NiceLab
@nicelab.bsky.social
We study antiviral immune responses of the intestinal epithelium, especially interferon lambda. We focus on how they are specialized for the gut, interactions with normal microbiota at homeostasis, and how they may go awry during inflammatory diseases.
We propose that TGFb and other barrier cytokines enable production of IFNL that acts on epithelium thereby shaping the IFN type profile of recruited pDC for maximum benefit.
August 30, 2025 at 1:44 AM
We propose that TGFb and other barrier cytokines enable production of IFNL that acts on epithelium thereby shaping the IFN type profile of recruited pDC for maximum benefit.
We found that upon recruitment to the gut pDC ‘open’ their IFNL gene locus and express other marks of TGFbeta response. Remarkably, treatment of a pDC cell line with TGFb amplifies its otherwise meager IFNL production
August 30, 2025 at 1:42 AM
We found that upon recruitment to the gut pDC ‘open’ their IFNL gene locus and express other marks of TGFbeta response. Remarkably, treatment of a pDC cell line with TGFb amplifies its otherwise meager IFNL production
We were surprised to find an abundance of pDC associated with the gut epithelium and even more surprised that some of them were stimulated by microbiota to produce IFNL but not type I IFN
August 30, 2025 at 1:39 AM
We were surprised to find an abundance of pDC associated with the gut epithelium and even more surprised that some of them were stimulated by microbiota to produce IFNL but not type I IFN