Ryan Hernandez
@rdhernand.bsky.social
From busboy/car washer to population geneticist at UCSF, co/Director of the BMI PhD program & UCSF PREP/PROPEL Programs!!!
Reposted by Ryan Hernandez
Putting on my hat as @asn-amnat.bsky.social ASN President for a minute for a string of announcements, please share widely!!!
1. Student research awards are open for applications, to fund research expenses for 10 graduate students ($2000 each)
nam10.safelinks.protection.outlook.com?url=https%3A...
1. Student research awards are open for applications, to fund research expenses for 10 graduate students ($2000 each)
nam10.safelinks.protection.outlook.com?url=https%3A...
Student Research Award
<p>The ASN Student Research Awards support research by student members that advances the goals of the society: the conceptual unification of ecology, evolution, and behavior. Each award consists of a ...
nam10.safelinks.protection.outlook.com
November 25, 2025 at 5:55 PM
Putting on my hat as @asn-amnat.bsky.social ASN President for a minute for a string of announcements, please share widely!!!
1. Student research awards are open for applications, to fund research expenses for 10 graduate students ($2000 each)
nam10.safelinks.protection.outlook.com?url=https%3A...
1. Student research awards are open for applications, to fund research expenses for 10 graduate students ($2000 each)
nam10.safelinks.protection.outlook.com?url=https%3A...
Reposted by Ryan Hernandez
Grateful to share our paper on gene-specific selective sweeps in human gut microbiomes, now out in Nature! It has been a joy to work with @rwolff.bsky.social, whose insights and hard work made this possible.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Gene-specific selective sweeps are pervasive across human gut microbiomes - Nature
Development and application of the integrated linkage disequilibrium score (iLDS) reveals both selective pressures impacting the human gut microbiome and the mechanisms by which gut bacteria adapt to ...
www.nature.com
December 17, 2025 at 6:53 PM
Grateful to share our paper on gene-specific selective sweeps in human gut microbiomes, now out in Nature! It has been a joy to work with @rwolff.bsky.social, whose insights and hard work made this possible.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ryan Hernandez
What a beautiful paper! www.nature.com/articles/s41...
Gene-specific selective sweeps are pervasive across human gut microbiomes - Nature
Development and application of the integrated linkage disequilibrium score (iLDS) reveals both selective pressures impacting the human gut microbiome and the mechanisms by which gut bacteria adapt to ...
www.nature.com
December 17, 2025 at 6:18 PM
What a beautiful paper! www.nature.com/articles/s41...
Reposted by Ryan Hernandez
Our latest preprint revisits the classic model of mutation-selection balance.
Do human recessive genes fit Haldane's 100-year old model?
This work is by the wonderful @jonj-udd.bsky.social, and co-mentored by @jeffspence.github.io
www.biorxiv.org/content/10.6...
Do human recessive genes fit Haldane's 100-year old model?
This work is by the wonderful @jonj-udd.bsky.social, and co-mentored by @jeffspence.github.io
www.biorxiv.org/content/10.6...
Allele Frequencies at Recessive Disease Genes are Mainly Determined by Pleiotropic Effects in Heterozygotes
The classic theory of mutation-selection balance predicts the equilibrium frequency of genetic variation under negative selection. The model predicts a simple relationship between the total frequency ...
www.biorxiv.org
December 13, 2025 at 4:45 PM
Our latest preprint revisits the classic model of mutation-selection balance.
Do human recessive genes fit Haldane's 100-year old model?
This work is by the wonderful @jonj-udd.bsky.social, and co-mentored by @jeffspence.github.io
www.biorxiv.org/content/10.6...
Do human recessive genes fit Haldane's 100-year old model?
This work is by the wonderful @jonj-udd.bsky.social, and co-mentored by @jeffspence.github.io
www.biorxiv.org/content/10.6...
Reposted by Ryan Hernandez
Normalization of glucose in people with prediabetes, i.e. achieving remission, is linked to halving of major cardiovascular adverse events over ensuing decades
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Prediabetes remission and cardiovascular morbidity and mortality: post-hoc analyses from the Diabetes Prevention Program Outcome study and the DaQing Diabetes Prevention Outcome study
Reaching prediatbetes remission is linked to a decades-long benefit, halving the risk
of cardiovascular death or hospitalisation for heart failure in diverse populations.
Targeting remission might rep...
www.thelancet.com
December 13, 2025 at 12:43 AM
Normalization of glucose in people with prediabetes, i.e. achieving remission, is linked to halving of major cardiovascular adverse events over ensuing decades
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Faculty at OHSU, UIowa, UCSF, UW–Madison, and VCU: Your next amazing mentee could be one 10‑minute conversation away. PROPEL Virtual Matchmaking Event is Jan 30: 9–1 PT. Faculty registration deadline extended to 5pm PT on Wed Dec 10: propelscholars.org/matchmaking-...
