I’m happy to share our new preprint on stem cell regeneration in the human colon! Using new CRISPR knockins in organoids, we show that after stem cell loss, non-stem cells rapidly regenerate them. This process is normally inhibited by the stem cells themselves. Manuscript link: tinyurl.com/3ky4ccxf

🔊 Paper alert
1/ Tuft cells are perhaps the coolest cells in our gut orchestrating host defense, but how do they manage? @julian-buissant.bsky.social provides new insights into tuft cell differentiation, and the development of accurate in vitro models for experimental cell biology 🧫🔬🧬
rdcu.be/exou9

Big thanks to all our co-authors and in particular @jorihag.bsky.social for conceiving and spearheading this cool project 👏👏 🙌 💪

📢 New preprint 🔥
1/ Stem cell regeneration is often viewed as an actively induced process, triggered by damage. But what if plasticity is actively suppressed by the stem cells themselves? We explored plasticity with 'new' cell type ablation tech in normal human colon organoids
tinyurl.com/3ky4ccxf

Our #Cancer #Evolution summer school runs again 30 June-3 July at the beautiful Genome Campus in Hinxton, UK sponsored by @wellcometrust.bsky.social

Ideal for starters in the field; this year's focus is on using genomic data for cancer evo research.

Brilliant & inspiring faculty! bit.ly/40nLdDD

📢 Organoid enthusiast: We are preparing for the 3rd edition of OrganoidNL - April 11th!
🔥 Check amazing line up of speakers 🔥
Calvin Kuo @priscaliberali.bsky.social Nicolas Rivron, Ina Sonnen @kaikretzschmar.bsky.social Mina Gouti, and others. Be fast to register in time
amolf.nl/organoidnl-s...

Massive congrats to Shania, Svetlana & Noha (not on Bsky) identifying the mechanistic and phenotype cascades underpinning the anti-metastatic response triggered by viral mimicry

TLDR; aggressive CMS4 tumours can be reprogrammed towards less aggressive CMS1

biorxiv.org/content/10.1...

thread 👇

Very happy that our tuft cell story is now on BioRxiv! If you want to know how to induce mature tuft cell phenotypes in organoids check out the preprint

📢📢📢

New work on #tuft cells, rare guardians of our #gut against invaders. How they work is not known. We show that intestinal tuft types 1&2 are sequentially expressed phenotypes during differentiation. And…we can now generate mature immune-related tuft-2’s in #organoids for more 🔬🧫🧬🔥
shorturl.at/EImjA

New work on #tuft cells, rare guardians of our #gut against invaders. How they work is not known. We show that intestinal tuft types 1&2 are sequentially expressed phenotypes during differentiation. And…we can now generate mature immune-related tuft-2’s in #organoids for more 🔬🧫🧬🔥
shorturl.at/EImjA

We are looking for a motivated Postdoctoral Researcher to work on cutting-edge computational genomics projects in our lab!
werkenbijprinsesmaximacentrum.nl/vacature/pos...

Hey all, we are pretty new here
Our team likes to be creative with #organoids to solve science questions that excite us.
We mostly focus on early-stage colorectal #cancer using #patient #samples.
We'll post new work soon 🔥. First an adventurous detour 😊 on #tuft cell differentiation, stay tuned…