NiceLab
@nicelab.bsky.social
We study antiviral immune responses of the intestinal epithelium, especially interferon lambda. We focus on how they are specialized for the gut, interactions with normal microbiota at homeostasis, and how they may go awry during inflammatory diseases.
Pinned
NiceLab
@nicelab.bsky.social
· Feb 4
Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda
Enteric viral infections are a major public health problem in newborns. Ramirez Reyes
et al. find that the immature intestinal epithelium of newborn mice is developmentally
programmed for the homeosta...
www.cell.com
Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda: Cell Reports www.cell.com/cell-reports...
Newborns lack immune memory to viral pathogens, so wouldn't it make sense to pre-emptively turn on antiviral defenses in barrier tissues such as the intestine at birth?
Newborns lack immune memory to viral pathogens, so wouldn't it make sense to pre-emptively turn on antiviral defenses in barrier tissues such as the intestine at birth?
Reposted by NiceLab
Excited to announce that we have a new faculty search opening in the Department of Microbiology and Immunology at the University of Minnesota for a tenure track Assistant Professor in RNA Virology. More info can be found here: hr.myu.umn.edu/jobs/ext/365...
Careers
Minimum qualifications:PhD, MD, or equivalent in a relevant field of study, plus applicable postdoctoral experience.
hr.myu.umn.edu
October 26, 2025 at 2:41 PM
Excited to announce that we have a new faculty search opening in the Department of Microbiology and Immunology at the University of Minnesota for a tenure track Assistant Professor in RNA Virology. More info can be found here: hr.myu.umn.edu/jobs/ext/365...
Reposted by NiceLab
There are unprecedented challenges for science, calling for bold action and collective effort. Training the next generation of scientific leaders has never been more important. Join us as we grow National PROPEL to answer this call. Learn more: propelscholars.org @propelscholars.bsky.social 🧪🧬🖥️🧵
October 9, 2025 at 5:20 AM
There are unprecedented challenges for science, calling for bold action and collective effort. Training the next generation of scientific leaders has never been more important. Join us as we grow National PROPEL to answer this call. Learn more: propelscholars.org @propelscholars.bsky.social 🧪🧬🖥️🧵
Reposted by NiceLab
Last week we had another amazing department retreat, expertly organized by @laurenrodda.bsky.social and @jnpruneda.bsky.social . Thank you to our fantastic invited speaker @harmitmalik.bsky.social and all the trainees for a day of wonderful science discussions.
September 15, 2025 at 5:34 PM
Last week we had another amazing department retreat, expertly organized by @laurenrodda.bsky.social and @jnpruneda.bsky.social . Thank you to our fantastic invited speaker @harmitmalik.bsky.social and all the trainees for a day of wonderful science discussions.
Reposted by NiceLab
@biorxivpreprint.bsky.social TGF-β triggers IFN-λ from intestine plasmacytoid DCs at homeostasis, contributing to tonic localized innate immune responses
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 30, 2025 at 1:01 AM
@biorxivpreprint.bsky.social TGF-β triggers IFN-λ from intestine plasmacytoid DCs at homeostasis, contributing to tonic localized innate immune responses
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Excited to share the most recent work from our lab! In which we seek out the cellular source of homeostatic IFNL in the gut and find that gut pDC are ‘rewired’ to produce IFNL over type I IFNs.
Plasmacytoid dendritic cells in the intestine preferentially produce interferon lambda at homeostasis contributing to tonic localized innate immune responses https://www.biorxiv.org/content/10.1101/2025.08.25.672167v1
August 30, 2025 at 1:35 AM
Excited to share the most recent work from our lab! In which we seek out the cellular source of homeostatic IFNL in the gut and find that gut pDC are ‘rewired’ to produce IFNL over type I IFNs.
Reposted by NiceLab
Come be my boss! We’re looking for a passionate and supportive leader for our Department of Molecular Microbiology and Immunology. Research in MMI spans diverse models and systems of host-pathogen interactions. Come join us in the beautiful Pacific NW!
facultycareers-ohsu.icims.com/jobs/35624/c...
facultycareers-ohsu.icims.com/jobs/35624/c...
Faculty Portal | OHSU
facultycareers-ohsu.icims.com
August 26, 2025 at 1:58 AM
Come be my boss! We’re looking for a passionate and supportive leader for our Department of Molecular Microbiology and Immunology. Research in MMI spans diverse models and systems of host-pathogen interactions. Come join us in the beautiful Pacific NW!
facultycareers-ohsu.icims.com/jobs/35624/c...
facultycareers-ohsu.icims.com/jobs/35624/c...
Reposted by NiceLab
Abstract deadline extended to Monday, June 30! And travel grants are still available to student and post-doc members. Don't miss out - REPOST to share the info with others.