December 8, 2025 at 10:22 PM
Faculty at OHSU, UIowa, UCSF, UW–Madison, and VCU: Your next amazing mentee could be one 10‑minute conversation away. PROPEL Virtual Matchmaking Event is Jan 30: 9–1 PT. Faculty registration deadline extended to 5pm PT on Wed Dec 10: propelscholars.org/matchmaking-...
Reposted by Ryan Hernandez
"Prebunking works by exposing people to the techniques used to create misleading arguments before they encounter them in the wild."
Finland has emerged as a global leader in countering “fake news”. Here's how they've done it
Teaching when to trust
As fake news accelerates, we need to teach our children how to think critically. Finnish schools are leading the charge
newhumanist.org.uk
December 7, 2025 at 5:56 PM
"Prebunking works by exposing people to the techniques used to create misleading arguments before they encounter them in the wild."
Amazing to be at the #CAGI7 conference. As a data PRODUCER, no less! Fascinating discussions about variants of unknown significance, and how to get rid of them. Sad they are almost always acronymized as VUS, and only once was it VOUS.
December 7, 2025 at 4:46 PM
Amazing to be at the #CAGI7 conference. As a data PRODUCER, no less! Fascinating discussions about variants of unknown significance, and how to get rid of them. Sad they are almost always acronymized as VUS, and only once was it VOUS.
Reposted by Ryan Hernandez
My quote of the day
The probability that we may fail in the struggle ought not to deter us from the support of a cause we believe to be just.
Abraham Lincoln
The probability that we may fail in the struggle ought not to deter us from the support of a cause we believe to be just.
Abraham Lincoln
December 7, 2025 at 10:18 AM
My quote of the day
The probability that we may fail in the struggle ought not to deter us from the support of a cause we believe to be just.
Abraham Lincoln
The probability that we may fail in the struggle ought not to deter us from the support of a cause we believe to be just.
Abraham Lincoln
Reposted by Ryan Hernandez
A study on 1.7 million people in Hong Kong shows superior hybrid immunity to Covid in people who got vaccinated before infection vs. people who got infected first. "Our findings are a direct rebuttal to arguments for natural immunity," the authors write. doi.org/10.1016/j.va...
Redirecting
doi.org
December 6, 2025 at 5:02 PM
A study on 1.7 million people in Hong Kong shows superior hybrid immunity to Covid in people who got vaccinated before infection vs. people who got infected first. "Our findings are a direct rebuttal to arguments for natural immunity," the authors write. doi.org/10.1016/j.va...
Reposted by Ryan Hernandez
Did you publish with researchers outside your lab during grad school? Or published as faculty with a student not under your supervision?
I’m collecting examples of cross-lab collaboration in graduate training.
Please share your experience & this post!
Repository: bit.ly/4pT66BE
I’m collecting examples of cross-lab collaboration in graduate training.
Please share your experience & this post!
Repository: bit.ly/4pT66BE
December 6, 2025 at 8:05 PM
Did you publish with researchers outside your lab during grad school? Or published as faculty with a student not under your supervision?
I’m collecting examples of cross-lab collaboration in graduate training.
Please share your experience & this post!
Repository: bit.ly/4pT66BE
I’m collecting examples of cross-lab collaboration in graduate training.
Please share your experience & this post!
Repository: bit.ly/4pT66BE
Reposted by Ryan Hernandez
The era of coding agents is here. How do we approach this as scientists?
Wednesday Dec 10th at 9am PT I'll livestream an interactive demo of what I have learned (matsen.group/agentic.html) about how to leverage agentic coding to do rigorous science.
www.youtube.com/watch?v=Rbhs...
Wednesday Dec 10th at 9am PT I'll livestream an interactive demo of what I have learned (matsen.group/agentic.html) about how to leverage agentic coding to do rigorous science.
www.youtube.com/watch?v=Rbhs...
Agentic Coding for Scientists (Dec 2025 edition)
YouTube video by Erick Matsen
www.youtube.com
December 2, 2025 at 6:57 PM
The era of coding agents is here. How do we approach this as scientists?
Wednesday Dec 10th at 9am PT I'll livestream an interactive demo of what I have learned (matsen.group/agentic.html) about how to leverage agentic coding to do rigorous science.
www.youtube.com/watch?v=Rbhs...
Wednesday Dec 10th at 9am PT I'll livestream an interactive demo of what I have learned (matsen.group/agentic.html) about how to leverage agentic coding to do rigorous science.
www.youtube.com/watch?v=Rbhs...
