Pankaj Kapahi
@pkapahi.bsky.social
Professor at Buck Institute & UCSF. Interests- Aging, glycation, TOR, CR, circadian clocks, menopause & antagonistic pleiotropy.
Reposted by Pankaj Kapahi
It's clear that most people don't read to learn, to enjoy.
They read to sound smart, appear clever, and tell others they've read so and so "classic" writers.
They lose twice: They don't enjoy something enjoyable. And it debases their hearts and closes their minds.
They read to sound smart, appear clever, and tell others they've read so and so "classic" writers.
They lose twice: They don't enjoy something enjoyable. And it debases their hearts and closes their minds.
December 29, 2025 at 9:15 AM
It's clear that most people don't read to learn, to enjoy.
They read to sound smart, appear clever, and tell others they've read so and so "classic" writers.
They lose twice: They don't enjoy something enjoyable. And it debases their hearts and closes their minds.
They read to sound smart, appear clever, and tell others they've read so and so "classic" writers.
They lose twice: They don't enjoy something enjoyable. And it debases their hearts and closes their minds.
Reposted by Pankaj Kapahi
Multidisciplinary training, over time, produces the highest impact people
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Recent discoveries on the acquisition of the highest levels of human performance
Scientists have long debated the origins of exceptional human achievements. This literature review summarizes recent evidence from multiple domains on the acquisition of world-class performance. We re...
www.science.org
December 20, 2025 at 11:49 PM
Multidisciplinary training, over time, produces the highest impact people
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Pankaj Kapahi
A study in Nature finds that five groups of disorders share most of their genetic risk in a screen of 14 psychiatric conditions, including depression, anxiety, and schizophrenia. The findings could help to improve diagnoses and lead to new treatments that work across several conditions. 🧬 🧪
Mapping the genetic landscape across 14 psychiatric disorders - Nature
Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.
go.nature.com
December 21, 2025 at 2:38 AM
A study in Nature finds that five groups of disorders share most of their genetic risk in a screen of 14 psychiatric conditions, including depression, anxiety, and schizophrenia. The findings could help to improve diagnoses and lead to new treatments that work across several conditions. 🧬 🧪
Reposted by Pankaj Kapahi
Top #Altmetric 2025: 7️⃣🧪
@pkapahi.bsky.social et al ( @buckinstitute.org ) show that neuronal glycogen feeds the PPP and contributes to redox homeostasis, thus counteracting tauopathy-associated oxidative stress in Drosophila melanogaster.
@pkapahi.bsky.social et al ( @buckinstitute.org ) show that neuronal glycogen feeds the PPP and contributes to redox homeostasis, thus counteracting tauopathy-associated oxidative stress in Drosophila melanogaster.
Neuronal glycogen breakdown mitigates tauopathy via pentose-phosphate-pathway-mediated oxidative stress reduction - Nature Metabolism
Bar et al. show that neuronal glycogen feeds the pentose phosphate pathway and contributes to redox homeostasis, thus counteracting tauopathy-associated oxidative stress in Drosophila melanogaster.
bit.ly
December 11, 2025 at 6:31 PM
Top #Altmetric 2025: 7️⃣🧪
@pkapahi.bsky.social et al ( @buckinstitute.org ) show that neuronal glycogen feeds the PPP and contributes to redox homeostasis, thus counteracting tauopathy-associated oxidative stress in Drosophila melanogaster.
@pkapahi.bsky.social et al ( @buckinstitute.org ) show that neuronal glycogen feeds the PPP and contributes to redox homeostasis, thus counteracting tauopathy-associated oxidative stress in Drosophila melanogaster.
Reposted by Pankaj Kapahi
🚀 Postdoc opportunity!
The Kapahi Lab at Buck Institute for Research on Aging is hiring two postdoctoral researchers to lead cutting-edge studies on how nutrient signaling and circadian rhythms influence neurodegeneration & aging — combining fly, worm, and mammalian models with genomics. 📈
👉
The Kapahi Lab at Buck Institute for Research on Aging is hiring two postdoctoral researchers to lead cutting-edge studies on how nutrient signaling and circadian rhythms influence neurodegeneration & aging — combining fly, worm, and mammalian models with genomics. 📈
👉
Postdoctoral Researcher positions-Kapahi lab - Buck Institute - Career Page
The Kapahi lab seeks postdocs to lead innovative projects exploring how circadian clocks & nutrient-responsive pathways influence eye & neuronal degeneration.
buckinstitute.applytojob.com
November 30, 2025 at 2:09 AM
🚀 Postdoc opportunity!
The Kapahi Lab at Buck Institute for Research on Aging is hiring two postdoctoral researchers to lead cutting-edge studies on how nutrient signaling and circadian rhythms influence neurodegeneration & aging — combining fly, worm, and mammalian models with genomics. 📈
👉
The Kapahi Lab at Buck Institute for Research on Aging is hiring two postdoctoral researchers to lead cutting-edge studies on how nutrient signaling and circadian rhythms influence neurodegeneration & aging — combining fly, worm, and mammalian models with genomics. 📈
👉
The Kapahi Lab is looking for two creative, motivated postdocs to join our team.
