Pankaj Kapahi
@pkapahi.bsky.social
Professor at Buck Institute & UCSF. Interests- Aging, glycation, TOR, CR, circadian clocks, menopause & antagonistic pleiotropy.
Reposted by Pankaj Kapahi
#Throwback 🧪
REVIEW | Cellular and organismal function of choline metabolism
M Abu-Remaileh, K Birsoy et al.
REVIEW | Cellular and organismal function of choline metabolism
M Abu-Remaileh, K Birsoy et al.
Cellular and organismal function of choline metabolism - Nature Metabolism
Kenny and Scharenberg et al. provide a broad overview of the fundamental aspects of choline metabolism and cellular handling, and how it impacts physiology and pathology.
bit.ly
November 23, 2025 at 7:01 PM
#Throwback 🧪
REVIEW | Cellular and organismal function of choline metabolism
M Abu-Remaileh, K Birsoy et al.
REVIEW | Cellular and organismal function of choline metabolism
M Abu-Remaileh, K Birsoy et al.
Reposted by Pankaj Kapahi
Deadline closing soon!
Apply for AGE’s Early Career Scholar’s Program — designed to support underrepresented minorities in aging research.
📅 Deadline: Dec 10, 2025
🔗 age.memberclicks.net
#AgingResearch #DiversityInScience #Geroscience #AGE2025 #CareerInScience
Apply for AGE’s Early Career Scholar’s Program — designed to support underrepresented minorities in aging research.
📅 Deadline: Dec 10, 2025
🔗 age.memberclicks.net
#AgingResearch #DiversityInScience #Geroscience #AGE2025 #CareerInScience
November 23, 2025 at 5:47 AM
Deadline closing soon!
Apply for AGE’s Early Career Scholar’s Program — designed to support underrepresented minorities in aging research.
📅 Deadline: Dec 10, 2025
🔗 age.memberclicks.net
#AgingResearch #DiversityInScience #Geroscience #AGE2025 #CareerInScience
Apply for AGE’s Early Career Scholar’s Program — designed to support underrepresented minorities in aging research.
📅 Deadline: Dec 10, 2025
🔗 age.memberclicks.net
#AgingResearch #DiversityInScience #Geroscience #AGE2025 #CareerInScience
Reposted by Pankaj Kapahi
Women derive more benefit from physical activity than men with respect to reduction of cardiovascular risk and related mortality, and can achieve protection at lower levels of engagement. From ~85,000 participants, open-access (blue=men)
nature.com/articles/s44...
nature.com/articles/s44...
October 27, 2025 at 4:42 PM
Women derive more benefit from physical activity than men with respect to reduction of cardiovascular risk and related mortality, and can achieve protection at lower levels of engagement. From ~85,000 participants, open-access (blue=men)
nature.com/articles/s44...
nature.com/articles/s44...
Reposted by Pankaj Kapahi
The war zone in Portland is out of control.
October 18, 2025 at 1:09 AM
The war zone in Portland is out of control.
Reposted by Pankaj Kapahi
Can a cocktail of glycation-lowering compounds curb #hunger, lower #insulin resistance and extend #lifespan? It does in mice! Buck scientists fight the sugary chemistry of #aging. www.buckinstitute.org/news/glycati... @cp-cellreports.bsky.social, @pkapahi.bsky.social
Glycation-lowering compounds curb hunger, lower insulin resistance and extend lifespan in mice
Buck scientists fight the sugary chemistry of aging The same chemical reaction that makes a piece of freshly toasted bread delicious also happens in our bodies, with far less appetizing consequences. ...
www.buckinstitute.org
October 14, 2025 at 6:51 PM
Can a cocktail of glycation-lowering compounds curb #hunger, lower #insulin resistance and extend #lifespan? It does in mice! Buck scientists fight the sugary chemistry of #aging. www.buckinstitute.org/news/glycati... @cp-cellreports.bsky.social, @pkapahi.bsky.social
Had a wonderful time at the Barshop aging Meeting at Banderas!
October 12, 2025 at 2:06 AM
Had a wonderful time at the Barshop aging Meeting at Banderas!
Reposted by Pankaj Kapahi
The Ig Nobel is incredible , one year an Indian guy won it for calculating the average surface area of an elephant and during his acceptance they had an elephant hold up a sign with the surface area of the scientist on it, they do showbiz better than the Oscars
Video: a Japanese scientist was attacked by flies while giving the acceptance speech for his Ig Nobel Prize-winning research paper that proved painting Zebra-like stripes on cows led to a decrease in biting fly attacks.
October 4, 2025 at 2:11 PM
The Ig Nobel is incredible , one year an Indian guy won it for calculating the average surface area of an elephant and during his acceptance they had an elephant hold up a sign with the surface area of the scientist on it, they do showbiz better than the Oscars
Reposted by Pankaj Kapahi
Dr. Jane Goodall filmed an interview with Netflix in March 2025 that she understood would only be released after her death.
