Siegenthaler Lab
@siegenthalerlab.bsky.social
Neuroscience, meninges, blood-brain barrier, cake (or cookies)
http://siegenthalerlabcu.weebly.com/
http://siegenthalerlabcu.weebly.com/
Pinned
Hi Bluesky! I am Julie Siegenthaler, I am research faculty in Pediatrics at the University of Colorado, Anschutz Medical Campus in Aurora, Colorado USA - the @siegenthalerlab.bsky.social studies the meninges & brain vasculature & we ❤️ all CNS barriers...but the ones in the meninges are the best.
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Congratulations to @zaminiqbal.bsky.social from @milnerevolution.bsky.social on being awarded the 2026 Mary Lyon Medal!
November 14, 2025 at 12:36 PM
Congratulations to @zaminiqbal.bsky.social from @milnerevolution.bsky.social on being awarded the 2026 Mary Lyon Medal!
Reposted by Siegenthaler Lab
Congratulations to Joe Felsenstein on being awarded the 2026 Mendel Medal!
November 14, 2025 at 12:41 PM
Congratulations to Joe Felsenstein on being awarded the 2026 Mendel Medal!
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Congratulations @hilarycmartin.bsky.social from @sangerinstitute.bsky.social on being awarded the 2026 Balfour Lecture!
November 14, 2025 at 12:35 PM
Congratulations @hilarycmartin.bsky.social from @sangerinstitute.bsky.social on being awarded the 2026 Balfour Lecture!
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Congratulations to @vinuesalab.bsky.social from @crick.ac.uk on winning the 2026 JBS Haldane Lecture. Carola will present her JBS Haldane Lecture next year at @rigb.org!
November 14, 2025 at 12:39 PM
Congratulations to @vinuesalab.bsky.social from @crick.ac.uk on winning the 2026 JBS Haldane Lecture. Carola will present her JBS Haldane Lecture next year at @rigb.org!
Reposted by Siegenthaler Lab
“The prohibited activities would include joint research, co-authorship on papers, and advising a foreign graduate student or postdoctoral fellow. The language is retroactive, meaning any interactions during the previous 5 years could make a scientist ineligible for future federal funding.”
U.S. Congress considers sweeping ban on Chinese collaborations
Researchers speak out against proposal that would bar funding for U.S. scientists working with Chinese partners or training Chinese students
www.science.org
November 14, 2025 at 1:03 AM
“The prohibited activities would include joint research, co-authorship on papers, and advising a foreign graduate student or postdoctoral fellow. The language is retroactive, meaning any interactions during the previous 5 years could make a scientist ineligible for future federal funding.”
Reposted by Siegenthaler Lab
Just got an email from my SRO for the study section that was missed in October. Good news is that they are trying to reschedule ASAP (Dec/Jan). The bad news is that CSR is mandating that only the the top third (not half) of applications will get discussed for the next 2 rounds.
November 13, 2025 at 10:34 PM
Just got an email from my SRO for the study section that was missed in October. Good news is that they are trying to reschedule ASAP (Dec/Jan). The bad news is that CSR is mandating that only the the top third (not half) of applications will get discussed for the next 2 rounds.
Reposted by Siegenthaler Lab
November 13, 2025 at 7:23 PM
Reposted by Siegenthaler Lab
For solving a 50-year mystery by uncovering the machinery behind BMP, a molecule with protective effects against various disorders, Uche Medoh is the winner of the 2025 Science & SciLifeLab Prize for Young Scientists.
🎉 Learn more about the work: https://scim.ag/4qVpK1a
🎉 Learn more about the work: https://scim.ag/4qVpK1a
November 13, 2025 at 8:34 PM
For solving a 50-year mystery by uncovering the machinery behind BMP, a molecule with protective effects against various disorders, Uche Medoh is the winner of the 2025 Science & SciLifeLab Prize for Young Scientists.
🎉 Learn more about the work: https://scim.ag/4qVpK1a
🎉 Learn more about the work: https://scim.ag/4qVpK1a
Reposted by Siegenthaler Lab
Adding more signs of how NIH science is/was broken: my lab team could not show up for 3 more accepted talks at scientific conferences, totaling 9 for the year now. If you interview current NIH trainees for grad or med schools please understand that we are giving them the best experience we can.
While the government was shut down, 379 NIH study section meetings (containing 24,380 grant applications) were postponed. NIH is committed to getting these reviewed, but please be patient and understanding with staff, as this is a complex and heavy lift.