Don't forget 📆 Abstract deadline for poster or oral presentations is June 18. Please repost to your network to spread the word! More info or register at seattle.cytokinesociety.org
June 25, 2025 at 6:59 PM
Abstract deadline extended to Monday, June 30! And travel grants are still available to student and post-doc members. Don't miss out - REPOST to share the info with others.
Reposted by NiceLab
Excited to share with you my postdoctoral work published today in Nature Microbiology!
www.nature.com/articles/s41...
We have known for a while that stress can impact the outcome of infectious diseases; however, we reveal in our paper that it is not always detrimental.
www.nature.com/articles/s41...
We have known for a while that stress can impact the outcome of infectious diseases; however, we reveal in our paper that it is not always detrimental.
Environmental stress drives clearance of a persistent enteric virus in mice - Nature Microbiology
Cage change of mice with persistent murine astrovirus infection triggers stress responses marked by corticosterone fluctuation, which is followed by CD8 T cell activation and induction of epithelial a...
www.nature.com
June 25, 2025 at 11:55 AM
Excited to share with you my postdoctoral work published today in Nature Microbiology!
www.nature.com/articles/s41...
We have known for a while that stress can impact the outcome of infectious diseases; however, we reveal in our paper that it is not always detrimental.
www.nature.com/articles/s41...
We have known for a while that stress can impact the outcome of infectious diseases; however, we reveal in our paper that it is not always detrimental.
Reposted by NiceLab
Cytokines 2025: Submit your abstract for an oral or poster presentation by June 30th! Student and post-doctoral travel grants are still available. Don’t miss out!
seattle.cytokinesociety.org
#Cytokines #Immunology #innate #adaptive #conferences #Seattle
seattle.cytokinesociety.org
#Cytokines #Immunology #innate #adaptive #conferences #Seattle
June 25, 2025 at 7:45 PM
Cytokines 2025: Submit your abstract for an oral or poster presentation by June 30th! Student and post-doctoral travel grants are still available. Don’t miss out!
seattle.cytokinesociety.org
#Cytokines #Immunology #innate #adaptive #conferences #Seattle
seattle.cytokinesociety.org
#Cytokines #Immunology #innate #adaptive #conferences #Seattle
Reposted by NiceLab
Valerie Rodriguez Irizarry’s tour de force paper on murine norovirus adaptation/egress is now out in peer-reviewed form @plosbiology.org. It highlights the power of forward genetics in virology research. 🧵 1/10 journals.plos.org/plosbiology/...
June 25, 2025 at 1:36 PM
Valerie Rodriguez Irizarry’s tour de force paper on murine norovirus adaptation/egress is now out in peer-reviewed form @plosbiology.org. It highlights the power of forward genetics in virology research. 🧵 1/10 journals.plos.org/plosbiology/...
Reposted by NiceLab
This cool study on compounds that can kill Plasmodium inside mosquitoes and can be applied to bed-nets was contributed to by the Riscoe lab at MMI!
Excellent new study from the Catteruccia lab, co-led by Alexandra Probst and Douglas Paton www.nature.com/articles/s41...
In vivo screen of Plasmodium targets for mosquito-based malaria control - Nature
An in vivo screen of small-molecule compounds to inhibit the mosquito-stage development of Plasmodium identified hits that can be incorporated into bed nets and led to effective parasite killing in th...
www.nature.com
May 23, 2025 at 11:40 PM
This cool study on compounds that can kill Plasmodium inside mosquitoes and can be applied to bed-nets was contributed to by the Riscoe lab at MMI!
Reposted by NiceLab
Congratulations Xiaomin Yao and Eugene Rudensky for publishing this story @cp-immunity.bsky.social! Big thank you to NIH for making this work possible. Here’s a brief summary of this 🤯 finding about a gene variant that YOU 🫵 most likely have 1/n
kwnsfk27.r.eu-west-1.awstrack.me
May 17, 2025 at 10:25 PM
Congratulations Xiaomin Yao and Eugene Rudensky for publishing this story @cp-immunity.bsky.social! Big thank you to NIH for making this work possible. Here’s a brief summary of this 🤯 finding about a gene variant that YOU 🫵 most likely have 1/n
Reposted by NiceLab
Norovirus tropism depends partly on entry receptors, but what is the role of cellular #lipids? @orchardlab.bsky.social &co show that TMEM30a-mediated lipid asymmetry is crucial for murine #norovirus infection, influencing membrane fluidity, viral binding & entry @plosbiology.org 🧪 plos.io/4409MtI
April 24, 2025 at 8:02 AM
Norovirus tropism depends partly on entry receptors, but what is the role of cellular #lipids? @orchardlab.bsky.social &co show that TMEM30a-mediated lipid asymmetry is crucial for murine #norovirus infection, influencing membrane fluidity, viral binding & entry @plosbiology.org 🧪 plos.io/4409MtI
Reposted by NiceLab
💐 To NIH and NSF program officers, and anyone else trying to keep those institutions alive:
Thank you for trying to do an impossible job in an impossible time. I’m sorry for all of us that this is the world we’re living in. 1/n
Thank you for trying to do an impossible job in an impossible time. I’m sorry for all of us that this is the world we’re living in. 1/n
Just before bedtime last night I got a message from inside NIH which read:
“It’s so, so bad and no one cares (who has any influence)”
I asked “What, in particular?”