We use Drosophila as a powerful discovery engine to study neurodegeneration and aging -combine it with human genetics, and mammalian models to uncover fundamental mechanisms of aging.
pkapahi@buckinstitute.org
We use Drosophila as a powerful discovery engine to study neurodegeneration and aging -combine it with human genetics, and mammalian models to uncover fundamental mechanisms of aging.
pkapahi@buckinstitute.org
November 28, 2025 at 7:24 PM
The Kapahi Lab is looking for two creative, motivated postdocs to join our team.
We use Drosophila as a powerful discovery engine to study neurodegeneration and aging -combine it with human genetics, and mammalian models to uncover fundamental mechanisms of aging.
pkapahi@buckinstitute.org
We use Drosophila as a powerful discovery engine to study neurodegeneration and aging -combine it with human genetics, and mammalian models to uncover fundamental mechanisms of aging.
pkapahi@buckinstitute.org
Reposted by Pankaj Kapahi
#Throwback 🧪
REVIEW | The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research
S Deota, S Panda et al.
REVIEW | The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research
S Deota, S Panda et al.
The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research - Nature Metabolism
This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental factors affecting circadian rhythms in metabolic studies in rodents.
bit.ly
November 26, 2025 at 7:01 PM
#Throwback 🧪
REVIEW | The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research
S Deota, S Panda et al.
REVIEW | The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research
S Deota, S Panda et al.
Reposted by Pankaj Kapahi
Thrilled to share our new paper!
With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste.
Link @nature.com: www.nature.com/articles/s41...
With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste.
Link @nature.com: www.nature.com/articles/s41...
Evolution of taste processing shifts dietary preference - Nature
Calcium imaging of taste neurons and the ventral brain provides insight into evolutionary divergence of food choice in Drosophila species, supporting a role of sensorimotor processing in addition to p...
www.nature.com
November 26, 2025 at 4:33 PM
Thrilled to share our new paper!
With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste.
Link @nature.com: www.nature.com/articles/s41...
With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste.
Link @nature.com: www.nature.com/articles/s41...
Reposted by Pankaj Kapahi
#Throwback 🧪
REVIEW | Cellular and organismal function of choline metabolism
M Abu-Remaileh, K Birsoy et al.
REVIEW | Cellular and organismal function of choline metabolism
M Abu-Remaileh, K Birsoy et al.
Cellular and organismal function of choline metabolism - Nature Metabolism
Kenny and Scharenberg et al. provide a broad overview of the fundamental aspects of choline metabolism and cellular handling, and how it impacts physiology and pathology.
bit.ly
November 23, 2025 at 7:01 PM
#Throwback 🧪
REVIEW | Cellular and organismal function of choline metabolism
M Abu-Remaileh, K Birsoy et al.
REVIEW | Cellular and organismal function of choline metabolism
M Abu-Remaileh, K Birsoy et al.
Reposted by Pankaj Kapahi
Deadline closing soon!
Apply for AGE’s Early Career Scholar’s Program — designed to support underrepresented minorities in aging research.
📅 Deadline: Dec 10, 2025
🔗 age.memberclicks.net
#AgingResearch #DiversityInScience #Geroscience #AGE2025 #CareerInScience
Apply for AGE’s Early Career Scholar’s Program — designed to support underrepresented minorities in aging research.
📅 Deadline: Dec 10, 2025
🔗 age.memberclicks.net
#AgingResearch #DiversityInScience #Geroscience #AGE2025 #CareerInScience
November 23, 2025 at 5:47 AM
Deadline closing soon!
Apply for AGE’s Early Career Scholar’s Program — designed to support underrepresented minorities in aging research.
📅 Deadline: Dec 10, 2025
🔗 age.memberclicks.net
#AgingResearch #DiversityInScience #Geroscience #AGE2025 #CareerInScience
Apply for AGE’s Early Career Scholar’s Program — designed to support underrepresented minorities in aging research.
📅 Deadline: Dec 10, 2025
🔗 age.memberclicks.net
#AgingResearch #DiversityInScience #Geroscience #AGE2025 #CareerInScience
Reposted by Pankaj Kapahi
Women derive more benefit from physical activity than men with respect to reduction of cardiovascular risk and related mortality, and can achieve protection at lower levels of engagement. From ~85,000 participants, open-access (blue=men)
nature.com/articles/s44...
nature.com/articles/s44...
October 27, 2025 at 4:42 PM
Women derive more benefit from physical activity than men with respect to reduction of cardiovascular risk and related mortality, and can achieve protection at lower levels of engagement. From ~85,000 participants, open-access (blue=men)
nature.com/articles/s44...
nature.com/articles/s44...
Reposted by Pankaj Kapahi
The war zone in Portland is out of control.
October 18, 2025 at 1:09 AM
The war zone in Portland is out of control.