November 13, 2025 at 2:10 PM
Adding more signs of how NIH science is/was broken: my lab team could not show up for 3 more accepted talks at scientific conferences, totaling 9 for the year now. If you interview current NIH trainees for grad or med schools please understand that we are giving them the best experience we can.
Reposted by Siegenthaler Lab
While the government was shut down, 379 NIH study section meetings (containing 24,380 grant applications) were postponed. NIH is committed to getting these reviewed, but please be patient and understanding with staff, as this is a complex and heavy lift.
November 13, 2025 at 1:25 PM
While the government was shut down, 379 NIH study section meetings (containing 24,380 grant applications) were postponed. NIH is committed to getting these reviewed, but please be patient and understanding with staff, as this is a complex and heavy lift.
Reposted by Siegenthaler Lab
Even with the gov't open, study sections won't be able to instantly restart. Apart from rescheduling, sections scheduled to meet in the next week or two would have been paralyzed by the shutdown with reviews not yet assigned, reviews not yet come in, discussion order not set, etc. 🧪
While the government was shut down, 379 NIH study section meetings (containing 24,380 grant applications) were postponed. NIH is committed to getting these reviewed, but please be patient and understanding with staff, as this is a complex and heavy lift.
November 13, 2025 at 3:07 PM
Even with the gov't open, study sections won't be able to instantly restart. Apart from rescheduling, sections scheduled to meet in the next week or two would have been paralyzed by the shutdown with reviews not yet assigned, reviews not yet come in, discussion order not set, etc. 🧪
Reposted by Siegenthaler Lab
"In 2025, 40% of women aged 15 to 44 say they would move abroad permanently if they had the opportunity. The current figure is four times higher than the 10% who shared this desire in 2014, when it was generally in line with other age and gender groups."
Record Numbers of Younger Women Want to Leave the U.S.
The percentage of younger women in the U.S. who express a desire to migrate permanently has surged in the past decade.
news.gallup.com
November 13, 2025 at 3:10 PM
"In 2025, 40% of women aged 15 to 44 say they would move abroad permanently if they had the opportunity. The current figure is four times higher than the 10% who shared this desire in 2014, when it was generally in line with other age and gender groups."
Reposted by Siegenthaler Lab
I’ve been in Toronto at the #astmh meeting these past few days and last night some very good news was presented here: A new malaria drug has proven efficacious in a large trial and could soon be approved.🧪
My story in @science.org (and 🧵on why it's important to come):
www.science.org/content/arti...
My story in @science.org (and 🧵on why it's important to come):
www.science.org/content/arti...
‘A sigh of relief’: New malaria drug succeeds in large clinical trial
As existing drugs falter because of resistance, the world gets a backup—but hard choices loom on how to use it
www.science.org
November 13, 2025 at 1:27 PM
I’ve been in Toronto at the #astmh meeting these past few days and last night some very good news was presented here: A new malaria drug has proven efficacious in a large trial and could soon be approved.🧪
My story in @science.org (and 🧵on why it's important to come):
www.science.org/content/arti...
My story in @science.org (and 🧵on why it's important to come):
www.science.org/content/arti...
Reposted by Siegenthaler Lab
This paper clearly articulates what is, in my opinion, one of the major ethical problems with polygenic embryo testing companies--that they are *companies* that sell health as a private commodity. from @gaiaghirardi.bsky.social & @arnovanhootegem.bsky.social
www.fertstert.org/news-do/embr...
www.fertstert.org/news-do/embr...
Embryo selection based on polygenic prediction risks reinforcing social inequality
The rise of companies offering embryo selection based on genetic testing has triggered heated debate about ethical acceptability, as well as the accuracy and scientific validity of these techniques. W...
www.fertstert.org
November 13, 2025 at 2:35 PM
This paper clearly articulates what is, in my opinion, one of the major ethical problems with polygenic embryo testing companies--that they are *companies* that sell health as a private commodity. from @gaiaghirardi.bsky.social & @arnovanhootegem.bsky.social
www.fertstert.org/news-do/embr...
www.fertstert.org/news-do/embr...
Reposted by Siegenthaler Lab
The trend here is remarkable, but will just note that this is the epitome of an expressive responding question -- answering yes is a way to signal profound dissatisfaction, not really a declaration of intention to move.