My friend responded “Everything”
“It’s so, so bad and no one cares (who has any influence)”
I asked “What, in particular?”
My friend responded “Everything”
March 28, 2025 at 11:27 AM
💐 To NIH and NSF program officers, and anyone else trying to keep those institutions alive:
Thank you for trying to do an impossible job in an impossible time. I’m sorry for all of us that this is the world we’re living in. 1/n
Thank you for trying to do an impossible job in an impossible time. I’m sorry for all of us that this is the world we’re living in. 1/n
Reposted by NiceLab
Co-Chairs, Michael Gale, Jr. and @ramlabuw.bsky.social invite abstract submissions for Cytokines2025. Topics include adaptive immunity, cytokine signaling, interferon stimulated genes, structure- function, and more. Submit: seattle.cytokinesociety.org/call-for-abs...
Deadline is May 18, 2025.
Deadline is May 18, 2025.
March 26, 2025 at 6:38 PM
Co-Chairs, Michael Gale, Jr. and @ramlabuw.bsky.social invite abstract submissions for Cytokines2025. Topics include adaptive immunity, cytokine signaling, interferon stimulated genes, structure- function, and more. Submit: seattle.cytokinesociety.org/call-for-abs...
Deadline is May 18, 2025.
Deadline is May 18, 2025.
Reposted by NiceLab
Repost if you're planning to go.
Cytokines 2025: Call for abstracts for oral or poster presentations. Topics include adaptive immunity, cytokine signaling, clinical applications, interferon stimulated genes, structure- function of cytokines, and more.
seattle.cytokinesociety.org/call-for-abs...
The deadline is May 18, 2025.
seattle.cytokinesociety.org/call-for-abs...
The deadline is May 18, 2025.
March 26, 2025 at 6:40 PM
Repost if you're planning to go.
Reposted by NiceLab
Congratulations Ying-Han Chen and Kim Zaldana for showing how B cells are altered when lab mice 🐭 are released outdoors! www.science.org/doi/10.1126/...
Here’s some context for the paper followed by how gov’t 💰 + other sources combine to make these types of studies possible 1/n
Here’s some context for the paper followed by how gov’t 💰 + other sources combine to make these types of studies possible 1/n
Rewilding catalyzes maturation of the humoral immune system
Releasing laboratory mice into the natural environment enhanced maturation and activation of the humoral immune system.
www.science.org
March 8, 2025 at 2:40 PM
Congratulations Ying-Han Chen and Kim Zaldana for showing how B cells are altered when lab mice 🐭 are released outdoors! www.science.org/doi/10.1126/...
Here’s some context for the paper followed by how gov’t 💰 + other sources combine to make these types of studies possible 1/n
Here’s some context for the paper followed by how gov’t 💰 + other sources combine to make these types of studies possible 1/n
Reposted by NiceLab
Today, immunologists nationwide are making their voices heard! Our AAI Public Policy Fellows are on Capitol Hill, advocating for critical research funding and policies. Join them by participating in our letter-writing campaign: ow.ly/QLvQ50VaY23.
#PPFPHillDay #SciPol #Advocacy
#PPFPHillDay #SciPol #Advocacy
March 5, 2025 at 1:43 PM
Today, immunologists nationwide are making their voices heard! Our AAI Public Policy Fellows are on Capitol Hill, advocating for critical research funding and policies. Join them by participating in our letter-writing campaign: ow.ly/QLvQ50VaY23.
#PPFPHillDay #SciPol #Advocacy
#PPFPHillDay #SciPol #Advocacy
Reposted by NiceLab
NEW: In every way, shape, form, actions being taken say ‘don’t go into science,’ Donna Ginther told me as NIH forced to cancel programs to train future researchers. More than 1,000 students, including one who emailed 60 PIs, now scrambling to find positions. www.statnews.com/2025/03/05/t...
