Mike Schumacher
@schumacherama.bsky.social
Gut physiologist studying epithelial-immune dysfunction in the gastrointestinal tract 🧪 gutsciencelab.com
🔬 #organoids #macrophages #stemcells #ibd
🔬 #organoids #macrophages #stemcells #ibd
Pinned
Reposted by Mike Schumacher
Thrilled for our wonderful postdoc @lizihegarty.bsky.social whose #PhD work on colonic #macrophages and #colitis with @bainlab.bsky.social @edinuni-irr.bsky.social has been accepted for publication in @mucosalimmunol.bsky.social 🔬
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Tissue resident colonic macrophages persist through acute inflammation and adapt to aid tissue repair
Macrophages are crucial for the maintenance of intestinal homeostasis, are considered key proinflammatory effector cells during intestinal inflammatio…
www.sciencedirect.com
November 19, 2025 at 5:09 PM
Thrilled for our wonderful postdoc @lizihegarty.bsky.social whose #PhD work on colonic #macrophages and #colitis with @bainlab.bsky.social @edinuni-irr.bsky.social has been accepted for publication in @mucosalimmunol.bsky.social 🔬
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Mike Schumacher
Join me & keynote speaker Dr. Florian Rieder at #CCCongress26, Jan. 22-24 in Vegas. @ibd-flomd.bsky.social does an outstanding job bridging #IBD basic science and clinical research, so this is sure to be a great talk Register by 10/21 & SAVE: 🔗 bit.ly/4m85s1N
#IBDsky #GIsky #Gastrosky
#IBDsky #GIsky #Gastrosky
Home 2026
Join colleagues across the entire spectrum of clinical care and science at the premier conference on inflammatory bowel disease (IBD).
bit.ly
October 2, 2025 at 2:06 PM
Join me & keynote speaker Dr. Florian Rieder at #CCCongress26, Jan. 22-24 in Vegas. @ibd-flomd.bsky.social does an outstanding job bridging #IBD basic science and clinical research, so this is sure to be a great talk Register by 10/21 & SAVE: 🔗 bit.ly/4m85s1N
#IBDsky #GIsky #Gastrosky
#IBDsky #GIsky #Gastrosky
Reposted by Mike Schumacher
#Bcells are emerging as key players in #IBD, far beyond a T-cell story.
From IgA protection to pro-inflammatory subsets, we highlight how understanding B cell diversity can unlock precise #Immunotherapy in #IBD.
Check Fran and Bianca's review 👇
doi.org/10.1016/j.im...
From IgA protection to pro-inflammatory subsets, we highlight how understanding B cell diversity can unlock precise #Immunotherapy in #IBD.
Check Fran and Bianca's review 👇
doi.org/10.1016/j.im...
August 20, 2025 at 2:11 PM
#Bcells are emerging as key players in #IBD, far beyond a T-cell story.
From IgA protection to pro-inflammatory subsets, we highlight how understanding B cell diversity can unlock precise #Immunotherapy in #IBD.
Check Fran and Bianca's review 👇
doi.org/10.1016/j.im...
From IgA protection to pro-inflammatory subsets, we highlight how understanding B cell diversity can unlock precise #Immunotherapy in #IBD.
Check Fran and Bianca's review 👇
doi.org/10.1016/j.im...
Reposted by Mike Schumacher
📚NEW #gdTcell PAPER ALERT! 'Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling' is now out in @mucosalimmunol.bsky.social! #gastrosky #GIsky #IBDsky Join us for a Bluetorial 🧵...
Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling
Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mi…
www.sciencedirect.com
August 7, 2025 at 9:36 PM
📚NEW #gdTcell PAPER ALERT! 'Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling' is now out in @mucosalimmunol.bsky.social! #gastrosky #GIsky #IBDsky Join us for a Bluetorial 🧵...