November 13, 2025 at 2:20 PM
The trend here is remarkable, but will just note that this is the epitome of an expressive responding question -- answering yes is a way to signal profound dissatisfaction, not really a declaration of intention to move.
Reposted by Siegenthaler Lab
It's that time again.
For the next 24 hours, drop any infectious disease and/or vaccine-related questions below in response to this post, and I will do my best to answer them. Responses are for information only and are NOT medical advice.
#AskAnIDDoc November 2025 edition.
For the next 24 hours, drop any infectious disease and/or vaccine-related questions below in response to this post, and I will do my best to answer them. Responses are for information only and are NOT medical advice.
#AskAnIDDoc November 2025 edition.
a man is standing in a kitchen drinking from a cup and talking about flu season .
ALT: a man is standing in a kitchen drinking from a cup and talking about flu season .
media.tenor.com
November 13, 2025 at 1:25 PM
It's that time again.
For the next 24 hours, drop any infectious disease and/or vaccine-related questions below in response to this post, and I will do my best to answer them. Responses are for information only and are NOT medical advice.
#AskAnIDDoc November 2025 edition.
For the next 24 hours, drop any infectious disease and/or vaccine-related questions below in response to this post, and I will do my best to answer them. Responses are for information only and are NOT medical advice.
#AskAnIDDoc November 2025 edition.
Reposted by Siegenthaler Lab
Do you love the monthly #preprint lists on @the-node.bsky.social?
Good news, our #preLighters have teamed up with the Node to nominate standout articles and share one-paragraph insights on why they’re excited.
Check out their October highlights ⬇️ 👀
thenode.biologists.com/prelighters-...
Good news, our #preLighters have teamed up with the Node to nominate standout articles and share one-paragraph insights on why they’re excited.
Check out their October highlights ⬇️ 👀
thenode.biologists.com/prelighters-...
November 13, 2025 at 12:35 PM
Do you love the monthly #preprint lists on @the-node.bsky.social?
Good news, our #preLighters have teamed up with the Node to nominate standout articles and share one-paragraph insights on why they’re excited.
Check out their October highlights ⬇️ 👀
thenode.biologists.com/prelighters-...
Good news, our #preLighters have teamed up with the Node to nominate standout articles and share one-paragraph insights on why they’re excited.
Check out their October highlights ⬇️ 👀
thenode.biologists.com/prelighters-...
Reposted by Siegenthaler Lab
Primary Cilia Dysfunction in Brown Fat Results in Fatal Thermogenesis Failure in Neonatal Mice https://www.biorxiv.org/content/10.1101/2025.11.12.687971v1
November 13, 2025 at 12:35 PM
Primary Cilia Dysfunction in Brown Fat Results in Fatal Thermogenesis Failure in Neonatal Mice https://www.biorxiv.org/content/10.1101/2025.11.12.687971v1
Reposted by Siegenthaler Lab
Has anyone had this problem? A hydrophobic water objective? The objective is great but we struggle to keep the water on the lens...
-> Maybe a solution is to paint a circle around the nose with a 'hydrophobic barrier pap pen" (link below). Has anyone tried this?
www.fishersci.com/shop/product...
-> Maybe a solution is to paint a circle around the nose with a 'hydrophobic barrier pap pen" (link below). Has anyone tried this?
www.fishersci.com/shop/product...
November 12, 2025 at 12:56 AM
Has anyone had this problem? A hydrophobic water objective? The objective is great but we struggle to keep the water on the lens...
-> Maybe a solution is to paint a circle around the nose with a 'hydrophobic barrier pap pen" (link below). Has anyone tried this?
www.fishersci.com/shop/product...
-> Maybe a solution is to paint a circle around the nose with a 'hydrophobic barrier pap pen" (link below). Has anyone tried this?
www.fishersci.com/shop/product...
Reposted by Siegenthaler Lab
Here, we show that deep below, corals and feather stars don’t just share space – they share microbes. Endozoicomonadaceae + Nitrosopumilaceae inhabit both hosts in a “promiscuous” symbiosis that may fuel nitrogen cycling in the deep sea.
doi.org/10.1186/s401... 🌊🪸🧪 #Bioinformatics 🧬💻 #SymbioSky
doi.org/10.1186/s401... 🌊🪸🧪 #Bioinformatics 🧬💻 #SymbioSky
November 13, 2025 at 6:11 AM
Here, we show that deep below, corals and feather stars don’t just share space – they share microbes. Endozoicomonadaceae + Nitrosopumilaceae inhabit both hosts in a “promiscuous” symbiosis that may fuel nitrogen cycling in the deep sea.