Cancellation of NIH summer internships disrupts ‘vital’ training program for U.S. scientists
The NIH cancelled an internship program that gave more than 1,000 college students hands-on research training each summer
www.statnews.com
March 5, 2025 at 12:20 PM
NEW: In every way, shape, form, actions being taken say ‘don’t go into science,’ Donna Ginther told me as NIH forced to cancel programs to train future researchers. More than 1,000 students, including one who emailed 60 PIs, now scrambling to find positions. www.statnews.com/2025/03/05/t...
Reposted by NiceLab
@laurenrodda.bsky.social, @nicelab.bsky.social , @jnpruneda.bsky.social and I wrote an OpEd on the impacts of NIH cuts on Oregon: www.bizjournals.com/portland/new...
It was signed by over 450 OHSU researchers!
It’s unfortunately paywalled, DM me if you’d like a gift link or a pdf of it.
It was signed by over 450 OHSU researchers!
It’s unfortunately paywalled, DM me if you’d like a gift link or a pdf of it.
Opinion: Scientists on how NIH cuts will hurt all Oregonians. - Portland Business Journal
"These cuts will cripple biomedical research and drug development in the U.S. We should be investing more in science, not less."
www.bizjournals.com
March 4, 2025 at 9:24 PM
@laurenrodda.bsky.social, @nicelab.bsky.social , @jnpruneda.bsky.social and I wrote an OpEd on the impacts of NIH cuts on Oregon: www.bizjournals.com/portland/new...
It was signed by over 450 OHSU researchers!
It’s unfortunately paywalled, DM me if you’d like a gift link or a pdf of it.
It was signed by over 450 OHSU researchers!
It’s unfortunately paywalled, DM me if you’d like a gift link or a pdf of it.
Reposted by NiceLab
First post on Bluesky! Excited to share the first paper from our lab in 2025! cell.com/cell-host-mi.... Our study demonstrates that UV-inactivated replication-defective rotaviruses can cause diarrhea in neonatal mice, suggesting the host response also contributes to diarrhea to flush out the virus.
Innate immune sensing of rotavirus by intestinal epithelial cells leads to diarrhea
Hou et al. demonstrate in an infant mouse model that innate immune sensing of enteric
viruses induces IFN-λ signaling, which downregulates an apical chloride exchanger
that leads to increased intestin...
cell.com
March 3, 2025 at 5:53 PM
First post on Bluesky! Excited to share the first paper from our lab in 2025! cell.com/cell-host-mi.... Our study demonstrates that UV-inactivated replication-defective rotaviruses can cause diarrhea in neonatal mice, suggesting the host response also contributes to diarrhea to flush out the virus.
Reposted by NiceLab
Today is Rare Disease Day, and a great reminder of the importance of NIH and science funding in driving hope 🧬⬇️
www.rarediseaseday.org
www.rarediseaseday.org
Rare Disease Day 2025 – Raising awareness for people living with rare diseases and their families worldwide.
www.rarediseaseday.org
March 1, 2025 at 3:56 AM
Today is Rare Disease Day, and a great reminder of the importance of NIH and science funding in driving hope 🧬⬇️
www.rarediseaseday.org
www.rarediseaseday.org
Reposted by NiceLab
Mark your calendars Cytokines 2025 Westin Seattle! Abstract submission is opening soon. Make sure to note these important deadlines:
-Abstract Submission deadline: Wednesday 18 June
-Early-Bird Registration Deadline: Friday 25 July
Group room rate $236 seattle.cytokinesociety.org for more details
-Abstract Submission deadline: Wednesday 18 June
-Early-Bird Registration Deadline: Friday 25 July
Group room rate $236 seattle.cytokinesociety.org for more details
January 18, 2025 at 1:47 PM
Mark your calendars Cytokines 2025 Westin Seattle! Abstract submission is opening soon. Make sure to note these important deadlines:
-Abstract Submission deadline: Wednesday 18 June
-Early-Bird Registration Deadline: Friday 25 July
Group room rate $236 seattle.cytokinesociety.org for more details
-Abstract Submission deadline: Wednesday 18 June
-Early-Bird Registration Deadline: Friday 25 July
Group room rate $236 seattle.cytokinesociety.org for more details
Reposted by NiceLab
Reposted by NiceLab
The restriction on Federal Register posts appear to be still in effect. This is blocking the (legal) scheduling of study sections and, soon, advisory council meetings. I have heard that some study section meetings that had been scheduled have been cancelled.
4/n
4/n
a white cat is sitting on a box with the words `` why why '' written above it .
ALT: a white cat is sitting on a box with the words `` why why '' written above it .
media.tenor.com
February 17, 2025 at 10:24 PM
The restriction on Federal Register posts appear to be still in effect. This is blocking the (legal) scheduling of study sections and, soon, advisory council meetings. I have heard that some study section meetings that had been scheduled have been cancelled.
4/n
4/n