October 5, 2025 at 9:08 AM
Dr. Jane Goodall filmed an interview with Netflix in March 2025 that she understood would only be released after her death.
“How we spend our days is, of course, how we spend our lives.” Annie Dillard
October 2, 2025 at 1:12 PM
“How we spend our days is, of course, how we spend our lives.” Annie Dillard
Reposted by Pankaj Kapahi
Sad news: Jane Goodall has died. She did more than any other human for our understanding and appreciation of our closest relatives, the chimpanzees.
That chimpanzees are Endangered tells you everything about our species and about what made her so exceptional.
www.nytimes.com/2025/10/01/o...
That chimpanzees are Endangered tells you everything about our species and about what made her so exceptional.
www.nytimes.com/2025/10/01/o...
Jane Goodall, Eminent Primatologist Who Chronicled the Lives of Chimps, Dies at 91
www.nytimes.com
October 1, 2025 at 7:52 PM
Sad news: Jane Goodall has died. She did more than any other human for our understanding and appreciation of our closest relatives, the chimpanzees.
That chimpanzees are Endangered tells you everything about our species and about what made her so exceptional.
www.nytimes.com/2025/10/01/o...
That chimpanzees are Endangered tells you everything about our species and about what made her so exceptional.
www.nytimes.com/2025/10/01/o...
Reposted by Pankaj Kapahi
Wise cartoon posted outside a @princetonneuro.bsky.social PhD student office. Let’s all remember to enjoy the journey today (and all days).
October 1, 2025 at 11:07 AM
Wise cartoon posted outside a @princetonneuro.bsky.social PhD student office. Let’s all remember to enjoy the journey today (and all days).
Reposted by Pankaj Kapahi
Congratulations to Rachel Buckley @bucklr01.bsky.social on being a finalist for a National Association of Science Writers @sciencewriters.org award. Read Rachel's essay,
www.thetransmitter.org/sex-differen...
#neuroskyence
www.thetransmitter.org/sex-differen...
#neuroskyence
Brains, biases and amyloid beta: Why the female brain deserves a closer look in Alzheimer’s research
New results suggest the disease progresses differently in women, but we need more basic science to unpack the mechanisms involved.
www.thetransmitter.org
September 30, 2025 at 9:36 PM
Congratulations to Rachel Buckley @bucklr01.bsky.social on being a finalist for a National Association of Science Writers @sciencewriters.org award. Read Rachel's essay,
www.thetransmitter.org/sex-differen...
#neuroskyence
www.thetransmitter.org/sex-differen...
#neuroskyence
Reposted by Pankaj Kapahi
thank you to all the NIH staff who stand by their duty and put in heroic efforts to get it done. I'll never forget it and will be eternally grateful.
The fiscal year ends tomorrow.
Here are results from NIH Reporter downloaded an hour ago.
The total amount of funding committed for FY2025 at this point is 99.0% of that for FY2024. The same difference could be due to a variety of technical factors.
1/3
Here are results from NIH Reporter downloaded an hour ago.
The total amount of funding committed for FY2025 at this point is 99.0% of that for FY2024. The same difference could be due to a variety of technical factors.
1/3
September 29, 2025 at 6:31 PM
thank you to all the NIH staff who stand by their duty and put in heroic efforts to get it done. I'll never forget it and will be eternally grateful.
Reposted by Pankaj Kapahi
#vss365
The world may be going to Hell in a handbasket, but there are still beautiful sunsets, autumn colours, and birdsong.
And in any #eventuality, somewhat may, there will always be love.
The world may be going to Hell in a handbasket, but there are still beautiful sunsets, autumn colours, and birdsong.
And in any #eventuality, somewhat may, there will always be love.
September 24, 2025 at 7:23 AM
#vss365
The world may be going to Hell in a handbasket, but there are still beautiful sunsets, autumn colours, and birdsong.
And in any #eventuality, somewhat may, there will always be love.
The world may be going to Hell in a handbasket, but there are still beautiful sunsets, autumn colours, and birdsong.
And in any #eventuality, somewhat may, there will always be love.
Reposted by Pankaj Kapahi
Reviewed as a ‘fundamental’ discovery, this study identifies lymphatic muscle cells as innate pacemakers driving lymphatic pumping.
buff.ly/kWvdl5i
buff.ly/kWvdl5i
September 20, 2025 at 10:44 PM
Reviewed as a ‘fundamental’ discovery, this study identifies lymphatic muscle cells as innate pacemakers driving lymphatic pumping.
buff.ly/kWvdl5i
buff.ly/kWvdl5i
Reposted by Pankaj Kapahi
about the $100K H1B fee, here's some interesting details: "If an employee is in the U.S., he or she will not be subject if (i) applying to extend or amend H-1B status, or (ii) applying to change from another visa category into H-1B status from within the U.S."