Giggling her way into 3 months old
July 24, 2025 at 6:58 PM
Giggling her way into 3 months old
Reposted by Mike Schumacher
🔊 Paper alert
1/ Tuft cells are perhaps the coolest cells in our gut orchestrating host defense, but how do they manage? @julian-buissant.bsky.social provides new insights into tuft cell differentiation, and the development of accurate in vitro models for experimental cell biology 🧫🔬🧬
rdcu.be/exou9
1/ Tuft cells are perhaps the coolest cells in our gut orchestrating host defense, but how do they manage? @julian-buissant.bsky.social provides new insights into tuft cell differentiation, and the development of accurate in vitro models for experimental cell biology 🧫🔬🧬
rdcu.be/exou9
July 23, 2025 at 7:09 PM
🔊 Paper alert
1/ Tuft cells are perhaps the coolest cells in our gut orchestrating host defense, but how do they manage? @julian-buissant.bsky.social provides new insights into tuft cell differentiation, and the development of accurate in vitro models for experimental cell biology 🧫🔬🧬
rdcu.be/exou9
1/ Tuft cells are perhaps the coolest cells in our gut orchestrating host defense, but how do they manage? @julian-buissant.bsky.social provides new insights into tuft cell differentiation, and the development of accurate in vitro models for experimental cell biology 🧫🔬🧬
rdcu.be/exou9
Immune cell stratification in the inflamed intestinal epithelium
#immunofluorescence #microscopy #ibd
#immunofluorescence #microscopy #ibd
July 23, 2025 at 6:01 PM
Immune cell stratification in the inflamed intestinal epithelium
#immunofluorescence #microscopy #ibd
#immunofluorescence #microscopy #ibd
Reposted by Mike Schumacher
Review the contributions of mucus-associated microbes who are “Living on the Edge” in the colon:
www.mucosalimmunology.org/article/S193...
www.mucosalimmunology.org/article/S193...
June 6, 2025 at 2:07 PM
Review the contributions of mucus-associated microbes who are “Living on the Edge” in the colon:
www.mucosalimmunology.org/article/S193...
www.mucosalimmunology.org/article/S193...
Reposted by Mike Schumacher
Breaking News: A baby with a rare disorder made medical history by receiving the first custom gene-editing treatment. The technique used has the potential to help people with thousands of other uncommon genetic diseases. nyti.ms/4j49xBy
May 15, 2025 at 5:09 PM
Breaking News: A baby with a rare disorder made medical history by receiving the first custom gene-editing treatment. The technique used has the potential to help people with thousands of other uncommon genetic diseases. nyti.ms/4j49xBy
Reposted by Mike Schumacher
We’re excited to share our recently published story
“A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as modulators of mucosal healing”
in @mucosalimmunol.bsky.social
Fantastic work led by @ramoralescastro.bsky.social !
www.mucosalimmunology.org/article/S193...
“A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as modulators of mucosal healing”
in @mucosalimmunol.bsky.social
Fantastic work led by @ramoralescastro.bsky.social !
www.mucosalimmunology.org/article/S193...
A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as major modulators of mucosal healing
The intestine is a semipermeable tissue responsible for the absorption of essential
nutrients while limiting exposure to harmful environmental factors. To maintain these
functions, the intestinal epit...
www.mucosalimmunology.org
May 14, 2025 at 8:17 PM
We’re excited to share our recently published story
“A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as modulators of mucosal healing”
in @mucosalimmunol.bsky.social
Fantastic work led by @ramoralescastro.bsky.social !
www.mucosalimmunology.org/article/S193...
“A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as modulators of mucosal healing”
in @mucosalimmunol.bsky.social
Fantastic work led by @ramoralescastro.bsky.social !
www.mucosalimmunology.org/article/S193...
Reposted by Mike Schumacher
Integrated Organoid Atlas benchmarks new protocols, even more impressive as a Highly Variable Cohort for comparison against perturbation and disease models: nature.com/articles/s41... Lead by @quanxu.bsky.social, in collaboration with Lennard Halle and @fabiantheis.bsky.social
An integrated transcriptomic cell atlas of human endoderm-derived organoids - Nature Genetics
The human endoderm-derived organoid cell atlas (HEOCA) presents an integrative analysis of single-cell transcriptomes across different conditions, sources and protocols. It compares cell types and sta...
nature.com
May 12, 2025 at 9:23 PM
Integrated Organoid Atlas benchmarks new protocols, even more impressive as a Highly Variable Cohort for comparison against perturbation and disease models: nature.com/articles/s41... Lead by @quanxu.bsky.social, in collaboration with Lennard Halle and @fabiantheis.bsky.social
Reposted by Mike Schumacher
The colonic mucus barrier & sentinel goblet cells protect the distal gut from microbial challenges. Johansson, @gobletcellguy.bsky.social et al show that microbial colonization drives sequential development of both of these barrier mechanisms in the pre-weaning intestine. rupress.org/jem/article/...
