Mike Schumacher
@schumacherama.bsky.social
Gut physiologist studying epithelial-immune dysfunction in the gastrointestinal tract 🧪 gutsciencelab.com
🔬 #organoids #macrophages #stemcells #ibd
🔬 #organoids #macrophages #stemcells #ibd
Giggling her way into 3 months old
July 24, 2025 at 6:58 PM
Giggling her way into 3 months old
Immune cell stratification in the inflamed intestinal epithelium
#immunofluorescence #microscopy #ibd
#immunofluorescence #microscopy #ibd
July 23, 2025 at 6:01 PM
Immune cell stratification in the inflamed intestinal epithelium
#immunofluorescence #microscopy #ibd
#immunofluorescence #microscopy #ibd
Household mischief level about to double, welcome home baby two 🙃
April 21, 2025 at 6:01 PM
Household mischief level about to double, welcome home baby two 🙃
January 2, 2025 at 5:32 PM
Z-stacking thru a goblet cell stained enteroid #immunofluorescence #microscopy
December 10, 2024 at 10:07 PM
Z-stacking thru a goblet cell stained enteroid #immunofluorescence #microscopy
Our previous work suggested that epithelial Il33 is driven by beta-catenin activation, so we tested that in organoids and in vivo
And found Wnt-induced beta-catenin activation drastically elevated Il33 levels /4
And found Wnt-induced beta-catenin activation drastically elevated Il33 levels /4
December 1, 2024 at 11:12 PM
Our previous work suggested that epithelial Il33 is driven by beta-catenin activation, so we tested that in organoids and in vivo
And found Wnt-induced beta-catenin activation drastically elevated Il33 levels /4
And found Wnt-induced beta-catenin activation drastically elevated Il33 levels /4
By complementary transcriptomic analyses with scRNAseq and in situ, we were surprised to find Il33 is highly localized to the proliferative stem and progenitor cell niche in the colon /3
December 1, 2024 at 11:12 PM
By complementary transcriptomic analyses with scRNAseq and in situ, we were surprised to find Il33 is highly localized to the proliferative stem and progenitor cell niche in the colon /3
We know everything about IL-33 already, right?
No! In fact we know very little about IL-33 in the colonic epithelium
Our recent paper finds IL-33 is highly enriched in colonic stem cells suggesting an immunoregulatory role for this niche in injury🧵
www.mucosalimmunology.org/article/S193...
No! In fact we know very little about IL-33 in the colonic epithelium
Our recent paper finds IL-33 is highly enriched in colonic stem cells suggesting an immunoregulatory role for this niche in injury🧵
www.mucosalimmunology.org/article/S193...
December 1, 2024 at 11:12 PM
We know everything about IL-33 already, right?
No! In fact we know very little about IL-33 in the colonic epithelium
Our recent paper finds IL-33 is highly enriched in colonic stem cells suggesting an immunoregulatory role for this niche in injury🧵
www.mucosalimmunology.org/article/S193...
No! In fact we know very little about IL-33 in the colonic epithelium
Our recent paper finds IL-33 is highly enriched in colonic stem cells suggesting an immunoregulatory role for this niche in injury🧵
www.mucosalimmunology.org/article/S193...
November 27, 2024 at 8:14 PM
A mucus-enriched colonic organoid
November 23, 2024 at 7:10 PM
A mucus-enriched colonic organoid
Excited to dive into #SciSky! Celebrating with a celestial field of intestinal organoids 🎉 #microscopy
November 19, 2024 at 9:37 PM
Excited to dive into #SciSky! Celebrating with a celestial field of intestinal organoids 🎉 #microscopy