"I love Slate! Everything is so intuitive and seamless!!"
- No grad program director or program manager I've ever met...
For those who attempted to submit your apps to PhD programs and have gotten strange errors, my apologies for the added stress... Folks are working hard to resolve issues!! 🤞🏽
- No grad program director or program manager I've ever met...
For those who attempted to submit your apps to PhD programs and have gotten strange errors, my apologies for the added stress... Folks are working hard to resolve issues!! 🤞🏽
December 2, 2025 at 8:38 PM
"I love Slate! Everything is so intuitive and seamless!!"
- No grad program director or program manager I've ever met...
For those who attempted to submit your apps to PhD programs and have gotten strange errors, my apologies for the added stress... Folks are working hard to resolve issues!! 🤞🏽
- No grad program director or program manager I've ever met...
For those who attempted to submit your apps to PhD programs and have gotten strange errors, my apologies for the added stress... Folks are working hard to resolve issues!! 🤞🏽
Reposted by Ryan Hernandez
I have a new preprint demonstrating a genome-architecture-aware approach to inferring species trees and introgression landscapes from a small number of genomes. If you are interested in phylogenomics, birds, or hybridization, this is for you! www.biorxiv.org/content/10.1...
December 1, 2025 at 7:35 PM
I have a new preprint demonstrating a genome-architecture-aware approach to inferring species trees and introgression landscapes from a small number of genomes. If you are interested in phylogenomics, birds, or hybridization, this is for you! www.biorxiv.org/content/10.1...
Reposted by Ryan Hernandez
It's the home stretch teaching undergrad Evolutionary Genetics with @aneil-agrawal.bsky.social using my Primer of Mol Pop Gen text! Grateful it's free for all 67 of our students courtesy @uoftlibraries.bsky.social LMK if you use it and suggestions for improvements! global.oup.com/academic/pro...
November 25, 2025 at 7:45 PM
It's the home stretch teaching undergrad Evolutionary Genetics with @aneil-agrawal.bsky.social using my Primer of Mol Pop Gen text! Grateful it's free for all 67 of our students courtesy @uoftlibraries.bsky.social LMK if you use it and suggestions for improvements! global.oup.com/academic/pro...
Reposted by Ryan Hernandez
Reminder to everyone - mental health issues and depression generally do not just magically go away - it is important to be vigilant if you or ones you love have or are going through such issues www.espn.com/nfl/story/_/...
Records: WMU police called twice to aid Kneeland
Western Michigan University police were twice called to perform welfare checks on former Cowboys defensive end Marshawn Kneeland while he played for the school.
www.espn.com
November 22, 2025 at 2:30 AM
Reminder to everyone - mental health issues and depression generally do not just magically go away - it is important to be vigilant if you or ones you love have or are going through such issues www.espn.com/nfl/story/_/...
Reposted by Ryan Hernandez
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
The missing heritability question is now (mostly) answered
Not with a bang but with a whimper
theinfinitesimal.substack.com
November 21, 2025 at 10:34 PM
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
Reposted by Ryan Hernandez
PROPEL builds community in science! Hear directly from our scholars at our 5th annual PROPEL Symposium!
November 20, 2025 at 10:23 PM
PROPEL builds community in science! Hear directly from our scholars at our 5th annual PROPEL Symposium!
Reposted by Ryan Hernandez
For the first time in my career, I can’t tell people to trust what the CDC website says. And that is an incredibly sad and devastating place for this country to be.
CDC has overhauled its website to assert that “the claim ‘vaccines do not cause autism’ is not an evidence-based claim”
November 20, 2025 at 4:22 AM
For the first time in my career, I can’t tell people to trust what the CDC website says. And that is an incredibly sad and devastating place for this country to be.
Reposted by Ryan Hernandez
I wrote about the recent autism-microbiome paper, why I think it's the most important microbiome paper this year, and what it says about the field
open.substack.com/pub/blekhman...
open.substack.com/pub/blekhman...
The Autism-Microbiome Hypothesis Is Falling Apart
Why this new review paper should be required reading for every microbiome researcher
open.substack.com
November 19, 2025 at 5:12 PM
I wrote about the recent autism-microbiome paper, why I think it's the most important microbiome paper this year, and what it says about the field
open.substack.com/pub/blekhman...
open.substack.com/pub/blekhman...
Reposted by Ryan Hernandez
The 2026 EMBL symposium 'Reconstructing the human past using ancient and modern genomics' is live with a fantastic invited speaker lineup!
Abstract deadline 9 June. If work is ongoing, plan for Heidelberg in September😉.