doi.org/10.1186/s401... 🌊🪸🧪 #Bioinformatics 🧬💻 #SymbioSky
doi.org/10.1186/s401... 🌊🪸🧪 #Bioinformatics 🧬💻 #SymbioSky
Reposted by Siegenthaler Lab
#DBfeature
Multidisciplinary educational approach to reproductive technology links developmental biology, ethics, and law to prepare biologists for real-world controversies
By J Azzi, Z Wehbi, P Hussein Kobeissy, R Kerek
tinyurl.com/2xvm64ue
#SpecialIssue in Teaching #DevBio for Social Change
Multidisciplinary educational approach to reproductive technology links developmental biology, ethics, and law to prepare biologists for real-world controversies
By J Azzi, Z Wehbi, P Hussein Kobeissy, R Kerek
tinyurl.com/2xvm64ue
#SpecialIssue in Teaching #DevBio for Social Change
November 12, 2025 at 1:51 PM
#DBfeature
Multidisciplinary educational approach to reproductive technology links developmental biology, ethics, and law to prepare biologists for real-world controversies
By J Azzi, Z Wehbi, P Hussein Kobeissy, R Kerek
tinyurl.com/2xvm64ue
#SpecialIssue in Teaching #DevBio for Social Change
Multidisciplinary educational approach to reproductive technology links developmental biology, ethics, and law to prepare biologists for real-world controversies
By J Azzi, Z Wehbi, P Hussein Kobeissy, R Kerek
tinyurl.com/2xvm64ue
#SpecialIssue in Teaching #DevBio for Social Change
Reposted by Siegenthaler Lab
University of Durham is hiring:
Postdoctoral Research Associate in Plant Developmental Biology
Postdoctoral Research Associate in Plant Developmental Biology
November 13, 2025 at 9:32 AM
University of Durham is hiring:
Postdoctoral Research Associate in Plant Developmental Biology
Postdoctoral Research Associate in Plant Developmental Biology
Reposted by Siegenthaler Lab
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Proteome-wide in silico screening for human protein-protein interactions
Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...
biorxiv.org
November 12, 2025 at 9:26 PM
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Reposted by Siegenthaler Lab
Postdoctoral Research Fellow in vascular and immune biology at the UK Dementia Research Institute, Edinburgh seeking a researcher skilled in molecular biology and imaging. Closing date: 26th November
www.dementiaresearcher.nihr.ac.uk/job/postdoct...
www.dementiaresearcher.nihr.ac.uk/job/postdoct...
Postdoctoral Researcher: Vascular-immune dysfunction
Postdoc Researcher in vascular and immune biology at the UK Dementia Research Institute, Edinburgh seeking a researcher skilled in molecular biology and imaging
www.dementiaresearcher.nihr.ac.uk
November 13, 2025 at 12:05 PM
Postdoctoral Research Fellow in vascular and immune biology at the UK Dementia Research Institute, Edinburgh seeking a researcher skilled in molecular biology and imaging. Closing date: 26th November
www.dementiaresearcher.nihr.ac.uk/job/postdoct...
www.dementiaresearcher.nihr.ac.uk/job/postdoct...
Reposted by Siegenthaler Lab
Excited to have my piece on perimenopause published @thetransmitter.bsky.social
"Perimenopause: An important—and understudied—transition for the brain"
We need more studies & better education -we need this to be mainstream- knowledge is power! #WomensHealth
www.thetransmitter.org/sex-hormones...
"Perimenopause: An important—and understudied—transition for the brain"
We need more studies & better education -we need this to be mainstream- knowledge is power! #WomensHealth
www.thetransmitter.org/sex-hormones...
Perimenopause: An understudied transition for the brain
We know little about the mechanisms underlying well-known perimenopause symptoms in the brain. More research—in animals and humans—is essential.
www.thetransmitter.org
November 12, 2025 at 8:14 AM
Excited to have my piece on perimenopause published @thetransmitter.bsky.social
"Perimenopause: An important—and understudied—transition for the brain"
We need more studies & better education -we need this to be mainstream- knowledge is power! #WomensHealth
www.thetransmitter.org/sex-hormones...
"Perimenopause: An important—and understudied—transition for the brain"
We need more studies & better education -we need this to be mainstream- knowledge is power! #WomensHealth
www.thetransmitter.org/sex-hormones...