September 20, 2025 at 6:17 PM
about the $100K H1B fee, here's some interesting details: "If an employee is in the U.S., he or she will not be subject if (i) applying to extend or amend H-1B status, or (ii) applying to change from another visa category into H-1B status from within the U.S."
Reposted by Pankaj Kapahi
Early #puberty and early childbirth may come with a cost. Study in @elife.bsky.social shows reproductive timing can accelerate aging and disease, quadrupling the risk of severe metabolic disorders. Congrats @pkapahi.bsky.social www.buckinstitute.org/news/early-p...
Early puberty and early childbirth may come with a cost
Reproductive timing can accelerate aging and disease
www.buckinstitute.org
August 18, 2025 at 5:59 PM
Early #puberty and early childbirth may come with a cost. Study in @elife.bsky.social shows reproductive timing can accelerate aging and disease, quadrupling the risk of severe metabolic disorders. Congrats @pkapahi.bsky.social www.buckinstitute.org/news/early-p...
Reposted by Pankaj Kapahi
RESEARCH | 🧪
S Bar, @pkapahi.bsky.social et al
@buckinstitute.org
Neuronal glycogen feeds the pentose phosphate pathway and contributes to redox homeostasis, thus counteracting tauopathy-associated oxidative stress in Drosophila melanogaster
www.nature.com/articles/s42...
S Bar, @pkapahi.bsky.social et al
@buckinstitute.org
Neuronal glycogen feeds the pentose phosphate pathway and contributes to redox homeostasis, thus counteracting tauopathy-associated oxidative stress in Drosophila melanogaster
www.nature.com/articles/s42...
Neuronal glycogen breakdown mitigates tauopathy via pentose-phosphate-pathway-mediated oxidative stress reduction - Nature Metabolism
Bar et al. show that neuronal glycogen feeds the pentose phosphate pathway and contributes to redox homeostasis, thus counteracting tauopathy-associated oxidative stress in Drosophila melanogaster.
www.nature.com
August 7, 2025 at 2:08 PM
RESEARCH | 🧪
S Bar, @pkapahi.bsky.social et al
@buckinstitute.org
Neuronal glycogen feeds the pentose phosphate pathway and contributes to redox homeostasis, thus counteracting tauopathy-associated oxidative stress in Drosophila melanogaster
www.nature.com/articles/s42...
S Bar, @pkapahi.bsky.social et al
@buckinstitute.org
Neuronal glycogen feeds the pentose phosphate pathway and contributes to redox homeostasis, thus counteracting tauopathy-associated oxidative stress in Drosophila melanogaster
www.nature.com/articles/s42...
Reposted by Pankaj Kapahi
Neurons burn #sugar differently. The discovery from the Kapahi lab could save the brain. Study in Nature Metabolism
provides new approach in #Alzheimers research and could explain why #GLP1 drugs show promise against #dementia buckinstitute.org/news/neurons...
@pkapahi.bsky.social
provides new approach in #Alzheimers research and could explain why #GLP1 drugs show promise against #dementia buckinstitute.org/news/neurons...
@pkapahi.bsky.social
Neurons burn sugar differently. The discovery could save the brain.
In addition to a new approach in Alzheimer’s research, study from Buck Institute could explain why GLP-1 drugs show promise against dementia.
buckinstitute.org
June 30, 2025 at 2:19 PM
Neurons burn #sugar differently. The discovery from the Kapahi lab could save the brain. Study in Nature Metabolism
provides new approach in #Alzheimers research and could explain why #GLP1 drugs show promise against #dementia buckinstitute.org/news/neurons...
@pkapahi.bsky.social
provides new approach in #Alzheimers research and could explain why #GLP1 drugs show promise against #dementia buckinstitute.org/news/neurons...
@pkapahi.bsky.social
Reposted by Pankaj Kapahi
Cannot emphasize this too strongly.
So: In 2017, Congress made this happen:
NIH: Proposed 22% cut --> 9% increase
NSF: Proposed 11% cut --> 4% increase
NOAA: Proposed 16% cut --> 4% increase
Obviously, 2025 is not 2017. A lot is diff now. But still:
💰 Congress, not WH, sets budgets.
📞 Public support & calls to Congress matter.
NIH: Proposed 22% cut --> 9% increase
NSF: Proposed 11% cut --> 4% increase
NOAA: Proposed 16% cut --> 4% increase
Obviously, 2025 is not 2017. A lot is diff now. But still:
💰 Congress, not WH, sets budgets.
📞 Public support & calls to Congress matter.
May 2, 2025 at 9:25 PM
Cannot emphasize this too strongly.