May 5, 2025 at 4:23 PM
The colonic mucus barrier & sentinel goblet cells protect the distal gut from microbial challenges. Johansson, @gobletcellguy.bsky.social et al show that microbial colonization drives sequential development of both of these barrier mechanisms in the pre-weaning intestine. rupress.org/jem/article/...
Household mischief level about to double, welcome home baby two 🙃
April 21, 2025 at 6:01 PM
Household mischief level about to double, welcome home baby two 🙃
Reposted by Mike Schumacher
📚NEW #gdTcell PAPER ALERT! Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis | Science Immunology
Bluetorial coming soon!!! #gastrosky #GIsky #IBDsky @nbgolovchenko.bsky.social @squeakyanimal.bsky.social @andrewfong.bsky.social
Bluetorial coming soon!!! #gastrosky #GIsky #IBDsky @nbgolovchenko.bsky.social @squeakyanimal.bsky.social @andrewfong.bsky.social
Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis
Multiple layers of γδ IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis.
www.science.org
March 21, 2025 at 6:14 PM
📚NEW #gdTcell PAPER ALERT! Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis | Science Immunology
Bluetorial coming soon!!! #gastrosky #GIsky #IBDsky @nbgolovchenko.bsky.social @squeakyanimal.bsky.social @andrewfong.bsky.social
Bluetorial coming soon!!! #gastrosky #GIsky #IBDsky @nbgolovchenko.bsky.social @squeakyanimal.bsky.social @andrewfong.bsky.social
Reposted by Mike Schumacher
Bluetorial: The path to a new pain medication with little potential for addiction
Perhaps a good story to share with folks who want to learn about how biomedical research works and where advances come from.
Perhaps a good story to share with folks who want to learn about how biomedical research works and where advances come from.
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
media.tenor.com
February 22, 2025 at 10:20 AM
Bluetorial: The path to a new pain medication with little potential for addiction
Perhaps a good story to share with folks who want to learn about how biomedical research works and where advances come from.
Perhaps a good story to share with folks who want to learn about how biomedical research works and where advances come from.
Reposted by Mike Schumacher
A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb.
https://go.nature.com/41a7Zzj
https://go.nature.com/41a7Zzj
Rare genetic disorder treated in womb for the first time
The child, who is now almost three years old, shows no signs of the often fatal motor neuron disease.
go.nature.com
February 20, 2025 at 11:17 AM
A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb.
https://go.nature.com/41a7Zzj
https://go.nature.com/41a7Zzj
Reposted by Mike Schumacher
1/ I am seeing a lot of comments on the slashing of NIH support along the lines of “universities should just spend their huge endowments.”
I’m the last person to cheer on the institutional stratification rising endowments have contributed to. But let me explain why this is not a solution.
I’m the last person to cheer on the institutional stratification rising endowments have contributed to. But let me explain why this is not a solution.
February 18, 2025 at 1:48 PM
1/ I am seeing a lot of comments on the slashing of NIH support along the lines of “universities should just spend their huge endowments.”
I’m the last person to cheer on the institutional stratification rising endowments have contributed to. But let me explain why this is not a solution.
I’m the last person to cheer on the institutional stratification rising endowments have contributed to. But let me explain why this is not a solution.
Reposted by Mike Schumacher
Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda: Cell Reports www.cell.com/cell-reports...
Newborns lack immune memory to viral pathogens, so wouldn't it make sense to pre-emptively turn on antiviral defenses in barrier tissues such as the intestine at birth?
Newborns lack immune memory to viral pathogens, so wouldn't it make sense to pre-emptively turn on antiviral defenses in barrier tissues such as the intestine at birth?
Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda
Enteric viral infections are a major public health problem in newborns. Ramirez Reyes
et al. find that the immature intestinal epithelium of newborn mice is developmentally
programmed for the homeosta...
www.cell.com
February 4, 2025 at 5:11 PM
Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda: Cell Reports www.cell.com/cell-reports...
