakers...follow @neuraldevgrc.bsky.social!
🧠🪰🐭🐙🐸🦎🧒🏻🧫🧪🧠
🧠🪰🐭🐙🐸🦎🧒🏻🧫🧪🧠
Thanks so much to the @diffjournal.bsky.social editors for an opportunity to talk about our paper on retinoic acid in retinal vascular development! Looking forward to attending these sessions in the future AND continuing to submit our work for publication in Differentiation! 🧠 👁️🐭🔬
July 11, 2025 at 7:56 PM
Thanks so much to the @diffjournal.bsky.social editors for an opportunity to talk about our paper on retinoic acid in retinal vascular development! Looking forward to attending these sessions in the future AND continuing to submit our work for publication in Differentiation! 🧠 👁️🐭🔬
Next week is 13 yrs since I started at @cuanschutz.bsky.social & opened the Siegenthaler Lab...very grateful for every trainee, every colleague & collaborator, every grant/foundation $$ that contributed to our discoveries. Even now, over a decade in, I am happy to be @ the 🔬 & imaging the meninges.
June 27, 2025 at 9:09 PM
Next week is 13 yrs since I started at @cuanschutz.bsky.social & opened the Siegenthaler Lab...very grateful for every trainee, every colleague & collaborator, every grant/foundation $$ that contributed to our discoveries. Even now, over a decade in, I am happy to be @ the 🔬 & imaging the meninges.
🤩 paper on CNS fibroblasts in leptomeninges medulloblastoma metastasis from Michael D. Taylor's group co-led by Namal Abeysundara, Alexandra Rasnitsyn, & Vernon Fong in @natcellbio.nature.com - more evidence that CNS fibroblasts are a 🔑 player in 🧠 tumor growth 🧪 www.nature.com/articles/s41...
April 24, 2025 at 12:32 PM
🤩 paper on CNS fibroblasts in leptomeninges medulloblastoma metastasis from Michael D. Taylor's group co-led by Namal Abeysundara, Alexandra Rasnitsyn, & Vernon Fong in @natcellbio.nature.com - more evidence that CNS fibroblasts are a 🔑 player in 🧠 tumor growth 🧪 www.nature.com/articles/s41...
Great new work led by @biomarina-vg.bsky.social on zebrafish meninges!
Particularly 🤩 is the descriptions of ependymin-expressing meningeal cells (not a fibroblast!) & ablation studies showing their essential role in viability. So much more to learn!
Congrats Marina & team on this great work! 🦓🐟🧠
Particularly 🤩 is the descriptions of ependymin-expressing meningeal cells (not a fibroblast!) & ablation studies showing their essential role in viability. So much more to learn!
Congrats Marina & team on this great work! 🦓🐟🧠
April 20, 2025 at 2:40 PM
Great new work led by @biomarina-vg.bsky.social on zebrafish meninges!
Particularly 🤩 is the descriptions of ependymin-expressing meningeal cells (not a fibroblast!) & ablation studies showing their essential role in viability. So much more to learn!
Congrats Marina & team on this great work! 🦓🐟🧠
Particularly 🤩 is the descriptions of ependymin-expressing meningeal cells (not a fibroblast!) & ablation studies showing their essential role in viability. So much more to learn!
Congrats Marina & team on this great work! 🦓🐟🧠
@cshlmeetings.bsky.social Brain Barriers 2025 is a wrap! It was an honor to co-organize this meeting in 2023 & 2025, a highlight of my scientific career.
I am amazed by all the great science presented by these awesome scientists over the last five days...the future of CNS barrier biology is 🤩 💫!
I am amazed by all the great science presented by these awesome scientists over the last five days...the future of CNS barrier biology is 🤩 💫!
April 12, 2025 at 8:01 PM
@cshlmeetings.bsky.social Brain Barriers 2025 is a wrap! It was an honor to co-organize this meeting in 2023 & 2025, a highlight of my scientific career.
I am amazed by all the great science presented by these awesome scientists over the last five days...the future of CNS barrier biology is 🤩 💫!
I am amazed by all the great science presented by these awesome scientists over the last five days...the future of CNS barrier biology is 🤩 💫!
Tonight I am a tired scientist who just turned in a R01 ...tomorrow I am a proud organizer with Joy Zuchero, Caroline Menard @caromenard666.bsky.social & Ayal Ben-Zvi @ayalbenzvi.bsky.social for the @cshlmeetings.bsky.social on Brain Barriers - just the boost of 🤩 science & colleagues my ❤️ & 🧠 needs
April 8, 2025 at 3:23 AM
Tonight I am a tired scientist who just turned in a R01 ...tomorrow I am a proud organizer with Joy Zuchero, Caroline Menard @caromenard666.bsky.social & Ayal Ben-Zvi @ayalbenzvi.bsky.social for the @cshlmeetings.bsky.social on Brain Barriers - just the boost of 🤩 science & colleagues my ❤️ & 🧠 needs
Dr. Maud Menten is on my 👩🔬👩🏽🔬👩🏻🔬 in STEM Wall of Fame. When I put this together in early 2025, a Christmas gift to myself, I knew that I, & others, would need a daily reminder of their great accomplishments & perseverance in the face of difficult odds. 🙏 @minouette.bsky.social for the beautiful prints!
March 20, 2025 at 4:56 PM
Dr. Maud Menten is on my 👩🔬👩🏽🔬👩🏻🔬 in STEM Wall of Fame. When I put this together in early 2025, a Christmas gift to myself, I knew that I, & others, would need a daily reminder of their great accomplishments & perseverance in the face of difficult odds. 🙏 @minouette.bsky.social for the beautiful prints!