Organised by Maanasa Raghavan, @matejahajdi.bsky.social, Choongwon Jeong & me.
Abstract deadline 9 June. If work is ongoing, plan for Heidelberg in September😉.
Organised by Maanasa Raghavan, @matejahajdi.bsky.social, Choongwon Jeong & me.
November 19, 2025 at 1:41 PM
The 2026 EMBL symposium 'Reconstructing the human past using ancient and modern genomics' is live with a fantastic invited speaker lineup!
Abstract deadline 9 June. If work is ongoing, plan for Heidelberg in September😉.
Organised by Maanasa Raghavan, @matejahajdi.bsky.social, Choongwon Jeong & me.
Abstract deadline 9 June. If work is ongoing, plan for Heidelberg in September😉.
Organised by Maanasa Raghavan, @matejahajdi.bsky.social, Choongwon Jeong & me.
Reposted by Ryan Hernandez
WE JUST KEEP WINNING. (UC President's Postdoctoral Fellowship Program RESTORED!!!!)
![On official UC letterhead:
UNIVERSITY
OF
CALIFORNIA
James B. Milliken President
Office of the President
1111 Franklin Street Oakland, CA 94607
universityofcalifornia.edu
CAMPUSES Berkeley
Davis
Irvine
UCLA
Merced
Riverside San Diego San Francisco
Santa Barbara Santa Cruz
MEDICAL CENTERS
Davis
Irvine
UCLA
San Diego
San Francisco
NATIONAL LABORATORIES Lawrence Berkeley Lawrence Livermore Los Alamos
DIVISION OF AGRICULTURE AND NATURAL RESOURCES
November 18, 2025
Dear Chancellors:
I'm writing with regard to the President's Postdoctoral Fellowship Program (PPFP) and the program's associated faculty hiring incentive.
As you know, for more than 40 years, PPFP has provided postdoctoral research fellowships, professional development, and faculty mentoring to scholars in all fields whose research, teaching, and service advance the academic and research missions of the University of California.
Since 2003, UC campuses that hire current and former PPFP fellows into ladder-rank positions have been eligible for a hiring incentive funded by the University that provides support for newly hired fellows for five years. Since the creation of the incentive, more than $162 million has been invested by the University to support PPFP faculty hires. This commitment has enabled our campuses to successfully recruit and retain outstanding faculty across a range of disciplines.
Given the myriad challenges currently facing UC - including disruptions to billions of dollars in annual federal support, as well as uncertainty around the state budget- reasonable questions were raised in recent months about whether the University could maintain the commitment to current levels of incentive funding. After considering a recommendation to sunset the incentive program due to these significant fiscal constraints, I consulted with all of you as well as faculty and campus academic administrators and systemwide Academic Senate leadership.
[continued on next image]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:rzn6yramffebefeitqifiqqz/bafkreigiwq5ongzwpj4wqmgjam3yfvhyjnv5e3dbq6cnrrbwblqvs624gq@jpeg)
November 18, 2025 at 10:34 PM
WE JUST KEEP WINNING. (UC President's Postdoctoral Fellowship Program RESTORED!!!!)
Reposted by Ryan Hernandez
I'm a longtime fan of Affinity Designer as an affordable Illustrator-killer for figures, and... it's now free?! www.canva.com/newsroom/new...
Highly recommended if you're sick of paying Adobe $. Maybe Canva can buy NPG too and get rid of the OA fees.
Highly recommended if you're sick of paying Adobe $. Maybe Canva can buy NPG too and get rid of the OA fees.
Why we made Affinity free, and how we’ll keep it that way
We’ve made Affinity completely free, empowering professional designers with studio-grade creative software, supported by Canva’s sustainable ecosystem.
www.canva.com
November 18, 2025 at 11:28 PM
I'm a longtime fan of Affinity Designer as an affordable Illustrator-killer for figures, and... it's now free?! www.canva.com/newsroom/new...
Highly recommended if you're sick of paying Adobe $. Maybe Canva can buy NPG too and get rid of the OA fees.
Highly recommended if you're sick of paying Adobe $. Maybe Canva can buy NPG too and get rid of the OA fees.
Reposted by Ryan Hernandez
Judge bars Trump from fining University of California over discrimination : NPR share.google/ZrIFMLciT7ct...
Judge indefinitely bars Trump from fining UC over alleged discrimination
The Trump administration demanded UCLA pay $1.2 billion to restore frozen research funding and ensure eligibility for future funding after accusing the school of allowing antisemitism on campus.
share.google
November 16, 2025 at 5:57 AM
Judge bars Trump from fining University of California over discrimination : NPR share.google/ZrIFMLciT7ct...
Reposted by Ryan Hernandez