Newborns lack immune memory to viral pathogens, so wouldn't it make sense to pre-emptively turn on antiviral defenses in barrier tissues such as the intestine at birth?
Newborns lack immune memory to viral pathogens, so wouldn't it make sense to pre-emptively turn on antiviral defenses in barrier tissues such as the intestine at birth?
Reposted by Mike Schumacher
New online! Understanding the therapeutic toolkit for inflammatory bowel disease
Understanding the therapeutic toolkit for inflammatory bowel disease
Nature Reviews Gastroenterology & Hepatology, Published online: 31 January 2025; doi:10.1038/s41575-024-01035-7The management of inflammatory bowel disease (IBD) continues to evolve. This Review is a practical guide on the therapeutic toolkit for IBD,…
www.nature.com
January 31, 2025 at 3:03 PM
New online! Understanding the therapeutic toolkit for inflammatory bowel disease
Reposted by Mike Schumacher
New: Lee et al. @harvardmed.bsky.social provide a compendium of early transcriptional responses to major inflammatory #cytokines across all major immunocyte lineages of the mouse, highlighting unappreciated relationships btwn these cytokines and with other cytokine families https://buff.ly/4gn71Fg
January 28, 2025 at 5:17 PM
New: Lee et al. @harvardmed.bsky.social provide a compendium of early transcriptional responses to major inflammatory #cytokines across all major immunocyte lineages of the mouse, highlighting unappreciated relationships btwn these cytokines and with other cytokine families https://buff.ly/4gn71Fg
Reposted by Mike Schumacher
A perfect start in the new year! 🌱 Regenerating tissues are just an amazing spatio temporal controlled process! Our new manuscript explores how cell heterogeneity and bistability orchestrate intestinal regeneration. 🧵 biorxiv.org/cgi/content/...
Cell heterogeneity and fate bistability drive tissue patterning during intestinal regeneration
Tissue regeneration relies on the ability of cells to undergo de novo patterning. While tissue patterning has been viewed as the transition from initially identical un-patterned cells to an arrangemen...
biorxiv.org
January 15, 2025 at 5:32 PM
A perfect start in the new year! 🌱 Regenerating tissues are just an amazing spatio temporal controlled process! Our new manuscript explores how cell heterogeneity and bistability orchestrate intestinal regeneration. 🧵 biorxiv.org/cgi/content/...
Reposted by Mike Schumacher
A little confocal time in the empty lab is the New Year's start that I needed!
January 2, 2025 at 2:54 PM
A little confocal time in the empty lab is the New Year's start that I needed!
January 2, 2025 at 5:32 PM
Reposted by Mike Schumacher
NEW Year-in-Review in #NatureReviewsGastroHep highlighting the key papers in #IBD in 2024
Biologic agents for IBD come of age as host–microbe interactions emerge
By Leolin Katsidzira & Benjamin Misselwitz
www.nature.com/articles/s41...
#IBDsky #GastroSky #Microsky 🧪
Biologic agents for IBD come of age as host–microbe interactions emerge
By Leolin Katsidzira & Benjamin Misselwitz
www.nature.com/articles/s41...
#IBDsky #GastroSky #Microsky 🧪
Biologic agents for IBD come of age as host–microbe interactions emerge - Nature Reviews Gastroenterology & Hepatology
In 2024, there were major advances in inflammatory bowel disease research. Treatment strategies with biologic agents for inflammatory bowel disease matured, and gut microbiota–bacteriophage–host inter...
www.nature.com
December 16, 2024 at 2:32 PM
NEW Year-in-Review in #NatureReviewsGastroHep highlighting the key papers in #IBD in 2024
Biologic agents for IBD come of age as host–microbe interactions emerge
By Leolin Katsidzira & Benjamin Misselwitz
www.nature.com/articles/s41...
#IBDsky #GastroSky #Microsky 🧪
Biologic agents for IBD come of age as host–microbe interactions emerge
By Leolin Katsidzira & Benjamin Misselwitz
www.nature.com/articles/s41...
#IBDsky #GastroSky #Microsky 🧪