Reposted by Pankaj Kapahi
Can a cocktail of glycation-lowering compounds curb #hunger, lower #insulin resistance and extend #lifespan? It does in mice! Buck scientists fight the sugary chemistry of #aging. www.buckinstitute.org/news/glycati... @cp-cellreports.bsky.social, @pkapahi.bsky.social
Glycation-lowering compounds curb hunger, lower insulin resistance and extend lifespan in mice
Buck scientists fight the sugary chemistry of aging The same chemical reaction that makes a piece of freshly toasted bread delicious also happens in our bodies, with far less appetizing consequences. ...
www.buckinstitute.org
October 14, 2025 at 6:51 PM
Can a cocktail of glycation-lowering compounds curb #hunger, lower #insulin resistance and extend #lifespan? It does in mice! Buck scientists fight the sugary chemistry of #aging. www.buckinstitute.org/news/glycati... @cp-cellreports.bsky.social, @pkapahi.bsky.social
Had a wonderful time at the Barshop aging Meeting at Banderas!
October 12, 2025 at 2:06 AM
Had a wonderful time at the Barshop aging Meeting at Banderas!
Reposted by Pankaj Kapahi
The Ig Nobel is incredible , one year an Indian guy won it for calculating the average surface area of an elephant and during his acceptance they had an elephant hold up a sign with the surface area of the scientist on it, they do showbiz better than the Oscars
Video: a Japanese scientist was attacked by flies while giving the acceptance speech for his Ig Nobel Prize-winning research paper that proved painting Zebra-like stripes on cows led to a decrease in biting fly attacks.
October 4, 2025 at 2:11 PM
The Ig Nobel is incredible , one year an Indian guy won it for calculating the average surface area of an elephant and during his acceptance they had an elephant hold up a sign with the surface area of the scientist on it, they do showbiz better than the Oscars
Reposted by Pankaj Kapahi
Dr. Jane Goodall filmed an interview with Netflix in March 2025 that she understood would only be released after her death.
October 5, 2025 at 9:08 AM
Dr. Jane Goodall filmed an interview with Netflix in March 2025 that she understood would only be released after her death.
“How we spend our days is, of course, how we spend our lives.” Annie Dillard
October 2, 2025 at 1:12 PM
“How we spend our days is, of course, how we spend our lives.” Annie Dillard
Reposted by Pankaj Kapahi
Sad news: Jane Goodall has died. She did more than any other human for our understanding and appreciation of our closest relatives, the chimpanzees.
That chimpanzees are Endangered tells you everything about our species and about what made her so exceptional.
www.nytimes.com/2025/10/01/o...
That chimpanzees are Endangered tells you everything about our species and about what made her so exceptional.
www.nytimes.com/2025/10/01/o...
Jane Goodall, Eminent Primatologist Who Chronicled the Lives of Chimps, Dies at 91
www.nytimes.com
October 1, 2025 at 7:52 PM
Sad news: Jane Goodall has died. She did more than any other human for our understanding and appreciation of our closest relatives, the chimpanzees.
That chimpanzees are Endangered tells you everything about our species and about what made her so exceptional.
www.nytimes.com/2025/10/01/o...
That chimpanzees are Endangered tells you everything about our species and about what made her so exceptional.
www.nytimes.com/2025/10/01/o...
Reposted by Pankaj Kapahi
Wise cartoon posted outside a @princetonneuro.bsky.social PhD student office. Let’s all remember to enjoy the journey today (and all days).
October 1, 2025 at 11:07 AM
Wise cartoon posted outside a @princetonneuro.bsky.social PhD student office. Let’s all remember to enjoy the journey today (and all days).
Reposted by Pankaj Kapahi
Congratulations to Rachel Buckley @bucklr01.bsky.social on being a finalist for a National Association of Science Writers @sciencewriters.org award. Read Rachel's essay,
www.thetransmitter.org/sex-differen...
#neuroskyence
www.thetransmitter.org/sex-differen...
#neuroskyence
Brains, biases and amyloid beta: Why the female brain deserves a closer look in Alzheimer’s research
New results suggest the disease progresses differently in women, but we need more basic science to unpack the mechanisms involved.
www.thetransmitter.org
September 30, 2025 at 9:36 PM
Congratulations to Rachel Buckley @bucklr01.bsky.social on being a finalist for a National Association of Science Writers @sciencewriters.org award. Read Rachel's essay,
www.thetransmitter.org/sex-differen...
#neuroskyence
www.thetransmitter.org/sex-differen...
#neuroskyence
Reposted by Pankaj Kapahi
thank you to all the NIH staff who stand by their duty and put in heroic efforts to get it done. I'll never forget it and will be eternally grateful.
The fiscal year ends tomorrow.
Here are results from NIH Reporter downloaded an hour ago.
The total amount of funding committed for FY2025 at this point is 99.0% of that for FY2024. The same difference could be due to a variety of technical factors.
1/3
Here are results from NIH Reporter downloaded an hour ago.
The total amount of funding committed for FY2025 at this point is 99.0% of that for FY2024. The same difference could be due to a variety of technical factors.
1/3
September 29, 2025 at 6:31 PM
thank you to all the NIH staff who stand by their duty and put in heroic efforts to get it done. I'll never forget it and will be eternally grateful.